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The map label for this gene is iscS1 [H]

Identifier: 57650504

GI number: 57650504

Start: 1706920

End: 1708062

Strand: Reverse

Name: iscS1 [H]

Synonym: SACOL1677

Alternate gene names: 57650504

Gene position: 1708062-1706920 (Counterclockwise)

Preceding gene: 57650506

Following gene: 57650503

Centisome position: 60.8

GC content: 34.73

Gene sequence:

>1143_bases
ATGGAAATTTATGCAGATTATGCTGCGACCACACCAGTAAAACCTGAAGTAGTAGATGCGATGATGACGATTTACAATTC
GCATTATGGTAATCCATCATCAATACATGCTAAGGGAAGAGATGCGCGTAAATATTTAGATGAGTCAAGACGTCAAATTG
CACAATTACTTGGTGCAGATACACATGAAATTATATTTACGAGTGGCGCAACAGAATCGAATAATACGGCAATTAAAGGC
ATAGTAAAAGCAAATGAACAATTGGGTAATCACATTATCACATCGAAGATTGAACATCATTCTGTGTTACATGTTTTTGA
ACAATTAGAGCGAGAAGGTTTTGATGTAACATATCTAGATGTTGATGATACAGGTGCTATTGATTTAGATCAACTTGAAG
AAACAATTACAGATAAGACGATTTTAGTATCTATTATGTTTGTAAATAATGAAGTTGGCACAGTGCAACAAATTTATGAT
ATTCAAGATATTATTGCTGAGACAAATGCATATTTCCATGTTGATGCGGTTCAAGCAATTGGACATCTTGATGTTAAGTT
TGACGAATTTGAGATCGACGCAATGAGTATTACTGCTCATAAGTTTGGCGGACCAAAAGGTGTCGGTGCATTACTAGTTA
AAGACCATGTTACACTAGATTATCCTCAACTTGGCGGTGAACAAGAATTGAAACGCCGTGCAGGCACTGAAAATCTTGCG
CAAATTGTTGGGATGGCTAAAGCATTACAATTAGCAGAAAAGAATCGAGACGATAACAATATTCATTTAATGAATTTAAA
AGAACAATTTTTAGTTAAATTACAAGAAAGAGCGATTCCATTTGAATTAAATGGTTCAATGACGGATGCTACAGGCCATA
TTGTAAATCTATATTTTCCGTTTGTTGAAGTTGAAACGATGTTAACATTGTTGGATATGGCACAAATCTATGTGTCGTCT
GGATCTGCATGTACAGCAGGCTCTACACAACCGTCGCATGTTTTAGATGCAATGTTCGAAGATGAGGAGCGATCAAATCA
TTCGATTCGATTTAGTTTTAACGAATTGACTACTGAAAATGAAATTAATGCAATTGTAGCTGAAATTCATAAAATATATT
TTAAATTTAAGGAGGAGTCATAA

Upstream 100 bases:

>100_bases
AATTAAAAACATTATAAATAAAGTTAAACAGAAAAGTAGAAAAATAGTATGTAAGGTGCTATTATTGGAACATTGATAAA
ATTGTGAGGAGTGTCCAAAC

Downstream 100 bases:

>100_bases
TTGTCAAATAAAGATATACGTGTTGTCGTTGGTATGTCAGGCGGTGTAGATAGTTCTGTAACAGCCCACGTCTTAAAAGA
ACAAGGTTATGATGTCATTG

Product: aminotransferase, class V

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 380; Mature: 380

Protein sequence:

>380_residues
MEIYADYAATTPVKPEVVDAMMTIYNSHYGNPSSIHAKGRDARKYLDESRRQIAQLLGADTHEIIFTSGATESNNTAIKG
IVKANEQLGNHIITSKIEHHSVLHVFEQLEREGFDVTYLDVDDTGAIDLDQLEETITDKTILVSIMFVNNEVGTVQQIYD
IQDIIAETNAYFHVDAVQAIGHLDVKFDEFEIDAMSITAHKFGGPKGVGALLVKDHVTLDYPQLGGEQELKRRAGTENLA
QIVGMAKALQLAEKNRDDNNIHLMNLKEQFLVKLQERAIPFELNGSMTDATGHIVNLYFPFVEVETMLTLLDMAQIYVSS
GSACTAGSTQPSHVLDAMFEDEERSNHSIRFSFNELTTENEINAIVAEIHKIYFKFKEES

Sequences:

>Translated_380_residues
MEIYADYAATTPVKPEVVDAMMTIYNSHYGNPSSIHAKGRDARKYLDESRRQIAQLLGADTHEIIFTSGATESNNTAIKG
IVKANEQLGNHIITSKIEHHSVLHVFEQLEREGFDVTYLDVDDTGAIDLDQLEETITDKTILVSIMFVNNEVGTVQQIYD
IQDIIAETNAYFHVDAVQAIGHLDVKFDEFEIDAMSITAHKFGGPKGVGALLVKDHVTLDYPQLGGEQELKRRAGTENLA
QIVGMAKALQLAEKNRDDNNIHLMNLKEQFLVKLQERAIPFELNGSMTDATGHIVNLYFPFVEVETMLTLLDMAQIYVSS
GSACTAGSTQPSHVLDAMFEDEERSNHSIRFSFNELTTENEINAIVAEIHKIYFKFKEES
>Mature_380_residues
MEIYADYAATTPVKPEVVDAMMTIYNSHYGNPSSIHAKGRDARKYLDESRRQIAQLLGADTHEIIFTSGATESNNTAIKG
IVKANEQLGNHIITSKIEHHSVLHVFEQLEREGFDVTYLDVDDTGAIDLDQLEETITDKTILVSIMFVNNEVGTVQQIYD
IQDIIAETNAYFHVDAVQAIGHLDVKFDEFEIDAMSITAHKFGGPKGVGALLVKDHVTLDYPQLGGEQELKRRAGTENLA
QIVGMAKALQLAEKNRDDNNIHLMNLKEQFLVKLQERAIPFELNGSMTDATGHIVNLYFPFVEVETMLTLLDMAQIYVSS
GSACTAGSTQPSHVLDAMFEDEERSNHSIRFSFNELTTENEINAIVAEIHKIYFKFKEES

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=381, Percent_Identity=40.1574803149606, Blast_Score=286, Evalue=3e-77,
Organism=Homo sapiens, GI156713448, Length=416, Percent_Identity=30.0480769230769, Blast_Score=178, Evalue=6e-45,
Organism=Escherichia coli, GI48994898, Length=386, Percent_Identity=42.7461139896373, Blast_Score=285, Evalue=3e-78,
Organism=Escherichia coli, GI1789175, Length=392, Percent_Identity=26.2755102040816, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1787970, Length=267, Percent_Identity=25.8426966292135, Blast_Score=94, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI25143064, Length=365, Percent_Identity=42.7397260273973, Blast_Score=285, Evalue=2e-77,
Organism=Caenorhabditis elegans, GI17533177, Length=335, Percent_Identity=30.7462686567164, Blast_Score=133, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6319831, Length=370, Percent_Identity=41.0810810810811, Blast_Score=278, Evalue=1e-75,
Organism=Drosophila melanogaster, GI20129463, Length=382, Percent_Identity=41.6230366492147, Blast_Score=276, Evalue=2e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 42485; Mature: 42485

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIYADYAATTPVKPEVVDAMMTIYNSHYGNPSSIHAKGRDARKYLDESRRQIAQLLGAD
CEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHCCC
THEIIFTSGATESNNTAIKGIVKANEQLGNHIITSKIEHHSVLHVFEQLEREGFDVTYLD
CCEEEEECCCCCCCCCEEEHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
VDDTGAIDLDQLEETITDKTILVSIMFVNNEVGTVQQIYDIQDIIAETNAYFHVDAVQAI
CCCCCCCCHHHHHHHHCCCEEEEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEHHHHH
GHLDVKFDEFEIDAMSITAHKFGGPKGVGALLVKDHVTLDYPQLGGEQELKRRAGTENLA
CCCCEEECCEEEEEEEEEEECCCCCCCCCEEEEECCEEECCCCCCCHHHHHHHCCHHHHH
QIVGMAKALQLAEKNRDDNNIHLMNLKEQFLVKLQERAIPFELNGSMTDATGHIVNLYFP
HHHHHHHHHHHHHCCCCCCCEEEEECHHHHHHHHHHCCCCEEECCCCCCCCCCEEEEEEH
FVEVETMLTLLDMAQIYVSSGSACTAGSTQPSHVLDAMFEDEERSNHSIRFSFNELTTEN
HHHHHHHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHCCCCCCCCEEEEEEHHHCCCH
EINAIVAEIHKIYFKFKEES
HHHHHHHHHHHHHHEEECCC
>Mature Secondary Structure
MEIYADYAATTPVKPEVVDAMMTIYNSHYGNPSSIHAKGRDARKYLDESRRQIAQLLGAD
CEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHCCC
THEIIFTSGATESNNTAIKGIVKANEQLGNHIITSKIEHHSVLHVFEQLEREGFDVTYLD
CCEEEEECCCCCCCCCEEEHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
VDDTGAIDLDQLEETITDKTILVSIMFVNNEVGTVQQIYDIQDIIAETNAYFHVDAVQAI
CCCCCCCCHHHHHHHHCCCEEEEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEHHHHH
GHLDVKFDEFEIDAMSITAHKFGGPKGVGALLVKDHVTLDYPQLGGEQELKRRAGTENLA
CCCCEEECCEEEEEEEEEEECCCCCCCCCEEEEECCEEECCCCCCCHHHHHHHCCHHHHH
QIVGMAKALQLAEKNRDDNNIHLMNLKEQFLVKLQERAIPFELNGSMTDATGHIVNLYFP
HHHHHHHHHHHHHCCCCCCCEEEEECHHHHHHHHHHCCCCEEECCCCCCCCCCEEEEEEH
FVEVETMLTLLDMAQIYVSSGSACTAGSTQPSHVLDAMFEDEERSNHSIRFSFNELTTEN
HHHHHHHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHCCCCCCCCEEEEEEHHHCCCH
EINAIVAEIHKIYFKFKEES
HHHHHHHHHHHHHHEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]