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The map label for this gene is ribH

Identifier: 57634639

GI number: 57634639

Start: 1902760

End: 1903224

Strand: Reverse

Name: ribH

Synonym: SAV1767

Alternate gene names: 57634639

Gene position: 1903224-1902760 (Counterclockwise)

Preceding gene: 15924759

Following gene: 15924755

Centisome position: 66.12

GC content: 33.12

Gene sequence:

>465_bases
ATGAATTTTGAAGGTAAATTAATTGGAAAAGATTTGAAAGTTGCAATCGTAGTTAGTCGATTTAATGATTTTATCACTGG
AAGATTACTTGAAGGTGCAAAAGATACTTTGATTCGACATGATGTTAATGAAGACAATATTGATGTAGCATTTGTTCCTG
GTGCGTTTGAAATTCCTTTAGTAGCTAAAAAATTAGCCTCATCAGGAAATTATGATGCAATAATTACATTAGGATGCGTA
ATTCGCGGTGCTACGTCTCATTATGATTATGTTTGTAATGAAGTCGCGAAAGGTGTTTCTAAAGTAAATGATCAAACTAA
TGTACCAGTCATATTTGGTATTTTAACGACTGAAAGTATTGAACAAGCTGTGGAAAGAGCAGGTACGAAAGCTGGTAATA
AAGGTGCCGAAGCAGCAGTAAGTGCAATTGAAATGGCTAATTTATTAAAATCTATAAAAGCATAG

Upstream 100 bases:

>100_bases
AGAAAGAATTGAAGTTATCGTACCAGAAACGGTACATAATCATGATTATATGGTAACGAAAAAAATAAAAATGGGTCATT
TAATATAGGAGGACTTTAAC

Downstream 100 bases:

>100_bases
AGCGCTGTTGTGAGTTCATAATCAAAGATTTATAAATGTTTCAGAACTGCCAATATAACATTTAGGAGCCTAGAACATTG
ATTATTGTTCCAGACTCCTA

Product: 6,7-dimethyl-8-ribityllumazine synthase

Products: NA

Alternate protein names: DMRL synthase; Lumazine synthase; Riboflavin synthase beta chain

Number of amino acids: Translated: 154; Mature: 154

Protein sequence:

>154_residues
MNFEGKLIGKDLKVAIVVSRFNDFITGRLLEGAKDTLIRHDVNEDNIDVAFVPGAFEIPLVAKKLASSGNYDAIITLGCV
IRGATSHYDYVCNEVAKGVSKVNDQTNVPVIFGILTTESIEQAVERAGTKAGNKGAEAAVSAIEMANLLKSIKA

Sequences:

>Translated_154_residues
MNFEGKLIGKDLKVAIVVSRFNDFITGRLLEGAKDTLIRHDVNEDNIDVAFVPGAFEIPLVAKKLASSGNYDAIITLGCV
IRGATSHYDYVCNEVAKGVSKVNDQTNVPVIFGILTTESIEQAVERAGTKAGNKGAEAAVSAIEMANLLKSIKA
>Mature_154_residues
MNFEGKLIGKDLKVAIVVSRFNDFITGRLLEGAKDTLIRHDVNEDNIDVAFVPGAFEIPLVAKKLASSGNYDAIITLGCV
IRGATSHYDYVCNEVAKGVSKVNDQTNVPVIFGILTTESIEQAVERAGTKAGNKGAEAAVSAIEMANLLKSIKA

Specific function: Riboflavin synthase is a bifunctional enzyme complex catalyzing the formation of riboflavin from 5-amino-6-(1'-D)- ribityl-amino-2,4(1H,3H)-pyrimidinedione and L-3,4-dihydrohy-2- butanone-4-phosphate via 6,7-dimethyl-8-lumazine. The beta subunit catalyzes

COG id: COG0054

COG function: function code H; Riboflavin synthase beta-chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DMRL synthase family

Homologues:

Organism=Escherichia coli, GI1786617, Length=156, Percent_Identity=56.4102564102564, Blast_Score=176, Evalue=6e-46,
Organism=Saccharomyces cerevisiae, GI6324429, Length=147, Percent_Identity=32.6530612244898, Blast_Score=90, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RISB_STAA1 (A7X3K7)

Other databases:

- EMBL:   AJ564300
- EMBL:   AP009324
- RefSeq:   YP_001442343.1
- ProteinModelPortal:   A7X3K7
- SMR:   A7X3K7
- STRING:   A7X3K7
- EnsemblBacteria:   EBSTAT00000004842
- GeneID:   5559714
- GenomeReviews:   AP009324_GR
- KEGG:   saw:SAHV_1753
- eggNOG:   COG0054
- GeneTree:   EBGT00050000024927
- HOGENOM:   HBG311126
- OMA:   KAGNKGW
- ProtClustDB:   PRK00061
- BioCyc:   SAUR418127:SAHV_1753-MONOMER
- HAMAP:   MF_00178
- InterPro:   IPR002180
- Gene3D:   G3DSA:3.40.50.960
- PANTHER:   PTHR21058
- TIGRFAMs:   TIGR00114

Pfam domain/function: PF00885 DMRL_synthase; SSF52121 DMRL_synthase

EC number: =2.5.1.9

Molecular weight: Translated: 16410; Mature: 16410

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFEGKLIGKDLKVAIVVSRFNDFITGRLLEGAKDTLIRHDVNEDNIDVAFVPGAFEIPL
CCCCCCEECCCEEEEEEEEHHHHHHHHHHHCCHHHHHHHCCCCCCCEEEEEECCCCCHHH
VAKKLASSGNYDAIITLGCVIRGATSHYDYVCNEVAKGVSKVNDQTNVPVIFGILTTESI
HHHHHHCCCCCCEEEEEEHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEECHHHH
EQAVERAGTKAGNKGAEAAVSAIEMANLLKSIKA
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNFEGKLIGKDLKVAIVVSRFNDFITGRLLEGAKDTLIRHDVNEDNIDVAFVPGAFEIPL
CCCCCCEECCCEEEEEEEEHHHHHHHHHHHCCHHHHHHHCCCCCCCEEEEEECCCCCHHH
VAKKLASSGNYDAIITLGCVIRGATSHYDYVCNEVAKGVSKVNDQTNVPVIFGILTTESI
HHHHHHCCCCCCEEEEEEHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEECHHHH
EQAVERAGTKAGNKGAEAAVSAIEMANLLKSIKA
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA