Click here to switch to the map view.

The map label for this gene is bcr [H]

Identifier: 54295080

GI number: 54295080

Start: 2467645

End: 2468868

Strand: Reverse

Name: bcr [H]

Synonym: lpl2160

Alternate gene names: 54295080

Gene position: 2468868-2467645 (Counterclockwise)

Preceding gene: 54295083

Following gene: 54295079

Centisome position: 73.79

GC content: 39.13

Gene sequence:

>1224_bases
ATGCATCAGGAACATCCAGGCCACACAGATACCCCAAAAATAGATCCTTGGTTAATATTTGTCATATTAATGTTGATGGC
TTTGATGCAAACTACAACCGATCAATACATTCCTTCTCTTCCAGCGATTACCACAGCCTTGAACAGCACTGAAGCATCGA
TTCAGTTAACTATTTCTATGTTTATGTTGGGTTTAAGCCTATCTCATATCTTTTATGGCCCCTTGTCAGACAAAATAGGA
CGCAAACCTCCGTTAATGTTCGGTGTTGGGTTAAGTATATTAGGCAGTTTGGTTTGTTTTTTTGCGCCCAACGTCAGTGT
GTTAATCTTGGGTCGATTTCTTCAGGGGTTTGGAATTGGGTGTTGCAATTCAGTGGGGCGATCTCTGGTGAGAGATTTAT
TCACCGATCGTTTGCTGGCTAAAATTGGTTCTTATGTCGGTGTTGTCAGTATTTTTATTATGGCAGCCTCACCCACTTTA
GGAGGATTTATTCAAGAGATGGCTGGATGGAAAGCCAATTTTATGTTCTTATTTGTTTTTGGAATCCTGGTTTGGCTTTT
GGCCTTTAGCATTCTTCCTGAAACGAATAAACACTTAAATCCTGAAGCTACAAAAATCAAAGTGATGGCGAAGAATTATT
TTATCTTATTACGTAGCAAGATCTTTGTGGGATATACACTGTGTGCTTGCTTTGCTTTTGCAGGAATGGTTTCTTATCTT
ACGATTGCGCCATTTTTATTTCAAAATACCATGGGATTGAGTCCCTTGGAATTTGGACGTTTAACTTTTTTTATTGCGGG
TGCCATCTGTTTTAGCGGGATTGTCAACAGTCAGCTGGTCATGCGTAAAGGAATATCCTTTATGGTTTGTACCGGTGTTC
TTTTTATGATTGCCGGTGGTTTAAGCCTGTTATTAATTACGATGCTGGGTTGGTCGCAAATCTATTTTATTATGATTTCA
ATGACATTATTTAGTGCTGGCGCCGGATTTACATTTATTAATGCCTTTGCCGGTGCGTTTCATCCTTTTCCGCAAATGGC
TGGAACAGTTGGAGCTTTATATGCCAGCATGCAGGATTTAAGTGCAGCATTGACCAGTGGTTTTATTGCGGGAATGAAGG
GGTATGGTCAATATTCTTTAGCTATGATATTACTGATTTTAGGTTTAAGTTCTTTAGTGGCATGGTATTATCTTGGATTG
CAAGATGACGCTATTTCAAATTAA

Upstream 100 bases:

>100_bases
AGACGTTGTGGCCTATGCCTTATTTTCTAATACTTTTGTTTTGCTTGTAAATAATGATATTGTTATCAGCCTTGTTAGAA
ATCATTCTAAAGGATATTTG

Downstream 100 bases:

>100_bases
GGGGTATTAATGAAAATTACCGATGAAGAATTGAAAAAAATTATCAGCAAATTATCTGGCTCCAAAGCCGATGACATTCA
AGATGATACGGCCCTAATAG

Product: hypothetical protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 407; Mature: 407

Protein sequence:

>407_residues
MHQEHPGHTDTPKIDPWLIFVILMLMALMQTTTDQYIPSLPAITTALNSTEASIQLTISMFMLGLSLSHIFYGPLSDKIG
RKPPLMFGVGLSILGSLVCFFAPNVSVLILGRFLQGFGIGCCNSVGRSLVRDLFTDRLLAKIGSYVGVVSIFIMAASPTL
GGFIQEMAGWKANFMFLFVFGILVWLLAFSILPETNKHLNPEATKIKVMAKNYFILLRSKIFVGYTLCACFAFAGMVSYL
TIAPFLFQNTMGLSPLEFGRLTFFIAGAICFSGIVNSQLVMRKGISFMVCTGVLFMIAGGLSLLLITMLGWSQIYFIMIS
MTLFSAGAGFTFINAFAGAFHPFPQMAGTVGALYASMQDLSAALTSGFIAGMKGYGQYSLAMILLILGLSSLVAWYYLGL
QDDAISN

Sequences:

>Translated_407_residues
MHQEHPGHTDTPKIDPWLIFVILMLMALMQTTTDQYIPSLPAITTALNSTEASIQLTISMFMLGLSLSHIFYGPLSDKIG
RKPPLMFGVGLSILGSLVCFFAPNVSVLILGRFLQGFGIGCCNSVGRSLVRDLFTDRLLAKIGSYVGVVSIFIMAASPTL
GGFIQEMAGWKANFMFLFVFGILVWLLAFSILPETNKHLNPEATKIKVMAKNYFILLRSKIFVGYTLCACFAFAGMVSYL
TIAPFLFQNTMGLSPLEFGRLTFFIAGAICFSGIVNSQLVMRKGISFMVCTGVLFMIAGGLSLLLITMLGWSQIYFIMIS
MTLFSAGAGFTFINAFAGAFHPFPQMAGTVGALYASMQDLSAALTSGFIAGMKGYGQYSLAMILLILGLSSLVAWYYLGL
QDDAISN
>Mature_407_residues
MHQEHPGHTDTPKIDPWLIFVILMLMALMQTTTDQYIPSLPAITTALNSTEASIQLTISMFMLGLSLSHIFYGPLSDKIG
RKPPLMFGVGLSILGSLVCFFAPNVSVLILGRFLQGFGIGCCNSVGRSLVRDLFTDRLLAKIGSYVGVVSIFIMAASPTL
GGFIQEMAGWKANFMFLFVFGILVWLLAFSILPETNKHLNPEATKIKVMAKNYFILLRSKIFVGYTLCACFAFAGMVSYL
TIAPFLFQNTMGLSPLEFGRLTFFIAGAICFSGIVNSQLVMRKGISFMVCTGVLFMIAGGLSLLLITMLGWSQIYFIMIS
MTLFSAGAGFTFINAFAGAFHPFPQMAGTVGALYASMQDLSAALTSGFIAGMKGYGQYSLAMILLILGLSSLVAWYYLGL
QDDAISN

Specific function: Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance. Probable membrane translocase [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI1788509, Length=347, Percent_Identity=28.2420749279539, Blast_Score=125, Evalue=6e-30,
Organism=Escherichia coli, GI1790146, Length=354, Percent_Identity=27.1186440677966, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI87082312, Length=357, Percent_Identity=27.4509803921569, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI48994889, Length=336, Percent_Identity=27.0833333333333, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1787065, Length=260, Percent_Identity=22.3076923076923, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI87081983, Length=163, Percent_Identity=30.6748466257669, Blast_Score=69, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6324264, Length=247, Percent_Identity=24.6963562753036, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 44231; Mature: 44231

Theoretical pI: Translated: 8.64; Mature: 8.64

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
5.7 %Met     (Translated Protein)
7.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
5.7 %Met     (Mature Protein)
7.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCC
>Mature Secondary Structure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HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]