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The map label for this gene is glmU

Identifier: 57650040

GI number: 57650040

Start: 549902

End: 551254

Strand: Direct

Name: glmU

Synonym: SACOL0543

Alternate gene names: 57650040

Gene position: 549902-551254 (Clockwise)

Preceding gene: 57650039

Following gene: 57650041

Centisome position: 19.57

GC content: 39.47

Gene sequence:

>1353_bases
ATGCGAAGACACGCGATAATTTTGGCAGCAGGTAAAGGCACAAGAATGAAATCTAAAAAGTATAAAGTGCTACACGAGGT
TGCTGGGAAACCTATGGTCGAACATGTATTGGAAAGTGTGAAAGGCTCTGGTGTCGATCAAGTTGTAACCATCGTAGGAC
ATGGTGCTGAAAGTGTAAAAGGACATTTAGGCGAGCGTTCTTTATACAGTTTTCAAGAGGAACAACTCGGTACTGCGCAT
GCAGTGCAAATGGCGAAATCACACTTAGAAGACAAGGAAGGTACGACAATCGTTGTATGTGGTGACACACCGCTCATCAC
AAAGGAAACATTAGAAACATTGATTGCGCATCACGAGGATGCTAATGCTCAAGCAACTGTATTATCTGCATCGATTCAAC
AACCATATGGATACGGAAGAATCGTTCGAAATGCGTCAGGTCGTTTAGAACGCATAGTTGAAGAGAAAGATGCAACGCAA
GCTGAAAAGGATATTAATGAAATTAGTTCAGGTATTTTTGCGTTTAATAATAAAACGTTGTTTGAAAAATTAACACAAGT
GAAAAATGATAATGCGCAAGGTGAATATTACCTCCCTGATGTATTGTCGTTAATTTTAAATGATGGCGGCATCGTAGAAG
TCTATCGTACCAATGATGTTGAAGAAATCATGGGTGTAAATGATCGTGTAATGCTTAGTCAGGCTGAGAAGGCGATGCAA
CGTCGTACGAATCATTATCACATGCTAAATGGTGTGACAATCATCGATCCTGACAGCACTTATATTGGTCCAGACGTTAC
AATTGGTAGTGATACAGTCATTGAACCAGGCGTACGAATTAATGGTCGTACAGAAATTGGCGAAGATGTTGTTATTGGTC
AGTACTCTGAAATTAACAATAGTACGATTGAAAATGGTGCATGTATTCAACAGTCTGTTGTTAATGATGCTAGCGTAGGA
GCGAATACTAAGGTCGGACCGTTTGCGCAATTGAGACCAGGCGCGCAATTAGGTGCAGATGTTAAGGTTGGAAATTTTGT
AGAAATTAAAAAAGCAGATCTTAAAGATGGTGCCAAGGTTTCACATTTAAGTTATATTGGCGATGCTGTAATTGGCGAAC
GTACTAATATTGGTTGCGGAACGATTACAGTTAACTATGATGGTGAAAATAAATTTAAAACTATCGTCGGCAAAGATTCA
TTTGTAGGTTGCAATGTTAATTTAGTAGCACCTGTAACAATTGGTGATGATGTATTGGTGGCAGCTGGTTCCACAATCAC
AGATGACGTACCAAATGACAGTTTAGCTGTGGCAAGAGCAAGACAAACAACAAAAGAAGGATATAGGAAATAA

Upstream 100 bases:

>100_bases
TTACAACGAATTAAAAACAATGCCTTTTATATGTTGAAAGAGTATTGCAGATTAAATTATAATAATGACGAAGTGTAAAA
TTTAATGGGGGTTAATGTTC

Downstream 100 bases:

>100_bases
TCATTTACGTATTTAAAATGGCTAGGATAAAAGGATAATCCTATGTAATATTAATGTAATCTTTATGATTTAATGATTCG
CATAGTAATGGAGTTACATT

Product: bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase

Number of amino acids: Translated: 450; Mature: 450

Protein sequence:

>450_residues
MRRHAIILAAGKGTRMKSKKYKVLHEVAGKPMVEHVLESVKGSGVDQVVTIVGHGAESVKGHLGERSLYSFQEEQLGTAH
AVQMAKSHLEDKEGTTIVVCGDTPLITKETLETLIAHHEDANAQATVLSASIQQPYGYGRIVRNASGRLERIVEEKDATQ
AEKDINEISSGIFAFNNKTLFEKLTQVKNDNAQGEYYLPDVLSLILNDGGIVEVYRTNDVEEIMGVNDRVMLSQAEKAMQ
RRTNHYHMLNGVTIIDPDSTYIGPDVTIGSDTVIEPGVRINGRTEIGEDVVIGQYSEINNSTIENGACIQQSVVNDASVG
ANTKVGPFAQLRPGAQLGADVKVGNFVEIKKADLKDGAKVSHLSYIGDAVIGERTNIGCGTITVNYDGENKFKTIVGKDS
FVGCNVNLVAPVTIGDDVLVAAGSTITDDVPNDSLAVARARQTTKEGYRK

Sequences:

>Translated_450_residues
MRRHAIILAAGKGTRMKSKKYKVLHEVAGKPMVEHVLESVKGSGVDQVVTIVGHGAESVKGHLGERSLYSFQEEQLGTAH
AVQMAKSHLEDKEGTTIVVCGDTPLITKETLETLIAHHEDANAQATVLSASIQQPYGYGRIVRNASGRLERIVEEKDATQ
AEKDINEISSGIFAFNNKTLFEKLTQVKNDNAQGEYYLPDVLSLILNDGGIVEVYRTNDVEEIMGVNDRVMLSQAEKAMQ
RRTNHYHMLNGVTIIDPDSTYIGPDVTIGSDTVIEPGVRINGRTEIGEDVVIGQYSEINNSTIENGACIQQSVVNDASVG
ANTKVGPFAQLRPGAQLGADVKVGNFVEIKKADLKDGAKVSHLSYIGDAVIGERTNIGCGTITVNYDGENKFKTIVGKDS
FVGCNVNLVAPVTIGDDVLVAAGSTITDDVPNDSLAVARARQTTKEGYRK
>Mature_450_residues
MRRHAIILAAGKGTRMKSKKYKVLHEVAGKPMVEHVLESVKGSGVDQVVTIVGHGAESVKGHLGERSLYSFQEEQLGTAH
AVQMAKSHLEDKEGTTIVVCGDTPLITKETLETLIAHHEDANAQATVLSASIQQPYGYGRIVRNASGRLERIVEEKDATQ
AEKDINEISSGIFAFNNKTLFEKLTQVKNDNAQGEYYLPDVLSLILNDGGIVEVYRTNDVEEIMGVNDRVMLSQAEKAMQ
RRTNHYHMLNGVTIIDPDSTYIGPDVTIGSDTVIEPGVRINGRTEIGEDVVIGQYSEINNSTIENGACIQQSVVNDASVG
ANTKVGPFAQLRPGAQLGADVKVGNFVEIKKADLKDGAKVSHLSYIGDAVIGERTNIGCGTITVNYDGENKFKTIVGKDS
FVGCNVNLVAPVTIGDDVLVAAGSTITDDVPNDSLAVARARQTTKEGYRK

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family

Homologues:

Organism=Homo sapiens, GI11761621, Length=393, Percent_Identity=22.9007633587786, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI11761619, Length=357, Percent_Identity=21.8487394957983, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1790168, Length=449, Percent_Identity=43.8752783964365, Blast_Score=344, Evalue=7e-96,
Organism=Caenorhabditis elegans, GI133931050, Length=320, Percent_Identity=27.1875, Blast_Score=99, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6320148, Length=390, Percent_Identity=24.8717948717949, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21355443, Length=370, Percent_Identity=25.9459459459459, Blast_Score=92, Evalue=8e-19,
Organism=Drosophila melanogaster, GI24644084, Length=370, Percent_Identity=25.9459459459459, Blast_Score=92, Evalue=8e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMU_STAA3 (Q2FJE2)

Other databases:

- EMBL:   CP000255
- RefSeq:   YP_493186.1
- ProteinModelPortal:   Q2FJE2
- SMR:   Q2FJE2
- STRING:   Q2FJE2
- EnsemblBacteria:   EBSTAT00000036211
- GeneID:   3914305
- GenomeReviews:   CP000255_GR
- KEGG:   saa:SAUSA300_0477
- eggNOG:   COG1207
- GeneTree:   EBGT00050000024596
- HOGENOM:   HBG688195
- OMA:   GSKVNHL
- ProtClustDB:   PRK14354
- GO:   GO:0005737
- HAMAP:   MF_01631
- InterPro:   IPR005882
- InterPro:   IPR018357
- InterPro:   IPR005835
- InterPro:   IPR011004
- TIGRFAMs:   TIGR01173

Pfam domain/function: PF00483 NTP_transferase; SSF51161 Trimer_LpxA_like

EC number: =2.7.7.23; =2.3.1.157

Molecular weight: Translated: 48533; Mature: 48533

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: PS00101 HEXAPEP_TRANSFERASES; PS00622 HTH_LUXR_1

Important sites: ACT_SITE 362-362 BINDING 72-72 BINDING 139-139 BINDING 154-154 BINDING 386-386 BINDING 422-422 BINDING 439-439

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRHAIILAAGKGTRMKSKKYKVLHEVAGKPMVEHVLESVKGSGVDQVVTIVGHGAESVK
CCCEEEEEECCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHEEEEECCCHHHHH
GHLGERSLYSFQEEQLGTAHAVQMAKSHLEDKEGTTIVVCGDTPLITKETLETLIAHHED
HHCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHCCC
ANAQATVLSASIQQPYGYGRIVRNASGRLERIVEEKDATQAEKDINEISSGIFAFNNKTL
CCCEEEEEEHHHCCCCCCHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCHH
FEKLTQVKNDNAQGEYYLPDVLSLILNDGGIVEVYRTNDVEEIMGVNDRVMLSQAEKAMQ
HHHHHHHCCCCCCCCEEHHHHHHHHHCCCCEEEEEECCCHHHHHCCCCHHHHHHHHHHHH
RRTNHYHMLNGVTIIDPDSTYIGPDVTIGSDTVIEPGVRINGRTEIGEDVVIGQYSEINN
HHCCCEEEECCEEEECCCCCCCCCCEEECCCCEECCCCEECCCCCCCCCEEEECHHHCCC
STIENGACIQQSVVNDASVGANTKVGPFAQLRPGAQLGADVKVGNFVEIKKADLKDGAKV
CCCCCCCHHHHHHHCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCC
SHLSYIGDAVIGERTNIGCGTITVNYDGENKFKTIVGKDSFVGCNVNLVAPVTIGDDVLV
HHHHHHHHHHHCCCCCCCEEEEEEEECCCCCEEEEECCCCEEECCEEEEEEEEECCCEEE
AAGSTITDDVPNDSLAVARARQTTKEGYRK
ECCCCCCCCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRRHAIILAAGKGTRMKSKKYKVLHEVAGKPMVEHVLESVKGSGVDQVVTIVGHGAESVK
CCCEEEEEECCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHEEEEECCCHHHHH
GHLGERSLYSFQEEQLGTAHAVQMAKSHLEDKEGTTIVVCGDTPLITKETLETLIAHHED
HHCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHCCC
ANAQATVLSASIQQPYGYGRIVRNASGRLERIVEEKDATQAEKDINEISSGIFAFNNKTL
CCCEEEEEEHHHCCCCCCHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCHH
FEKLTQVKNDNAQGEYYLPDVLSLILNDGGIVEVYRTNDVEEIMGVNDRVMLSQAEKAMQ
HHHHHHHCCCCCCCCEEHHHHHHHHHCCCCEEEEEECCCHHHHHCCCCHHHHHHHHHHHH
RRTNHYHMLNGVTIIDPDSTYIGPDVTIGSDTVIEPGVRINGRTEIGEDVVIGQYSEINN
HHCCCEEEECCEEEECCCCCCCCCCEEECCCCEECCCCEECCCCCCCCCEEEECHHHCCC
STIENGACIQQSVVNDASVGANTKVGPFAQLRPGAQLGADVKVGNFVEIKKADLKDGAKV
CCCCCCCHHHHHHHCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCC
SHLSYIGDAVIGERTNIGCGTITVNYDGENKFKTIVGKDSFVGCNVNLVAPVTIGDDVLV
HHHHHHHHHHHCCCCCCCEEEEEEEECCCCCEEEEECCCCEEECCEEEEEEEEECCCEEE
AAGSTITDDVPNDSLAVARARQTTKEGYRK
ECCCCCCCCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA