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The map label for this gene is cfrA [H]

Identifier: 57237601

GI number: 57237601

Start: 783895

End: 785985

Strand: Direct

Name: cfrA [H]

Synonym: CJE0847

Alternate gene names: 57237601

Gene position: 783895-785985 (Clockwise)

Preceding gene: 57237600

Following gene: 57237602

Centisome position: 44.09

GC content: 33.24

Gene sequence:

>2091_bases
ATGAAGAAATTATGTCTATCGGTTTGTGCCATTGGCCTTTTGGCTTCTAATGCTATATCGCAAAATGTAGAGCTAGACAG
TTCGATCATTAGTGCTTCTGGATTTGCTCAAGATATTAAAGAAGCTCCTGCTACTATCAATGTTATTAGTAAAAAAGAAT
TACAAAGTAAGCCTTATAGAGATGTTGCAGAGGCTATCGCAGATATTCCAGGCGTTGATTTATATGCTAGCAAGGGAAAA
ACAGGTTCTTATAATATCACTATGAGGGGTATTACTGGATATACTTTGGTTTTGATTGATGGGCGTCGTCAGGGTATTGG
CGGAGAGGTGGGCCCTAATGGTTTTAATGAAATTTCAAATTCTTTCTTACCTCCGATTTCTAGTATAGAAAGGATAGAAG
TTATAAAAGGTCCTATGAGTACTTTATATGGCTCTGAAGCTTTAGGCGGGGTGGTAAATATCATTACCAAAAAAGTAAGT
GATAAATGGGAAACTTCTGTAAGTTTGGATGCTCTTTTAAATGAAAATAAAGATTGGGGTAATACTTATGGAACGAGTAT
TTATTCTAGTGGTCCTTTGATGAATGACAAATTGGGTCTAACACTTCGATTTAGAGAATTTTACAGACAGCAATCTAATG
TTGAATTTACAAATGGAAGTGGACAAAGAGTTCCAGGAGATCAAGCTCAAAGTCCTACAAAGGCAAATAATTTTAACATA
GGAACAAGAGTCAGTTATTTGGCTAATGATTATAATACCTTTATATTTGATATAGATTTTTCAAGAAATCATTATGATAA
TAAACAAGGTCAATTAGGAACCATCACAAGTCCAGATAGTACACAAGGTAGCTTAACGGGTGGTTATGCAGATATTATGG
AAGTTGATAAATTTGTGACTTATTTAAGCCATGAGGGTGTTTATGAAAACTTTTCTATCACTTCTGGTTTGCAATACAAT
AGGGTAAGCAATGATGGCCGTGAAGTCGTAGGGCAAGCTACACAGCCGTTTTTGGGAGAAAATAGAGATATAGTCGCAGA
AGATATTATCTTAGATACAAAATCTGTCATTCCTTTAGGACAGAATCATATTTTAAGCGCAGGTGGTGAATATAGGCTTG
AAAAAATGCAAGATAAAATAGCTAATCCGACCAATTTTGATCAGTATTTATTGGCAATATTTGCAGAGGATGAGTATAGT
ATAAAAGATAACTTAAGATTGACTTTTGGAGCAAGATACAATCATCATGAAATTTTTGGAAACAATGTTTCGCCAAGAGC
TTATCTAGTTTATAATCCTACTGATGAACTTACTTTAAAAGGCGGTGTATCTACGGGTTTTAGGACTCCTTATGCAAATC
GTTTGATAAATGGAGCTTATAATTATAGTGGTCAAGGTAGATTTCCTATATATGGAAATCCTGATTTAAAAGAAGAGACA
TCTTTAAATTATGAAATAGCAGCTATTTACAATAATGATTTGTTTTATGTTTCTGCGACAGGTTTTTTAACAAATTTTAA
AGATAAAATTTCAACCCAAAGATATGACAAAAATAATATGATTCCAGGAATTGGTACTTGTAATGCTGATAGATGTTTTA
GAGCGATCAATCATGGTAAGGTTGAGTACAAAGGTGTAGAGCTTGGAGCAGGGATAAGCCCTCTTGATAATTTAAATATA
AATTTTGCTTATACTTATCTTGATAGTGAGGTTAAAGAAGCACAAGATAAAAGTGTGATAGGTAAACCTGAGCAGGATAG
TTTAAAACATAATATTATGTTGAAAACTGAATACAGCTTCTATAATAAAATTACCCCTTGGATAAAAGGCGAATGGCAAA
TAGATCGCTATATGGGTGATACTAATATAAATAGGGAATATTATAAGGATATCTTTTTAGCTTCTATGGGTGTGCGTTAT
GATATCAATAAGCAATGGAATATCAACGCAGCTATTTATAATCTTTTTAACAAAAGTTTTACAGATGGTTGGGAATCTTA
TCAAAATAGCGGTACTACTACTTGGGTCAATACTTACAATCGCATAGAAGAAGGAAGAAGAATATATATTTCCATTAATG
GTAGTTTTTAA

Upstream 100 bases:

>100_bases
ATTAATACTAATTATCACAATTGATACAAAATTTATCTTAAATTAATAATTATTATCATAATATTCTGATTTCTAATTAA
TATTTAATAAAAGGAGAAAA

Downstream 100 bases:

>100_bases
GCTTTGATAGAAAAGCCAAAGAGCTTGTAAAGGCTTCTTTGGTTTTTTGTTTATAGCATCTTGTGCTTTTAAAAAAGTTA
AATTATCGAATCTATATTAA

Product: ferric receptor CfrA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 696; Mature: 696

Protein sequence:

>696_residues
MKKLCLSVCAIGLLASNAISQNVELDSSIISASGFAQDIKEAPATINVISKKELQSKPYRDVAEAIADIPGVDLYASKGK
TGSYNITMRGITGYTLVLIDGRRQGIGGEVGPNGFNEISNSFLPPISSIERIEVIKGPMSTLYGSEALGGVVNIITKKVS
DKWETSVSLDALLNENKDWGNTYGTSIYSSGPLMNDKLGLTLRFREFYRQQSNVEFTNGSGQRVPGDQAQSPTKANNFNI
GTRVSYLANDYNTFIFDIDFSRNHYDNKQGQLGTITSPDSTQGSLTGGYADIMEVDKFVTYLSHEGVYENFSITSGLQYN
RVSNDGREVVGQATQPFLGENRDIVAEDIILDTKSVIPLGQNHILSAGGEYRLEKMQDKIANPTNFDQYLLAIFAEDEYS
IKDNLRLTFGARYNHHEIFGNNVSPRAYLVYNPTDELTLKGGVSTGFRTPYANRLINGAYNYSGQGRFPIYGNPDLKEET
SLNYEIAAIYNNDLFYVSATGFLTNFKDKISTQRYDKNNMIPGIGTCNADRCFRAINHGKVEYKGVELGAGISPLDNLNI
NFAYTYLDSEVKEAQDKSVIGKPEQDSLKHNIMLKTEYSFYNKITPWIKGEWQIDRYMGDTNINREYYKDIFLASMGVRY
DINKQWNINAAIYNLFNKSFTDGWESYQNSGTTTWVNTYNRIEEGRRIYISINGSF

Sequences:

>Translated_696_residues
MKKLCLSVCAIGLLASNAISQNVELDSSIISASGFAQDIKEAPATINVISKKELQSKPYRDVAEAIADIPGVDLYASKGK
TGSYNITMRGITGYTLVLIDGRRQGIGGEVGPNGFNEISNSFLPPISSIERIEVIKGPMSTLYGSEALGGVVNIITKKVS
DKWETSVSLDALLNENKDWGNTYGTSIYSSGPLMNDKLGLTLRFREFYRQQSNVEFTNGSGQRVPGDQAQSPTKANNFNI
GTRVSYLANDYNTFIFDIDFSRNHYDNKQGQLGTITSPDSTQGSLTGGYADIMEVDKFVTYLSHEGVYENFSITSGLQYN
RVSNDGREVVGQATQPFLGENRDIVAEDIILDTKSVIPLGQNHILSAGGEYRLEKMQDKIANPTNFDQYLLAIFAEDEYS
IKDNLRLTFGARYNHHEIFGNNVSPRAYLVYNPTDELTLKGGVSTGFRTPYANRLINGAYNYSGQGRFPIYGNPDLKEET
SLNYEIAAIYNNDLFYVSATGFLTNFKDKISTQRYDKNNMIPGIGTCNADRCFRAINHGKVEYKGVELGAGISPLDNLNI
NFAYTYLDSEVKEAQDKSVIGKPEQDSLKHNIMLKTEYSFYNKITPWIKGEWQIDRYMGDTNINREYYKDIFLASMGVRY
DINKQWNINAAIYNLFNKSFTDGWESYQNSGTTTWVNTYNRIEEGRRIYISINGSF
>Mature_696_residues
MKKLCLSVCAIGLLASNAISQNVELDSSIISASGFAQDIKEAPATINVISKKELQSKPYRDVAEAIADIPGVDLYASKGK
TGSYNITMRGITGYTLVLIDGRRQGIGGEVGPNGFNEISNSFLPPISSIERIEVIKGPMSTLYGSEALGGVVNIITKKVS
DKWETSVSLDALLNENKDWGNTYGTSIYSSGPLMNDKLGLTLRFREFYRQQSNVEFTNGSGQRVPGDQAQSPTKANNFNI
GTRVSYLANDYNTFIFDIDFSRNHYDNKQGQLGTITSPDSTQGSLTGGYADIMEVDKFVTYLSHEGVYENFSITSGLQYN
RVSNDGREVVGQATQPFLGENRDIVAEDIILDTKSVIPLGQNHILSAGGEYRLEKMQDKIANPTNFDQYLLAIFAEDEYS
IKDNLRLTFGARYNHHEIFGNNVSPRAYLVYNPTDELTLKGGVSTGFRTPYANRLINGAYNYSGQGRFPIYGNPDLKEET
SLNYEIAAIYNNDLFYVSATGFLTNFKDKISTQRYDKNNMIPGIGTCNADRCFRAINHGKVEYKGVELGAGISPLDNLNI
NFAYTYLDSEVKEAQDKSVIGKPEQDSLKHNIMLKTEYSFYNKITPWIKGEWQIDRYMGDTNINREYYKDIFLASMGVRY
DINKQWNINAAIYNLFNKSFTDGWESYQNSGTTTWVNTYNRIEEGRRIYISINGSF

Specific function: Involved in the initial step of iron uptake by binding ferric vibriobactin, an iron chelatin siderophore that allows V.cholerae to extract iron from the environment [H]

COG id: COG4771

COG function: function code P; Outer membrane receptor for ferrienterochelin and colicins

Gene ontology:

Cell location: Cell outer membrane [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tonB-dependent receptor family [H]

Homologues:

Organism=Escherichia coli, GI1788478, Length=725, Percent_Identity=29.7931034482759, Blast_Score=257, Evalue=1e-69,
Organism=Escherichia coli, GI1786798, Length=765, Percent_Identity=26.9281045751634, Blast_Score=150, Evalue=3e-37,
Organism=Escherichia coli, GI1790405, Length=203, Percent_Identity=30.5418719211823, Blast_Score=87, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012910
- InterPro:   IPR000531
- InterPro:   IPR010916
- InterPro:   IPR010917 [H]

Pfam domain/function: PF07715 Plug; PF00593 TonB_dep_Rec [H]

EC number: NA

Molecular weight: Translated: 77817; Mature: 77817

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS01156 TONB_DEPENDENT_REC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLCLSVCAIGLLASNAISQNVELDSSIISASGFAQDIKEAPATINVISKKELQSKPYR
CHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCHHHHHHHHCCCEEEEEEHHHHHCCCHH
DVAEAIADIPGVDLYASKGKTGSYNITMRGITGYTLVLIDGRRQGIGGEVGPNGFNEISN
HHHHHHHCCCCCEEEECCCCCCEEEEEEECCCCEEEEEECCCCCCCCCCCCCCCHHHHHH
SFLPPISSIERIEVIKGPMSTLYGSEALGGVVNIITKKVSDKWETSVSLDALLNENKDWG
HCCCCCHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHCCHHCCCEEHHHHHCCCCCCC
NTYGTSIYSSGPLMNDKLGLTLRFREFYRQQSNVEFTNGSGQRVPGDQAQSPTKANNFNI
CCCCCCEECCCCCCCCCCCEEEEHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCCCCCCC
GTRVSYLANDYNTFIFDIDFSRNHYDNKQGQLGTITSPDSTQGSLTGGYADIMEVDKFVT
CCEEEEEECCCCEEEEEEECCCCCCCCCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHH
YLSHEGVYENFSITSGLQYNRVSNDGREVVGQATQPFLGENRDIVAEDIILDTKSVIPLG
HHHCCCCCCCCEECCCCEECCCCCCHHHHHCCCCCCCCCCCCCEEEHHEEECCCCCCCCC
QNHILSAGGEYRLEKMQDKIANPTNFDQYLLAIFAEDEYSIKDNLRLTFGARYNHHEIFG
CCCEECCCCCHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCEEEEEECCCCCCEECC
NNVSPRAYLVYNPTDELTLKGGVSTGFRTPYANRLINGAYNYSGQGRFPIYGNPDLKEET
CCCCCCEEEEECCCCCEEEECCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
SLNYEIAAIYNNDLFYVSATGFLTNFKDKISTQRYDKNNMIPGIGTCNADRCFRAINHGK
CCCEEEEEEEECCEEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCC
VEYKGVELGAGISPLDNLNINFAYTYLDSEVKEAQDKSVIGKPEQDSLKHNIMLKTEYSF
EEEEEEEECCCCCCCCCCCEEEEEEEECHHHHHHHCCCCCCCCCHHCCCCEEEEEEEHHH
YNKITPWIKGEWQIDRYMGDTNINREYYKDIFLASMGVRYDINKQWNINAAIYNLFNKSF
HHCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHH
TDGWESYQNSGTTTWVNTYNRIEEGRRIYISINGSF
CHHHHHHHCCCCEEEEHHHHHHCCCCEEEEEECCCC
>Mature Secondary Structure
MKKLCLSVCAIGLLASNAISQNVELDSSIISASGFAQDIKEAPATINVISKKELQSKPYR
CHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCHHHHHHHHCCCEEEEEEHHHHHCCCHH
DVAEAIADIPGVDLYASKGKTGSYNITMRGITGYTLVLIDGRRQGIGGEVGPNGFNEISN
HHHHHHHCCCCCEEEECCCCCCEEEEEEECCCCEEEEEECCCCCCCCCCCCCCCHHHHHH
SFLPPISSIERIEVIKGPMSTLYGSEALGGVVNIITKKVSDKWETSVSLDALLNENKDWG
HCCCCCHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHCCHHCCCEEHHHHHCCCCCCC
NTYGTSIYSSGPLMNDKLGLTLRFREFYRQQSNVEFTNGSGQRVPGDQAQSPTKANNFNI
CCCCCCEECCCCCCCCCCCEEEEHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCCCCCCC
GTRVSYLANDYNTFIFDIDFSRNHYDNKQGQLGTITSPDSTQGSLTGGYADIMEVDKFVT
CCEEEEEECCCCEEEEEEECCCCCCCCCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHH
YLSHEGVYENFSITSGLQYNRVSNDGREVVGQATQPFLGENRDIVAEDIILDTKSVIPLG
HHHCCCCCCCCEECCCCEECCCCCCHHHHHCCCCCCCCCCCCCEEEHHEEECCCCCCCCC
QNHILSAGGEYRLEKMQDKIANPTNFDQYLLAIFAEDEYSIKDNLRLTFGARYNHHEIFG
CCCEECCCCCHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCEEEEEECCCCCCEECC
NNVSPRAYLVYNPTDELTLKGGVSTGFRTPYANRLINGAYNYSGQGRFPIYGNPDLKEET
CCCCCCEEEEECCCCCEEEECCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
SLNYEIAAIYNNDLFYVSATGFLTNFKDKISTQRYDKNNMIPGIGTCNADRCFRAINHGK
CCCEEEEEEEECCEEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCC
VEYKGVELGAGISPLDNLNINFAYTYLDSEVKEAQDKSVIGKPEQDSLKHNIMLKTEYSF
EEEEEEEECCCCCCCCCCCEEEEEEEECHHHHHHHCCCCCCCCCHHCCCCEEEEEEEHHH
YNKITPWIKGEWQIDRYMGDTNINREYYKDIFLASMGVRYDINKQWNINAAIYNLFNKSF
HHCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHH
TDGWESYQNSGTTTWVNTYNRIEEGRRIYISINGSF
CHHHHHHHCCCCEEEEHHHHHHCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1406279; 2174861 [H]