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The map label for this gene is menE [H]

Identifier: 57650582

GI number: 57650582

Start: 1898269

End: 1899747

Strand: Reverse

Name: menE [H]

Synonym: SACOL1844

Alternate gene names: 57650582

Gene position: 1899747-1898269 (Counterclockwise)

Preceding gene: 57650583

Following gene: 57650581

Centisome position: 67.62

GC content: 35.97

Gene sequence:

>1479_bases
ATGGACTTTTGGTTATATAAACAAGCACAACAAAATGGACATCATATTGCGATAACAGACGGTCAAGAATCTTATACTTA
TCAAAATTTATACTGTGAAGCGAGTCTATTGGCTAAAAGACTCAAGGCTTATCAACAATCTCGTGTTGGGCTATACATAG
ATAATTCGATTCAATCGATCATTTTAATACATGCATGTTGGTTGGCAAATATTGAAATTGCGATGATTAATACAAGGTTG
ACACCTAATGAGATGACGAATCAGATGAAGTCAATCGATGTACAATTGATTTTTTGTACCTTGCCACTGGAATTACGAGG
GTTTCAAATTGTATCGCTGGATGATATTGAATTCGCTGGAAGGGATATTACAACGAACAGTTTGTTGGACAACACAATGG
GTATCCAATATGAAACATCGAATGAAACTGTGGTGCCGAAAGAGTCGCCGTCCAACATATTAAATACATCATTTAATTTA
GATGACATTGCATCGATTATGTTTACATCAGGGACAACGGGCCCTCAAAAAGCGGTGCCACAAACGTTTCGTAATCATTA
TGCCAGTGCAATCGGATGTAAAGAGAGCTTGGGATTTGATCGTGACACTAATTGGCTATCTGTCTTGCCGATTTATCATA
TTTCGGGTCTCAGTGTACTTTTAAGAGCTGTTATTGAAGGTTTTACTGTGCGCATTGTTGATAAATTCAATGCCGAACAA
ATTTTAACGATGATTAAAAATGAACGAATCACGCACATTTCGCTTGTGCCACAAACTTTAAATTGGCTTATGCAACAAGG
TTTACATGAACCTTATAATTTACAAAAAATATTACTCGGCGGTGCTAAATTATCTGCCACTATGATAGAGACGGCATTAC
AATATAACCTGCCAATTTATAATTCATTTGGTATGACTGAGACATGTTCGCAATTTTTAACAGCAACACCGGAAATGTTG
CATGCACGTCCTGACACTGTAGGGATGCCAAGTGCCAATGTTGACGTAAAAATTAAAAATCCTAATAAAGAAGGTCATGG
AGAATTAATGATTAAAGGCGCCAATGTGATGAATGTATATTTGTATCCAACAGATTTAACGGGTACGTTTGAAAATGGTT
ATTTTAATACGGGTGACATTGCTGAAATAGATCATGAAGGTTATGTCATGATTTATGACCGACGTAAAGATTTAATTATT
AGTGGCGGTGAAAATATTTATCCATATCAAATTGAAACGGTAGCGAAGCAATTTCCAGGTATCAGTGACGCAGTATGTGT
AGGGCATCCTGATGATACTTGGGGCCAAGTGCCTAAATTATATTTTGTCAGTGAAAGTGACATTTCAAAGGCACAATTGA
TTGCATATTTATCACAACATTTAGCGAAATATAAAGTACCGAAACACTTTGAAAAGGTTGATACTTTACCTTATACATCA
ACAGGTAAATTACAAAGAAATAAGTTGTATAGAGGATGA

Upstream 100 bases:

>100_bases
CATCAATTCGTCTACTTTTTTATATTTTTAAACATAACCACTGCTAGAATGTCATAAAATCGTTATAATTATAATGTAAA
TGATTTTGGAGGAATAACGC

Downstream 100 bases:

>100_bases
TTTGATGAAGTTGACAGCTTTGCATTTTTATAAATATAGTGAGCCATTTAAGTCACAAATTGTAACACCGAAAGTCACTT
TAACGCATCGTGATTGTTTG

Product: O-succinylbenzoic acid--CoA ligase

Products: NA

Alternate protein names: OSB-CoA synthetase; o-succinylbenzoyl-CoA synthetase [H]

Number of amino acids: Translated: 492; Mature: 492

Protein sequence:

>492_residues
MDFWLYKQAQQNGHHIAITDGQESYTYQNLYCEASLLAKRLKAYQQSRVGLYIDNSIQSIILIHACWLANIEIAMINTRL
TPNEMTNQMKSIDVQLIFCTLPLELRGFQIVSLDDIEFAGRDITTNSLLDNTMGIQYETSNETVVPKESPSNILNTSFNL
DDIASIMFTSGTTGPQKAVPQTFRNHYASAIGCKESLGFDRDTNWLSVLPIYHISGLSVLLRAVIEGFTVRIVDKFNAEQ
ILTMIKNERITHISLVPQTLNWLMQQGLHEPYNLQKILLGGAKLSATMIETALQYNLPIYNSFGMTETCSQFLTATPEML
HARPDTVGMPSANVDVKIKNPNKEGHGELMIKGANVMNVYLYPTDLTGTFENGYFNTGDIAEIDHEGYVMIYDRRKDLII
SGGENIYPYQIETVAKQFPGISDAVCVGHPDDTWGQVPKLYFVSESDISKAQLIAYLSQHLAKYKVPKHFEKVDTLPYTS
TGKLQRNKLYRG

Sequences:

>Translated_492_residues
MDFWLYKQAQQNGHHIAITDGQESYTYQNLYCEASLLAKRLKAYQQSRVGLYIDNSIQSIILIHACWLANIEIAMINTRL
TPNEMTNQMKSIDVQLIFCTLPLELRGFQIVSLDDIEFAGRDITTNSLLDNTMGIQYETSNETVVPKESPSNILNTSFNL
DDIASIMFTSGTTGPQKAVPQTFRNHYASAIGCKESLGFDRDTNWLSVLPIYHISGLSVLLRAVIEGFTVRIVDKFNAEQ
ILTMIKNERITHISLVPQTLNWLMQQGLHEPYNLQKILLGGAKLSATMIETALQYNLPIYNSFGMTETCSQFLTATPEML
HARPDTVGMPSANVDVKIKNPNKEGHGELMIKGANVMNVYLYPTDLTGTFENGYFNTGDIAEIDHEGYVMIYDRRKDLII
SGGENIYPYQIETVAKQFPGISDAVCVGHPDDTWGQVPKLYFVSESDISKAQLIAYLSQHLAKYKVPKHFEKVDTLPYTS
TGKLQRNKLYRG
>Mature_492_residues
MDFWLYKQAQQNGHHIAITDGQESYTYQNLYCEASLLAKRLKAYQQSRVGLYIDNSIQSIILIHACWLANIEIAMINTRL
TPNEMTNQMKSIDVQLIFCTLPLELRGFQIVSLDDIEFAGRDITTNSLLDNTMGIQYETSNETVVPKESPSNILNTSFNL
DDIASIMFTSGTTGPQKAVPQTFRNHYASAIGCKESLGFDRDTNWLSVLPIYHISGLSVLLRAVIEGFTVRIVDKFNAEQ
ILTMIKNERITHISLVPQTLNWLMQQGLHEPYNLQKILLGGAKLSATMIETALQYNLPIYNSFGMTETCSQFLTATPEML
HARPDTVGMPSANVDVKIKNPNKEGHGELMIKGANVMNVYLYPTDLTGTFENGYFNTGDIAEIDHEGYVMIYDRRKDLII
SGGENIYPYQIETVAKQFPGISDAVCVGHPDDTWGQVPKLYFVSESDISKAQLIAYLSQHLAKYKVPKHFEKVDTLPYTS
TGKLQRNKLYRG

Specific function: Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl- CoA (OSB-CoA) [H]

COG id: COG0318

COG function: function code IQ; Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II

Gene ontology:

Cell location: Partially Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily [H]

Homologues:

Organism=Homo sapiens, GI42544132, Length=362, Percent_Identity=25.6906077348066, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI115511026, Length=380, Percent_Identity=27.1052631578947, Blast_Score=106, Evalue=6e-23,
Organism=Homo sapiens, GI38505220, Length=362, Percent_Identity=27.6243093922652, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI187761345, Length=551, Percent_Identity=23.4119782214156, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI187761343, Length=551, Percent_Identity=23.4119782214156, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI156151445, Length=354, Percent_Identity=25.1412429378531, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI157311624, Length=361, Percent_Identity=26.0387811634349, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI157311622, Length=361, Percent_Identity=26.0387811634349, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI58082049, Length=361, Percent_Identity=25.7617728531856, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI122937307, Length=268, Percent_Identity=27.9850746268657, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI27477105, Length=158, Percent_Identity=32.9113924050633, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI1788107, Length=503, Percent_Identity=26.2425447316103, Blast_Score=139, Evalue=5e-34,
Organism=Escherichia coli, GI145693145, Length=531, Percent_Identity=25.2354048964218, Blast_Score=133, Evalue=3e-32,
Organism=Escherichia coli, GI1786810, Length=349, Percent_Identity=27.7936962750716, Blast_Score=122, Evalue=7e-29,
Organism=Escherichia coli, GI1788595, Length=309, Percent_Identity=29.126213592233, Blast_Score=120, Evalue=3e-28,
Organism=Escherichia coli, GI221142682, Length=467, Percent_Identity=26.1241970021413, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI1789201, Length=489, Percent_Identity=23.5173824130879, Blast_Score=100, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17538037, Length=372, Percent_Identity=28.494623655914, Blast_Score=136, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17557194, Length=372, Percent_Identity=27.6881720430108, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17559526, Length=362, Percent_Identity=27.3480662983425, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17558820, Length=473, Percent_Identity=27.2727272727273, Blast_Score=119, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI32563687, Length=385, Percent_Identity=27.7922077922078, Blast_Score=116, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17560308, Length=519, Percent_Identity=25.0481695568401, Blast_Score=115, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI71996755, Length=466, Percent_Identity=25.3218884120172, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17531443, Length=474, Percent_Identity=27.2151898734177, Blast_Score=109, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI71994694, Length=348, Percent_Identity=25.8620689655172, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71994690, Length=348, Percent_Identity=25.8620689655172, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71994703, Length=348, Percent_Identity=25.8620689655172, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17560140, Length=528, Percent_Identity=22.3484848484848, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI71985884, Length=346, Percent_Identity=26.878612716763, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI25141359, Length=469, Percent_Identity=25.7995735607676, Blast_Score=95, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI17556356, Length=260, Percent_Identity=25, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6319699, Length=340, Percent_Identity=29.7058823529412, Blast_Score=129, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6319264, Length=554, Percent_Identity=20.5776173285199, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24581924, Length=355, Percent_Identity=28.7323943661972, Blast_Score=108, Evalue=9e-24,
Organism=Drosophila melanogaster, GI21355181, Length=512, Percent_Identity=22.65625, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI18859661, Length=516, Percent_Identity=25.1937984496124, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI20130357, Length=475, Percent_Identity=24.2105263157895, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21356947, Length=358, Percent_Identity=24.8603351955307, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24648260, Length=348, Percent_Identity=25.5747126436782, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24648257, Length=452, Percent_Identity=22.3451327433628, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24656500, Length=354, Percent_Identity=24.2937853107345, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17933690, Length=140, Percent_Identity=34.2857142857143, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24653035, Length=472, Percent_Identity=22.4576271186441, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI19921316, Length=161, Percent_Identity=31.6770186335404, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI21355225, Length=542, Percent_Identity=20.2952029520295, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI161076582, Length=479, Percent_Identity=22.1294363256785, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000873
- InterPro:   IPR010192
- InterPro:   IPR023015 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.26 [H]

Molecular weight: Translated: 55416; Mature: 55416

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFWLYKQAQQNGHHIAITDGQESYTYQNLYCEASLLAKRLKAYQQSRVGLYIDNSIQSI
CCCEEEEHHHCCCCEEEEECCCCCCEEEHEEECHHHHHHHHHHHHHCCCEEEECCCHHHH
ILIHACWLANIEIAMINTRLTPNEMTNQMKSIDVQLIFCTLPLELRGFQIVSLDDIEFAG
HHHHHHHHCCEEEEEEEECCCHHHHHHHHHHCEEEEEEEECCEEECCEEEEEECCCHHCC
RDITTNSLLDNTMGIQYETSNETVVPKESPSNILNTSFNLDDIASIMFTSGTTGPQKAVP
CCCCCHHHHHCCCCCEEECCCCEECCCCCCCCHHCCCCCHHHHHHHHEECCCCCCHHHHH
QTFRNHYASAIGCKESLGFDRDTNWLSVLPIYHISGLSVLLRAVIEGFTVRIVDKFNAEQ
HHHHHHHHHHCCCHHHCCCCCCCCEEEEEEEHHHHHHHHHHHHHHCCCEEEEEECCCHHH
ILTMIKNERITHISLVPQTLNWLMQQGLHEPYNLQKILLGGAKLSATMIETALQYNLPIY
HHHHHHCCCEEEEEECHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHHCCCEE
NSFGMTETCSQFLTATPEMLHARPDTVGMPSANVDVKIKNPNKEGHGELMIKGANVMNVY
ECCCCHHHHHHHHHCCHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCEEEEECCCEEEEE
LYPTDLTGTFENGYFNTGDIAEIDHEGYVMIYDRRKDLIISGGENIYPYQIETVAKQFPG
EEECCCCCCCCCCCCCCCCCEEECCCCEEEEEECCCEEEEECCCEECCCHHHHHHHHCCC
ISDAVCVGHPDDTWGQVPKLYFVSESDISKAQLIAYLSQHLAKYKVPKHFEKVDTLPYTS
CCCEEEECCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCC
TGKLQRNKLYRG
CCCHHCCCCCCC
>Mature Secondary Structure
MDFWLYKQAQQNGHHIAITDGQESYTYQNLYCEASLLAKRLKAYQQSRVGLYIDNSIQSI
CCCEEEEHHHCCCCEEEEECCCCCCEEEHEEECHHHHHHHHHHHHHCCCEEEECCCHHHH
ILIHACWLANIEIAMINTRLTPNEMTNQMKSIDVQLIFCTLPLELRGFQIVSLDDIEFAG
HHHHHHHHCCEEEEEEEECCCHHHHHHHHHHCEEEEEEEECCEEECCEEEEEECCCHHCC
RDITTNSLLDNTMGIQYETSNETVVPKESPSNILNTSFNLDDIASIMFTSGTTGPQKAVP
CCCCCHHHHHCCCCCEEECCCCEECCCCCCCCHHCCCCCHHHHHHHHEECCCCCCHHHHH
QTFRNHYASAIGCKESLGFDRDTNWLSVLPIYHISGLSVLLRAVIEGFTVRIVDKFNAEQ
HHHHHHHHHHCCCHHHCCCCCCCCEEEEEEEHHHHHHHHHHHHHHCCCEEEEEECCCHHH
ILTMIKNERITHISLVPQTLNWLMQQGLHEPYNLQKILLGGAKLSATMIETALQYNLPIY
HHHHHHCCCEEEEEECHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHHCCCEE
NSFGMTETCSQFLTATPEMLHARPDTVGMPSANVDVKIKNPNKEGHGELMIKGANVMNVY
ECCCCHHHHHHHHHCCHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCEEEEECCCEEEEE
LYPTDLTGTFENGYFNTGDIAEIDHEGYVMIYDRRKDLIISGGENIYPYQIETVAKQFPG
EEECCCCCCCCCCCCCCCCCEEECCCCEEEEEECCCEEEEECCCEECCCHHHHHHHHCCC
ISDAVCVGHPDDTWGQVPKLYFVSESDISKAQLIAYLSQHLAKYKVPKHFEKVDTLPYTS
CCCEEEECCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCC
TGKLQRNKLYRG
CCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA