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The map label for this gene is pyrH

Identifier: 55980828

GI number: 55980828

Start: 820511

End: 821212

Strand: Reverse

Name: pyrH

Synonym: TTHA0859

Alternate gene names: 55980828

Gene position: 821212-820511 (Counterclockwise)

Preceding gene: 55980829

Following gene: 55980827

Centisome position: 44.4

GC content: 67.09

Gene sequence:

>702_bases
ATGAAGTACAAGCGGGTTCTCCTGAAGCTTTCCGGCGAGTTCCTGACCCGAAACGGCTTCGGCATTGAGCCCGAGGCCAC
CCAGGCCCTGGCCCGGGAGATCAAGGCCGCCTACGACACCGGGGTCCAGCTCGCCATCGTCATCGGGGCGGGCAACCTCT
GGCGGGGCGCCCGCCAGGGGGTGGGGATGGACCGGGCCACCGCCGACTACATCGGCATGCTGGCCACCATCATGAACGCC
CTCGCCCTCCAAGACGCCCTGGAATCCCTGGGCGTCCCCACCCGGGTCCAGACCGCCCTCACCATCACCCAGGTGGCCGA
GCCCTACATCCGCCGCAGGGCCCTCCGCCACCTGGAGAAGGAGCGGATCGTGATCTTCGGCGGGGGGACGGGCAACCCCT
TCTTCTCCACGGACACCGCCGCCGCCCTCCGGGCCCTCGAGGTGGGGGCCGAGGTGGTCCTCATGGCCAAAAACAAGGTG
GACGGGGTCTACTCCGACGACCCGCGCAAGAACCCCGAGGCGGTGCGTTTTGACGAGCTCACCTACCTGGAGGTCCTGAA
CCGGGGCCTCCAGGTGATGGACACCACCGCCATCACCCTGTGCATGGAGGCGGGGCTCCCCATCGTGGTCTTTGACATCT
TCAAACCCGGCGCCCTGGTGGGTATTATCCAGGGGGAAAAAGTGGGCACCCTCATCCACTAG

Upstream 100 bases:

>100_bases
ACATCGTGGTCCGACGCTTCTGCCGCTTTGAGCTGGGGGCGTAAGCCATGAAGGCGCACCGGGGCCCGGCGTTTCCGGGG
CCCCGGTTTTCCATGAAGCC

Downstream 100 bases:

>100_bases
AAAGGAGGCGGTATGACCCTGAAGGAGCTTTACGCGGAAACCCGAAGCCACATGCAAAAGAGCCTCGAGGTCCTGGAGCA
CAACCTGGCGGGCCTCCGCA

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 233; Mature: 233

Protein sequence:

>233_residues
MKYKRVLLKLSGEFLTRNGFGIEPEATQALAREIKAAYDTGVQLAIVIGAGNLWRGARQGVGMDRATADYIGMLATIMNA
LALQDALESLGVPTRVQTALTITQVAEPYIRRRALRHLEKERIVIFGGGTGNPFFSTDTAAALRALEVGAEVVLMAKNKV
DGVYSDDPRKNPEAVRFDELTYLEVLNRGLQVMDTTAITLCMEAGLPIVVFDIFKPGALVGIIQGEKVGTLIH

Sequences:

>Translated_233_residues
MKYKRVLLKLSGEFLTRNGFGIEPEATQALAREIKAAYDTGVQLAIVIGAGNLWRGARQGVGMDRATADYIGMLATIMNA
LALQDALESLGVPTRVQTALTITQVAEPYIRRRALRHLEKERIVIFGGGTGNPFFSTDTAAALRALEVGAEVVLMAKNKV
DGVYSDDPRKNPEAVRFDELTYLEVLNRGLQVMDTTAITLCMEAGLPIVVFDIFKPGALVGIIQGEKVGTLIH
>Mature_233_residues
MKYKRVLLKLSGEFLTRNGFGIEPEATQALAREIKAAYDTGVQLAIVIGAGNLWRGARQGVGMDRATADYIGMLATIMNA
LALQDALESLGVPTRVQTALTITQVAEPYIRRRALRHLEKERIVIFGGGTGNPFFSTDTAAALRALEVGAEVVLMAKNKV
DGVYSDDPRKNPEAVRFDELTYLEVLNRGLQVMDTTAITLCMEAGLPIVVFDIFKPGALVGIIQGEKVGTLIH

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=232, Percent_Identity=49.5689655172414, Blast_Score=214, Evalue=5e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_THET2 (Q72KD9)

Other databases:

- EMBL:   AE017221
- RefSeq:   YP_004482.1
- HSSP:   P0A7E9
- ProteinModelPortal:   Q72KD9
- SMR:   Q72KD9
- STRING:   Q72KD9
- GeneID:   2775918
- GenomeReviews:   AE017221_GR
- eggNOG:   COG0528
- HOGENOM:   HBG497552
- OMA:   RHMEKGR
- PhylomeDB:   Q72KD9
- ProtClustDB:   PRK00358
- BioCyc:   TTHE262724:TT_C0507-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01220_B
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02075

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 25275; Mature: 25275

Theoretical pI: Translated: 7.51; Mature: 7.51

Prosite motif: NA

Important sites: BINDING 51-51 BINDING 55-55 BINDING 69-69 BINDING 158-158 BINDING 164-164 BINDING 167-167

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYKRVLLKLSGEFLTRNGFGIEPEATQALAREIKAAYDTGVQLAIVIGAGNLWRGARQG
CCHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHC
VGMDRATADYIGMLATIMNALALQDALESLGVPTRVQTALTITQVAEPYIRRRALRHLEK
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
ERIVIFGGGTGNPFFSTDTAAALRALEVGAEVVLMAKNKVDGVYSDDPRKNPEAVRFDEL
CEEEEEECCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCEEHHHH
TYLEVLNRGLQVMDTTAITLCMEAGLPIVVFDIFKPGALVGIIQGEKVGTLIH
HHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEEECCCCCCCCC
>Mature Secondary Structure
MKYKRVLLKLSGEFLTRNGFGIEPEATQALAREIKAAYDTGVQLAIVIGAGNLWRGARQG
CCHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHC
VGMDRATADYIGMLATIMNALALQDALESLGVPTRVQTALTITQVAEPYIRRRALRHLEK
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
ERIVIFGGGTGNPFFSTDTAAALRALEVGAEVVLMAKNKVDGVYSDDPRKNPEAVRFDEL
CEEEEEECCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCEEHHHH
TYLEVLNRGLQVMDTTAITLCMEAGLPIVVFDIFKPGALVGIIQGEKVGTLIH
HHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA