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The map label for this gene is zraS [H]

Identifier: 55980784

GI number: 55980784

Start: 778279

End: 780780

Strand: Reverse

Name: zraS [H]

Synonym: TTHA0815

Alternate gene names: 55980784

Gene position: 780780-778279 (Counterclockwise)

Preceding gene: 55980785

Following gene: 55980783

Centisome position: 42.21

GC content: 73.3

Gene sequence:

>2502_bases
ATGAGCCCGGAAGCCCTCCTCGCCGGCCTCTTCCTTTACCTGGGCCTCCTCTTCCTCCTCGCCCGCCTGGGGGAAGAGCG
GGGAGGGCGCCTCTTCCAAAGCCCCTGGACCTACACCCTCTCCCTGGGGGTCTACGCCACCGCCTGGACCTTCTTCGGCA
GCGCCGGCTGGGCCGCCACCTCGGGACCCCTCTTCCTCACCATCTACCTGGGGCCCACCCTGGCCCTGGCCCTCTGGCCC
CTTCTCCACCTGCGCCTTCTGCGCCTGGCCCGGGCCCACCGCCTCACCTCCTGGGCCGACTTCCTCTACCTGCGCTACGG
CCGGGACCCCCTCTTGGGGGCGGTGGCCGCGGGGTTTCTCGTCCTGGGCCTCCTCCCCTACCTCGCCCTCCAGCTCAAGG
CCATCGCCCAGGCCTTCCTCTTCCTGAGTGGGGAGGCGCGCCCCCTGGGGGACGTGGCCCTCTACACCGCCCTCCTCCTC
GCCTTCTTCACCATCCTCTTCGGCACCCGCCGCCTGGACCCCACGGAGCGGCACCGGGGCCTGGTCCTGGCCGTGGCCTT
TGAGGGGGGGGTGAAGCTCTTCGCCATGCTGGCCCTGGGCCTTTACGCCCTCCTTGGGCACGGGGCCGAGCCCTTCCGCG
AGGCCGTCCGCCGGGGCCTTGACCCCCTCCTCCTTCCCCCCCAGGGCCTCGAGGGCCACCTGGCCTGGACCGGCCTCACC
TTCCTCGCCCTCCTCGCCTTCCTCTTCCTCCCCCGGCAGTTCCACGTGGCCGTGGTGGAAAACACGGACGAGCGCCACCT
GGCCCTGGCCTCCTGGGCCTTCCCCCTCTACCTCCTCCTCCTGAACCTGCCCATCCTGCCCCTGGCCCTCCTGGGCCGCC
TGCACCACCCGGAGGTGCCCCCCGACCTCTACGTCCTCGCCGTGGCCCGGGAGGGCGGCGCGGCCCTGGCCTTCCTCGCC
TTTTTGGGCGGGGTCTCGGCGGCCACGGCCATGGTGGTGGTGGAGACCCTCGCCCTCTCCATCCTCGTCTCCCACCACCT
CCTCGCCCCCCTCCTCCTCCGCCGCCAAGCCCTCGGGCACCTCCTCCTCTTCCGGCGGGGCACGGTCCTCGCCGTCCTCC
TCCTCGCCTACCTCTACTTCCGCCTGGCGGGGGAGGCCTACGCCCTGGTGGGCATGGGGCTCATCTCCTTCGTGGCCGTG
GCCCAGCTCGCCCCGGCGGGGCTTCTCGGCCTCTTCTGGCAGGGGAGCACCCGGGAAGGGGCCCTCGCGGGCCTTTTCGG
GGGCATCCTGGTCTGGGCCTACACCCTCCTCCTGCCCGCCCTCGTCCGCTCCGGGTGGCTCCCCCAGGACCTCTTCGCCG
CCCTTCCCTCCTTCCTCCACCCGGAGGGGCTTTTTGGGGTGCGGGGGCTTGACCCCGTGGTCCACGGCTTCCTGGCGAGC
CTCCTCGCGAACACGGGGCTCCACCTCCTCGTCTCCTTGCGGCAACCCCCCTCCCCGCCGCCCTCCGGCCGGGCCGGGGA
GGAGGAGGCCCTGGCCGACCTCCTGGAGAGGTTCCTGGGCCCCGAGGCCCGGGAAAGCCTAAAGGCCTACGCGAGGAGCC
TCAAGGGGCCAGATAAAGCGGAGCGCCTCGCCGAGCGGGCGGAGGCCCTCCTCGCCGGGGCCCTGGGGCCCGCCACCGCC
CGCCTCCTCCTCCTCTCCGCCACCCGGGAGGTCCCCAGGGAGGCGGTGGAGGCGGCGGCCCGGGAGTCGCAACGGGTGCG
GGCCTATGCTCAGGCCCTGGAGGCCGCCCGGCGCGAACTGGAGGCCGCCTACCGGCGCCTTGAGGAGATGGACCGCCTGA
AGGACGAGTTCCTCGCCACCGTCTCCCACGAGCTCAAGACCCCCCTCACCGCGGTGAGGGCCCTGGCGGAGATTCTGGCC
CAGGAGGAGGTGGGGGAGGAGGAAAGGCGGCGCTTCACCGCCCTCCTCGCCCAGGAGGCGGCCCGCCTCTCCCGGCTCGT
GGAGGAGATCCTGGCCTACACCCGCCTGGAGGCCCGCCCCGAGGAGCCCCCGGCCCCCGTGGACCTGGAGGCCCTGGCCC
GGGAGGCCCTGGCCCTTTCGGAGCCCCTGGCCCGGGAGCGGGGCCTCCGCCTCGAGGCCCGGCTCCAGCCCCTCCGGGTC
CGGACCCACCGGGACCGGGCCCTCCAGGTCCTCCTCAACCTCCTCGCCAACGCCCTGCGCCACGCCCGAAGCCGGGTGGT
CCTGGAGCTTCGCGCGGAAGCGGGGGAGGCCCGCTTCCGCGTGGTGGACGACGGCCCCGGGGTCCCCGAGGCCCTGAGGG
AACACATCTTCGCCCCCTTCCAGAGCTACGCCGGGGGGACGGGCCTGGGCCTCGCCATCGCCCGGAGGCTCTCGGAGGCC
CTGGGCGGGCGGGTCTTTTTGGAAGACGGGGAAGGCGGGGTCTTCGTCTTCGCGTTACCCTTGGAGGGAGACCATGGCCG
AGGTGCTGATCGTGGACGATGA

Upstream 100 bases:

>100_bases
CCGAGCCTTTAGGGCCCTGGGGGCTCCCGCCCTTCTACCTCTACCTCTTCCTCGCCTGGGCAGGGTTCGTCCTCCTCCTC
TTCCTCAACGCCAGGAGGCC

Downstream 100 bases:

>100_bases
GGAAAGCATCCTGGTTCCCCTGGAGTTTCTCTTTCGCAAGGCCGGGCACCGGGTGGAGCTGGCGAGGACGGGGGAGGAGG
CCCTAAGCCGCCTCGCCGAG

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 833; Mature: 832

Protein sequence:

>833_residues
MSPEALLAGLFLYLGLLFLLARLGEERGGRLFQSPWTYTLSLGVYATAWTFFGSAGWAATSGPLFLTIYLGPTLALALWP
LLHLRLLRLARAHRLTSWADFLYLRYGRDPLLGAVAAGFLVLGLLPYLALQLKAIAQAFLFLSGEARPLGDVALYTALLL
AFFTILFGTRRLDPTERHRGLVLAVAFEGGVKLFAMLALGLYALLGHGAEPFREAVRRGLDPLLLPPQGLEGHLAWTGLT
FLALLAFLFLPRQFHVAVVENTDERHLALASWAFPLYLLLLNLPILPLALLGRLHHPEVPPDLYVLAVAREGGAALAFLA
FLGGVSAATAMVVVETLALSILVSHHLLAPLLLRRQALGHLLLFRRGTVLAVLLLAYLYFRLAGEAYALVGMGLISFVAV
AQLAPAGLLGLFWQGSTREGALAGLFGGILVWAYTLLLPALVRSGWLPQDLFAALPSFLHPEGLFGVRGLDPVVHGFLAS
LLANTGLHLLVSLRQPPSPPPSGRAGEEEALADLLERFLGPEARESLKAYARSLKGPDKAERLAERAEALLAGALGPATA
RLLLLSATREVPREAVEAAARESQRVRAYAQALEAARRELEAAYRRLEEMDRLKDEFLATVSHELKTPLTAVRALAEILA
QEEVGEEERRRFTALLAQEAARLSRLVEEILAYTRLEARPEEPPAPVDLEALAREALALSEPLARERGLRLEARLQPLRV
RTHRDRALQVLLNLLANALRHARSRVVLELRAEAGEARFRVVDDGPGVPEALREHIFAPFQSYAGGTGLGLAIARRLSEA
LGGRVFLEDGEGGVFVFALPLEGDHGRGADRGR

Sequences:

>Translated_833_residues
MSPEALLAGLFLYLGLLFLLARLGEERGGRLFQSPWTYTLSLGVYATAWTFFGSAGWAATSGPLFLTIYLGPTLALALWP
LLHLRLLRLARAHRLTSWADFLYLRYGRDPLLGAVAAGFLVLGLLPYLALQLKAIAQAFLFLSGEARPLGDVALYTALLL
AFFTILFGTRRLDPTERHRGLVLAVAFEGGVKLFAMLALGLYALLGHGAEPFREAVRRGLDPLLLPPQGLEGHLAWTGLT
FLALLAFLFLPRQFHVAVVENTDERHLALASWAFPLYLLLLNLPILPLALLGRLHHPEVPPDLYVLAVAREGGAALAFLA
FLGGVSAATAMVVVETLALSILVSHHLLAPLLLRRQALGHLLLFRRGTVLAVLLLAYLYFRLAGEAYALVGMGLISFVAV
AQLAPAGLLGLFWQGSTREGALAGLFGGILVWAYTLLLPALVRSGWLPQDLFAALPSFLHPEGLFGVRGLDPVVHGFLAS
LLANTGLHLLVSLRQPPSPPPSGRAGEEEALADLLERFLGPEARESLKAYARSLKGPDKAERLAERAEALLAGALGPATA
RLLLLSATREVPREAVEAAARESQRVRAYAQALEAARRELEAAYRRLEEMDRLKDEFLATVSHELKTPLTAVRALAEILA
QEEVGEEERRRFTALLAQEAARLSRLVEEILAYTRLEARPEEPPAPVDLEALAREALALSEPLARERGLRLEARLQPLRV
RTHRDRALQVLLNLLANALRHARSRVVLELRAEAGEARFRVVDDGPGVPEALREHIFAPFQSYAGGTGLGLAIARRLSEA
LGGRVFLEDGEGGVFVFALPLEGDHGRGADRGR
>Mature_832_residues
SPEALLAGLFLYLGLLFLLARLGEERGGRLFQSPWTYTLSLGVYATAWTFFGSAGWAATSGPLFLTIYLGPTLALALWPL
LHLRLLRLARAHRLTSWADFLYLRYGRDPLLGAVAAGFLVLGLLPYLALQLKAIAQAFLFLSGEARPLGDVALYTALLLA
FFTILFGTRRLDPTERHRGLVLAVAFEGGVKLFAMLALGLYALLGHGAEPFREAVRRGLDPLLLPPQGLEGHLAWTGLTF
LALLAFLFLPRQFHVAVVENTDERHLALASWAFPLYLLLLNLPILPLALLGRLHHPEVPPDLYVLAVAREGGAALAFLAF
LGGVSAATAMVVVETLALSILVSHHLLAPLLLRRQALGHLLLFRRGTVLAVLLLAYLYFRLAGEAYALVGMGLISFVAVA
QLAPAGLLGLFWQGSTREGALAGLFGGILVWAYTLLLPALVRSGWLPQDLFAALPSFLHPEGLFGVRGLDPVVHGFLASL
LANTGLHLLVSLRQPPSPPPSGRAGEEEALADLLERFLGPEARESLKAYARSLKGPDKAERLAERAEALLAGALGPATAR
LLLLSATREVPREAVEAAARESQRVRAYAQALEAARRELEAAYRRLEEMDRLKDEFLATVSHELKTPLTAVRALAEILAQ
EEVGEEERRRFTALLAQEAARLSRLVEEILAYTRLEARPEEPPAPVDLEALAREALALSEPLARERGLRLEARLQPLRVR
THRDRALQVLLNLLANALRHARSRVVLELRAEAGEARFRVVDDGPGVPEALREHIFAPFQSYAGGTGLGLAIARRLSEAL
GGRVFLEDGEGGVFVFALPLEGDHGRGADRGR

Specific function: Member of the two-component regulatory system zraS/zraR. May function as a membrane-associated protein kinase that phosphorylates zraR in response to high concentrations of zinc or lead in the medium [H]

COG id: COG0591

COG function: function code ER; Na+/proline symporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI48994928, Length=229, Percent_Identity=32.3144104803493, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1790436, Length=239, Percent_Identity=31.3807531380753, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1787894, Length=223, Percent_Identity=32.7354260089686, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1789149, Length=334, Percent_Identity=25.748502994012, Blast_Score=92, Evalue=2e-19,
Organism=Escherichia coli, GI1788549, Length=243, Percent_Identity=29.2181069958848, Blast_Score=89, Evalue=1e-18,
Organism=Escherichia coli, GI145693157, Length=247, Percent_Identity=29.5546558704453, Blast_Score=84, Evalue=5e-17,
Organism=Escherichia coli, GI1790861, Length=243, Percent_Identity=33.7448559670782, Blast_Score=83, Evalue=7e-17,
Organism=Escherichia coli, GI87082128, Length=227, Percent_Identity=28.6343612334802, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1789808, Length=224, Percent_Identity=29.0178571428571, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1788393, Length=244, Percent_Identity=32.7868852459016, Blast_Score=81, Evalue=3e-16,
Organism=Escherichia coli, GI1786600, Length=231, Percent_Identity=27.7056277056277, Blast_Score=81, Evalue=3e-16,
Organism=Escherichia coli, GI87081816, Length=268, Percent_Identity=30.5970149253731, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1786912, Length=240, Percent_Identity=30.4166666666667, Blast_Score=73, Evalue=8e-14,
Organism=Escherichia coli, GI1788713, Length=226, Percent_Identity=26.5486725663717, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1790346, Length=226, Percent_Identity=29.2035398230088, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1786783, Length=234, Percent_Identity=27.3504273504274, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1790300, Length=213, Percent_Identity=30.5164319248826, Blast_Score=64, Evalue=4e-11,
Organism=Escherichia coli, GI1789403, Length=206, Percent_Identity=28.6407766990291, Blast_Score=63, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 90656; Mature: 90525

Theoretical pI: Translated: 8.60; Mature: 8.60

Prosite motif: PS50109 HIS_KIN ; PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
0.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPEALLAGLFLYLGLLFLLARLGEERGGRLFQSPWTYTLSLGVYATAWTFFGSAGWAAT
CCHHHHHHHHHHHHHHHHHHHHHCHHHCCCEECCCCCEEEEHHHHHHHHHHHCCCCCCCC
SGPLFLTIYLGPTLALALWPLLHLRLLRLARAHRLTSWADFLYLRYGRDPLLGAVAAGFL
CCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
VLGLLPYLALQLKAIAQAFLFLSGEARPLGDVALYTALLLAFFTILFGTRRLDPTERHRG
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCC
LVLAVAFEGGVKLFAMLALGLYALLGHGAEPFREAVRRGLDPLLLPPQGLEGHLAWTGLT
EEEEEEECCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHH
FLALLAFLFLPRQFHVAVVENTDERHLALASWAFPLYLLLLNLPILPLALLGRLHHPEVP
HHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCC
PDLYVLAVAREGGAALAFLAFLGGVSAATAMVVVETLALSILVSHHLLAPLLLRRQALGH
CCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLLFRRGTVLAVLLLAYLYFRLAGEAYALVGMGLISFVAVAQLAPAGLLGLFWQGSTREG
HHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCC
ALAGLFGGILVWAYTLLLPALVRSGWLPQDLFAALPSFLHPEGLFGVRGLDPVVHGFLAS
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHH
LLANTGLHLLVSLRQPPSPPPSGRAGEEEALADLLERFLGPEARESLKAYARSLKGPDKA
HHHCCCHHEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHH
ERLAERAEALLAGALGPATARLLLLSATREVPREAVEAAARESQRVRAYAQALEAARREL
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EAAYRRLEEMDRLKDEFLATVSHELKTPLTAVRALAEILAQEEVGEEERRRFTALLAQEA
HHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
ARLSRLVEEILAYTRLEARPEEPPAPVDLEALAREALALSEPLARERGLRLEARLQPLRV
HHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHH
RTHRDRALQVLLNLLANALRHARSRVVLELRAEAGEARFRVVDDGPGVPEALREHIFAPF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHH
QSYAGGTGLGLAIARRLSEALGGRVFLEDGEGGVFVFALPLEGDHGRGADRGR
HHCCCCCHHHHHHHHHHHHHHCCEEEEECCCCCEEEEEEEECCCCCCCCCCCC
>Mature Secondary Structure 
SPEALLAGLFLYLGLLFLLARLGEERGGRLFQSPWTYTLSLGVYATAWTFFGSAGWAAT
CHHHHHHHHHHHHHHHHHHHHHCHHHCCCEECCCCCEEEEHHHHHHHHHHHCCCCCCCC
SGPLFLTIYLGPTLALALWPLLHLRLLRLARAHRLTSWADFLYLRYGRDPLLGAVAAGFL
CCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
VLGLLPYLALQLKAIAQAFLFLSGEARPLGDVALYTALLLAFFTILFGTRRLDPTERHRG
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCC
LVLAVAFEGGVKLFAMLALGLYALLGHGAEPFREAVRRGLDPLLLPPQGLEGHLAWTGLT
EEEEEEECCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHH
FLALLAFLFLPRQFHVAVVENTDERHLALASWAFPLYLLLLNLPILPLALLGRLHHPEVP
HHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCC
PDLYVLAVAREGGAALAFLAFLGGVSAATAMVVVETLALSILVSHHLLAPLLLRRQALGH
CCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLLFRRGTVLAVLLLAYLYFRLAGEAYALVGMGLISFVAVAQLAPAGLLGLFWQGSTREG
HHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCC
ALAGLFGGILVWAYTLLLPALVRSGWLPQDLFAALPSFLHPEGLFGVRGLDPVVHGFLAS
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHH
LLANTGLHLLVSLRQPPSPPPSGRAGEEEALADLLERFLGPEARESLKAYARSLKGPDKA
HHHCCCHHEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHH
ERLAERAEALLAGALGPATARLLLLSATREVPREAVEAAARESQRVRAYAQALEAARREL
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EAAYRRLEEMDRLKDEFLATVSHELKTPLTAVRALAEILAQEEVGEEERRRFTALLAQEA
HHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
ARLSRLVEEILAYTRLEARPEEPPAPVDLEALAREALALSEPLARERGLRLEARLQPLRV
HHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHH
RTHRDRALQVLLNLLANALRHARSRVVLELRAEAGEARFRVVDDGPGVPEALREHIFAPF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHH
QSYAGGTGLGLAIARRLSEALGGRVFLEDGEGGVFVFALPLEGDHGRGADRGR
HHCCCCCHHHHHHHHHHHHHHCCEEEEECCCCCEEEEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11243806 [H]