BacMap

Definition	Campylobacter jejuni RM1221, complete genome.
Accession	NC_003912
Length	1,777,831

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The map label for this gene is gmk [H]

Identifier: 57238049

GI number: 57238049

Start: 1224779

End: 1225396

Strand: Reverse

Name: gmk [H]

Synonym: CJE1311

Alternate gene names: 57238049

Gene position: 1225396-1224779 (Counterclockwise)

Preceding gene: 57238050

Following gene: 57238048

Centisome position: 68.93

GC content: 29.77

Gene sequence:

>618_bases
TTGCAAGGTTTTGTTTTGTTGATTTCAGGTCCTAGTGGTGCTGGAAAATCAACTCTTTTAAAAAAACTTTTTGATGAATT
TGAAGATGAGCTTTATTTTTCTATTTCTTCAACAACTCGCAAACCAAGAGAGGGTGAAAAAAATGGAATACATTATCATT
TTATATCCCATGAAGAATTTCAAAAAGGTATAGATAGTGATCATTTTTTAGAATGGGCTAGAGTGCATGAAAATTTTTAT
GGTACTTCTTTAAAGCACACTCAAAATGCTTTAGATAATGGAAAAATAGTTGTTTTTGATATTGATGTGCAAGGATTTAA
AATAGCCAGAAAAAAAATGGCTGATAAGATTGTTTCTGTTTTTATTACTACAAAAAATAAAGATGAGTTAAAAAAAAGAC
TTATTAAGCGAAATACTGATACAATAATACAACTAGAAAAAAGATTACAAAACGCTAGTGATGAGATGAAAGAGCTTAGC
GAGTATGATTATCTTATCATTAACGATGAGTTAAAGCAAAGTTATGAAGCATTGCGAGCGATTTTAATCGCCCATAAATT
TAGAACCAAAGGGCAGAATCTAGGGCAAATTCAAAATATTTGGAATGAAGGAGAATAA

Upstream 100 bases:

>100_bases
GAGCGATCACTTCAAGTATTAAAGATGATACCTTAAAAGCTGCTCTTAAGGGTATGAATATGAATATAAATATAAACATT
AGTTTTAAAGAGGATTGAAA

Downstream 100 bases:

>100_bases
AATGGGTGGTTGGTCAAGTCCAAGTCATTGGTTGATTATTTTATTGATTGTTGTATTGCTTTTTGGAGCAAAAAAAATTC
CAGAACTTGCAAAGGGTTTA

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 205; Mature: 205

Protein sequence:

>205_residues
MQGFVLLISGPSGAGKSTLLKKLFDEFEDELYFSISSTTRKPREGEKNGIHYHFISHEEFQKGIDSDHFLEWARVHENFY
GTSLKHTQNALDNGKIVVFDIDVQGFKIARKKMADKIVSVFITTKNKDELKKRLIKRNTDTIIQLEKRLQNASDEMKELS
EYDYLIINDELKQSYEALRAILIAHKFRTKGQNLGQIQNIWNEGE

Sequences:

>Translated_205_residues
MQGFVLLISGPSGAGKSTLLKKLFDEFEDELYFSISSTTRKPREGEKNGIHYHFISHEEFQKGIDSDHFLEWARVHENFY
GTSLKHTQNALDNGKIVVFDIDVQGFKIARKKMADKIVSVFITTKNKDELKKRLIKRNTDTIIQLEKRLQNASDEMKELS
EYDYLIINDELKQSYEALRAILIAHKFRTKGQNLGQIQNIWNEGE
>Mature_205_residues
MQGFVLLISGPSGAGKSTLLKKLFDEFEDELYFSISSTTRKPREGEKNGIHYHFISHEEFQKGIDSDHFLEWARVHENFY
GTSLKHTQNALDNGKIVVFDIDVQGFKIARKKMADKIVSVFITTKNKDELKKRLIKRNTDTIIQLEKRLQNASDEMKELS
EYDYLIINDELKQSYEALRAILIAHKFRTKGQNLGQIQNIWNEGE

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874833, Length=182, Percent_Identity=41.2087912087912, Blast_Score=128, Evalue=4e-30,
Organism=Homo sapiens, GI4504221, Length=182, Percent_Identity=41.2087912087912, Blast_Score=128, Evalue=4e-30,
Organism=Homo sapiens, GI226874831, Length=182, Percent_Identity=41.2087912087912, Blast_Score=128, Evalue=4e-30,
Organism=Homo sapiens, GI38570142, Length=189, Percent_Identity=24.8677248677249, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI262118259, Length=123, Percent_Identity=31.7073170731707, Blast_Score=77, Evalue=9e-15,
Organism=Homo sapiens, GI4505237, Length=123, Percent_Identity=31.7073170731707, Blast_Score=77, Evalue=9e-15,
Organism=Homo sapiens, GI262118263, Length=123, Percent_Identity=31.7073170731707, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI262118255, Length=123, Percent_Identity=31.7073170731707, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI186700627, Length=175, Percent_Identity=28, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI186972120, Length=175, Percent_Identity=28, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI186700629, Length=175, Percent_Identity=28, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI21361598, Length=195, Percent_Identity=26.1538461538462, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI14780902, Length=182, Percent_Identity=26.3736263736264, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI52630447, Length=195, Percent_Identity=24.1025641025641, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI21536464, Length=185, Percent_Identity=24.3243243243243, Blast_Score=65, Evalue=3e-11,
Organism=Homo sapiens, GI119943106, Length=183, Percent_Identity=27.3224043715847, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1790080, Length=194, Percent_Identity=41.7525773195876, Blast_Score=141, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17508835, Length=186, Percent_Identity=37.6344086021505, Blast_Score=125, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI193203132, Length=186, Percent_Identity=37.6344086021505, Blast_Score=125, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI71988048, Length=179, Percent_Identity=27.9329608938547, Blast_Score=81, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI71988041, Length=179, Percent_Identity=27.9329608938547, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17557440, Length=181, Percent_Identity=26.5193370165746, Blast_Score=73, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17556244, Length=89, Percent_Identity=30.3370786516854, Blast_Score=64, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6320662, Length=183, Percent_Identity=42.0765027322404, Blast_Score=150, Evalue=2e-37,
Organism=Drosophila melanogaster, GI21356141, Length=181, Percent_Identity=37.5690607734807, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI45554481, Length=178, Percent_Identity=28.0898876404494, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI85724806, Length=178, Percent_Identity=28.0898876404494, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24640542, Length=178, Percent_Identity=28.0898876404494, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI45554489, Length=178, Percent_Identity=28.0898876404494, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI116007136, Length=178, Percent_Identity=28.0898876404494, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI161077626, Length=178, Percent_Identity=28.0898876404494, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI281362230, Length=179, Percent_Identity=26.2569832402235, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24648808, Length=179, Percent_Identity=26.2569832402235, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI161078485, Length=175, Percent_Identity=26.8571428571429, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24648810, Length=175, Percent_Identity=26.8571428571429, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI281362232, Length=175, Percent_Identity=26.8571428571429, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI161078487, Length=175, Percent_Identity=26.8571428571429, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI85816281, Length=127, Percent_Identity=27.5590551181102, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI85816106, Length=127, Percent_Identity=27.5590551181102, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI45551002, Length=126, Percent_Identity=27.7777777777778, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI45554804, Length=176, Percent_Identity=27.8409090909091, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI161077752, Length=176, Percent_Identity=27.8409090909091, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI281360700, Length=173, Percent_Identity=27.7456647398844, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24641280, Length=173, Percent_Identity=27.7456647398844, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24641282, Length=173, Percent_Identity=27.7456647398844, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI45554818, Length=173, Percent_Identity=27.7456647398844, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI161077754, Length=190, Percent_Identity=27.3684210526316, Blast_Score=64, Evalue=9e-11,
Organism=Drosophila melanogaster, GI45554791, Length=190, Percent_Identity=27.3684210526316, Blast_Score=64, Evalue=9e-11,
Organism=Drosophila melanogaster, GI45554813, Length=183, Percent_Identity=27.8688524590164, Blast_Score=64, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 23784; Mature: 23784

Theoretical pI: Translated: 7.94; Mature: 7.94

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQGFVLLISGPSGAGKSTLLKKLFDEFEDELYFSISSTTRKPREGEKNGIHYHFISHEEF
CCCEEEEEECCCCCCHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCEEEEEECHHHH
QKGIDSDHFLEWARVHENFYGTSLKHTQNALDNGKIVVFDIDVQGFKIARKKMADKIVSV
HHCCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHH
FITTKNKDELKKRLIKRNTDTIIQLEKRLQNASDEMKELSEYDYLIINDELKQSYEALRA
HEECCCHHHHHHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHCCEEEECHHHHHHHHHHHH
ILIAHKFRTKGQNLGQIQNIWNEGE
HHHHHHHHHCCCCCHHHHHHHCCCC
>Mature Secondary Structure
MQGFVLLISGPSGAGKSTLLKKLFDEFEDELYFSISSTTRKPREGEKNGIHYHFISHEEF
CCCEEEEEECCCCCCHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCEEEEEECHHHH
QKGIDSDHFLEWARVHENFYGTSLKHTQNALDNGKIVVFDIDVQGFKIARKKMADKIVSV
HHCCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHH
FITTKNKDELKKRLIKRNTDTIIQLEKRLQNASDEMKELSEYDYLIINDELKQSYEALRA
HEECCCHHHHHHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHCCEEEECHHHHHHHHHHHH
ILIAHKFRTKGQNLGQIQNIWNEGE
HHHHHHHHHCCCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10688204 [H]