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The map label for this gene is proC [H]

Identifier: 57237958

GI number: 57237958

Start: 1136359

End: 1137090

Strand: Direct

Name: proC [H]

Synonym: CJE1219

Alternate gene names: 57237958

Gene position: 1136359-1137090 (Clockwise)

Preceding gene: 57237957

Following gene: 57237959

Centisome position: 63.92

GC content: 33.47

Gene sequence:

>732_bases
ATGCTCTATATACTTGCAAATGGATCTATGGCAACAGCCTTAGCCTATGGGTTAAAAGATGATTATGAAATTTGTATAGT
AGGAAGAAGTATAGAAAAACTTCAAGCCCTCGCCAAAGAAGGCTTTAAAACCTTACTTTACAAAGATTTTAACATAGAAG
GTAAAGATGTTATTTTAGCATTTAAACCTTATGCTTTAGAAAATATTGCTCAAATGCTAAAAGGACAAGCACGTATCTTA
ATCTCTGTTTTAGCCAATGTTGATTTTGAAAAACTACAAACCATCAAAGCTCAAAATTATGTTAGAATAATACCCAATAC
AGCAGCTAAATACAAGGCTTCAACCACACCATATATACTTAAAAACTCTCATTTTGAAAATGAAATTTTAGACATTTTAA
AAACTTTTGGCTCGGCTTATAAATTAGATAATGAAATACAAATGAATGCAGCTATGGCGATTAGCGGCTGCGCTCCTGCT
TTTTTAGCACTTATAGCAGAAAGCATTGCTAATGCTGGAGTTTATGAAGGTTTGTCAAAAGAACTTAGTCTCAATCTTAC
GCGCTCTTTATTTAAAAGCTCTAGTGCTTTACTAGAACATGAACATCCAGCTATTATCAAAGAAAATATTTGCTCCCCTG
GCGGAGTTACAATAAAAGGCATAAAAATACTCGAACAAAAAGGAATTCGCGGAAGTTTTTTTGAAGCCATAAATGCTAGC
AGCGCTAAATGA

Upstream 100 bases:

>100_bases
TTAATCTTGATAATAATACTATGGTACAAGTGATACTAGATACAGTTAATTATCCCGACTTTTTTCAAGCTGATCAAATT
GCTAATTATATTAAAAAATA

Downstream 100 bases:

>100_bases
AAAAGGCTTTCATACTTATAGAAAGCATTAGTGCTATAACGATCATATCTTTAATTTTCATTGGCATTTTTTATTACTAT
ATTCAACTTTACAAAAACTA

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 243; Mature: 243

Protein sequence:

>243_residues
MLYILANGSMATALAYGLKDDYEICIVGRSIEKLQALAKEGFKTLLYKDFNIEGKDVILAFKPYALENIAQMLKGQARIL
ISVLANVDFEKLQTIKAQNYVRIIPNTAAKYKASTTPYILKNSHFENEILDILKTFGSAYKLDNEIQMNAAMAISGCAPA
FLALIAESIANAGVYEGLSKELSLNLTRSLFKSSSALLEHEHPAIIKENICSPGGVTIKGIKILEQKGIRGSFFEAINAS
SAK

Sequences:

>Translated_243_residues
MLYILANGSMATALAYGLKDDYEICIVGRSIEKLQALAKEGFKTLLYKDFNIEGKDVILAFKPYALENIAQMLKGQARIL
ISVLANVDFEKLQTIKAQNYVRIIPNTAAKYKASTTPYILKNSHFENEILDILKTFGSAYKLDNEIQMNAAMAISGCAPA
FLALIAESIANAGVYEGLSKELSLNLTRSLFKSSSALLEHEHPAIIKENICSPGGVTIKGIKILEQKGIRGSFFEAINAS
SAK
>Mature_243_residues
MLYILANGSMATALAYGLKDDYEICIVGRSIEKLQALAKEGFKTLLYKDFNIEGKDVILAFKPYALENIAQMLKGQARIL
ISVLANVDFEKLQTIKAQNYVRIIPNTAAKYKASTTPYILKNSHFENEILDILKTFGSAYKLDNEIQMNAAMAISGCAPA
FLALIAESIANAGVYEGLSKELSLNLTRSLFKSSSALLEHEHPAIIKENICSPGGVTIKGIKILEQKGIRGSFFEAINAS
SAK

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI21361454, Length=224, Percent_Identity=29.0178571428571, Blast_Score=78, Evalue=6e-15,
Organism=Homo sapiens, GI24797097, Length=222, Percent_Identity=27.9279279279279, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI24797095, Length=222, Percent_Identity=27.9279279279279, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI198041662, Length=199, Percent_Identity=26.6331658291457, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI1786585, Length=167, Percent_Identity=29.940119760479, Blast_Score=89, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17569021, Length=254, Percent_Identity=24.4094488188976, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17540664, Length=278, Percent_Identity=27.3381294964029, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320861, Length=191, Percent_Identity=26.7015706806283, Blast_Score=79, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24648116, Length=264, Percent_Identity=27.6515151515151, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI21358587, Length=257, Percent_Identity=22.1789883268482, Blast_Score=67, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 26560; Mature: 26560

Theoretical pI: Translated: 8.72; Mature: 8.72

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYILANGSMATALAYGLKDDYEICIVGRSIEKLQALAKEGFKTLLYKDFNIEGKDVILA
CEEEEECCCHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEE
FKPYALENIAQMLKGQARILISVLANVDFEKLQTIKAQNYVRIIPNTAAKYKASTTPYIL
ECCHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHCCEEEECCCCCHHCCCCCCCEEE
KNSHFENEILDILKTFGSAYKLDNEIQMNAAMAISGCAPAFLALIAESIANAGVYEGLSK
ECCCCHHHHHHHHHHHHHHHCCCCCEEHHHHHEECCHHHHHHHHHHHHHHCCHHHHCCHH
ELSLNLTRSLFKSSSALLEHEHPAIIKENICSPGGVTIKGIKILEQKGIRGSFFEAINAS
HHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCEEEEEEEEEHHCCCCHHHHHHHCCC
SAK
CCC
>Mature Secondary Structure
MLYILANGSMATALAYGLKDDYEICIVGRSIEKLQALAKEGFKTLLYKDFNIEGKDVILA
CEEEEECCCHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEE
FKPYALENIAQMLKGQARILISVLANVDFEKLQTIKAQNYVRIIPNTAAKYKASTTPYIL
ECCHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHCCEEEECCCCCHHCCCCCCCEEE
KNSHFENEILDILKTFGSAYKLDNEIQMNAAMAISGCAPAFLALIAESIANAGVYEGLSK
ECCCCHHHHHHHHHHHHHHHCCCCCEEHHHHHEECCHHHHHHHHHHHHHHCCHHHHCCHH
ELSLNLTRSLFKSSSALLEHEHPAIIKENICSPGGVTIKGIKILEQKGIRGSFFEAINAS
HHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCEEEEEEEEEHHCCCCHHHHHHHCCC
SAK
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]