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The map label for this gene is pepD [H]

Identifier: 57237807

GI number: 57237807

Start: 991124

End: 992392

Strand: Direct

Name: pepD [H]

Synonym: CJE1062

Alternate gene names: 57237807

Gene position: 991124-992392 (Clockwise)

Preceding gene: 57237804

Following gene: 57237810

Centisome position: 55.75

GC content: 33.25

Gene sequence:

>1269_bases
ATGCAAAATGTTATAGAAAATTTTAAACAATTATGCAAAATTCCTCATTGCAGTTATGAAACAGAACAAATGAAAGAATT
TTTAAGCTCTTACGCCAAAGATAAAGGCTTTAAGGTGAGTGTAGATAAGGCAGGAAATATCCATGCCATAAAAGGCAAAC
CAAAAATTTGTCTACAAAGCCATTATGATATGGTCTGTATGGGCGATGCACCAAACTTAGAAGTTTATGAAGAAAATGGC
TTTTTAAGAGCCAAAAATTCAAGTCTTGGTGCAGATAATGGCATAGGTATAGCCATCATGATGAGTGCTATGGCTGAATT
TGAAAATTTAGAATGTCTTTTTACAAACGATGAAGAAGTAGGACTCATGGGAGTGAATTCACTCGAGCACACTTTAGAAT
CTAAAATGCTTTTAAATTTAGATCATGAAAGCGATGATGAGATCATGATAGGCTGTGCAGGTGGAGTAGATATAGAAGCA
AGTTTGTCTTTTAATACCCTTAGAAAAAAGGGTAAAATTTATGAGCTTTGTGCGCAAAATTTTAAAGGTGGACACTCAGG
CATAAATATCATACGCAATGAAAAAAGTTCCATCAAAGAAATGGCTAAATTCATACAAGAGAATGAAGGAGAAATCATTT
CTTTTGAAGGCGGAGAAAGAATCAATTCTATACCTAAACACGCCAAAGCTTTAGTGCATTTTAAAGATGAAGTAAAGAGC
AACGACTGGATAAAATGCGAATTTAAAGAAGAAAATGAATTTGAAATTTGCGATCAAAGTAAAAAACTTTTAAGCCTTAT
AAATTCTTTCACTCATGGAGTTAGAGCTTATGATGAAAATCTAGATATAGTTCAAACAAGCATTAACCTAGCTACTTTAA
GAATGCAAGATAACCAAATCAAATTCGCACTTTTTGCAAGATCTAATATACTTGATGGACTTAAGCAAGTAGAATTTGAA
ACTTTAGAATTTTTCAAGGCTTTTGATTTTAAAGTAAGAAGTTTTAATTTCTATCCACCTTGGGAAGGCAAACCAAACGC
ACTTAGCGACATGGTTTTTAAAGCGCTTAAAAAAGTATCGCCTAATGCCAAAGTTTCAGCTATTCATGCAGGGCTTGAGT
GTGGCATTATAGAGAAAAAACAAGAGCTTTTATGCGCTTCTATAGGCCCAAATATCCATAATCCTCATTCAACTGATGAG
CATTGTGAAATCGCTTCAGTTGAAAAAATATCTAAGGTTGTTTTTGAAGTTTTAAAAGACAATGCTTAA

Upstream 100 bases:

>100_bases
TAGATTAAATAATTTTTTATAATTTATTCTCATTTTTTAATCATTTTGCCTTTAAATTTTAAAAAATATGCCATAATTTT
ATCAAAACAAAGGAGATAAA

Downstream 100 bases:

>100_bases
TTCTTTAATCTTGCTTCTTGCAAAAACGCGTTTTAACAAAAACACGCAAAGCAAGGAACAAGATCCCACTATAGCAAGAT
AAATACCCAAATACTCTTTA

Product: aminoacyl-histidine dipeptidase

Products: NA

Alternate protein names: Beta-alanyl-histidine dipeptidase; Carnosinase; Cysteinylglycinase; Peptidase D; Xaa-His dipeptidase; X-His dipeptidase [H]

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MQNVIENFKQLCKIPHCSYETEQMKEFLSSYAKDKGFKVSVDKAGNIHAIKGKPKICLQSHYDMVCMGDAPNLEVYEENG
FLRAKNSSLGADNGIGIAIMMSAMAEFENLECLFTNDEEVGLMGVNSLEHTLESKMLLNLDHESDDEIMIGCAGGVDIEA
SLSFNTLRKKGKIYELCAQNFKGGHSGINIIRNEKSSIKEMAKFIQENEGEIISFEGGERINSIPKHAKALVHFKDEVKS
NDWIKCEFKEENEFEICDQSKKLLSLINSFTHGVRAYDENLDIVQTSINLATLRMQDNQIKFALFARSNILDGLKQVEFE
TLEFFKAFDFKVRSFNFYPPWEGKPNALSDMVFKALKKVSPNAKVSAIHAGLECGIIEKKQELLCASIGPNIHNPHSTDE
HCEIASVEKISKVVFEVLKDNA

Sequences:

>Translated_422_residues
MQNVIENFKQLCKIPHCSYETEQMKEFLSSYAKDKGFKVSVDKAGNIHAIKGKPKICLQSHYDMVCMGDAPNLEVYEENG
FLRAKNSSLGADNGIGIAIMMSAMAEFENLECLFTNDEEVGLMGVNSLEHTLESKMLLNLDHESDDEIMIGCAGGVDIEA
SLSFNTLRKKGKIYELCAQNFKGGHSGINIIRNEKSSIKEMAKFIQENEGEIISFEGGERINSIPKHAKALVHFKDEVKS
NDWIKCEFKEENEFEICDQSKKLLSLINSFTHGVRAYDENLDIVQTSINLATLRMQDNQIKFALFARSNILDGLKQVEFE
TLEFFKAFDFKVRSFNFYPPWEGKPNALSDMVFKALKKVSPNAKVSAIHAGLECGIIEKKQELLCASIGPNIHNPHSTDE
HCEIASVEKISKVVFEVLKDNA
>Mature_422_residues
MQNVIENFKQLCKIPHCSYETEQMKEFLSSYAKDKGFKVSVDKAGNIHAIKGKPKICLQSHYDMVCMGDAPNLEVYEENG
FLRAKNSSLGADNGIGIAIMMSAMAEFENLECLFTNDEEVGLMGVNSLEHTLESKMLLNLDHESDDEIMIGCAGGVDIEA
SLSFNTLRKKGKIYELCAQNFKGGHSGINIIRNEKSSIKEMAKFIQENEGEIISFEGGERINSIPKHAKALVHFKDEVKS
NDWIKCEFKEENEFEICDQSKKLLSLINSFTHGVRAYDENLDIVQTSINLATLRMQDNQIKFALFARSNILDGLKQVEFE
TLEFFKAFDFKVRSFNFYPPWEGKPNALSDMVFKALKKVSPNAKVSAIHAGLECGIIEKKQELLCASIGPNIHNPHSTDE
HCEIASVEKISKVVFEVLKDNA

Specific function: Dipeptidase with broad substrate specificity. Requires dipeptide substrates with an unblocked N-terminus and the amino group in the alpha or beta position. Non-protein amino acids and proline are not accepted in the C-terminal position, whereas some dipep

COG id: COG2195

COG function: function code E; Di- and tripeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20C family [H]

Homologues:

Organism=Escherichia coli, GI1786432, Length=475, Percent_Identity=30.1052631578947, Blast_Score=195, Evalue=5e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002933
- InterPro:   IPR011650
- InterPro:   IPR001160 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.4.13.3 [H]

Molecular weight: Translated: 47404; Mature: 47404

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNVIENFKQLCKIPHCSYETEQMKEFLSSYAKDKGFKVSVDKAGNIHAIKGKPKICLQS
CCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCEEEECCCCCEEEEC
HYDMVCMGDAPNLEVYEENGFLRAKNSSLGADNGIGIAIMMSAMAEFENLECLFTNDEEV
CCCEEEECCCCCCEEEECCCEEEECCCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCE
GLMGVNSLEHTLESKMLLNLDHESDDEIMIGCAGGVDIEASLSFNTLRKKGKIYELCAQN
EEEECHHHHHHHHHCEEEECCCCCCCCEEEEECCCCEEEEECCHHHHHHCCHHHHHHHHH
FKGGHSGINIIRNEKSSIKEMAKFIQENEGEIISFEGGERINSIPKHAKALVHFKDEVKS
CCCCCCCCEEEECCHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCC
NDWIKCEFKEENEFEICDQSKKLLSLINSFTHGVRAYDENLDIVQTSINLATLRMQDNQI
CCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEEEEECCCE
KFALFARSNILDGLKQVEFETLEFFKAFDFKVRSFNFYPPWEGKPNALSDMVFKALKKVS
EEEEEEHHHHHHHHHHHHHHHHHHHHHHCEEEEEEECCCCCCCCCCHHHHHHHHHHHHCC
PNAKVSAIHAGLECGIIEKKQELLCASIGPNIHNPHSTDEHCEIASVEKISKVVFEVLKD
CCCEEEEEECCCCCCEEHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHC
NA
CC
>Mature Secondary Structure
MQNVIENFKQLCKIPHCSYETEQMKEFLSSYAKDKGFKVSVDKAGNIHAIKGKPKICLQS
CCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCEEEECCCCCEEEEC
HYDMVCMGDAPNLEVYEENGFLRAKNSSLGADNGIGIAIMMSAMAEFENLECLFTNDEEV
CCCEEEECCCCCCEEEECCCEEEECCCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCE
GLMGVNSLEHTLESKMLLNLDHESDDEIMIGCAGGVDIEASLSFNTLRKKGKIYELCAQN
EEEECHHHHHHHHHCEEEECCCCCCCCEEEEECCCCEEEEECCHHHHHHCCHHHHHHHHH
FKGGHSGINIIRNEKSSIKEMAKFIQENEGEIISFEGGERINSIPKHAKALVHFKDEVKS
CCCCCCCCEEEECCHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCC
NDWIKCEFKEENEFEICDQSKKLLSLINSFTHGVRAYDENLDIVQTSINLATLRMQDNQI
CCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEEEEECCCE
KFALFARSNILDGLKQVEFETLEFFKAFDFKVRSFNFYPPWEGKPNALSDMVFKALKKVS
EEEEEEHHHHHHHHHHHHHHHHHHHHHHCEEEEEEECCCCCCCCCCHHHHHHHHHHHHCC
PNAKVSAIHAGLECGIIEKKQELLCASIGPNIHNPHSTDEHCEIASVEKISKVVFEVLKD
CCCEEEEEECCCCCCEEHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHC
NA
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1695895; 9278503; 2651887 [H]