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The map label for this gene is thrC [H]

Identifier: 57237657

GI number: 57237657

Start: 841535

End: 842947

Strand: Direct

Name: thrC [H]

Synonym: CJE0903

Alternate gene names: 57237657

Gene position: 841535-842947 (Clockwise)

Preceding gene: 57237656

Following gene: 57237658

Centisome position: 47.33

GC content: 30.71

Gene sequence:

>1413_bases
ATGAAATTAGTCGAGAGTAGAAATGTAAATAATGTATCAAGTTTTAAGGAAGCTTTGATTAACCCAAACGCCCCAGAAGG
AGGGCTTTACTCGCCTTTAAATTTGCCTATTTTTGAAGGAGAAAAATATGCCAATTTGTCTTATAAAGATTTTGCTTTAA
AGCTTATAGAAAGTTTTGGTTTTGGCGAAGAAGAGCTTTTTAAAAAGGCTTTGAAAAGTTACGAAAGCTTTGATGATAAA
AATACACCTATTTCTTTGCAAAAAATCTCTGAAAAAACCTATATTAACGAGCTTTGGCATGGGCCTACAAGAGCTTTTAA
AGATATGGCTTTACAGCCTTTTGGCGTGCTTTTAAGCGAATTTTCAAAGGATAAAAATATTTTAATTATTTGTGCTACGA
GCGGCGATACAGGACCTGCAACCCTAAAAAGCTTTGAAAATGCAAAAAATGTTAAAGTAGCTTGTATGTATCCAAAAGGT
GGCACAAGTGGAGTTCAAGAGTTGCAAATGCGAGCTTTAGATAAGGATAATTTGAAAGTTTTTGCTATAGATGAGGATTT
TGACGCAGCGCAACGCACTTTAAAAGAATTGCTTTTTTCAAAAGATTTTCAAAACAAAATTAAAGCTTTAAATTATGAGC
TTTGCGCAGCGAATTCTGTAAATTTTGGGCGTATTTTATTTCAGATTATTTATCATTATTATGCGAGTTTAAAACTTTTT
AATGAGTTTTTAGAAGAAGTACAAATCATTGTTCCAAGTGGAAATTTTGGCAATGCTTTAGGAGCTTTTTATGCTAAAAA
AATGGGAGCTAAAATTTCAAAAATCAAAATCGCTTCAAATGTGAATAATATTTTGAGTGAATTTTTTAATCATGGCGTTT
ATGATTTGCGTGAAAAAAGTCTTAAGAAGACTATTTCTCCAGCTATGGATATACTTATTTCATCTAATATCGAAAGACTT
TTGTTTGCGAAATTTAAAGATAAAAGAACCAAAGAACTGATGAATTTGTTGAAAAATGAGAGATATTTTAAACTTGAAAA
AGAAGAATTGCAAAGTTTACAAGAAGATTTTGAGGCGGATTTTTGCACCGATGAAGAATGTATGCAATTTATCAAACAAA
GCAAGATTTTAATCGATCCGCACACCGCAACTTGTTTTAAAATGCTTGATCCTTTAAAACCTAGCATTATTACCTCTACA
GCAGAATGGACAAAATTTACTCCAAGTATGATAAAAGCTTTATACGATAGGGATTCTAAGAATGAAAAAGAAGATTTAAA
ATTTATAGCTAAAGAGTTTAATGTCCAAGTTAAAGATGAAATTTTGGCTTTATTTGACTTGAAAAATAGCGATGAAAAGG
TATTTGAAGCCAAAAATATAAAAAAAGAAATTTTAGATTGGATGCAAAAATGA

Upstream 100 bases:

>100_bases
TTAAAGATTTTGGTTTTAAATGTCAAATTATAGAATTAAATATAGAATTAAAAGATTCATTAAGGGAAAAAATAAAAACT
TATATCAAGGAGTTTGAGCA

Downstream 100 bases:

>100_bases
TTATTATCCCTGCAAGATTAAAATCAAGTCGTTTTCATGAGAAAATTTTATGTGATGTAGGTGGAGTGCCTATGTTTGTG
GCTACTGCAAGAAGGGTAAG

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 470; Mature: 470

Protein sequence:

>470_residues
MKLVESRNVNNVSSFKEALINPNAPEGGLYSPLNLPIFEGEKYANLSYKDFALKLIESFGFGEEELFKKALKSYESFDDK
NTPISLQKISEKTYINELWHGPTRAFKDMALQPFGVLLSEFSKDKNILIICATSGDTGPATLKSFENAKNVKVACMYPKG
GTSGVQELQMRALDKDNLKVFAIDEDFDAAQRTLKELLFSKDFQNKIKALNYELCAANSVNFGRILFQIIYHYYASLKLF
NEFLEEVQIIVPSGNFGNALGAFYAKKMGAKISKIKIASNVNNILSEFFNHGVYDLREKSLKKTISPAMDILISSNIERL
LFAKFKDKRTKELMNLLKNERYFKLEKEELQSLQEDFEADFCTDEECMQFIKQSKILIDPHTATCFKMLDPLKPSIITST
AEWTKFTPSMIKALYDRDSKNEKEDLKFIAKEFNVQVKDEILALFDLKNSDEKVFEAKNIKKEILDWMQK

Sequences:

>Translated_470_residues
MKLVESRNVNNVSSFKEALINPNAPEGGLYSPLNLPIFEGEKYANLSYKDFALKLIESFGFGEEELFKKALKSYESFDDK
NTPISLQKISEKTYINELWHGPTRAFKDMALQPFGVLLSEFSKDKNILIICATSGDTGPATLKSFENAKNVKVACMYPKG
GTSGVQELQMRALDKDNLKVFAIDEDFDAAQRTLKELLFSKDFQNKIKALNYELCAANSVNFGRILFQIIYHYYASLKLF
NEFLEEVQIIVPSGNFGNALGAFYAKKMGAKISKIKIASNVNNILSEFFNHGVYDLREKSLKKTISPAMDILISSNIERL
LFAKFKDKRTKELMNLLKNERYFKLEKEELQSLQEDFEADFCTDEECMQFIKQSKILIDPHTATCFKMLDPLKPSIITST
AEWTKFTPSMIKALYDRDSKNEKEDLKFIAKEFNVQVKDEILALFDLKNSDEKVFEAKNIKKEILDWMQK
>Mature_470_residues
MKLVESRNVNNVSSFKEALINPNAPEGGLYSPLNLPIFEGEKYANLSYKDFALKLIESFGFGEEELFKKALKSYESFDDK
NTPISLQKISEKTYINELWHGPTRAFKDMALQPFGVLLSEFSKDKNILIICATSGDTGPATLKSFENAKNVKVACMYPKG
GTSGVQELQMRALDKDNLKVFAIDEDFDAAQRTLKELLFSKDFQNKIKALNYELCAANSVNFGRILFQIIYHYYASLKLF
NEFLEEVQIIVPSGNFGNALGAFYAKKMGAKISKIKIASNVNNILSEFFNHGVYDLREKSLKKTISPAMDILISSNIERL
LFAKFKDKRTKELMNLLKNERYFKLEKEELQSLQEDFEADFCTDEECMQFIKQSKILIDPHTATCFKMLDPLKPSIITST
AEWTKFTPSMIKALYDRDSKNEKEDLKFIAKEFNVQVKDEILALFDLKNSDEKVFEAKNIKKEILDWMQK

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI153792148, Length=429, Percent_Identity=34.965034965035, Blast_Score=238, Evalue=6e-63,
Organism=Homo sapiens, GI149193323, Length=440, Percent_Identity=29.0909090909091, Blast_Score=181, Evalue=1e-45,
Organism=Escherichia coli, GI1786185, Length=422, Percent_Identity=29.8578199052133, Blast_Score=151, Evalue=7e-38,
Organism=Saccharomyces cerevisiae, GI6319901, Length=414, Percent_Identity=35.024154589372, Blast_Score=221, Evalue=2e-58,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 53850; Mature: 53850

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLVESRNVNNVSSFKEALINPNAPEGGLYSPLNLPIFEGEKYANLSYKDFALKLIESFG
CCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEECCCCCCCCCHHHHHHHHHHHHC
FGEEELFKKALKSYESFDDKNTPISLQKISEKTYINELWHGPTRAFKDMALQPFGVLLSE
CCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHH
FSKDKNILIICATSGDTGPATLKSFENAKNVKVACMYPKGGTSGVQELQMRALDKDNLKV
HCCCCCEEEEEECCCCCCHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCEEE
FAIDEDFDAAQRTLKELLFSKDFQNKIKALNYELCAANSVNFGRILFQIIYHYYASLKLF
EEECCCHHHHHHHHHHHHHCCCHHHHHHHHCHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
NEFLEEVQIIVPSGNFGNALGAFYAKKMGAKISKIKIASNVNNILSEFFNHGVYDLREKS
HHHHHHHEEEECCCCCCHHHHHHHHHHHCCHHHEEEHHHHHHHHHHHHHHCCHHHHHHHH
LKKTISPAMDILISSNIERLLFAKFKDKRTKELMNLLKNERYFKLEKEELQSLQEDFEAD
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHCCC
FCTDEECMQFIKQSKILIDPHTATCFKMLDPLKPSIITSTAEWTKFTPSMIKALYDRDSK
CCCCHHHHHHHHHCCEEECCCHHHHHHHHCCCCCHHCCCCHHHHHCCHHHHHHHHCCCCC
NEKEDLKFIAKEFNVQVKDEILALFDLKNSDEKVFEAKNIKKEILDWMQK
CHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKLVESRNVNNVSSFKEALINPNAPEGGLYSPLNLPIFEGEKYANLSYKDFALKLIESFG
CCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEECCCCCCCCCHHHHHHHHHHHHC
FGEEELFKKALKSYESFDDKNTPISLQKISEKTYINELWHGPTRAFKDMALQPFGVLLSE
CCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHH
FSKDKNILIICATSGDTGPATLKSFENAKNVKVACMYPKGGTSGVQELQMRALDKDNLKV
HCCCCCEEEEEECCCCCCHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCEEE
FAIDEDFDAAQRTLKELLFSKDFQNKIKALNYELCAANSVNFGRILFQIIYHYYASLKLF
EEECCCHHHHHHHHHHHHHCCCHHHHHHHHCHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
NEFLEEVQIIVPSGNFGNALGAFYAKKMGAKISKIKIASNVNNILSEFFNHGVYDLREKS
HHHHHHHEEEECCCCCCHHHHHHHHHHHCCHHHEEEHHHHHHHHHHHHHHCCHHHHHHHH
LKKTISPAMDILISSNIERLLFAKFKDKRTKELMNLLKNERYFKLEKEELQSLQEDFEAD
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHCCC
FCTDEECMQFIKQSKILIDPHTATCFKMLDPLKPSIITSTAEWTKFTPSMIKALYDRDSK
CCCCHHHHHHHHHCCEEECCCHHHHHHHHCCCCCHHCCCCHHHHHCCHHHHHHHHCCCCC
NEKEDLKFIAKEFNVQVKDEILALFDLKNSDEKVFEAKNIKKEILDWMQK
CHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]