Click here to switch to the map view.

The map label for this gene is pepA [H]

Identifier: 54295473

GI number: 54295473

Start: 2921802

End: 2923166

Strand: Reverse

Name: pepA [H]

Synonym: lpl2559

Alternate gene names: 54295473

Gene position: 2923166-2921802 (Counterclockwise)

Preceding gene: 54295474

Following gene: 54295472

Centisome position: 87.37

GC content: 42.34

Gene sequence:

>1365_bases
ATGCAAGCAGAAGTATTTTACAAAAGTTATGGCGATAGGATAGTTCCTGTCCATCTCATTTCTCAATCGCAATGGGACGA
AGGAATTGAAAATCTAACCCCCATGGAACGCAATTGTTTTTCTGTACGCCAGTTTAAGGGCAAATTAGGCGATTATTGTT
TTATCCTCAATGCGGATGGCGTGATTGAAAAAGCTTTTATTGGATCGGGAACTGGTAATCAGGAAAGTGCTTTGGCCAAT
GCCGCACTTTTATTGCCTCCAGGCAACTATCAATTTCAAGATAAGTTAAGTCGTGAGTCTGGCGTAGTTTGGGCATTAGC
ACAATATCGATTTGATGAGTATAAAAAGTACGAGTTACAGCCTCGAGTTTTAATTGTTGAGGCAAATGATAGAGATTATA
TTTTATCCTTGGCGAATTCTTTATTTCTCGTGCGGGATCTCATTAACACGCCAACCTCCGATATGGGGCCAGAATCGCTA
GCTCATGTTGTCGAAGAATTGGCTAAAACCCACAAGGCTTGCTTTAAGCAATGGATTGGAGAGGAATTGATAAAGGATAA
TTTTCCTGCTATTCATGCGGTTGGAAGAGCTTCTGCTTTAACGCCTCGTTTATTATCCTTGCATTGGGGAAATGAGAAAC
ATCCACGTGTAACTTTGATTGGAAAGGGTGTTTGTTTTGATAGTGGTGGGCTTGATATCAAACCTTCATCAGGCATGCGT
TTGATGAAAAAAGATATGGGTGGTGCCGCACACGTCATAGGTTTAGCCCAGTGGATAATGGTTCAGCGTTTGCCGATTCG
ATTACAGGTATTAATCCCCGCTGTTGAAAACGCCATTGGTCCGAATGCTTTTAGGCCAGGAGATGTTTTAACCATGCGCA
ACGGATTAACCGTAGAAATAGAAAACACTGATGCAGAAGGTCGATTGATTCTGGCAGATGCTTTGGCTATGGCTTGTGAA
GAAAAACCAGATTTGATCATTGATTTTGCTACTTTAACAGGTGCTGCTCGTGTCGCTGTCGGAACTGAAATTGCAGCCAT
GTTTTCTAATCATGATCAACTGGCTCAGGATATAGTAGCGGCATCTAATAAAGTCTCAGACCCCGTCTGGCGGTTGCCTT
TATTTTCAGCATACGAAGAGTTATTGAATTCGAATATTGCAGACATGAGCAATTCCAGTTCTTCGTCCTATGCTGGGGCT
ATTACTGCCGGCTTATTTCTACAACGATTTGTGACAAAATCAATACCATGGGTTCATTTTGATATCATGGCCTGGAATGC
AGTAAGTAAGCCAGGAAAGCCAGAAGGTGGTGAAGCAATGGGCTTGCGAGCGGTTGCCGAGTATTTATTACAGACTTACG
GATAG

Upstream 100 bases:

>100_bases
TTAGCTCATGTGTTCGTCACCGTAGTCATCTATTTATTAGTTTTAGGTATAATAGGGCTTAGGCCTAGCCACTTCCGTGG
CCAGATAAAGGATTAAAAAG

Downstream 100 bases:

>100_bases
AATTTTCAGTTGGGAGCTAGTTATGTTTGTGACTTTTAGTTGTGATGCATATGAGAACATTACTTATTTTGAAAATGTGG
CAAAACAATTATTGTTGTTA

Product: hypothetical protein

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 454; Mature: 454

Protein sequence:

>454_residues
MQAEVFYKSYGDRIVPVHLISQSQWDEGIENLTPMERNCFSVRQFKGKLGDYCFILNADGVIEKAFIGSGTGNQESALAN
AALLLPPGNYQFQDKLSRESGVVWALAQYRFDEYKKYELQPRVLIVEANDRDYILSLANSLFLVRDLINTPTSDMGPESL
AHVVEELAKTHKACFKQWIGEELIKDNFPAIHAVGRASALTPRLLSLHWGNEKHPRVTLIGKGVCFDSGGLDIKPSSGMR
LMKKDMGGAAHVIGLAQWIMVQRLPIRLQVLIPAVENAIGPNAFRPGDVLTMRNGLTVEIENTDAEGRLILADALAMACE
EKPDLIIDFATLTGAARVAVGTEIAAMFSNHDQLAQDIVAASNKVSDPVWRLPLFSAYEELLNSNIADMSNSSSSSYAGA
ITAGLFLQRFVTKSIPWVHFDIMAWNAVSKPGKPEGGEAMGLRAVAEYLLQTYG

Sequences:

>Translated_454_residues
MQAEVFYKSYGDRIVPVHLISQSQWDEGIENLTPMERNCFSVRQFKGKLGDYCFILNADGVIEKAFIGSGTGNQESALAN
AALLLPPGNYQFQDKLSRESGVVWALAQYRFDEYKKYELQPRVLIVEANDRDYILSLANSLFLVRDLINTPTSDMGPESL
AHVVEELAKTHKACFKQWIGEELIKDNFPAIHAVGRASALTPRLLSLHWGNEKHPRVTLIGKGVCFDSGGLDIKPSSGMR
LMKKDMGGAAHVIGLAQWIMVQRLPIRLQVLIPAVENAIGPNAFRPGDVLTMRNGLTVEIENTDAEGRLILADALAMACE
EKPDLIIDFATLTGAARVAVGTEIAAMFSNHDQLAQDIVAASNKVSDPVWRLPLFSAYEELLNSNIADMSNSSSSSYAGA
ITAGLFLQRFVTKSIPWVHFDIMAWNAVSKPGKPEGGEAMGLRAVAEYLLQTYG
>Mature_454_residues
MQAEVFYKSYGDRIVPVHLISQSQWDEGIENLTPMERNCFSVRQFKGKLGDYCFILNADGVIEKAFIGSGTGNQESALAN
AALLLPPGNYQFQDKLSRESGVVWALAQYRFDEYKKYELQPRVLIVEANDRDYILSLANSLFLVRDLINTPTSDMGPESL
AHVVEELAKTHKACFKQWIGEELIKDNFPAIHAVGRASALTPRLLSLHWGNEKHPRVTLIGKGVCFDSGGLDIKPSSGMR
LMKKDMGGAAHVIGLAQWIMVQRLPIRLQVLIPAVENAIGPNAFRPGDVLTMRNGLTVEIENTDAEGRLILADALAMACE
EKPDLIIDFATLTGAARVAVGTEIAAMFSNHDQLAQDIVAASNKVSDPVWRLPLFSAYEELLNSNIADMSNSSSSSYAGA
ITAGLFLQRFVTKSIPWVHFDIMAWNAVSKPGKPEGGEAMGLRAVAEYLLQTYG

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=321, Percent_Identity=37.0716510903427, Blast_Score=192, Evalue=7e-49,
Organism=Homo sapiens, GI47155554, Length=307, Percent_Identity=34.2019543973941, Blast_Score=155, Evalue=5e-38,
Organism=Escherichia coli, GI87082123, Length=358, Percent_Identity=37.7094972067039, Blast_Score=222, Evalue=5e-59,
Organism=Escherichia coli, GI1790710, Length=317, Percent_Identity=41.9558359621451, Blast_Score=212, Evalue=4e-56,
Organism=Caenorhabditis elegans, GI17556903, Length=364, Percent_Identity=33.5164835164835, Blast_Score=155, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI17565172, Length=220, Percent_Identity=31.3636363636364, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI221379063, Length=284, Percent_Identity=36.2676056338028, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI221379062, Length=284, Percent_Identity=36.2676056338028, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI21357381, Length=284, Percent_Identity=36.2676056338028, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI21355725, Length=328, Percent_Identity=32.6219512195122, Blast_Score=153, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24661038, Length=295, Percent_Identity=34.9152542372881, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI161077148, Length=334, Percent_Identity=29.6407185628743, Blast_Score=128, Evalue=9e-30,
Organism=Drosophila melanogaster, GI20130057, Length=334, Percent_Identity=29.6407185628743, Blast_Score=128, Evalue=9e-30,
Organism=Drosophila melanogaster, GI24662227, Length=298, Percent_Identity=27.1812080536913, Blast_Score=118, Evalue=9e-27,
Organism=Drosophila melanogaster, GI20129969, Length=342, Percent_Identity=26.6081871345029, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI19922386, Length=346, Percent_Identity=26.878612716763, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI21355645, Length=343, Percent_Identity=25.0728862973761, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24662223, Length=343, Percent_Identity=25.0728862973761, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI20129963, Length=379, Percent_Identity=25.065963060686, Blast_Score=112, Evalue=8e-25,
Organism=Drosophila melanogaster, GI24646701, Length=173, Percent_Identity=35.8381502890173, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24646703, Length=173, Percent_Identity=35.8381502890173, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI21358201, Length=173, Percent_Identity=35.8381502890173, Blast_Score=86, Evalue=7e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 49860; Mature: 49860

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQAEVFYKSYGDRIVPVHLISQSQWDEGIENLTPMERNCFSVRQFKGKLGDYCFILNADG
CCCEEEEHHCCCEEEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEEECCC
VIEKAFIGSGTGNQESALANAALLLPPGNYQFQDKLSRESGVVWALAQYRFDEYKKYELQ
CEEHHEECCCCCCCHHHHHCEEEEECCCCCCHHHHHCCCCCEEEEHHHHHHHHHHHEECC
PRVLIVEANDRDYILSLANSLFLVRDLINTPTSDMGPESLAHVVEELAKTHKACFKQWIG
CEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EELIKDNFPAIHAVGRASALTPRLLSLHWGNEKHPRVTLIGKGVCFDSGGLDIKPSSGMR
HHHHHCCCCCEECCCCHHHCCCHHEEEECCCCCCCEEEEEECCEEECCCCCEECCCCCCH
LMKKDMGGAAHVIGLAQWIMVQRLPIRLQVLIPAVENAIGPNAFRPGDVLTMRNGLTVEI
HHHHHCCCHHHHHHHHHHHHHHCCCEEEEEEEHHHHHCCCCCCCCCCCEEEECCCEEEEE
ENTDAEGRLILADALAMACEEKPDLIIDFATLTGAARVAVGTEIAAMFSNHDQLAQDIVA
ECCCCCCCEEHHHHHHHHHCCCCCEEEEEHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHH
ASNKVSDPVWRLPLFSAYEELLNSNIADMSNSSSSSYAGAITAGLFLQRFVTKSIPWVHF
HCCCCCCCHHHCHHHHHHHHHHCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEE
DIMAWNAVSKPGKPEGGEAMGLRAVAEYLLQTYG
EEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQAEVFYKSYGDRIVPVHLISQSQWDEGIENLTPMERNCFSVRQFKGKLGDYCFILNADG
CCCEEEEHHCCCEEEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEEECCC
VIEKAFIGSGTGNQESALANAALLLPPGNYQFQDKLSRESGVVWALAQYRFDEYKKYELQ
CEEHHEECCCCCCCHHHHHCEEEEECCCCCCHHHHHCCCCCEEEEHHHHHHHHHHHEECC
PRVLIVEANDRDYILSLANSLFLVRDLINTPTSDMGPESLAHVVEELAKTHKACFKQWIG
CEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EELIKDNFPAIHAVGRASALTPRLLSLHWGNEKHPRVTLIGKGVCFDSGGLDIKPSSGMR
HHHHHCCCCCEECCCCHHHCCCHHEEEECCCCCCCEEEEEECCEEECCCCCEECCCCCCH
LMKKDMGGAAHVIGLAQWIMVQRLPIRLQVLIPAVENAIGPNAFRPGDVLTMRNGLTVEI
HHHHHCCCHHHHHHHHHHHHHHCCCEEEEEEEHHHHHCCCCCCCCCCCEEEECCCEEEEE
ENTDAEGRLILADALAMACEEKPDLIIDFATLTGAARVAVGTEIAAMFSNHDQLAQDIVA
ECCCCCCCEEHHHHHHHHHCCCCCEEEEEHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHH
ASNKVSDPVWRLPLFSAYEELLNSNIADMSNSSSSSYAGAITAGLFLQRFVTKSIPWVHF
HCCCCCCCHHHCHHHHHHHHHHCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEE
DIMAWNAVSKPGKPEGGEAMGLRAVAEYLLQTYG
EEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA