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The map label for this gene is lpxK [H]

Identifier: 54294705

GI number: 54294705

Start: 1993847

End: 1994818

Strand: Reverse

Name: lpxK [H]

Synonym: lpl1782

Alternate gene names: 54294705

Gene position: 1994818-1993847 (Counterclockwise)

Preceding gene: 54294706

Following gene: 54294704

Centisome position: 59.62

GC content: 36.21

Gene sequence:

>972_bases
ATGTCATTTTTTGTGAACAGGGTATGGTATGGTAACCATTTTTTACAGTGGATACTGGTTCCATTTTCCTGGTTATACAG
AATTGTTATACGAACCAGGCGATGGTATTTACAGCGTTTCTGCCAACAGCTGTACCCTATACCAATTATTGTAGTGGGAA
ATGTGACCGTAGGAGGAGTAGGCAAGACGCCTCTGGTCATTGAAATTGCTAAAAAAATACAGCAAAAAGGTTTAAAAGTA
GGGATTGTAAGTCGTGGCTACAAAGCAGCAATAAAACATTTTCCATACGAAGTAAAATTAAATGATTCAGCTGAATTAGT
AGGCGACGAGCCGCTCATGATGGCAAGAAAAATTAATTGTCCAGTGGTTATTGCGCCTAAACGCAATGAGGCAGTAAGGT
ACCTTTTAGACAAGCATTCGGTTGAAATTATTATCAGTGATGATGGCTTGCAACATTATAAAATGGGGCGATCTATTGAA
ATTGTAGTAATAGATGGGATGCGAAAACTGGGTAATGGTTTTTGTCTACCCGCTGGACCATTAAGGGAACCTGATTCACG
ATTAAAACAAGTTGATTTTGTTATTGTTAATCAAGGTGCTGCAGGAGGTGCTTATTCTATGGAATTAATTCCTAAAAACA
TAGTTCGATTGTCAACTCAGGAAGAAGTCAGTAAGGATTCGTTTACTTCTGAAGTAGCTGCTGTAGCAGGAATTGGTAAC
CCGCAACGATTCTATTCTACATTAAGTCAATTAGGTATAAAATTTAATCCATATTCTTATCCCGATCATCATCAATTTAA
ACCTCATGATTTAAATGATATCGATCTACCAGTTATAATGACAGAAAAGGATGCTGTAAAATGTTATTCATTTAGTTCAG
ATAAATTATATTATTTACCCGTTGAAGCAAAGTTGAATGATTCCTTTTGGGAAGCATTTTGGTCACATCAACAATTACAA
GGTTATTACTAA

Upstream 100 bases:

>100_bases
AGCAAGGTAGTCATCAAGAATTACTTGATATGGATGGTCATTACGCTCAACTGTATAAAGTGCAGCAATTTGGCAGGGTT
AATGAGGAAGTGGTAGTTTA

Downstream 100 bases:

>100_bases
TATGATGCCAAAACGAATTTGGTTATTGCTATTATCCATGTTTTTATTTTTAAGTGGCAGTGTTTTTGCAGTGGAAGAGC
CAGAGGAAGACAAAGTAGTC

Product: tetraacyldisaccharide 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase [H]

Number of amino acids: Translated: 323; Mature: 322

Protein sequence:

>323_residues
MSFFVNRVWYGNHFLQWILVPFSWLYRIVIRTRRWYLQRFCQQLYPIPIIVVGNVTVGGVGKTPLVIEIAKKIQQKGLKV
GIVSRGYKAAIKHFPYEVKLNDSAELVGDEPLMMARKINCPVVIAPKRNEAVRYLLDKHSVEIIISDDGLQHYKMGRSIE
IVVIDGMRKLGNGFCLPAGPLREPDSRLKQVDFVIVNQGAAGGAYSMELIPKNIVRLSTQEEVSKDSFTSEVAAVAGIGN
PQRFYSTLSQLGIKFNPYSYPDHHQFKPHDLNDIDLPVIMTEKDAVKCYSFSSDKLYYLPVEAKLNDSFWEAFWSHQQLQ
GYY

Sequences:

>Translated_323_residues
MSFFVNRVWYGNHFLQWILVPFSWLYRIVIRTRRWYLQRFCQQLYPIPIIVVGNVTVGGVGKTPLVIEIAKKIQQKGLKV
GIVSRGYKAAIKHFPYEVKLNDSAELVGDEPLMMARKINCPVVIAPKRNEAVRYLLDKHSVEIIISDDGLQHYKMGRSIE
IVVIDGMRKLGNGFCLPAGPLREPDSRLKQVDFVIVNQGAAGGAYSMELIPKNIVRLSTQEEVSKDSFTSEVAAVAGIGN
PQRFYSTLSQLGIKFNPYSYPDHHQFKPHDLNDIDLPVIMTEKDAVKCYSFSSDKLYYLPVEAKLNDSFWEAFWSHQQLQ
GYY
>Mature_322_residues
SFFVNRVWYGNHFLQWILVPFSWLYRIVIRTRRWYLQRFCQQLYPIPIIVVGNVTVGGVGKTPLVIEIAKKIQQKGLKVG
IVSRGYKAAIKHFPYEVKLNDSAELVGDEPLMMARKINCPVVIAPKRNEAVRYLLDKHSVEIIISDDGLQHYKMGRSIEI
VVIDGMRKLGNGFCLPAGPLREPDSRLKQVDFVIVNQGAAGGAYSMELIPKNIVRLSTQEEVSKDSFTSEVAAVAGIGNP
QRFYSTLSQLGIKFNPYSYPDHHQFKPHDLNDIDLPVIMTEKDAVKCYSFSSDKLYYLPVEAKLNDSFWEAFWSHQQLQG
YY

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) [H]

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family [H]

Homologues:

Organism=Escherichia coli, GI1787144, Length=313, Percent_Identity=40.5750798722045, Blast_Score=246, Evalue=1e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003758 [H]

Pfam domain/function: PF02606 LpxK [H]

EC number: =2.7.1.130 [H]

Molecular weight: Translated: 36895; Mature: 36764

Theoretical pI: Translated: 9.26; Mature: 9.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFFVNRVWYGNHFLQWILVPFSWLYRIVIRTRRWYLQRFCQQLYPIPIIVVGNVTVGGV
CCEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCEEECCC
GKTPLVIEIAKKIQQKGLKVGIVSRGYKAAIKHFPYEVKLNDSAELVGDEPLMMARKINC
CCCCHHHHHHHHHHHCCCEEEEECCCHHHHHHHCCEEEEECCCHHHCCCCCCHHHEECCC
PVVIAPKRNEAVRYLLDKHSVEIIISDDGLQHYKMGRSIEIVVIDGMRKLGNGFCLPAGP
CEEEECCCCHHHHHHHCCCCEEEEEECCCCHHHHCCCEEEEEEECCHHHHCCCEECCCCC
LREPDSRLKQVDFVIVNQGAAGGAYSMELIPKNIVRLSTQEEVSKDSFTSEVAAVAGIGN
CCCCHHHHHEEEEEEEECCCCCCEEEEEECCHHHHCCCCHHHHHHHHHHHHHHHHHCCCC
PQRFYSTLSQLGIKFNPYSYPDHHQFKPHDLNDIDLPVIMTEKDAVKCYSFSSDKLYYLP
HHHHHHHHHHCCEEECCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEEECCCEEEEEE
VEAKLNDSFWEAFWSHQQLQGYY
EECCCCHHHHHHHHCHHHHCCCC
>Mature Secondary Structure 
SFFVNRVWYGNHFLQWILVPFSWLYRIVIRTRRWYLQRFCQQLYPIPIIVVGNVTVGGV
CEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCEEECCC
GKTPLVIEIAKKIQQKGLKVGIVSRGYKAAIKHFPYEVKLNDSAELVGDEPLMMARKINC
CCCCHHHHHHHHHHHCCCEEEEECCCHHHHHHHCCEEEEECCCHHHCCCCCCHHHEECCC
PVVIAPKRNEAVRYLLDKHSVEIIISDDGLQHYKMGRSIEIVVIDGMRKLGNGFCLPAGP
CEEEECCCCHHHHHHHCCCCEEEEEECCCCHHHHCCCEEEEEEECCHHHHCCCEECCCCC
LREPDSRLKQVDFVIVNQGAAGGAYSMELIPKNIVRLSTQEEVSKDSFTSEVAAVAGIGN
CCCCHHHHHEEEEEEEECCCCCCEEEEEECCHHHHCCCCHHHHHHHHHHHHHHHHHCCCC
PQRFYSTLSQLGIKFNPYSYPDHHQFKPHDLNDIDLPVIMTEKDAVKCYSFSSDKLYYLP
HHHHHHHHHHCCEEECCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEEECCCEEEEEE
VEAKLNDSFWEAFWSHQQLQGYY
EECCCCHHHHHHHHCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA