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The map label for this gene is ykgC [H]

Identifier: 57650051

GI number: 57650051

Start: 671727

End: 673049

Strand: Reverse

Name: ykgC [H]

Synonym: SACOL0640

Alternate gene names: 57650051

Gene position: 673049-671727 (Counterclockwise)

Preceding gene: 57650052

Following gene: 57651462

Centisome position: 23.96

GC content: 35.15

Gene sequence:

>1323_bases
ATGAAAACATATGATTTAATTGTAATAGGATTTGGGAAAGCTGGTAAAACTTTAGCGAAATACGCTGCATCAACAGGTCA
ACACGTCGCAGTTATCGAACAATCTCCGAAAATGTATGGAGGCACTTGTATAAACATAGGATGTATACCTTCGAAGACAC
TTGTACATGATGGATTAGAAGGCAAATCTTTTGAAGCAAGTTATAACCGTAAAAACGATGTTGTCAATGCGCTAAACAAT
AAAAATTACCACTTATTAGCAGACGATAACAACATTGATGTACTGGATTTTAAAGCGCAGTTTAAATCTAATACTGAAGT
GAATTTATTAGATCAACATGACGATATCGTCGATAGTATTACTGCACCTCATATCATTATTAATACCGGTGCTACCTCTG
TCATTCCTAACATTAAAGGCCTTGATCAAGCTAAACACGTCTTCGATTCGACAGGTTTATTAAACATTAGCTATCAACCT
AAGCACCTCGTTATTGTAGGTGGCGGTTATATCGCCTTAGAATTTGCTTCAATGTTTGCGAATTTAGGTAGTAAGGTAAC
AGTATTAGAACGTGGCGAATCATTTATGCCACGCGAAGATCAAGATGTCGTTGCATATGGTATTACTGACTTAGAAAATA
AAGGCATTGCATTGCATACAAATGTTGAAACGACTGAATTGTCATCTGACAATCATCATACAACAGTCCATACCAACGTT
GATAACTTTGAGGCTGATGCAGTACTTTTGGCTATCGGGCGCAAACCGAATACGGATTTAGCTTTAGAAAATACTGATAT
CGAATTAGGCGACAGAGGCGAAATTAAAGTCAATGCTCATCTTCAAACAACTGTGCCGCATATTTATGCTGCAGGTGATG
TTAAAGGCGGACTTCAATTTACGTATATATCTTTAGATGATTATCGAATTATCAAATCAGCGTTATATGGTAATCAGTCA
CGTACGACTGACAATAGAGGCAGCGTGCCTTATACAGTATTTATAGATCCACCATTATCACGTGTTGGATTAACTAGTAA
AGAAGCTGCCGCTCAACATTATGATTACACTGAACATCAACTTTTAGTAAGTGCTATACCTCGTCATAAAATTAACAATG
ATCCAAGAGGTTTATTTAAAGTAGTCATTAATAATGAAAATAATATGATTTTAGGTGCTACATTATATGGTAAGCAATCT
GAAGAATTAATTAATATAATTAAACTTGCGATTGATCAAAACATTCCATATACCGTATTACGAGATAATATTTATACGCA
TCCTACGATGGCCGAATCATTTAATGATTTATTTAATTTCTAG

Upstream 100 bases:

>100_bases
TCACATTATCAGCAAGACGAACAGAATATCATTATTAATTTTTATAATGGAAAAACAATCAAAGATGTCATTGAAGACAT
TCAAAAGGAGGATTTATGTC

Downstream 100 bases:

>100_bases
ACAAAACATAAAAAACCTGGTGGCACGCATTGAATGATGCTGCCATCAGGCTTTATTGTTGTGCTTTTCGCTTTTCTAAT
TTTTCTTTAAGCTTTCTATC

Product: pyridine nucleotide-disulfide oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 440; Mature: 440

Protein sequence:

>440_residues
MKTYDLIVIGFGKAGKTLAKYAASTGQHVAVIEQSPKMYGGTCINIGCIPSKTLVHDGLEGKSFEASYNRKNDVVNALNN
KNYHLLADDNNIDVLDFKAQFKSNTEVNLLDQHDDIVDSITAPHIIINTGATSVIPNIKGLDQAKHVFDSTGLLNISYQP
KHLVIVGGGYIALEFASMFANLGSKVTVLERGESFMPREDQDVVAYGITDLENKGIALHTNVETTELSSDNHHTTVHTNV
DNFEADAVLLAIGRKPNTDLALENTDIELGDRGEIKVNAHLQTTVPHIYAAGDVKGGLQFTYISLDDYRIIKSALYGNQS
RTTDNRGSVPYTVFIDPPLSRVGLTSKEAAAQHYDYTEHQLLVSAIPRHKINNDPRGLFKVVINNENNMILGATLYGKQS
EELINIIKLAIDQNIPYTVLRDNIYTHPTMAESFNDLFNF

Sequences:

>Translated_440_residues
MKTYDLIVIGFGKAGKTLAKYAASTGQHVAVIEQSPKMYGGTCINIGCIPSKTLVHDGLEGKSFEASYNRKNDVVNALNN
KNYHLLADDNNIDVLDFKAQFKSNTEVNLLDQHDDIVDSITAPHIIINTGATSVIPNIKGLDQAKHVFDSTGLLNISYQP
KHLVIVGGGYIALEFASMFANLGSKVTVLERGESFMPREDQDVVAYGITDLENKGIALHTNVETTELSSDNHHTTVHTNV
DNFEADAVLLAIGRKPNTDLALENTDIELGDRGEIKVNAHLQTTVPHIYAAGDVKGGLQFTYISLDDYRIIKSALYGNQS
RTTDNRGSVPYTVFIDPPLSRVGLTSKEAAAQHYDYTEHQLLVSAIPRHKINNDPRGLFKVVINNENNMILGATLYGKQS
EELINIIKLAIDQNIPYTVLRDNIYTHPTMAESFNDLFNF
>Mature_440_residues
MKTYDLIVIGFGKAGKTLAKYAASTGQHVAVIEQSPKMYGGTCINIGCIPSKTLVHDGLEGKSFEASYNRKNDVVNALNN
KNYHLLADDNNIDVLDFKAQFKSNTEVNLLDQHDDIVDSITAPHIIINTGATSVIPNIKGLDQAKHVFDSTGLLNISYQP
KHLVIVGGGYIALEFASMFANLGSKVTVLERGESFMPREDQDVVAYGITDLENKGIALHTNVETTELSSDNHHTTVHTNV
DNFEADAVLLAIGRKPNTDLALENTDIELGDRGEIKVNAHLQTTVPHIYAAGDVKGGLQFTYISLDDYRIIKSALYGNQS
RTTDNRGSVPYTVFIDPPLSRVGLTSKEAAAQHYDYTEHQLLVSAIPRHKINNDPRGLFKVVINNENNMILGATLYGKQS
EELINIIKLAIDQNIPYTVLRDNIYTHPTMAESFNDLFNF

Specific function: Unknown

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=462, Percent_Identity=27.4891774891775, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI50301238, Length=466, Percent_Identity=27.4678111587983, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI22035672, Length=483, Percent_Identity=27.3291925465839, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI33519430, Length=438, Percent_Identity=26.027397260274, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI33519428, Length=438, Percent_Identity=26.027397260274, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI33519426, Length=438, Percent_Identity=26.027397260274, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI148277065, Length=438, Percent_Identity=26.027397260274, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI148277071, Length=439, Percent_Identity=26.1958997722096, Blast_Score=106, Evalue=6e-23,
Organism=Homo sapiens, GI291045266, Length=463, Percent_Identity=25.0539956803456, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI291045268, Length=459, Percent_Identity=23.3115468409586, Blast_Score=92, Evalue=1e-18,
Organism=Escherichia coli, GI87081717, Length=441, Percent_Identity=49.4331065759637, Blast_Score=413, Evalue=1e-116,
Organism=Escherichia coli, GI87082354, Length=459, Percent_Identity=28.9760348583878, Blast_Score=170, Evalue=2e-43,
Organism=Escherichia coli, GI1786307, Length=453, Percent_Identity=27.3730684326711, Blast_Score=162, Evalue=4e-41,
Organism=Escherichia coli, GI1789915, Length=441, Percent_Identity=26.984126984127, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1787114, Length=190, Percent_Identity=27.8947368421053, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI32565766, Length=460, Percent_Identity=28.695652173913, Blast_Score=165, Evalue=5e-41,
Organism=Caenorhabditis elegans, GI17557007, Length=475, Percent_Identity=28.2105263157895, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI71983429, Length=463, Percent_Identity=26.133909287257, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI71983419, Length=463, Percent_Identity=26.133909287257, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI71982272, Length=492, Percent_Identity=24.7967479674797, Blast_Score=112, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6325166, Length=473, Percent_Identity=27.6955602536998, Blast_Score=151, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6321091, Length=471, Percent_Identity=27.6008492569002, Blast_Score=149, Evalue=9e-37,
Organism=Saccharomyces cerevisiae, GI6325240, Length=478, Percent_Identity=26.5690376569038, Blast_Score=118, Evalue=2e-27,
Organism=Drosophila melanogaster, GI21358499, Length=464, Percent_Identity=30.1724137931034, Blast_Score=168, Evalue=7e-42,
Organism=Drosophila melanogaster, GI24640549, Length=479, Percent_Identity=27.9749478079332, Blast_Score=125, Evalue=6e-29,
Organism=Drosophila melanogaster, GI24640553, Length=479, Percent_Identity=27.9749478079332, Blast_Score=125, Evalue=7e-29,
Organism=Drosophila melanogaster, GI24640551, Length=477, Percent_Identity=27.4633123689727, Blast_Score=124, Evalue=9e-29,
Organism=Drosophila melanogaster, GI17737741, Length=480, Percent_Identity=26.25, Blast_Score=112, Evalue=4e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: NA

Molecular weight: Translated: 48474; Mature: 48474

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTYDLIVIGFGKAGKTLAKYAASTGQHVAVIEQSPKMYGGTCINIGCIPSKTLVHDGLE
CCEEEEEEEEECCCCHHHHHHHHCCCCEEEEEECCCCCCCCEEEEEECCCCHHHHHCCCC
GKSFEASYNRKNDVVNALNNKNYHLLADDNNIDVLDFKAQFKSNTEVNLLDQHDDIVDSI
CCCEECCCCCCHHHHHHHCCCCEEEEECCCCEEEEEEEEECCCCCEEEEECCCCHHHHHC
TAPHIIINTGATSVIPNIKGLDQAKHVFDSTGLLNISYQPKHLVIVGGGYIALEFASMFA
CCCEEEEECCCHHCCCCCCCCHHHHHHHCCCCEEEEEECCCEEEEECCCEEEHHHHHHHH
NLGSKVTVLERGESFMPREDQDVVAYGITDLENKGIALHTNVETTELSSDNHHTTVHTNV
HCCCEEEEEECCCCCCCCCCCCEEEEEEEECCCCCEEEEECCCEEEECCCCCEEEEEECC
DNFEADAVLLAIGRKPNTDLALENTDIELGDRGEIKVNAHLQTTVPHIYAAGDVKGGLQF
CCCCCCEEEEEECCCCCCCEEEECCCEEECCCCCEEEEEEEEECCCEEEEECCCCCCEEE
TYISLDDYRIIKSALYGNQSRTTDNRGSVPYTVFIDPPLSRVGLTSKEAAAQHYDYTEHQ
EEEECCCHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCHHHHCCCCHHHHHHHCCCHHHH
LLVSAIPRHKINNDPRGLFKVVINNENNMILGATLYGKQSEELINIIKLAIDQNIPYTVL
HHHHHCCCCCCCCCCCEEEEEEEECCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCEEEE
RDNIYTHPTMAESFNDLFNF
ECCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MKTYDLIVIGFGKAGKTLAKYAASTGQHVAVIEQSPKMYGGTCINIGCIPSKTLVHDGLE
CCEEEEEEEEECCCCHHHHHHHHCCCCEEEEEECCCCCCCCEEEEEECCCCHHHHHCCCC
GKSFEASYNRKNDVVNALNNKNYHLLADDNNIDVLDFKAQFKSNTEVNLLDQHDDIVDSI
CCCEECCCCCCHHHHHHHCCCCEEEEECCCCEEEEEEEEECCCCCEEEEECCCCHHHHHC
TAPHIIINTGATSVIPNIKGLDQAKHVFDSTGLLNISYQPKHLVIVGGGYIALEFASMFA
CCCEEEEECCCHHCCCCCCCCHHHHHHHCCCCEEEEEECCCEEEEECCCEEEHHHHHHHH
NLGSKVTVLERGESFMPREDQDVVAYGITDLENKGIALHTNVETTELSSDNHHTTVHTNV
HCCCEEEEEECCCCCCCCCCCCEEEEEEEECCCCCEEEEECCCEEEECCCCCEEEEEECC
DNFEADAVLLAIGRKPNTDLALENTDIELGDRGEIKVNAHLQTTVPHIYAAGDVKGGLQF
CCCCCCEEEEEECCCCCCCEEEECCCEEECCCCCEEEEEEEEECCCEEEEECCCCCCEEE
TYISLDDYRIIKSALYGNQSRTTDNRGSVPYTVFIDPPLSRVGLTSKEAAAQHYDYTEHQ
EEEECCCHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCHHHHCCCCHHHHHHHCCCHHHH
LLVSAIPRHKINNDPRGLFKVVINNENNMILGATLYGKQSEELINIIKLAIDQNIPYTVL
HHHHHCCCCCCCCCCCEEEEEEEECCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCEEEE
RDNIYTHPTMAESFNDLFNF
ECCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: FAD. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]