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The map label for this gene is tcpJ [H]

Identifier: 57650534

GI number: 57650534

Start: 1737375

End: 1738082

Strand: Reverse

Name: tcpJ [H]

Synonym: SACOL1708

Alternate gene names: 57650534

Gene position: 1738082-1737375 (Counterclockwise)

Preceding gene: 57650535

Following gene: 57650533

Centisome position: 61.87

GC content: 28.39

Gene sequence:

>708_bases
TTGGTAGTATTGTTATCTTATAGTTGCAGTTGTATTTTTAGTTTTCTATATCAATTTATATCTATAGAAGAAACGTCATT
TGATTATTTACATAGAAGATCGAAATGTGATTATTGTAATTCGTCACTCAAATGGTATGAATTAATGCCGATTATTAGTT
TTTTATTATTAAAAGGGCGATGTCGAAACTGTCGAAAGCGTATTTCCCTAACACATTTCTTAGGGGAAACCTTTGCTTTA
ATACCTATCGTCTTTATTAAGTATGATTTCACATACGTAAATGCTACGCTATTTATAACTACATATGTTTTTCTGCTTAT
TTTTACTATGACCGATATCACTTCTTTAATGTTAGATTGTCGCTTAATTATAATTTATTGTATCGTTTCTCTCTCGTTAA
GTATGATTTATCCAGTAGCTTTTATCATTATTAGTATGACCACGCATATATTCTACTTTTTATTTCGGGCATATATTGGT
TATGGTGACGTTTTACTAATATCTGCACTTTCTTTGTTTTTCCCTCTCCAATTCACTATTTATGTCATTTTATTTACATT
TGTCATTGCTGGTTTAGTTGCTTTAATTACCATGATATTTAAGCCGATTAAACTATTACCCCTTGTTCCATTTATATTTA
TTTCCTTTTTTATCAATTCACTTTTTTATAATGATATCCATCAATTTTTAGGAGGCGTATATTTTTGA

Upstream 100 bases:

>100_bases
ATTGAAAAATTTAAATGAAAAAGCGGTTCAATTCTTGAAAAATAGTGTATATTTACATTTTGGTAATAACTAACTATAAT
TTACATAAGGAGGTTGTCAT

Downstream 100 bases:

>100_bases
AAATTAAAGAAATGGTAACTTCAGAAATGCCAAGAGAACGTTTGTTAAGCCATGGTGCAAAAAGTCTTTCGAATACAGAA
TTATTAGCTATATTAATTAA

Product: type III leader peptidase family protein

Products: NA

Alternate protein names: Leader peptidase; Prepilin peptidase; N-methyltransferase [H]

Number of amino acids: Translated: 235; Mature: 235

Protein sequence:

>235_residues
MVVLLSYSCSCIFSFLYQFISIEETSFDYLHRRSKCDYCNSSLKWYELMPIISFLLLKGRCRNCRKRISLTHFLGETFAL
IPIVFIKYDFTYVNATLFITTYVFLLIFTMTDITSLMLDCRLIIIYCIVSLSLSMIYPVAFIIISMTTHIFYFLFRAYIG
YGDVLLISALSLFFPLQFTIYVILFTFVIAGLVALITMIFKPIKLLPLVPFIFISFFINSLFYNDIHQFLGGVYF

Sequences:

>Translated_235_residues
MVVLLSYSCSCIFSFLYQFISIEETSFDYLHRRSKCDYCNSSLKWYELMPIISFLLLKGRCRNCRKRISLTHFLGETFAL
IPIVFIKYDFTYVNATLFITTYVFLLIFTMTDITSLMLDCRLIIIYCIVSLSLSMIYPVAFIIISMTTHIFYFLFRAYIG
YGDVLLISALSLFFPLQFTIYVILFTFVIAGLVALITMIFKPIKLLPLVPFIFISFFINSLFYNDIHQFLGGVYF
>Mature_235_residues
MVVLLSYSCSCIFSFLYQFISIEETSFDYLHRRSKCDYCNSSLKWYELMPIISFLLLKGRCRNCRKRISLTHFLGETFAL
IPIVFIKYDFTYVNATLFITTYVFLLIFTMTDITSLMLDCRLIIIYCIVSLSLSMIYPVAFIIISMTTHIFYFLFRAYIG
YGDVLLISALSLFFPLQFTIYVILFTFVIAGLVALITMIFKPIKLLPLVPFIFISFFINSLFYNDIHQFLGGVYF

Specific function: Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue. Processes the tcpA pilin precursor during membrane translocation [H]

COG id: COG1989

COG function: function code NOU; Type II secretory pathway, prepilin signal peptidase PulO and related peptidases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A24 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010627
- InterPro:   IPR014032
- InterPro:   IPR000045 [H]

Pfam domain/function: PF06750 DiS_P_DiS; PF01478 Peptidase_A24 [H]

EC number: =3.4.23.43 [H]

Molecular weight: Translated: 27505; Mature: 27505

Theoretical pI: Translated: 8.36; Mature: 8.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVLLSYSCSCIFSFLYQFISIEETSFDYLHRRSKCDYCNSSLKWYELMPIISFLLLKGR
CEEEEECHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHCCCHHHHHHHHHHHHHHHHHH
CRNCRKRISLTHFLGETFALIPIVFIKYDFTYVNATLFITTYVFLLIFTMTDITSLMLDC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLIIIYCIVSLSLSMIYPVAFIIISMTTHIFYFLFRAYIGYGDVLLISALSLFFPLQFTI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
YVILFTFVIAGLVALITMIFKPIKLLPLVPFIFISFFINSLFYNDIHQFLGGVYF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MVVLLSYSCSCIFSFLYQFISIEETSFDYLHRRSKCDYCNSSLKWYELMPIISFLLLKGR
CEEEEECHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHCCCHHHHHHHHHHHHHHHHHH
CRNCRKRISLTHFLGETFALIPIVFIKYDFTYVNATLFITTYVFLLIFTMTDITSLMLDC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLIIIYCIVSLSLSMIYPVAFIIISMTTHIFYFLFRAYIGYGDVLLISALSLFFPLQFTI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
YVILFTFVIAGLVALITMIFKPIKLLPLVPFIFISFFINSLFYNDIHQFLGGVYF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1680773; 7894059; 11179381 [H]