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The map label for this gene is uppS

Identifier: 57237665

GI number: 57237665

Start: 849813

End: 850481

Strand: Direct

Name: uppS

Synonym: CJE0911

Alternate gene names: 57237665

Gene position: 849813-850481 (Clockwise)

Preceding gene: 57237664

Following gene: 57237666

Centisome position: 47.8

GC content: 31.69

Gene sequence:

>669_bases
ATGAATGAATTAAAACATCTTGCTGTTGTTATGGATGGCAATAGGCGCTGGGCTAGAGCTAAGGGTTTTTTGGCAAAGCT
TGGATATTCCCAAGGAGTCAAAACTATGCAAAAATTGATGGAAGTTTGCATGGAAGAAAATATTTCAAATTTAAGCCTTT
TTGCTTTTAGTACGGAAAATTGGAAGCGTCCTAAAGATGAAATTGATTTTATCTTTGAACTTTTAGATCGTTGTTTAGAT
GAAGCTTTAGAAAAATTTGAAAAAAATAATGTGCGTTTAAGAGCTATAGGTGATTTATCGCGCTTGGAAGATAAAGTAAG
AGAAAAAATTACCTTAGTTGAAGAAAAAACAAAGCATTGTGACGCACTTTGTGTTAATTTGGCTATAAGTTATGGTGCAA
GAGATGAGATTATAAGAGCTGCTAAGCGTGTGATTGAAAAAAAACTTGAGCTAAATGAAGAAAATTTAACGCAAAATTTA
GATTTACCTTTAGATGTGGATTTGATGCTTCGCGTTGGAAACGCTAAAAGACTTTCAAATTTCTTACTTTGGCAGTGTTC
ATATGCTGAAATTTATTTTAGTGAAACTTTATTTCCATCTCTTACCAAGAGAGAATTTAAAAGGATTATTAAAGAATTTA
GAAATAGAGAAAGAACTTTTGGAAAATGA

Upstream 100 bases:

>100_bases
AAAATTTTTAAACGAACATTTAGATTTTAATGTATCGCAAGAAAACAAGATTGAACCTTTGTTTGTTTTCAAAAGGCTTT
TTGATTTTAAAGGATGAAAA

Downstream 100 bases:

>100_bases
TATTTTTCATAATAATTCTAGGGGCTTGTTTGGGTTCTTTTTGCACAAGTTTGGCAAGTAGGATAATTGAAAAAAAGCCC
TTTTTTATCTCGCGCTCTTT

Product: undecaprenyl diphosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS

Number of amino acids: Translated: 222; Mature: 222

Protein sequence:

>222_residues
MNELKHLAVVMDGNRRWARAKGFLAKLGYSQGVKTMQKLMEVCMEENISNLSLFAFSTENWKRPKDEIDFIFELLDRCLD
EALEKFEKNNVRLRAIGDLSRLEDKVREKITLVEEKTKHCDALCVNLAISYGARDEIIRAAKRVIEKKLELNEENLTQNL
DLPLDVDLMLRVGNAKRLSNFLLWQCSYAEIYFSETLFPSLTKREFKRIIKEFRNRERTFGK

Sequences:

>Translated_222_residues
MNELKHLAVVMDGNRRWARAKGFLAKLGYSQGVKTMQKLMEVCMEENISNLSLFAFSTENWKRPKDEIDFIFELLDRCLD
EALEKFEKNNVRLRAIGDLSRLEDKVREKITLVEEKTKHCDALCVNLAISYGARDEIIRAAKRVIEKKLELNEENLTQNL
DLPLDVDLMLRVGNAKRLSNFLLWQCSYAEIYFSETLFPSLTKREFKRIIKEFRNRERTFGK
>Mature_222_residues
MNELKHLAVVMDGNRRWARAKGFLAKLGYSQGVKTMQKLMEVCMEENISNLSLFAFSTENWKRPKDEIDFIFELLDRCLD
EALEKFEKNNVRLRAIGDLSRLEDKVREKITLVEEKTKHCDALCVNLAISYGARDEIIRAAKRVIEKKLELNEENLTQNL
DLPLDVDLMLRVGNAKRLSNFLLWQCSYAEIYFSETLFPSLTKREFKRIIKEFRNRERTFGK

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family

Homologues:

Organism=Homo sapiens, GI45580738, Length=212, Percent_Identity=31.6037735849057, Blast_Score=108, Evalue=3e-24,
Organism=Homo sapiens, GI45580742, Length=212, Percent_Identity=31.6037735849057, Blast_Score=108, Evalue=3e-24,
Organism=Escherichia coli, GI1786371, Length=226, Percent_Identity=37.1681415929204, Blast_Score=177, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI71993029, Length=211, Percent_Identity=31.7535545023697, Blast_Score=106, Evalue=8e-24,
Organism=Saccharomyces cerevisiae, GI6319474, Length=192, Percent_Identity=34.375, Blast_Score=105, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6323748, Length=211, Percent_Identity=30.3317535545024, Blast_Score=102, Evalue=4e-23,
Organism=Drosophila melanogaster, GI18857969, Length=216, Percent_Identity=31.0185185185185, Blast_Score=113, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UPPS_CAMJE (Q9PP99)

Other databases:

- EMBL:   AL111168
- PIR:   H81354
- RefSeq:   YP_002344231.1
- ProteinModelPortal:   Q9PP99
- SMR:   Q9PP99
- IntAct:   Q9PP99
- GeneID:   905127
- GenomeReviews:   AL111168_GR
- KEGG:   cje:Cj0824
- HOGENOM:   HBG627837
- OMA:   FLWRIAY
- ProtClustDB:   CLSK878944
- BioCyc:   CJEJ192222:CJ0824-MONOMER
- BRENDA:   2.5.1.31
- HAMAP:   MF_01139
- InterPro:   IPR001441
- InterPro:   IPR018520
- Gene3D:   G3DSA:3.40.1180.10
- PANTHER:   PTHR10291
- TIGRFAMs:   TIGR00055

Pfam domain/function: PF01255 Prenyltransf; SSF64005 UPP_synth

EC number: =2.5.1.31

Molecular weight: Translated: 26088; Mature: 26088

Theoretical pI: Translated: 8.72; Mature: 8.72

Prosite motif: PS01066 UPP_SYNTHASE

Important sites: ACT_SITE 12-12

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNELKHLAVVMDGNRRWARAKGFLAKLGYSQGVKTMQKLMEVCMEENISNLSLFAFSTEN
CCCHHEEEEEECCCCHHHHHHHHHHHHCHHCCHHHHHHHHHHHHHCCCCCEEEEEEECCC
WKRPKDEIDFIFELLDRCLDEALEKFEKNNVRLRAIGDLSRLEDKVREKITLVEEKTKHC
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
DALCVNLAISYGARDEIIRAAKRVIEKKLELNEENLTQNLDLPLDVDLMLRVGNAKRLSN
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCHHHHEEECCHHHHHH
FLLWQCSYAEIYFSETLFPSLTKREFKRIIKEFRNRERTFGK
HHHEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNELKHLAVVMDGNRRWARAKGFLAKLGYSQGVKTMQKLMEVCMEENISNLSLFAFSTEN
CCCHHEEEEEECCCCHHHHHHHHHHHHCHHCCHHHHHHHHHHHHHCCCCCEEEEEEECCC
WKRPKDEIDFIFELLDRCLDEALEKFEKNNVRLRAIGDLSRLEDKVREKITLVEEKTKHC
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
DALCVNLAISYGARDEIIRAAKRVIEKKLELNEENLTQNLDLPLDVDLMLRVGNAKRLSN
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCHHHHEEECCHHHHHH
FLLWQCSYAEIYFSETLFPSLTKREFKRIIKEFRNRERTFGK
HHHEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10688204