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The map label for this gene is hssS [H]

Identifier: 55980709

GI number: 55980709

Start: 706136

End: 707113

Strand: Reverse

Name: hssS [H]

Synonym: TTHA0740

Alternate gene names: 55980709

Gene position: 707113-706136 (Counterclockwise)

Preceding gene: 55980710

Following gene: 55980707

Centisome position: 38.23

GC content: 73.31

Gene sequence:

>978_bases
ATGAGCCTAAGGGTTAGGCTCGCCCTGGTCATCGCCCTCCTCGCCTTCCTGCCCAACCTGGTCCTGGCCCTCACCCTGGG
GGCCCTGGGGGAAGGCCCCTGGCCTCCCCTCCTCCTCTGGCTTCTCCTCCTCGCCCTCCTCTCGGGCCTCGCGGGCTACT
TCCTGGCGAAGAGCCTCCTCAGGCCCCTGGAGGAGCTCACCCGGGCCCTGGCCTACCTCTCCTTGAAGGAGGGGCCCCTG
GAGGCCCTCCGCCTCCCCACCCCCAAGGAGCCCCCTCCGGAGGAGATCGCCCTCCTCCGCGCCCGGTTCTCCGAGCTCCT
CGCCCGGCTCAAGGAGCTCCTGGAGGCCCGGGAGGCCCTGTACGCCGCCCTGGCCCACGACCTCAAGACCCCCCTCCTTT
CCGCCCTGCGCCTCTTGGACTACCTGGAGAGGGCGGACGATCTGGGGAAGGAGCGGCGCGTCGCCCTCCTCCGCGCCCTG
AGGGAGGAGCTCGCCCGGGGCCACCGCCTGACGGAGAACCTCCTCGCCCTCGCCCGCCTCGAGGCCCGCCCCCCCCGGGG
CGAGACCCTGAACCTCAGGGCCCTGGCCGAGGACCTCCTCCTCCGCTACCGGGACGAGGCGAAGAGGCGGGGGCTCCTCG
TGGAGGTGGAAGGGGCGGGCCTCGCCCGGGGGGAAAGGCTCCTCGTGGAAAGGGCCCTCGCCAACCTCCTGGAAAACGCC
CTCCGCCACGCCAAAAGCCGCGTCCGGCTCCGGGTGGGGGAAGGCGTGCTCCTCGTGGAGGACGACGGCGCAGGCCTTCC
CCTGCCCCTGGAAGCCCTCGCCCGCCCCTTCCTCCAGGGGGAGGGCAGGAGGGGAAGCGCGGGCCTGGGCCTCTACACCG
CCAAGCGGGTGGCCGAGGCCCACGGAGGCAGGCTCTTCCCCTGCGAGGGCCCCCTGGGAGGGGCCTGCCTGGGCCTGGAA
CTCCCCAAGGGGGCCTAA

Upstream 100 bases:

>100_bases
CTTTTGGAGAAGCAGAAGGAGGGCAAGAAGCGCCTCAAGGCCATCGGCAAGGTGGAGGTTCCCCAGGAGGCCTTCCTGGC
GGTGCTCTCGGCGGGTCGCG

Downstream 100 bases:

>100_bases
GGCCACCCCATGCGGGCTTGGGAAAAGCCTGGGCGGGGAACGAACGCTTAGCCCATCACCGGGGGGATCTGCCGCACCCA
GAGGATGTAGGAGAGGTGCT

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 325; Mature: 324

Protein sequence:

>325_residues
MSLRVRLALVIALLAFLPNLVLALTLGALGEGPWPPLLLWLLLLALLSGLAGYFLAKSLLRPLEELTRALAYLSLKEGPL
EALRLPTPKEPPPEEIALLRARFSELLARLKELLEAREALYAALAHDLKTPLLSALRLLDYLERADDLGKERRVALLRAL
REELARGHRLTENLLALARLEARPPRGETLNLRALAEDLLLRYRDEAKRRGLLVEVEGAGLARGERLLVERALANLLENA
LRHAKSRVRLRVGEGVLLVEDDGAGLPLPLEALARPFLQGEGRRGSAGLGLYTAKRVAEAHGGRLFPCEGPLGGACLGLE
LPKGA

Sequences:

>Translated_325_residues
MSLRVRLALVIALLAFLPNLVLALTLGALGEGPWPPLLLWLLLLALLSGLAGYFLAKSLLRPLEELTRALAYLSLKEGPL
EALRLPTPKEPPPEEIALLRARFSELLARLKELLEAREALYAALAHDLKTPLLSALRLLDYLERADDLGKERRVALLRAL
REELARGHRLTENLLALARLEARPPRGETLNLRALAEDLLLRYRDEAKRRGLLVEVEGAGLARGERLLVERALANLLENA
LRHAKSRVRLRVGEGVLLVEDDGAGLPLPLEALARPFLQGEGRRGSAGLGLYTAKRVAEAHGGRLFPCEGPLGGACLGLE
LPKGA
>Mature_324_residues
SLRVRLALVIALLAFLPNLVLALTLGALGEGPWPPLLLWLLLLALLSGLAGYFLAKSLLRPLEELTRALAYLSLKEGPLE
ALRLPTPKEPPPEEIALLRARFSELLARLKELLEAREALYAALAHDLKTPLLSALRLLDYLERADDLGKERRVALLRALR
EELARGHRLTENLLALARLEARPPRGETLNLRALAEDLLLRYRDEAKRRGLLVEVEGAGLARGERLLVERALANLLENAL
RHAKSRVRLRVGEGVLLVEDDGAGLPLPLEALARPFLQGEGRRGSAGLGLYTAKRVAEAHGGRLFPCEGPLGGACLGLEL
PKGA

Specific function: Member of the two-component regulatory system hssS/hssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. HssS functions as a heme sensor histidine kinase which is autophosphorylated at a histidine residue and transfers

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=332, Percent_Identity=25.6024096385542, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1787894, Length=236, Percent_Identity=32.2033898305085, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1788279, Length=290, Percent_Identity=26.8965517241379, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1790346, Length=243, Percent_Identity=26.7489711934156, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI87081816, Length=100, Percent_Identity=38, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790551, Length=278, Percent_Identity=26.2589928057554, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1786783, Length=283, Percent_Identity=24.3816254416961, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1786912, Length=234, Percent_Identity=31.6239316239316, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1788393, Length=281, Percent_Identity=26.6903914590747, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 35507; Mature: 35375

Theoretical pI: Translated: 9.83; Mature: 9.83

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.3 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLRVRLALVIALLAFLPNLVLALTLGALGEGPWPPLLLWLLLLALLSGLAGYFLAKSLL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RPLEELTRALAYLSLKEGPLEALRLPTPKEPPPEEIALLRARFSELLARLKELLEAREAL
HHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YAALAHDLKTPLLSALRLLDYLERADDLGKERRVALLRALREELARGHRLTENLLALARL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EARPPRGETLNLRALAEDLLLRYRDEAKRRGLLVEVEGAGLARGERLLVERALANLLENA
HCCCCCCCEEHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHHHH
LRHAKSRVRLRVGEGVLLVEDDGAGLPLPLEALARPFLQGEGRRGSAGLGLYTAKRVAEA
HHHHHHHHEEEECCCEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
HGGRLFPCEGPLGGACLGLELPKGA
CCCEEEECCCCCCCEEEECCCCCCC
>Mature Secondary Structure 
SLRVRLALVIALLAFLPNLVLALTLGALGEGPWPPLLLWLLLLALLSGLAGYFLAKSLL
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RPLEELTRALAYLSLKEGPLEALRLPTPKEPPPEEIALLRARFSELLARLKELLEAREAL
HHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YAALAHDLKTPLLSALRLLDYLERADDLGKERRVALLRALREELARGHRLTENLLALARL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EARPPRGETLNLRALAEDLLLRYRDEAKRRGLLVEVEGAGLARGERLLVERALANLLENA
HCCCCCCCEEHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHHHH
LRHAKSRVRLRVGEGVLLVEDDGAGLPLPLEALARPFLQGEGRRGSAGLGLYTAKRVAEA
HHHHHHHHEEEECCCEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
HGGRLFPCEGPLGGACLGLELPKGA
CCCEEEECCCCCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA