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The map label for this gene is 54295102

Identifier: 54295102

GI number: 54295102

Start: 2496583

End: 2497941

Strand: Reverse

Name: 54295102

Synonym: lpl2182

Alternate gene names: NA

Gene position: 2497941-2496583 (Counterclockwise)

Preceding gene: 54295103

Following gene: 54295101

Centisome position: 74.66

GC content: 40.47

Gene sequence:

>1359_bases
ATGAAATTGTCTTTTTTAGGCGCTACCGGTACGGTTACCGGTTCTAAGTACCTGGTGGAATCAAATAATAAAAAGATTTT
GGTAGATTGTGGGCTTTTCCAAGGGTTAAAAGAATTGAGACTAAGAAACTGGTCACCCCTGCCTGTGTCTCCAGAATCGA
TAGATGCCGTTGTTTTGACCCATGCCCATATTGATCATAGTGGTTACTTGCCATTGTTGGTGAAACAGGGATTTAAGGGG
CGCATCTATGCAACAGCTGCAACAACCGATTTATGTTCTATCTTGCTGCCTGATAGCGGTTTTTTGCACGAGGAAGATGC
CAGAAGGGCAAATAAATATGGGTACAGCAAGCACCATCCGGCTTTACCTTTGTATACTCAGGAAGATGCAAATAATACCT
TAAAGTATTTTGAATCAGTAGAATATGACACCCCTTATCCTTTAATGGAGGATTGCGAAATCAGTTGGCATAGGGCAGGG
CATATATTAGGGTCTGCATTTATTCAATTTCAAACAAAGCAAATCAAGTTATTATTTAGTGGTGATATTGGAAGACTCAA
TGATCCTGTTATGAAGCCTTCCGAGTTAATGAAATATACCGATTATTTGGTGATTGAATCAACTTATGGGAATCGATTGC
ATGATAAAACCGATCCTTTAGCGTTTATAGCCAACATAGTTAATACGACTTGTAAAAGAGGCGGTACAGTGCTAATTCCT
GCTTTTGCAGTCGGTAGGGCACAAACTATGCTGTATTATTTGTATATTTTAAAACAAAAAAAATTAATTCCTGATGTCCC
TGTCTATCTCGACAGCCCTATGGCTATAGATGCCACTGAATTATTATTAAAACATCATAACGAACATCGCTTAAGTGCAG
AGGAGTGTCGAGCCGTCTGCCAAATAGCGACTTATGTCCATACCCCAAATGAATCCATGGCAGTGGATTGGGGGCGCGAA
TCTAAAATTATTATTTCTGCAAGTGGCATGATGACAGGGGGCAGGGTTTTGCATCATTTGAAGGTATATGCTCCTGATCC
TGCAAGTACTATCCTTTTGACCGGATTCCAGGCTGCTGGAACGAGAGGTGAAAAAATGTTAAATCATGAGCCGTCTGTTA
AAATCCATGGCGATGATTATCCAGTCAGGGCTCAGGTAGCTATGTTAACCAATGCCTCTGCTCACGCAGATTATGAGGAA
ATACTAGTTTGGCTAAAGCATTTTGAGAAAGCCCCAAAGGAAGTTTTTATTACCCATGGCGAGCCTCAAGCAGCATTAGG
GTTAAAGGAACATATTGAAGCGGAGCTAGGATGGAATTGCAAGATACCTAACTATCTTGAAAAAGTAAATTTGGATTAA

Upstream 100 bases:

>100_bases
AAGATTTACAATTTGAAACTTCAAATGACTTTAAAATAAATTGGTAATAGGTCGTATTATTCATTACAGTACTGAGAATG
ACATACAACAAGGTATTATT

Downstream 100 bases:

>100_bases
CGAATCCCCAAAATAACATTCGATTTAATATTCTGAGCAAGAGCTACAGAGACTCGGAAAACAGGGAACAATCATTCATA
TTCCAGTTTTTTTGCAATAT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 452; Mature: 452

Protein sequence:

>452_residues
MKLSFLGATGTVTGSKYLVESNNKKILVDCGLFQGLKELRLRNWSPLPVSPESIDAVVLTHAHIDHSGYLPLLVKQGFKG
RIYATAATTDLCSILLPDSGFLHEEDARRANKYGYSKHHPALPLYTQEDANNTLKYFESVEYDTPYPLMEDCEISWHRAG
HILGSAFIQFQTKQIKLLFSGDIGRLNDPVMKPSELMKYTDYLVIESTYGNRLHDKTDPLAFIANIVNTTCKRGGTVLIP
AFAVGRAQTMLYYLYILKQKKLIPDVPVYLDSPMAIDATELLLKHHNEHRLSAEECRAVCQIATYVHTPNESMAVDWGRE
SKIIISASGMMTGGRVLHHLKVYAPDPASTILLTGFQAAGTRGEKMLNHEPSVKIHGDDYPVRAQVAMLTNASAHADYEE
ILVWLKHFEKAPKEVFITHGEPQAALGLKEHIEAELGWNCKIPNYLEKVNLD

Sequences:

>Translated_452_residues
MKLSFLGATGTVTGSKYLVESNNKKILVDCGLFQGLKELRLRNWSPLPVSPESIDAVVLTHAHIDHSGYLPLLVKQGFKG
RIYATAATTDLCSILLPDSGFLHEEDARRANKYGYSKHHPALPLYTQEDANNTLKYFESVEYDTPYPLMEDCEISWHRAG
HILGSAFIQFQTKQIKLLFSGDIGRLNDPVMKPSELMKYTDYLVIESTYGNRLHDKTDPLAFIANIVNTTCKRGGTVLIP
AFAVGRAQTMLYYLYILKQKKLIPDVPVYLDSPMAIDATELLLKHHNEHRLSAEECRAVCQIATYVHTPNESMAVDWGRE
SKIIISASGMMTGGRVLHHLKVYAPDPASTILLTGFQAAGTRGEKMLNHEPSVKIHGDDYPVRAQVAMLTNASAHADYEE
ILVWLKHFEKAPKEVFITHGEPQAALGLKEHIEAELGWNCKIPNYLEKVNLD
>Mature_452_residues
MKLSFLGATGTVTGSKYLVESNNKKILVDCGLFQGLKELRLRNWSPLPVSPESIDAVVLTHAHIDHSGYLPLLVKQGFKG
RIYATAATTDLCSILLPDSGFLHEEDARRANKYGYSKHHPALPLYTQEDANNTLKYFESVEYDTPYPLMEDCEISWHRAG
HILGSAFIQFQTKQIKLLFSGDIGRLNDPVMKPSELMKYTDYLVIESTYGNRLHDKTDPLAFIANIVNTTCKRGGTVLIP
AFAVGRAQTMLYYLYILKQKKLIPDVPVYLDSPMAIDATELLLKHHNEHRLSAEECRAVCQIATYVHTPNESMAVDWGRE
SKIIISASGMMTGGRVLHHLKVYAPDPASTILLTGFQAAGTRGEKMLNHEPSVKIHGDDYPVRAQVAMLTNASAHADYEE
ILVWLKHFEKAPKEVFITHGEPQAALGLKEHIEAELGWNCKIPNYLEKVNLD

Specific function: Has endoribonuclease activity towards 23S and 16S rRNA (in vitro) [H]

COG id: COG1236

COG function: function code J; Predicted exonuclease of the beta-lactamase fold involved in RNA processing

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family [H]

Homologues:

Organism=Homo sapiens, GI7706427, Length=433, Percent_Identity=27.9445727482679, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI33300633, Length=463, Percent_Identity=26.5658747300216, Blast_Score=148, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI32566029, Length=444, Percent_Identity=27.9279279279279, Blast_Score=147, Evalue=9e-36,
Organism=Caenorhabditis elegans, GI32564696, Length=447, Percent_Identity=26.1744966442953, Blast_Score=138, Evalue=6e-33,
Organism=Saccharomyces cerevisiae, GI6323307, Length=450, Percent_Identity=24.4444444444444, Blast_Score=121, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24648013, Length=462, Percent_Identity=27.0562770562771, Blast_Score=151, Evalue=7e-37,
Organism=Drosophila melanogaster, GI21358523, Length=464, Percent_Identity=26.0775862068966, Blast_Score=124, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022712
- InterPro:   IPR001279
- InterPro:   IPR011108 [H]

Pfam domain/function: PF10996 Beta-Casp; PF00753 Lactamase_B; PF07521 RMMBL [H]

EC number: NA

Molecular weight: Translated: 50587; Mature: 50587

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLSFLGATGTVTGSKYLVESNNKKILVDCGLFQGLKELRLRNWSPLPVSPESIDAVVLT
CEEEEECCCCEECCCEEEEECCCCEEEEECHHHHHHHHHHHCCCCCCCCCCCCCCEEEEE
HAHIDHSGYLPLLVKQGFKGRIYATAATTDLCSILLPDSGFLHEEDARRANKYGYSKHHP
EEEECCCCCCHHHCCCCCCCEEEEEECHHHHHHEECCCCCCCCCHHHHHHHHCCCCCCCC
ALPLYTQEDANNTLKYFESVEYDTPYPLMEDCEISWHRAGHILGSAFIQFQTKQIKLLFS
CCCEEECCCCCHHHHHHHHCCCCCCCCCHHCCCCCHHHHHHHHHHHHEEEEEEEEEEEEE
GDIGRLNDPVMKPSELMKYTDYLVIESTYGNRLHDKTDPLAFIANIVNTTCKRGGTVLIP
CCCCCCCCCCCCHHHHHHHCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEE
AFAVGRAQTMLYYLYILKQKKLIPDVPVYLDSPMAIDATELLLKHHNEHRLSAEECRAVC
EHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCHHHHHHHCCCCCCCCHHHHHHHH
QIATYVHTPNESMAVDWGRESKIIISASGMMTGGRVLHHLKVYAPDPASTILLTGFQAAG
HHHHHEECCCCCEEEECCCCCEEEEEECCCCCCCCEEEEEEEECCCCCCEEEEECCHHCC
TRGEKMLNHEPSVKIHGDDYPVRAQVAMLTNASAHADYEEILVWLKHFEKAPKEVFITHG
CCCHHHHCCCCCEEECCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEECC
EPQAALGLKEHIEAELGWNCKIPNYLEKVNLD
CCHHHCCHHHHHHHHCCCCCCCCHHHHHCCCC
>Mature Secondary Structure
MKLSFLGATGTVTGSKYLVESNNKKILVDCGLFQGLKELRLRNWSPLPVSPESIDAVVLT
CEEEEECCCCEECCCEEEEECCCCEEEEECHHHHHHHHHHHCCCCCCCCCCCCCCEEEEE
HAHIDHSGYLPLLVKQGFKGRIYATAATTDLCSILLPDSGFLHEEDARRANKYGYSKHHP
EEEECCCCCCHHHCCCCCCCEEEEEECHHHHHHEECCCCCCCCCHHHHHHHHCCCCCCCC
ALPLYTQEDANNTLKYFESVEYDTPYPLMEDCEISWHRAGHILGSAFIQFQTKQIKLLFS
CCCEEECCCCCHHHHHHHHCCCCCCCCCHHCCCCCHHHHHHHHHHHHEEEEEEEEEEEEE
GDIGRLNDPVMKPSELMKYTDYLVIESTYGNRLHDKTDPLAFIANIVNTTCKRGGTVLIP
CCCCCCCCCCCCHHHHHHHCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEE
AFAVGRAQTMLYYLYILKQKKLIPDVPVYLDSPMAIDATELLLKHHNEHRLSAEECRAVC
EHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCHHHHHHHCCCCCCCCHHHHHHHH
QIATYVHTPNESMAVDWGRESKIIISASGMMTGGRVLHHLKVYAPDPASTILLTGFQAAG
HHHHHEECCCCCEEEECCCCCEEEEEECCCCCCCCEEEEEEEECCCCCCEEEEECCHHCC
TRGEKMLNHEPSVKIHGDDYPVRAQVAMLTNASAHADYEEILVWLKHFEKAPKEVFITHG
CCCHHHHCCCCCEEECCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEECC
EPQAALGLKEHIEAELGWNCKIPNYLEKVNLD
CCHHHCCHHHHHHHHCCCCCCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA