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The map label for this gene is guaC [H]

Identifier: 57650340

GI number: 57650340

Start: 1376437

End: 1377414

Strand: Direct

Name: guaC [H]

Synonym: SACOL1371

Alternate gene names: 57650340

Gene position: 1376437-1377414 (Clockwise)

Preceding gene: 57650339

Following gene: 57650342

Centisome position: 48.99

GC content: 33.44

Gene sequence:

>978_bases
GTGAAAATATTTGATTACGAAGATATTCAATTAATACCTAATAAATGCATAGTTGAAAGTAGGTCTGAATGTGATACAAC
TATCCAATTTGGTCCAAAAAAATTCAAGCTACCTGTAGTTCCTGCAAATATGCAAACAGTTATGAATGAGAAATTAGCGA
AATGGTTTGCTGAAAATGATTACTTTTATATCATGCATCGTTTTGATGAAGAAGCAAGAATACCTTTTATAAAACATATG
CAAAATTCAGGCTTATTTGCATCTATTTCAGTTGGTGTAAAGAAAGCGGAATTTGATTTTATTGAAAAGTTAGCTCAAGA
AAAATTAATCCCCGAATATATTACAATAGATATTGCGCATGGTCACTCAGATTCAGTGATAAACATGATTAAACATATAA
AAACCCATATACCTGATAGTTTTGTTATTGCTGGTAATGTTGGTACGCCAGAAGGTGTTAGAGAATTAGAAAATGCTGGT
GCTGATGCTACCAAAGTCGGTATAGGTCCTGGTAGAGTTTGTATTACAAAGATTAAAACAGGTTTTGGTACTGGTGGTTG
GCAGTTAGCGGCATTAAACATATGTAGTAAAGCAGCTCGTAAACCTTTGATTGCCGATGGTGGTATAAGAACGCATGGCG
ACATTGCTAAATCAATTAGATTTGGTGCATCAATGGTCATGATTGGTTCATTATTTGCGGCACACGAAGAATCACCTGGT
GAAACTGTAGAACTTGATGGTAAACAGTATAAAGAATATTTTGGTAGTGCATCTGAATTTCAAAAAGGCGAACATAAAAA
TGTAGAAGGTAAAAAAATGTTTGTAGAACATAAGGGTTCATTAATGGATACCTTAAAAGAAATGCAACAAGATTTACAAA
GCTCAATTTCATATGCCGGTGGAAAAGACTTGAAATCATTACGTACTGTAGATTATGTTATTGTTAGAAACTCTATTTTC
AACGGTGATAGAGATTAA

Upstream 100 bases:

>100_bases
TACGAATGCTATAAACTGAATGTTTTCTCATATTAATAAGGAAACATTCGGTTTTTAATTTGCATTTAAAAATAATTAGT
TTTTAAAGGGGCTATTTAAA

Downstream 100 bases:

>100_bases
TATTTATAGTAGGTGATGTAAATTAAAAAATTCATAGTAACTGTTGTTGCGTTTTTATCAATTATTATCATTGCGCCAAT
AACAGAATTTAAACCATTCA

Product: guanosine 5'-monophosphate oxidoreductase

Products: NA

Alternate protein names: Guanosine 5'-monophosphate oxidoreductase; Guanosine monophosphate reductase [H]

Number of amino acids: Translated: 325; Mature: 325

Protein sequence:

>325_residues
MKIFDYEDIQLIPNKCIVESRSECDTTIQFGPKKFKLPVVPANMQTVMNEKLAKWFAENDYFYIMHRFDEEARIPFIKHM
QNSGLFASISVGVKKAEFDFIEKLAQEKLIPEYITIDIAHGHSDSVINMIKHIKTHIPDSFVIAGNVGTPEGVRELENAG
ADATKVGIGPGRVCITKIKTGFGTGGWQLAALNICSKAARKPLIADGGIRTHGDIAKSIRFGASMVMIGSLFAAHEESPG
ETVELDGKQYKEYFGSASEFQKGEHKNVEGKKMFVEHKGSLMDTLKEMQQDLQSSISYAGGKDLKSLRTVDYVIVRNSIF
NGDRD

Sequences:

>Translated_325_residues
MKIFDYEDIQLIPNKCIVESRSECDTTIQFGPKKFKLPVVPANMQTVMNEKLAKWFAENDYFYIMHRFDEEARIPFIKHM
QNSGLFASISVGVKKAEFDFIEKLAQEKLIPEYITIDIAHGHSDSVINMIKHIKTHIPDSFVIAGNVGTPEGVRELENAG
ADATKVGIGPGRVCITKIKTGFGTGGWQLAALNICSKAARKPLIADGGIRTHGDIAKSIRFGASMVMIGSLFAAHEESPG
ETVELDGKQYKEYFGSASEFQKGEHKNVEGKKMFVEHKGSLMDTLKEMQQDLQSSISYAGGKDLKSLRTVDYVIVRNSIF
NGDRD
>Mature_325_residues
MKIFDYEDIQLIPNKCIVESRSECDTTIQFGPKKFKLPVVPANMQTVMNEKLAKWFAENDYFYIMHRFDEEARIPFIKHM
QNSGLFASISVGVKKAEFDFIEKLAQEKLIPEYITIDIAHGHSDSVINMIKHIKTHIPDSFVIAGNVGTPEGVRELENAG
ADATKVGIGPGRVCITKIKTGFGTGGWQLAALNICSKAARKPLIADGGIRTHGDIAKSIRFGASMVMIGSLFAAHEESPG
ETVELDGKQYKEYFGSASEFQKGEHKNVEGKKMFVEHKGSLMDTLKEMQQDLQSSISYAGGKDLKSLRTVDYVIVRNSIF
NGDRD

Specific function: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides [H]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI50541956, Length=338, Percent_Identity=33.7278106508876, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI50541954, Length=338, Percent_Identity=33.7278106508876, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI50541952, Length=338, Percent_Identity=33.7278106508876, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI50541948, Length=338, Percent_Identity=33.7278106508876, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI156104880, Length=342, Percent_Identity=30.1169590643275, Blast_Score=159, Evalue=2e-39,
Organism=Homo sapiens, GI66933016, Length=297, Percent_Identity=31.986531986532, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI217035146, Length=297, Percent_Identity=29.96632996633, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI217035148, Length=297, Percent_Identity=29.96632996633, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI217035150, Length=297, Percent_Identity=29.96632996633, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI217035152, Length=245, Percent_Identity=32.6530612244898, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI34328928, Length=245, Percent_Identity=32.2448979591837, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI34328930, Length=245, Percent_Identity=32.2448979591837, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI156616279, Length=297, Percent_Identity=29.96632996633, Blast_Score=105, Evalue=6e-23,
Organism=Escherichia coli, GI1786293, Length=337, Percent_Identity=31.4540059347181, Blast_Score=159, Evalue=2e-40,
Organism=Escherichia coli, GI1788855, Length=215, Percent_Identity=39.5348837209302, Blast_Score=111, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI17560440, Length=321, Percent_Identity=31.1526479750779, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI71994389, Length=132, Percent_Identity=40.1515151515151, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71994385, Length=132, Percent_Identity=40.1515151515151, Blast_Score=90, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6323585, Length=244, Percent_Identity=33.1967213114754, Blast_Score=110, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6323464, Length=244, Percent_Identity=33.1967213114754, Blast_Score=107, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6322012, Length=203, Percent_Identity=34.9753694581281, Blast_Score=104, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6319352, Length=139, Percent_Identity=34.5323741007194, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28571163, Length=310, Percent_Identity=30.9677419354839, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24641071, Length=310, Percent_Identity=30.9677419354839, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24641073, Length=310, Percent_Identity=30.9677419354839, Blast_Score=113, Evalue=2e-25,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005994
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00478 IMPDH [H]

EC number: =1.7.1.7 [H]

Molecular weight: Translated: 36117; Mature: 36117

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIFDYEDIQLIPNKCIVESRSECDTTIQFGPKKFKLPVVPANMQTVMNEKLAKWFAEND
CCCCCCCCCEECCCHHHHCCCCCCCCEEEECCCEEEEEECCCHHHHHHHHHHHHHHHCCC
YFYIMHRFDEEARIPFIKHMQNSGLFASISVGVKKAEFDFIEKLAQEKLIPEYITIDIAH
EEEEEEECCCCCCCCHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEEEEC
GHSDSVINMIKHIKTHIPDSFVIAGNVGTPEGVRELENAGADATKVGIGPGRVCITKIKT
CCCHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHCCCCCEEECCCCCCEEEEEECC
GFGTGGWQLAALNICSKAARKPLIADGGIRTHGDIAKSIRFGASMVMIGSLFAAHEESPG
CCCCCCEEHHHHHHHHHHHCCCCEECCCCCCCHHHHHHHHHCHHHHHHHHHHHHCCCCCC
ETVELDGKQYKEYFGSASEFQKGEHKNVEGKKMFVEHKGSLMDTLKEMQQDLQSSISYAG
CEEEECCHHHHHHCCCHHHHCCCCCCCCCCCEEHHHHCCHHHHHHHHHHHHHHHHHCCCC
GKDLKSLRTVDYVIVRNSIFNGDRD
CCHHHHHHHHHHEEEEHHHCCCCCC
>Mature Secondary Structure
MKIFDYEDIQLIPNKCIVESRSECDTTIQFGPKKFKLPVVPANMQTVMNEKLAKWFAEND
CCCCCCCCCEECCCHHHHCCCCCCCCEEEECCCEEEEEECCCHHHHHHHHHHHHHHHCCC
YFYIMHRFDEEARIPFIKHMQNSGLFASISVGVKKAEFDFIEKLAQEKLIPEYITIDIAH
EEEEEEECCCCCCCCHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEEEEC
GHSDSVINMIKHIKTHIPDSFVIAGNVGTPEGVRELENAGADATKVGIGPGRVCITKIKT
CCCHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHCCCCCEEECCCCCCEEEEEECC
GFGTGGWQLAALNICSKAARKPLIADGGIRTHGDIAKSIRFGASMVMIGSLFAAHEESPG
CCCCCCEEHHHHHHHHHHHCCCCEECCCCCCCHHHHHHHHHCHHHHHHHHHHHHCCCCCC
ETVELDGKQYKEYFGSASEFQKGEHKNVEGKKMFVEHKGSLMDTLKEMQQDLQSSISYAG
CEEEECCHHHHHHCCCHHHHCCCCCCCCCCCEEHHHHCCHHHHHHHHHHHHHHHHHCCCC
GKDLKSLRTVDYVIVRNSIFNGDRD
CCHHHHHHHHHHEEEEHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA