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The map label for this gene is mmgC [H]

Identifier: 55980758

GI number: 55980758

Start: 755390

End: 756547

Strand: Reverse

Name: mmgC [H]

Synonym: TTHA0789

Alternate gene names: 55980758

Gene position: 756547-755390 (Counterclockwise)

Preceding gene: 55980759

Following gene: 55980757

Centisome position: 40.9

GC content: 68.65

Gene sequence:

>1158_bases
ATGCTGGACTTCTACGCCCTGGAGGACCTCCTCACCCCGGAGGAGAAGGAGGTCCAGAAGGCCGCCCGCCGCTTCCTGGA
AAAGGAGGCCCTGCCCCACATCCGCGACTGGTGGGAGGAAGGGGTCTTCCCCACCCACCTCATCCCCAGATTCGCCGAGC
TCGGCTTCCTGGGCCCCACCCTGCCCCCCGAGTACGGGGGGGCGGGGGTGAGTAGCGCCGCCTACGGCCTCATCTGCTAC
GAGCTGGAGCGGGTGGACTCGGGGCTCAGGAGCTTCGTGAGCGTCCAGAGCTCCCTGGTGATGTACCCCATCTACGCCTA
CGGGAGCGAGGAGCAAAAGCGGGAGTTCCTCCCCAAGCTCGCCCGCGGGGAGATGGTGGGGTGCTTCGGCCTCACCGAGC
CCGACGGCGGCTCGGACCCCTACGGCAACATGAAGACCCGGGCCAGGCGCGAGGGGGACACCTGGGTCCTGAACGGCACC
AAGATGTGGATCACCAACGGCAACCTGGCCCATCTCGCCGTGATCTGGGCCAAGGACGAGGGGGGAGAGGTCCTGGGCTT
CCTCGTCCCCACGGACACCCCGGGCTTCCAGGCCCGGGAGGTGAAGCGCAAGATGTCCCTCCGCGCCTCGGTGACCAGCG
AGCTCGTCCTCGAGGAGGTGCGGGTGCCCGAGTCCTTGCGCCTCCCCAAGGCCCTAGGCCTCAAGGCCCCCCTTTCCTGC
CTCACCCAGGCCCGCTTCGGCATCGCCTGGGGGGCCATGGGGGCCCTGGAGGCGGTCTACGAGGAGGCGGTGGCCTTCGC
GAAAAGCCGCTCCACCTTCGGCGAGCCCCTCGCCAAGAAGCAGCTCGTCCAGGCCAAGCTCGCCGAGATGCTCGCCTGGC
ACACGGAGGGCCTCCTCCTCGCCTGGCGGCTCGCCCGCCTCAAGGACGAAGGGAAGCTCACCCCCGCCCAGGTCTCCCTC
GCCAAAAGGCAGAACGTCTGGAAGGCCCTCCAGGCCGCCCGCATGGCCCGGGACATCCTCGGGGGAAGCGGCATCACCCT
GGAGTACCACGCCATCCGCCACATGCTGAACCTGGAGACCGTCTACACCTACGAGGGCACCCACGACGTCCACACCCTGG
TCCTGGGACGGGAGATCACCGGCCTGAACGCCTTCTAA

Upstream 100 bases:

>100_bases
TCGGGTGTACGCCAAGCGGGCGAGCCCCTTCTGGGCCCCCTACCTGGGCCGGCCCCTGATCCACGAGGTCTGGGTGCGGG
ACCTGGGGTAGACTGAGCCC

Downstream 100 bases:

>100_bases
AGGCCCGCCGGGGCCTTTGGCGGACACTTAAGCCATGGTCATCGCCTTCACCGGGGATCCCTTCCTGGCGCGGGAGGCCC
TCTTAGAGGAGGCCAGGCTT

Product: glutaryl-CoA dehydrogenase

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MLDFYALEDLLTPEEKEVQKAARRFLEKEALPHIRDWWEEGVFPTHLIPRFAELGFLGPTLPPEYGGAGVSSAAYGLICY
ELERVDSGLRSFVSVQSSLVMYPIYAYGSEEQKREFLPKLARGEMVGCFGLTEPDGGSDPYGNMKTRARREGDTWVLNGT
KMWITNGNLAHLAVIWAKDEGGEVLGFLVPTDTPGFQAREVKRKMSLRASVTSELVLEEVRVPESLRLPKALGLKAPLSC
LTQARFGIAWGAMGALEAVYEEAVAFAKSRSTFGEPLAKKQLVQAKLAEMLAWHTEGLLLAWRLARLKDEGKLTPAQVSL
AKRQNVWKALQAARMARDILGGSGITLEYHAIRHMLNLETVYTYEGTHDVHTLVLGREITGLNAF

Sequences:

>Translated_385_residues
MLDFYALEDLLTPEEKEVQKAARRFLEKEALPHIRDWWEEGVFPTHLIPRFAELGFLGPTLPPEYGGAGVSSAAYGLICY
ELERVDSGLRSFVSVQSSLVMYPIYAYGSEEQKREFLPKLARGEMVGCFGLTEPDGGSDPYGNMKTRARREGDTWVLNGT
KMWITNGNLAHLAVIWAKDEGGEVLGFLVPTDTPGFQAREVKRKMSLRASVTSELVLEEVRVPESLRLPKALGLKAPLSC
LTQARFGIAWGAMGALEAVYEEAVAFAKSRSTFGEPLAKKQLVQAKLAEMLAWHTEGLLLAWRLARLKDEGKLTPAQVSL
AKRQNVWKALQAARMARDILGGSGITLEYHAIRHMLNLETVYTYEGTHDVHTLVLGREITGLNAF
>Mature_385_residues
MLDFYALEDLLTPEEKEVQKAARRFLEKEALPHIRDWWEEGVFPTHLIPRFAELGFLGPTLPPEYGGAGVSSAAYGLICY
ELERVDSGLRSFVSVQSSLVMYPIYAYGSEEQKREFLPKLARGEMVGCFGLTEPDGGSDPYGNMKTRARREGDTWVLNGT
KMWITNGNLAHLAVIWAKDEGGEVLGFLVPTDTPGFQAREVKRKMSLRASVTSELVLEEVRVPESLRLPKALGLKAPLSC
LTQARFGIAWGAMGALEAVYEEAVAFAKSRSTFGEPLAKKQLVQAKLAEMLAWHTEGLLLAWRLARLKDEGKLTPAQVSL
AKRQNVWKALQAARMARDILGGSGITLEYHAIRHMLNLETVYTYEGTHDVHTLVLGREITGLNAF

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4503943, Length=385, Percent_Identity=52.2077922077922, Blast_Score=383, Evalue=1e-106,
Organism=Homo sapiens, GI7669494, Length=365, Percent_Identity=51.2328767123288, Blast_Score=349, Evalue=3e-96,
Organism=Homo sapiens, GI4557233, Length=361, Percent_Identity=36.8421052631579, Blast_Score=221, Evalue=9e-58,
Organism=Homo sapiens, GI187960098, Length=377, Percent_Identity=32.3607427055703, Blast_Score=182, Evalue=4e-46,
Organism=Homo sapiens, GI4501859, Length=374, Percent_Identity=31.283422459893, Blast_Score=182, Evalue=4e-46,
Organism=Homo sapiens, GI4557231, Length=377, Percent_Identity=32.3607427055703, Blast_Score=182, Evalue=4e-46,
Organism=Homo sapiens, GI226958412, Length=376, Percent_Identity=27.9255319148936, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI4501857, Length=383, Percent_Identity=30.0261096605744, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI226958414, Length=335, Percent_Identity=29.5522388059701, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI21361497, Length=368, Percent_Identity=29.6195652173913, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI76496475, Length=393, Percent_Identity=28.7531806615776, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI4557235, Length=393, Percent_Identity=28.7531806615776, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI7656849, Length=374, Percent_Identity=26.7379679144385, Blast_Score=141, Evalue=9e-34,
Organism=Homo sapiens, GI211971008, Length=335, Percent_Identity=25.6716417910448, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI48976061, Length=335, Percent_Identity=25.6716417910448, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI38505218, Length=330, Percent_Identity=25.4545454545455, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1786223, Length=345, Percent_Identity=24.0579710144928, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI87081958, Length=380, Percent_Identity=25, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI87081702, Length=340, Percent_Identity=26.7647058823529, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17534353, Length=387, Percent_Identity=47.5452196382429, Blast_Score=367, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI17569725, Length=379, Percent_Identity=31.1345646437995, Blast_Score=184, Evalue=6e-47,
Organism=Caenorhabditis elegans, GI17538396, Length=378, Percent_Identity=31.7460317460317, Blast_Score=182, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17534899, Length=377, Percent_Identity=31.2997347480106, Blast_Score=177, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17508101, Length=366, Percent_Identity=29.7814207650273, Blast_Score=167, Evalue=8e-42,
Organism=Caenorhabditis elegans, GI17570075, Length=377, Percent_Identity=28.3819628647215, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17506239, Length=376, Percent_Identity=27.3936170212766, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17533517, Length=382, Percent_Identity=24.869109947644, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI71985184, Length=383, Percent_Identity=28.4595300261097, Blast_Score=138, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI71990804, Length=275, Percent_Identity=29.4545454545455, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI71985192, Length=317, Percent_Identity=29.3375394321767, Blast_Score=127, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI32563615, Length=232, Percent_Identity=30.1724137931034, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI17551932, Length=330, Percent_Identity=26.969696969697, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17505929, Length=330, Percent_Identity=26.6666666666667, Blast_Score=119, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI71982178, Length=272, Percent_Identity=27.9411764705882, Blast_Score=117, Evalue=8e-27,
Organism=Drosophila melanogaster, GI19920834, Length=387, Percent_Identity=48.8372093023256, Blast_Score=354, Evalue=5e-98,
Organism=Drosophila melanogaster, GI21356377, Length=376, Percent_Identity=33.7765957446808, Blast_Score=209, Evalue=3e-54,
Organism=Drosophila melanogaster, GI24646207, Length=376, Percent_Identity=34.5744680851064, Blast_Score=204, Evalue=7e-53,
Organism=Drosophila melanogaster, GI24660351, Length=378, Percent_Identity=32.8042328042328, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24666513, Length=375, Percent_Identity=29.0666666666667, Blast_Score=174, Evalue=9e-44,
Organism=Drosophila melanogaster, GI21355753, Length=379, Percent_Identity=30.0791556728232, Blast_Score=165, Evalue=5e-41,
Organism=Drosophila melanogaster, GI281363737, Length=403, Percent_Identity=29.7766749379653, Blast_Score=157, Evalue=9e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 42782; Mature: 42782

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDFYALEDLLTPEEKEVQKAARRFLEKEALPHIRDWWEEGVFPTHLIPRFAELGFLGPT
CCCHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHCCCCCC
LPPEYGGAGVSSAAYGLICYELERVDSGLRSFVSVQSSLVMYPIYAYGSEEQKREFLPKL
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCHHHHHHHHHHH
ARGEMVGCFGLTEPDGGSDPYGNMKTRARREGDTWVLNGTKMWITNGNLAHLAVIWAKDE
HCCCEEEEEECCCCCCCCCCCCCCHHHHHCCCCEEEECCEEEEEECCCEEEEEEEEEECC
GGEVLGFLVPTDTPGFQAREVKRKMSLRASVTSELVLEEVRVPESLRLPKALGLKAPLSC
CCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCHHHCCCCHHHH
LTQARFGIAWGAMGALEAVYEEAVAFAKSRSTFGEPLAKKQLVQAKLAEMLAWHTEGLLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHH
AWRLARLKDEGKLTPAQVSLAKRQNVWKALQAARMARDILGGSGITLEYHAIRHMLNLET
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHCCCE
VYTYEGTHDVHTLVLGREITGLNAF
EEEECCCCCCEEEEECCCCCCCCCC
>Mature Secondary Structure
MLDFYALEDLLTPEEKEVQKAARRFLEKEALPHIRDWWEEGVFPTHLIPRFAELGFLGPT
CCCHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHCCCCCC
LPPEYGGAGVSSAAYGLICYELERVDSGLRSFVSVQSSLVMYPIYAYGSEEQKREFLPKL
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCHHHHHHHHHHH
ARGEMVGCFGLTEPDGGSDPYGNMKTRARREGDTWVLNGTKMWITNGNLAHLAVIWAKDE
HCCCEEEEEECCCCCCCCCCCCCCHHHHHCCCCEEEECCEEEEEECCCEEEEEEEEEECC
GGEVLGFLVPTDTPGFQAREVKRKMSLRASVTSELVLEEVRVPESLRLPKALGLKAPLSC
CCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCHHHCCCCHHHH
LTQARFGIAWGAMGALEAVYEEAVAFAKSRSTFGEPLAKKQLVQAKLAEMLAWHTEGLLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHH
AWRLARLKDEGKLTPAQVSLAKRQNVWKALQAARMARDILGGSGITLEYHAIRHMLNLET
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHCCCE
VYTYEGTHDVHTLVLGREITGLNAF
EEEECCCCCCEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]