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The map label for this gene is plaA

Identifier: 54295184

GI number: 54295184

Start: 2581370

End: 2582299

Strand: Reverse

Name: plaA

Synonym: lpl2264

Alternate gene names: NA

Gene position: 2582299-2581370 (Counterclockwise)

Preceding gene: 54295186

Following gene: 54295183

Centisome position: 77.18

GC content: 39.46

Gene sequence:

>930_bases
ATGAAACTATTAGCATCTTTGTGTGCTTTTTTATTGTCGGGAGTTGTTAGCGCGACACCACTTAATAACATAGTTGTATT
TGGTGATAGTTTGTCGGATAACGGTAACTTATATGAATACATGAAACACCAACTTCCTCAATCCCCTCCTTATTTTGAAG
GTCGTTTTTCCAATGGCCCAGTATGGATAGAACGTCTGGCAGCTTCGTACTTCCCAAATGATCCCAATTCTCATTTGCTG
GATTATGCTTTTGGCGGGGCAGGAGTCTCTGTCGATGAAGAAGATGATGAAGTATTTTTTACCTTAAGAAGAGAAGTGAA
TTCTTATTTGTTAGCACATCAGGATAAAGCAAACCCTGACAGTCTTTTTGTTATTTGGATAGGGGCAAATAATTACCTCG
GAATGCCTGTTGAAGTGGAAGAAACGCTTAAAAATGTTAACCGAGGGATTACGGATAGCATACAACGTTTGGTAGACAAG
GGTGCGAAGCATATTTTAGTTCTCAATTTACCTGATTTGGGAAGAACTCCTGCCGCCCTGGAGTTTGGCTCTGTTGAAGA
GATGACCTATTTCTCAACACAGCATAATAATGCATTATCCAATACAGTGGATTATTTTAAAAAAACTTATCCTGAGGTTG
AGTGGTTGTTTTTTGACACGGGTAGTCATTTTGACCATGTGATAGAACATGCTGCAGAGTATGGATTTACAAATATAACA
GGTACCTGCTCCTTTTCGATAGTAGATGAGATTACTAAAAACTCCGTTTTGAAGATGGTTGCGTCTGTGAAACCAGAATT
GACAGAAAACGCATGTGATGGTTATTTGTTTTTTGATTTGGTTCATCCGACAGCGTTGGCACATAAAATAATGGCAGAAA
AAGCGCGTTTGATGCTGGATGAGGCTGGTGTAGAGTTCGCCGAGAATTAA

Upstream 100 bases:

>100_bases
ATATACAGTAATGTGTTAAATGCCGTGGAAAAATTGATAAATCATTATATAATTGAATGAACCTAAAGATATAAAATCAA
TCTATTACTTAAGGGGTTTC

Downstream 100 bases:

>100_bases
AAATTATTTTTATGGTAATAGCGAATGCAACTTGCATCGTCATTCAAATTGATCCGCAATGATATGGGGATTTTAGACTG
AGTGAAACCTAATGAGAGAA

Product: lysophospholipase A

Products: NA

Alternate protein names: Glycerophospholipid-cholesterol acyltransferase; GCAT [H]

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MKLLASLCAFLLSGVVSATPLNNIVVFGDSLSDNGNLYEYMKHQLPQSPPYFEGRFSNGPVWIERLAASYFPNDPNSHLL
DYAFGGAGVSVDEEDDEVFFTLRREVNSYLLAHQDKANPDSLFVIWIGANNYLGMPVEVEETLKNVNRGITDSIQRLVDK
GAKHILVLNLPDLGRTPAALEFGSVEEMTYFSTQHNNALSNTVDYFKKTYPEVEWLFFDTGSHFDHVIEHAAEYGFTNIT
GTCSFSIVDEITKNSVLKMVASVKPELTENACDGYLFFDLVHPTALAHKIMAEKARLMLDEAGVEFAEN

Sequences:

>Translated_309_residues
MKLLASLCAFLLSGVVSATPLNNIVVFGDSLSDNGNLYEYMKHQLPQSPPYFEGRFSNGPVWIERLAASYFPNDPNSHLL
DYAFGGAGVSVDEEDDEVFFTLRREVNSYLLAHQDKANPDSLFVIWIGANNYLGMPVEVEETLKNVNRGITDSIQRLVDK
GAKHILVLNLPDLGRTPAALEFGSVEEMTYFSTQHNNALSNTVDYFKKTYPEVEWLFFDTGSHFDHVIEHAAEYGFTNIT
GTCSFSIVDEITKNSVLKMVASVKPELTENACDGYLFFDLVHPTALAHKIMAEKARLMLDEAGVEFAEN
>Mature_309_residues
MKLLASLCAFLLSGVVSATPLNNIVVFGDSLSDNGNLYEYMKHQLPQSPPYFEGRFSNGPVWIERLAASYFPNDPNSHLL
DYAFGGAGVSVDEEDDEVFFTLRREVNSYLLAHQDKANPDSLFVIWIGANNYLGMPVEVEETLKNVNRGITDSIQRLVDK
GAKHILVLNLPDLGRTPAALEFGSVEEMTYFSTQHNNALSNTVDYFKKTYPEVEWLFFDTGSHFDHVIEHAAEYGFTNIT
GTCSFSIVDEITKNSVLKMVASVKPELTENACDGYLFFDLVHPTALAHKIMAEKARLMLDEAGVEFAEN

Specific function: Fatty acid transfer between phosphatidylcholine and cholesterol [H]

COG id: COG3240

COG function: function code IR; Phospholipase/lecithinase/hemolysin

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'GDSL' lipolytic enzyme family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013830
- InterPro:   IPR013831
- InterPro:   IPR001087
- InterPro:   IPR008265 [H]

Pfam domain/function: PF00657 Lipase_GDSL [H]

EC number: =2.3.1.43 [H]

Molecular weight: Translated: 34482; Mature: 34482

Theoretical pI: Translated: 4.43; Mature: 4.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLASLCAFLLSGVVSATPLNNIVVFGDSLSDNGNLYEYMKHQLPQSPPYFEGRFSNGP
CHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCC
VWIERLAASYFPNDPNSHLLDYAFGGAGVSVDEEDDEVFFTLRREVNSYLLAHQDKANPD
HHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCC
SLFVIWIGANNYLGMPVEVEETLKNVNRGITDSIQRLVDKGAKHILVLNLPDLGRTPAAL
EEEEEEEECCCCCCCCEEHHHHHHHHCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCEE
EFGSVEEMTYFSTQHNNALSNTVDYFKKTYPEVEWLFFDTGSHFDHVIEHAAEYGFTNIT
ECCCCHHHHEECCCCCCHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHCCCCCCC
GTCSFSIVDEITKNSVLKMVASVKPELTENACDGYLFFDLVHPTALAHKIMAEKARLMLD
CEEEHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHH
EAGVEFAEN
HHCCCCCCC
>Mature Secondary Structure
MKLLASLCAFLLSGVVSATPLNNIVVFGDSLSDNGNLYEYMKHQLPQSPPYFEGRFSNGP
CHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCC
VWIERLAASYFPNDPNSHLLDYAFGGAGVSVDEEDDEVFFTLRREVNSYLLAHQDKANPD
HHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCC
SLFVIWIGANNYLGMPVEVEETLKNVNRGITDSIQRLVDKGAKHILVLNLPDLGRTPAAL
EEEEEEEECCCCCCCCEEHHHHHHHHCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCEE
EFGSVEEMTYFSTQHNNALSNTVDYFKKTYPEVEWLFFDTGSHFDHVIEHAAEYGFTNIT
ECCCCHHHHEECCCCCCHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHCCCCCCC
GTCSFSIVDEITKNSVLKMVASVKPELTENACDGYLFFDLVHPTALAHKIMAEKARLMLD
CEEEHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHH
EAGVEFAEN
HHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2271578; 3280033; 1985976; 8294469 [H]