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The map label for this gene is bioC [H]

Identifier: 54295171

GI number: 54295171

Start: 2570097

End: 2570951

Strand: Reverse

Name: bioC [H]

Synonym: lpl2251

Alternate gene names: 54295171

Gene position: 2570951-2570097 (Counterclockwise)

Preceding gene: 54295173

Following gene: 54295166

Centisome position: 76.84

GC content: 41.64

Gene sequence:

>855_bases
ATGACGGTCAACAATGAAATAAGCAAGGCATTTAGCAAGCATGCCGATGACTATGAGCGTGTGGCCAAAGTTCAAAAAGA
AATCGGCAGTCGTTTGTTTGAGCGATTACAATATTTGAAAATTGCTCCTCGACGAATTCTTGATTTGGGGTGTGGGCCTG
GATTTTTTTCAAAAGAATTGGCTTTGTTATATCCGAAAGCGCAGATTGTTGGAATGGATTTGTCGTTTGCCATGTTAGAG
CAAGCCAGGAAAAAACAGGGTTGGCGTCGTAAATGGCCTTTAGTCAGTGCCGATATGCAGAAAATGCCTTTTGCAACAGG
CGTTTTTGATTTGGTTTTTGCTAACCAGGTTATTCACTGGAGTAGCTCATTAGGCACAGTTTTTCGGGAACTTAATCGTG
TAATGAATGTCAACGGATGCTTGATGTTTACTACCTTGGGTCCTGATACCTTCAAGGAATTACAAACGGCCTGGTCTGCC
GCTAATCAATATGCCCATGTTAATGAATTTGTTGATATGCATGATATTGGAGATTGTTTGGTTGCCGAGCATTTCATGGA
CCCGGTCATTGACATGGAATTACTGTCTATACATTACGAGACCCTTCCCCAATTGCTATTAGCTCTAAAAACTCAAGGGG
TAAGAAATATTAACCCTAAACGAAATCACGGGCTCACAGGTAAAAGTGCATGGAAACAATTTGAAGCACAATATGCTACT
ATGCGGACTACTACCGGCAAATATCCCTTAACTTATGAAGTGGTTTATGGGCAAGCCTGGAAGGGTGAGCAACGTAAAAT
GGAGCAAGGTATAGAAACCTGGATTCCTGTTTCACGTGTTGTTAGAAAGTCCTAA

Upstream 100 bases:

>100_bases
AGTGCATATTGAAGGTAAACGTAAGTTCTGTGTTATACTTAAGAATTTTTGGAGCACGATAGTTGGATTTCCAGCATTTA
ATTTTTCCCTGGTCTTTATA

Downstream 100 bases:

>100_bases
TTTAAAACGGATATCAATTGGATTGTCCGGTGCATCAATGGCGTCAAGACAAATTGCTACGATTTTGTAATTGTTTGGTT
AATTCAATTAATGCAGCCGC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 284; Mature: 283

Protein sequence:

>284_residues
MTVNNEISKAFSKHADDYERVAKVQKEIGSRLFERLQYLKIAPRRILDLGCGPGFFSKELALLYPKAQIVGMDLSFAMLE
QARKKQGWRRKWPLVSADMQKMPFATGVFDLVFANQVIHWSSSLGTVFRELNRVMNVNGCLMFTTLGPDTFKELQTAWSA
ANQYAHVNEFVDMHDIGDCLVAEHFMDPVIDMELLSIHYETLPQLLLALKTQGVRNINPKRNHGLTGKSAWKQFEAQYAT
MRTTTGKYPLTYEVVYGQAWKGEQRKMEQGIETWIPVSRVVRKS

Sequences:

>Translated_284_residues
MTVNNEISKAFSKHADDYERVAKVQKEIGSRLFERLQYLKIAPRRILDLGCGPGFFSKELALLYPKAQIVGMDLSFAMLE
QARKKQGWRRKWPLVSADMQKMPFATGVFDLVFANQVIHWSSSLGTVFRELNRVMNVNGCLMFTTLGPDTFKELQTAWSA
ANQYAHVNEFVDMHDIGDCLVAEHFMDPVIDMELLSIHYETLPQLLLALKTQGVRNINPKRNHGLTGKSAWKQFEAQYAT
MRTTTGKYPLTYEVVYGQAWKGEQRKMEQGIETWIPVSRVVRKS
>Mature_283_residues
TVNNEISKAFSKHADDYERVAKVQKEIGSRLFERLQYLKIAPRRILDLGCGPGFFSKELALLYPKAQIVGMDLSFAMLEQ
ARKKQGWRRKWPLVSADMQKMPFATGVFDLVFANQVIHWSSSLGTVFRELNRVMNVNGCLMFTTLGPDTFKELQTAWSAA
NQYAHVNEFVDMHDIGDCLVAEHFMDPVIDMELLSIHYETLPQLLLALKTQGVRNINPKRNHGLTGKSAWKQFEAQYATM
RTTTGKYPLTYEVVYGQAWKGEQRKMEQGIETWIPVSRVVRKS

Specific function: BioC is involved in an early, but chemically unexplored, step in the conversion of pimelic acid to biotin [H]

COG id: COG0500

COG function: function code QR; SAM-dependent methyltransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily [H]

Homologues:

Organism=Homo sapiens, GI40018642, Length=262, Percent_Identity=25.5725190839695, Blast_Score=85, Evalue=6e-17,
Organism=Escherichia coli, GI1786994, Length=240, Percent_Identity=29.1666666666667, Blast_Score=115, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17535003, Length=252, Percent_Identity=23.8095238095238, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI19922210, Length=247, Percent_Identity=26.3157894736842, Blast_Score=82, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011814
- InterPro:   IPR013216 [H]

Pfam domain/function: PF08241 Methyltransf_11 [H]

EC number: NA

Molecular weight: Translated: 32558; Mature: 32427

Theoretical pI: Translated: 9.59; Mature: 9.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TVNNEISKAFSKHADDYERVAKVQKEIGSRLFERLQYLKIAPRRILDLGCGPGFFSKEL
CCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCH
ALLYPKAQIVGMDLSFAMLEQARKKQGWRRKWPLVSADMQKMPFATGVFDLVFANQVIHW
HHEECCHHEEECCHHHHHHHHHHHHCCCHHCCCCCCCHHHHCCCHHHHHHHHHHHHHHHH
SSSLGTVFRELNRVMNVNGCLMFTTLGPDTFKELQTAWSAANQYAHVNEFVDMHDIGDCL
HHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VAEHFMDPVIDMELLSIHYETLPQLLLALKTQGVRNINPKRNHGLTGKSAWKQFEAQYAT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
MRTTTGKYPLTYEVVYGQAWKGEQRKMEQGIETWIPVSRVVRKS
HHCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3058702; 9278503 [H]