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The map label for this gene is hup

Identifier: 57650428

GI number: 57650428

Start: 1552269

End: 1552541

Strand: Reverse

Name: hup

Synonym: SACOL1513

Alternate gene names: 57650428

Gene position: 1552541-1552269 (Counterclockwise)

Preceding gene: 57650429

Following gene: 57650427

Centisome position: 55.26

GC content: 36.63

Gene sequence:

>273_bases
ATGAACAAAACAGATTTAATCAATGCAGTTGCAGAGCAAGCTGATTTAACTAAAAAAGAAGCTGGTTCAGCAGTAGATGC
TGTATTCGAATCAATCCAAAACTCACTTGCTAAAGGTGAAAAAGTACAATTAATTGGTTTCGGTAACTTTGAGGTACGTG
AACGTGCTGCACGTAAAGGTCGTAACCCTCAAACTGGTAAAGAAATTGATATCCCAGCAAGTAAAGTTCCAGCATTCAAA
GCTGGTAAAGCATTAAAAGATGCTGTAAAATAA

Upstream 100 bases:

>100_bases
TTTGCCACATAAATGATTGCGATTTATGTAATGCTTGTGTTAAAGTTTTACCATAATGATATAAACATATCATTATCAAA
CCTCAGGAGGTGAATGTCTA

Downstream 100 bases:

>100_bases
TTTTACTTAAAAAGCCCTGAATAAGGGCTTTTTATTTTGCTTTTAATACTTACAACCTGTACATAAATTGTAATGTTCTT
CTAAGTTTTTAATCTTTGGA

Product: DNA-binding protein HU

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 90; Mature: 90

Protein sequence:

>90_residues
MNKTDLINAVAEQADLTKKEAGSAVDAVFESIQNSLAKGEKVQLIGFGNFEVRERAARKGRNPQTGKEIDIPASKVPAFK
AGKALKDAVK

Sequences:

>Translated_90_residues
MNKTDLINAVAEQADLTKKEAGSAVDAVFESIQNSLAKGEKVQLIGFGNFEVRERAARKGRNPQTGKEIDIPASKVPAFK
AGKALKDAVK
>Mature_90_residues
MNKTDLINAVAEQADLTKKEAGSAVDAVFESIQNSLAKGEKVQLIGFGNFEVRERAARKGRNPQTGKEIDIPASKVPAFK
AGKALKDAVK

Specific function: Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions

COG id: COG0776

COG function: function code L; Bacterial nucleoid DNA-binding protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial histone-like protein family

Homologues:

Organism=Escherichia coli, GI1786644, Length=89, Percent_Identity=61.7977528089888, Blast_Score=114, Evalue=1e-27,
Organism=Escherichia coli, GI1790433, Length=90, Percent_Identity=58.8888888888889, Blast_Score=110, Evalue=2e-26,
Organism=Escherichia coli, GI1787141, Length=88, Percent_Identity=39.7727272727273, Blast_Score=77, Evalue=3e-16,
Organism=Escherichia coli, GI1788005, Length=90, Percent_Identity=38.8888888888889, Blast_Score=75, Evalue=8e-16,

Paralogues:

None

Copy number: 860 Molecules/Cell In: Growth-Phase, Minimal Media (Based on E. coli). 2040 Molecules/Cell In: Stationary-Phase, Rich-Media (Based on E. coli). [C]

Swissprot (AC and ID): DBH_STAAC (Q5HFV0)

Other databases:

- EMBL:   CP000046
- RefSeq:   YP_186357.1
- ProteinModelPortal:   Q5HFV0
- SMR:   Q5HFV0
- STRING:   Q5HFV0
- EnsemblBacteria:   EBSTAT00000008455
- GeneID:   3237552
- GenomeReviews:   CP000046_GR
- KEGG:   sac:SACOL1513
- TIGR:   SACOL1513
- eggNOG:   COG0776
- GeneTree:   EBGT00050000023760
- HOGENOM:   HBG705085
- OMA:   NESKTHF
- ProtClustDB:   CLSK885375
- BioCyc:   SAUR93062:SACOL1513-MONOMER
- InterPro:   IPR000119
- InterPro:   IPR020816
- InterPro:   IPR010992
- Gene3D:   G3DSA:4.10.520.10
- PRINTS:   PR01727
- SMART:   SM00411

Pfam domain/function: PF00216 Bac_DNA_binding; SSF47729 IHF_like_DNA_bnd

EC number: NA

Molecular weight: Translated: 9626; Mature: 9626

Theoretical pI: Translated: 10.32; Mature: 10.32

Prosite motif: PS00045 HISTONE_LIKE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKTDLINAVAEQADLTKKEAGSAVDAVFESIQNSLAKGEKVQLIGFGNFEVRERAARKG
CCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHCC
RNPQTGKEIDIPASKVPAFKAGKALKDAVK
CCCCCCCCCCCCCCCCCCHHCCHHHHHHCC
>Mature Secondary Structure
MNKTDLINAVAEQADLTKKEAGSAVDAVFESIQNSLAKGEKVQLIGFGNFEVRERAARKG
CCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHCC
RNPQTGKEIDIPASKVPAFKAGKALKDAVK
CCCCCCCCCCCCCCCCCCHHCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA