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The map label for this gene is argS [H]

Identifier: 54294929

GI number: 54294929

Start: 2250550

End: 2252319

Strand: Reverse

Name: argS [H]

Synonym: lpl2008

Alternate gene names: 54294929

Gene position: 2252319-2250550 (Counterclockwise)

Preceding gene: 54294930

Following gene: 54294928

Centisome position: 67.32

GC content: 41.75

Gene sequence:

>1770_bases
ATGAGAAGTATGAAAGCTATAATCGAATATCTTTTGAAACAGGCATTAATTAATCTGCAACAATCAGGCGAAATGCCAAT
TGATTTGGAGATTGAAATAAAAGTTGAGAATGCCAAAGATCCAGCTCATGGTGATTATGCGACTAATTTGGCACTGGTAT
TAGCTAAACCATGCCGACAAGCACCTAAAGTATTAGCCGAGCGATTGGTTGCAGTAATCCCCGCAGATCCGTCTGTAGAG
AAAATTGAGATAGCCGGGGCAGGATTTATTAATTTTTTCATGCGCAGCACGGCGCGCTCGCTCATCATTTCTGAAATTTT
GAATAAAGGCAAGGAGTTTGGCCAAGGTAATTTAGGACAGAGCCAAAAGGTATTGATTGAATTTGTTTCTGCCAATCCAA
CAGGGCCTTTACATGTAGGACATGGAAGAGGGGCTGCTTTCGGAGCAACTTTGGGTAATGTTTTAAAAGCCGCTGGTTAC
GATGTGACTTTGGAATATTATGTCAATGATGCGGGCAGGCAAATGAATATTCTCGCTGTGAGTGTGTGGCTGCGCTACCT
CGAATTGGCAGGTGAGCCAATTGCTTTTCCGGCGAATGGCTATAAAGGTCAATATGTTTATGAGATTGCACAAGAGATGT
GGTCAGAGCAGGGTAATCAATTCGTGCATCCATGGATTTCGGTAGTAGACAATTTACCTGCTGATGAACCCGAAGGTGGA
GATAAAGAGACTTATATCGATGCGATCATCGCGCGAGCGCAATCCTTACTGGGCAAGGATGGGTTTGCTAACTTCCATCA
ACATGCTTTAAAAACGGTATTGGATGATATAAAAGATGATTTGCAGGCGTTTGGTGTTCGTTTTGACAGTTGGTTTTCTG
AGCAATCGTTGTTTGAAGATGGTTCTATTGGGAAAGGTATTCAGGCCTTGAAAGATAGAGGCCACACTTATGAAAGAGAA
GGTGCTTTATGGTTTAGGGCAACTGATTTTGGTGATGAAAAAGATAGAGTATTAGTCCGGGCTAATGGGCAAACGACATA
TTTCGCTTCTGATGTTGCTTATCACTGGAATAAATATGATAGAGGTTTTGATCGTGTCATTGATATTTTTGGTGCTGATC
ATCATGGTTATGTCACGAGAATTAAAACAGCTGTTAAGGCATTAGGACATGATGAAAGTGCACTAGATGTTATTTTAGTG
CAGTTTGCCATTCTATATCGAGGTGGTGACAGGGTGCAAATGTCTACTCGCAGTGGTTCATTTGTTACTTTGAGAGAGCT
AAGAGAAGAAGTAGGAAATGATGCGGCTCGTTATTTTTATGTGGCAAGAAAACCTGAACAACACATGGATTTTGACCTGG
ACCTGGCAAAGTCCGAATCCAGTGACAATCCTGTGTATTATATTCAATACGCACATGCCCGTATCTGTAGTGTATTGAGA
CAGTTAAAAGAAAGGGGTTTGAAGTGGGATAAGGACATGGGACTTAAAAACCTTGATTTATTGGAGCAACAACATGAGGC
CACATTAATTTCTCTGATTGCCCGATATCCCGAAGTCATTCAATCTGCTGCCGCTTCTTGCGAGCCGCATCAGCTTGCTT
ACTATTTAAGAGAGCTAGCCAATGGGTTACACAGTTATTATAATGCGATTCAGCTATTATGCGAACAAGAACAATTGCGA
TGTGCGCGTTTGTGTTTGCTGGAGTCGGTTCGACAGGTTTTAAATAATGGTTTGGCTATATTAGGCGTATCAGCTCCTGA
GAGTATGTGA

Upstream 100 bases:

>100_bases
GCTATTGCTGTGTCTATTGTTGTAGTGATGGTGCTTCGGGGTTGAGAGCCTTTCCATATGGTATGAAAAAGAGCATAATA
TCGGTATTTTTGACGGATAA

Downstream 100 bases:

>100_bases
TGGCAAAAGATTATGGAAATAGGCGTGCTGCACGTCGCAACAGAGGACCTCACCAGTTTTTGGTTATTATTGTAACTTTT
TTGTTTGGATATATAACCGC

Product: arginyl-tRNA synthetase

Products: NA

Alternate protein names: Arginine--tRNA ligase; ArgRS [H]

Number of amino acids: Translated: 589; Mature: 589

Protein sequence:

>589_residues
MRSMKAIIEYLLKQALINLQQSGEMPIDLEIEIKVENAKDPAHGDYATNLALVLAKPCRQAPKVLAERLVAVIPADPSVE
KIEIAGAGFINFFMRSTARSLIISEILNKGKEFGQGNLGQSQKVLIEFVSANPTGPLHVGHGRGAAFGATLGNVLKAAGY
DVTLEYYVNDAGRQMNILAVSVWLRYLELAGEPIAFPANGYKGQYVYEIAQEMWSEQGNQFVHPWISVVDNLPADEPEGG
DKETYIDAIIARAQSLLGKDGFANFHQHALKTVLDDIKDDLQAFGVRFDSWFSEQSLFEDGSIGKGIQALKDRGHTYERE
GALWFRATDFGDEKDRVLVRANGQTTYFASDVAYHWNKYDRGFDRVIDIFGADHHGYVTRIKTAVKALGHDESALDVILV
QFAILYRGGDRVQMSTRSGSFVTLRELREEVGNDAARYFYVARKPEQHMDFDLDLAKSESSDNPVYYIQYAHARICSVLR
QLKERGLKWDKDMGLKNLDLLEQQHEATLISLIARYPEVIQSAAASCEPHQLAYYLRELANGLHSYYNAIQLLCEQEQLR
CARLCLLESVRQVLNNGLAILGVSAPESM

Sequences:

>Translated_589_residues
MRSMKAIIEYLLKQALINLQQSGEMPIDLEIEIKVENAKDPAHGDYATNLALVLAKPCRQAPKVLAERLVAVIPADPSVE
KIEIAGAGFINFFMRSTARSLIISEILNKGKEFGQGNLGQSQKVLIEFVSANPTGPLHVGHGRGAAFGATLGNVLKAAGY
DVTLEYYVNDAGRQMNILAVSVWLRYLELAGEPIAFPANGYKGQYVYEIAQEMWSEQGNQFVHPWISVVDNLPADEPEGG
DKETYIDAIIARAQSLLGKDGFANFHQHALKTVLDDIKDDLQAFGVRFDSWFSEQSLFEDGSIGKGIQALKDRGHTYERE
GALWFRATDFGDEKDRVLVRANGQTTYFASDVAYHWNKYDRGFDRVIDIFGADHHGYVTRIKTAVKALGHDESALDVILV
QFAILYRGGDRVQMSTRSGSFVTLRELREEVGNDAARYFYVARKPEQHMDFDLDLAKSESSDNPVYYIQYAHARICSVLR
QLKERGLKWDKDMGLKNLDLLEQQHEATLISLIARYPEVIQSAAASCEPHQLAYYLRELANGLHSYYNAIQLLCEQEQLR
CARLCLLESVRQVLNNGLAILGVSAPESM
>Mature_589_residues
MRSMKAIIEYLLKQALINLQQSGEMPIDLEIEIKVENAKDPAHGDYATNLALVLAKPCRQAPKVLAERLVAVIPADPSVE
KIEIAGAGFINFFMRSTARSLIISEILNKGKEFGQGNLGQSQKVLIEFVSANPTGPLHVGHGRGAAFGATLGNVLKAAGY
DVTLEYYVNDAGRQMNILAVSVWLRYLELAGEPIAFPANGYKGQYVYEIAQEMWSEQGNQFVHPWISVVDNLPADEPEGG
DKETYIDAIIARAQSLLGKDGFANFHQHALKTVLDDIKDDLQAFGVRFDSWFSEQSLFEDGSIGKGIQALKDRGHTYERE
GALWFRATDFGDEKDRVLVRANGQTTYFASDVAYHWNKYDRGFDRVIDIFGADHHGYVTRIKTAVKALGHDESALDVILV
QFAILYRGGDRVQMSTRSGSFVTLRELREEVGNDAARYFYVARKPEQHMDFDLDLAKSESSDNPVYYIQYAHARICSVLR
QLKERGLKWDKDMGLKNLDLLEQQHEATLISLIARYPEVIQSAAASCEPHQLAYYLRELANGLHSYYNAIQLLCEQEQLR
CARLCLLESVRQVLNNGLAILGVSAPESM

Specific function: Unknown

COG id: COG0018

COG function: function code J; Arginyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI15149476, Length=592, Percent_Identity=24.1554054054054, Blast_Score=111, Evalue=2e-24,
Organism=Escherichia coli, GI1788184, Length=622, Percent_Identity=23.1511254019293, Blast_Score=108, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI71985061, Length=595, Percent_Identity=21.8487394957983, Blast_Score=90, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71985068, Length=559, Percent_Identity=21.6457960644007, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320548, Length=563, Percent_Identity=26.6429840142096, Blast_Score=156, Evalue=7e-39,
Organism=Saccharomyces cerevisiae, GI6321883, Length=576, Percent_Identity=25.3472222222222, Blast_Score=120, Evalue=6e-28,
Organism=Drosophila melanogaster, GI18859963, Length=607, Percent_Identity=23.2289950576606, Blast_Score=100, Evalue=3e-21,

Paralogues:

None

Copy number: 789 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001412
- InterPro:   IPR001278
- InterPro:   IPR015945
- InterPro:   IPR005148
- InterPro:   IPR008909
- InterPro:   IPR014729
- InterPro:   IPR009080 [H]

Pfam domain/function: PF03485 Arg_tRNA_synt_N; PF05746 DALR_1; PF00750 tRNA-synt_1d [H]

EC number: =6.1.1.19 [H]

Molecular weight: Translated: 65878; Mature: 65878

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSMKAIIEYLLKQALINLQQSGEMPIDLEIEIKVENAKDPAHGDYATNLALVLAKPCRQ
CCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHH
APKVLAERLVAVIPADPSVEKIEIAGAGFINFFMRSTARSLIISEILNKGKEFGQGNLGQ
HHHHHHHHHHEEECCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
SQKVLIEFVSANPTGPLHVGHGRGAAFGATLGNVLKAAGYDVTLEYYVNDAGRQMNILAV
CHHHHHHEECCCCCCCEEECCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCEEHHHHH
SVWLRYLELAGEPIAFPANGYKGQYVYEIAQEMWSEQGNQFVHPWISVVDNLPADEPEGG
HHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHHCCCEEHHHHHHHHHCCCCCCCCCC
DKETYIDAIIARAQSLLGKDGFANFHQHALKTVLDDIKDDLQAFGVRFDSWFSEQSLFED
CHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCHHHHCCC
GSIGKGIQALKDRGHTYEREGALWFRATDFGDEKDRVLVRANGQTTYFASDVAYHWNKYD
CCCCHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCEEEEEECCCEEEEEHHHHHHHHHHC
RGFDRVIDIFGADHHGYVTRIKTAVKALGHDESALDVILVQFAILYRGGDRVQMSTRSGS
CHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCC
FVTLRELREEVGNDAARYFYVARKPEQHMDFDLDLAKSESSDNPVYYIQYAHARICSVLR
EEEHHHHHHHHCCCCEEEEEEECCCHHHCCCCCEECCCCCCCCCEEEEEEHHHHHHHHHH
QLKERGLKWDKDMGLKNLDLLEQQHEATLISLIARYPEVIQSAAASCEPHQLAYYLRELA
HHHHCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
NGLHSYYNAIQLLCEQEQLRCARLCLLESVRQVLNNGLAILGVSAPESM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCC
>Mature Secondary Structure
MRSMKAIIEYLLKQALINLQQSGEMPIDLEIEIKVENAKDPAHGDYATNLALVLAKPCRQ
CCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHH
APKVLAERLVAVIPADPSVEKIEIAGAGFINFFMRSTARSLIISEILNKGKEFGQGNLGQ
HHHHHHHHHHEEECCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
SQKVLIEFVSANPTGPLHVGHGRGAAFGATLGNVLKAAGYDVTLEYYVNDAGRQMNILAV
CHHHHHHEECCCCCCCEEECCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCEEHHHHH
SVWLRYLELAGEPIAFPANGYKGQYVYEIAQEMWSEQGNQFVHPWISVVDNLPADEPEGG
HHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHHCCCEEHHHHHHHHHCCCCCCCCCC
DKETYIDAIIARAQSLLGKDGFANFHQHALKTVLDDIKDDLQAFGVRFDSWFSEQSLFED
CHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCHHHHCCC
GSIGKGIQALKDRGHTYEREGALWFRATDFGDEKDRVLVRANGQTTYFASDVAYHWNKYD
CCCCHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCEEEEEECCCEEEEEHHHHHHHHHHC
RGFDRVIDIFGADHHGYVTRIKTAVKALGHDESALDVILVQFAILYRGGDRVQMSTRSGS
CHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCC
FVTLRELREEVGNDAARYFYVARKPEQHMDFDLDLAKSESSDNPVYYIQYAHARICSVLR
EEEHHHHHHHHCCCCEEEEEEECCCHHHCCCCCEECCCCCCCCCEEEEEEHHHHHHHHHH
QLKERGLKWDKDMGLKNLDLLEQQHEATLISLIARYPEVIQSAAASCEPHQLAYYLRELA
HHHHCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
NGLHSYYNAIQLLCEQEQLRCARLCLLESVRQVLNNGLAILGVSAPESM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA