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The map label for this gene is yedX [H]

Identifier: 57237017

GI number: 57237017

Start: 748135

End: 748548

Strand: Direct

Name: yedX [H]

Synonym: CJE0815

Alternate gene names: 57237017

Gene position: 748135-748548 (Clockwise)

Preceding gene: 57237016

Following gene: 57237018

Centisome position: 42.08

GC content: 30.19

Gene sequence:

>414_bases
ATGTTTTCTATTAAAAAAACTTTATTAATACTAGCAAGCGTGCCAATGTTTTTGAGTGCTACTGAATATCAATTAAGTAC
TCATGTCTTGGATATTACTTCTGGACAACCTGCTCCTAAAGTAAAAGTTGAGCTTTATAAGTTGGAAGCAAATCAACAGT
GGAAAAAAGTAAGTGAAGAATTTACCGAAGAAAATGGTAGAATAGGAGATTTATTACCATATGAAAAAGCTGAAAATAGG
GCTTTTGGAATTTATAAGCTTAAATTTTTTACAAAAGACTATTACACATCACACAAAATAAATACTTTTTATCCTTTTGT
AGAGGTAAGTTTTGAGCTTTCTAAAGATCAGAAACATTATCATGTTCCAATAACCCTTTCTCCTTTTGGTTATTCAACTT
ATAGAGGAAGCTGA

Upstream 100 bases:

>100_bases
TAAATAATTATAATTAATTTATAATTATTATTTATTTGATTTTAATTATTAATAATACTCTTGTATAATATTTCTTGTAA
ATATTATACAAGGAGAGAAA

Downstream 100 bases:

>100_bases
TAAATAAAACGAAAGAAAAAACCATGTGGGCTAAGAATTCTTGGAAAAACTATCCTATAAAACAGCAACCTATCTATCCA
GATCAAGAGGAAATGAATAG

Product: transthyretin-like protein

Products: NA

Alternate protein names: HIU hydrolase; HIUHase; Transthyretin-like protein; TLP; Transthyretin-related protein; TRP [H]

Number of amino acids: Translated: 137; Mature: 137

Protein sequence:

>137_residues
MFSIKKTLLILASVPMFLSATEYQLSTHVLDITSGQPAPKVKVELYKLEANQQWKKVSEEFTEENGRIGDLLPYEKAENR
AFGIYKLKFFTKDYYTSHKINTFYPFVEVSFELSKDQKHYHVPITLSPFGYSTYRGS

Sequences:

>Translated_137_residues
MFSIKKTLLILASVPMFLSATEYQLSTHVLDITSGQPAPKVKVELYKLEANQQWKKVSEEFTEENGRIGDLLPYEKAENR
AFGIYKLKFFTKDYYTSHKINTFYPFVEVSFELSKDQKHYHVPITLSPFGYSTYRGS
>Mature_137_residues
MFSIKKTLLILASVPMFLSATEYQLSTHVLDITSGQPAPKVKVELYKLEANQQWKKVSEEFTEENGRIGDLLPYEKAENR
AFGIYKLKFFTKDYYTSHKINTFYPFVEVSFELSKDQKHYHVPITLSPFGYSTYRGS

Specific function: Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) [H]

COG id: COG2351

COG function: function code R; Transthyretin-like protein

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788281, Length=126, Percent_Identity=38.8888888888889, Blast_Score=93, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI115532920, Length=138, Percent_Identity=40.5797101449275, Blast_Score=108, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI115532922, Length=113, Percent_Identity=45.1327433628319, Blast_Score=108, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI115534555, Length=126, Percent_Identity=40.4761904761905, Blast_Score=106, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24652571, Length=114, Percent_Identity=37.719298245614, Blast_Score=90, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014306
- InterPro:   IPR000895 [H]

Pfam domain/function: PF00576 Transthyretin [H]

EC number: =3.5.2.17 [H]

Molecular weight: Translated: 15920; Mature: 15920

Theoretical pI: Translated: 9.12; Mature: 9.12

Prosite motif: PS00768 TRANSTHYRETIN_1 ; PS00769 TRANSTHYRETIN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSIKKTLLILASVPMFLSATEYQLSTHVLDITSGQPAPKVKVELYKLEANQQWKKVSEE
CCCHHHHHHHHHCCCHHHCCCEEEEEEEEEEECCCCCCCCEEEEEEEECCCCHHHHHHHH
FTEENGRIGDLLPYEKAENRAFGIYKLKFFTKDYYTSHKINTFYPFVEVSFELSKDQKHY
HHHCCCCCCCCCCCCCCCCCEEEEEEEEEEECCCCCCCCCCEEECEEEEEEEECCCCCEE
HVPITLSPFGYSTYRGS
EEEEEECCCCCCCCCCC
>Mature Secondary Structure
MFSIKKTLLILASVPMFLSATEYQLSTHVLDITSGQPAPKVKVELYKLEANQQWKKVSEE
CCCHHHHHHHHHCCCHHHCCCEEEEEEEEEEECCCCCCCCEEEEEEEECCCCHHHHHHHH
FTEENGRIGDLLPYEKAENRAFGIYKLKFFTKDYYTSHKINTFYPFVEVSFELSKDQKHY
HHHCCCCCCCCCCCCCCCCCEEEEEEEEEEECCCCCCCCCCEEECEEEEEEEECCCCCEE
HVPITLSPFGYSTYRGS
EEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9723926 [H]