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The map label for this gene is accC [H]

Identifier: 57650483

GI number: 57650483

Start: 1605947

End: 1607302

Strand: Reverse

Name: accC [H]

Synonym: SACOL1571

Alternate gene names: 57650483

Gene position: 1607302-1605947 (Counterclockwise)

Preceding gene: 57650484

Following gene: 57650482

Centisome position: 57.21

GC content: 36.28

Gene sequence:

>1356_bases
ATGAAAAAGGTTTTAATTGCAAATCGCGGTGAAATCGCAGTTAGGATTATTCGCGCTTGTCGTGATTTAGGCATCCAAAC
TGTTGCAATCTATTCTGAAGGGGATAAAGATGCGCTACATACTCAAATTGCTGATGAAGCATATTGCGTAGGTCCCACTT
TGTCTAAAGATTCATATTTAAATATTCCGAACATCTTATCTATTGCAACTTCTACAGGTTGTGATGGCGTTCATCCGGGT
TATGGCTTTTTAGCTGAAAATGCTGATTTTGCAGAATTATGCGAAGCATGCCAATTGAAGTTCATTGGACCAAGTTATCA
ATCTATCCAAAAAATGGGTATCAAAGATGTTGCTAAGGCAGAAATGATCAAAGCCAATGTTCCAGTTGTTCCTGGTAGTG
ACGGTTTAATGAAAGACGTCTCAGAAGCTAAGAAAATCGCCAAAAAAATTGGCTATCCGGTCATCATTAAAGCTACTGCT
GGCGGTGGCGGAAAAGGTATCCGTGTTGCTCGTGATGAAAAAGAACTTGAAACTGGCTTCCGAATGACAGAACAAGAAGC
TCAAACTGCATTTGGTAATGGTGGACTTTATATGGAGAAATTCATCGAAAACTTCCGCCATATTGAAATCCAAATTGTTG
GGGACAGCTATGGTAATGTAATTCATTTAGGAGAACGTGATTGTACAATTCAAAGACGTATGCAGAAATTAGTGGAAGAA
GCACCTTCCCCAATTTTAGATGATGAAACACGTCGTGAAATGGGAAATGCCGCAGTTCGTGCAGCGAAAGCTGTAAATTA
TGAAAATGCGGGAACAATTGAGTTTATATATGATTTAAATGATAATAAATTTTATTTTATGGAAATGAATACACGTATTC
AAGTAGAACATCCTGTAACTGAAATGGTAACAGGAATTGATTTAGTTAAATTACAATTACAAGTTGCTATGGGTGACGTG
TTACCGTATAAACAAGAAGATATTAAATTAACAGGACACGCAATTGAATTTAGAATTAATGCTGAAAATCCTTACAAGAA
CTTTATGCCATCACCAGGTAAAATTGAGCAATATCTTGCACCAGGTGGATATGGTGTTCGAATAGAGTCAGCATGTTATA
CTAATTATACGATACCGCCATATTATGATTCGATGGTAGCGAAATTAATCATACATGAACCGACACGAGATGAAGCGATT
ATGGCTGGCATTCGTGCACTAAGTGAATTTGTGGTTCTTGGTATTGATACAACTATTCCATTCCATATTAAATTATTGAA
TAACGATATATTTAGAAGCGGTAAATTTAATACAAACTTTTTAGAGCAAAATAGCATTATGAATGATGAAGGTTAA

Upstream 100 bases:

>100_bases
TTAATGAAATTCAAGCAGAAATTTCAGGTGAAATTGTTGAAATCTTAGTAGAAGACGGACAAATGGTAGAGTATGGCCAA
CCGTTATTTAAGGTGAAATA

Downstream 100 bases:

>100_bases
TAGGAGGTCAATCCATGGTCAAAGTAACTGATTATTCAAATTCAAAATTAGGTAAAGTAGAAATAGCGCCAGAAGTGCTA
TCTGTTATTGCAAGTATAGC

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A 1; ACC 1 [H]

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MKKVLIANRGEIAVRIIRACRDLGIQTVAIYSEGDKDALHTQIADEAYCVGPTLSKDSYLNIPNILSIATSTGCDGVHPG
YGFLAENADFAELCEACQLKFIGPSYQSIQKMGIKDVAKAEMIKANVPVVPGSDGLMKDVSEAKKIAKKIGYPVIIKATA
GGGGKGIRVARDEKELETGFRMTEQEAQTAFGNGGLYMEKFIENFRHIEIQIVGDSYGNVIHLGERDCTIQRRMQKLVEE
APSPILDDETRREMGNAAVRAAKAVNYENAGTIEFIYDLNDNKFYFMEMNTRIQVEHPVTEMVTGIDLVKLQLQVAMGDV
LPYKQEDIKLTGHAIEFRINAENPYKNFMPSPGKIEQYLAPGGYGVRIESACYTNYTIPPYYDSMVAKLIIHEPTRDEAI
MAGIRALSEFVVLGIDTTIPFHIKLLNNDIFRSGKFNTNFLEQNSIMNDEG

Sequences:

>Translated_451_residues
MKKVLIANRGEIAVRIIRACRDLGIQTVAIYSEGDKDALHTQIADEAYCVGPTLSKDSYLNIPNILSIATSTGCDGVHPG
YGFLAENADFAELCEACQLKFIGPSYQSIQKMGIKDVAKAEMIKANVPVVPGSDGLMKDVSEAKKIAKKIGYPVIIKATA
GGGGKGIRVARDEKELETGFRMTEQEAQTAFGNGGLYMEKFIENFRHIEIQIVGDSYGNVIHLGERDCTIQRRMQKLVEE
APSPILDDETRREMGNAAVRAAKAVNYENAGTIEFIYDLNDNKFYFMEMNTRIQVEHPVTEMVTGIDLVKLQLQVAMGDV
LPYKQEDIKLTGHAIEFRINAENPYKNFMPSPGKIEQYLAPGGYGVRIESACYTNYTIPPYYDSMVAKLIIHEPTRDEAI
MAGIRALSEFVVLGIDTTIPFHIKLLNNDIFRSGKFNTNFLEQNSIMNDEG
>Mature_451_residues
MKKVLIANRGEIAVRIIRACRDLGIQTVAIYSEGDKDALHTQIADEAYCVGPTLSKDSYLNIPNILSIATSTGCDGVHPG
YGFLAENADFAELCEACQLKFIGPSYQSIQKMGIKDVAKAEMIKANVPVVPGSDGLMKDVSEAKKIAKKIGYPVIIKATA
GGGGKGIRVARDEKELETGFRMTEQEAQTAFGNGGLYMEKFIENFRHIEIQIVGDSYGNVIHLGERDCTIQRRMQKLVEE
APSPILDDETRREMGNAAVRAAKAVNYENAGTIEFIYDLNDNKFYFMEMNTRIQVEHPVTEMVTGIDLVKLQLQVAMGDV
LPYKQEDIKLTGHAIEFRINAENPYKNFMPSPGKIEQYLAPGGYGVRIESACYTNYTIPPYYDSMVAKLIIHEPTRDEAI
MAGIRALSEFVVLGIDTTIPFHIKLLNNDIFRSGKFNTNFLEQNSIMNDEG

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=445, Percent_Identity=46.5168539325843, Blast_Score=432, Evalue=1e-121,
Organism=Homo sapiens, GI189095269, Length=441, Percent_Identity=50.5668934240363, Blast_Score=429, Evalue=1e-120,
Organism=Homo sapiens, GI65506442, Length=441, Percent_Identity=50.5668934240363, Blast_Score=429, Evalue=1e-120,
Organism=Homo sapiens, GI295821183, Length=441, Percent_Identity=50.5668934240363, Blast_Score=429, Evalue=1e-120,
Organism=Homo sapiens, GI106049528, Length=449, Percent_Identity=48.1069042316258, Blast_Score=416, Evalue=1e-116,
Organism=Homo sapiens, GI106049295, Length=449, Percent_Identity=48.1069042316258, Blast_Score=416, Evalue=1e-116,
Organism=Homo sapiens, GI106049292, Length=449, Percent_Identity=48.1069042316258, Blast_Score=416, Evalue=1e-116,
Organism=Homo sapiens, GI38679974, Length=504, Percent_Identity=31.547619047619, Blast_Score=237, Evalue=1e-62,
Organism=Homo sapiens, GI38679960, Length=504, Percent_Identity=31.547619047619, Blast_Score=237, Evalue=1e-62,
Organism=Homo sapiens, GI38679977, Length=504, Percent_Identity=31.547619047619, Blast_Score=237, Evalue=2e-62,
Organism=Homo sapiens, GI38679967, Length=504, Percent_Identity=31.547619047619, Blast_Score=237, Evalue=2e-62,
Organism=Homo sapiens, GI38679971, Length=504, Percent_Identity=31.547619047619, Blast_Score=237, Evalue=2e-62,
Organism=Homo sapiens, GI134142062, Length=504, Percent_Identity=31.1507936507937, Blast_Score=232, Evalue=4e-61,
Organism=Escherichia coli, GI1789654, Length=444, Percent_Identity=53.3783783783784, Blast_Score=463, Evalue=1e-131,
Organism=Caenorhabditis elegans, GI17567343, Length=441, Percent_Identity=46.9387755102041, Blast_Score=401, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI71987519, Length=442, Percent_Identity=45.9276018099548, Blast_Score=390, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI17562816, Length=447, Percent_Identity=44.9664429530201, Blast_Score=374, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI133931226, Length=498, Percent_Identity=30.1204819277108, Blast_Score=211, Evalue=6e-55,
Organism=Caenorhabditis elegans, GI71997163, Length=512, Percent_Identity=29.1015625, Blast_Score=208, Evalue=5e-54,
Organism=Caenorhabditis elegans, GI71997168, Length=512, Percent_Identity=29.1015625, Blast_Score=208, Evalue=5e-54,
Organism=Saccharomyces cerevisiae, GI6319685, Length=438, Percent_Identity=43.8356164383562, Blast_Score=384, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6319695, Length=447, Percent_Identity=44.0715883668904, Blast_Score=357, Evalue=2e-99,
Organism=Saccharomyces cerevisiae, GI6321376, Length=447, Percent_Identity=45.8612975391499, Blast_Score=355, Evalue=1e-98,
Organism=Saccharomyces cerevisiae, GI6324343, Length=509, Percent_Identity=31.6306483300589, Blast_Score=227, Evalue=3e-60,
Organism=Saccharomyces cerevisiae, GI6323863, Length=468, Percent_Identity=32.4786324786325, Blast_Score=225, Evalue=1e-59,
Organism=Drosophila melanogaster, GI24651757, Length=445, Percent_Identity=44.7191011235955, Blast_Score=417, Evalue=1e-117,
Organism=Drosophila melanogaster, GI281363050, Length=449, Percent_Identity=48.5523385300668, Blast_Score=409, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652224, Length=449, Percent_Identity=48.5523385300668, Blast_Score=409, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652222, Length=449, Percent_Identity=48.5523385300668, Blast_Score=409, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652220, Length=449, Percent_Identity=48.5523385300668, Blast_Score=409, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652218, Length=449, Percent_Identity=48.5523385300668, Blast_Score=409, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652212, Length=449, Percent_Identity=48.5523385300668, Blast_Score=408, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652210, Length=449, Percent_Identity=48.5523385300668, Blast_Score=408, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652214, Length=449, Percent_Identity=48.5523385300668, Blast_Score=408, Evalue=1e-114,
Organism=Drosophila melanogaster, GI19921944, Length=449, Percent_Identity=48.5523385300668, Blast_Score=408, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652216, Length=449, Percent_Identity=48.5523385300668, Blast_Score=408, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24651759, Length=407, Percent_Identity=43.980343980344, Blast_Score=373, Evalue=1e-103,
Organism=Drosophila melanogaster, GI161076407, Length=498, Percent_Identity=31.7269076305221, Blast_Score=229, Evalue=3e-60,
Organism=Drosophila melanogaster, GI24586460, Length=498, Percent_Identity=31.7269076305221, Blast_Score=229, Evalue=3e-60,
Organism=Drosophila melanogaster, GI161076409, Length=498, Percent_Identity=31.7269076305221, Blast_Score=229, Evalue=3e-60,
Organism=Drosophila melanogaster, GI24586458, Length=498, Percent_Identity=31.7269076305221, Blast_Score=229, Evalue=4e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 50050; Mature: 50050

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKVLIANRGEIAVRIIRACRDLGIQTVAIYSEGDKDALHTQIADEAYCVGPTLSKDSYL
CCEEEEECCCHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHCCCCEEECCCCCCCCCC
NIPNILSIATSTGCDGVHPGYGFLAENADFAELCEACQLKFIGPSYQSIQKMGIKDVAKA
CCCHHHHHHCCCCCCCCCCCCCEEECCCCHHHHHHHHCEEECCCCHHHHHHCCHHHHHHH
EMIKANVPVVPGSDGLMKDVSEAKKIAKKIGYPVIIKATAGGGGKGIRVARDEKELETGF
HHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEECCHHHHHHHC
RMTEQEAQTAFGNGGLYMEKFIENFRHIEIQIVGDSYGNVIHLGERDCTIQRRMQKLVEE
CCCHHHHHHHCCCCCCHHHHHHHCCCEEEEEEEECCCCCEEEECCCCCHHHHHHHHHHHH
APSPILDDETRREMGNAAVRAAKAVNYENAGTIEFIYDLNDNKFYFMEMNTRIQVEHPVT
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEEECCEEEEECCHH
EMVTGIDLVKLQLQVAMGDVLPYKQEDIKLTGHAIEFRINAENPYKNFMPSPGKIEQYLA
HHHCCCCEEEEEEEEHHHCCCCCCCCCEEEEEEEEEEEECCCCCHHHCCCCCCCHHHHCC
PGGYGVRIESACYTNYTIPPYYDSMVAKLIIHEPTRDEAIMAGIRALSEFVVLGIDTTIP
CCCCCEEEECEEEECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHEEEEEECCCCC
FHIKLLNNDIFRSGKFNTNFLEQNSIMNDEG
EEEEEECCHHHCCCCCCCCEECCCCCCCCCC
>Mature Secondary Structure
MKKVLIANRGEIAVRIIRACRDLGIQTVAIYSEGDKDALHTQIADEAYCVGPTLSKDSYL
CCEEEEECCCHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHCCCCEEECCCCCCCCCC
NIPNILSIATSTGCDGVHPGYGFLAENADFAELCEACQLKFIGPSYQSIQKMGIKDVAKA
CCCHHHHHHCCCCCCCCCCCCCEEECCCCHHHHHHHHCEEECCCCHHHHHHCCHHHHHHH
EMIKANVPVVPGSDGLMKDVSEAKKIAKKIGYPVIIKATAGGGGKGIRVARDEKELETGF
HHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEECCHHHHHHHC
RMTEQEAQTAFGNGGLYMEKFIENFRHIEIQIVGDSYGNVIHLGERDCTIQRRMQKLVEE
CCCHHHHHHHCCCCCCHHHHHHHCCCEEEEEEEECCCCCEEEECCCCCHHHHHHHHHHHH
APSPILDDETRREMGNAAVRAAKAVNYENAGTIEFIYDLNDNKFYFMEMNTRIQVEHPVT
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEEECCEEEEECCHH
EMVTGIDLVKLQLQVAMGDVLPYKQEDIKLTGHAIEFRINAENPYKNFMPSPGKIEQYLA
HHHCCCCEEEEEEEEHHHCCCCCCCCCEEEEEEEEEEEECCCCCHHHCCCCCCCHHHHCC
PGGYGVRIESACYTNYTIPPYYDSMVAKLIIHEPTRDEAIMAGIRALSEFVVLGIDTTIP
CCCCCEEEECEEEECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHEEEEEECCCCC
FHIKLLNNDIFRSGKFNTNFLEQNSIMNDEG
EEEEEECCHHHCCCCCCCCEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7592499; 8969508; 9384377 [H]