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The map label for this gene is ydhC [H]

Identifier: 54294212

GI number: 54294212

Start: 1424239

End: 1425399

Strand: Reverse

Name: ydhC [H]

Synonym: lpl1277

Alternate gene names: 54294212

Gene position: 1425399-1424239 (Counterclockwise)

Preceding gene: 54294213

Following gene: 54294211

Centisome position: 42.6

GC content: 36.95

Gene sequence:

>1161_bases
ATGAAAAAAAATGCTCTTCTTATAGTGTTATTAACCTGGTTTCTTGGAAACATGGATATACATTTCCTTACTCCAGCCTT
GCCATCATTAGTTGATTACTTCTCGATAACCCCCAATACAGCTCAACTAACTATCAGTCTTTTTCTTTTGGGTAAAGCCC
TCAGTATGATTTTATGGGGTCTTCTTTCCGAACGTTATGGGAGAAAACCAATCTTCATTGGAGGGCTGTTGTTATTTATT
CTGAGCAATTTTCTGATTGCTCTAAACCACTCCATCCTTCTCTTTTTAGTATGCCGATTTCTCCAGGGAATTAGCGTAGG
CGCTACCCTTCTAATGGGTAGAGCAATGATTAACGATACCCATAATGAACAAAATGCCACAAAATACTTTGCGTGGTTAT
TTACTCTGGCTGGGCTGTTTATTTGCTTTCTTCCATTTTTTGGAGGCTTGATAAACAGTTATTGGAATTGGCAAATCGCC
TCTCTTATCATCGCTGCCTATGGCCTGCTTTTATTACCTTTATGTCGAGGTTTAAAAGAAACCAAACCCCATTATGTAAA
ATTCCCTCGCCTAGGCCATAGTATTATGGTGGTCTTCAACCATCCCCTTTTTGTTTCTTACCTCCTTATTTCTGCCTTGA
TGATGGCTGGAGAATCAGCGTTTAATACCAGCGCCTCTTTTATTCTTATTAAAGGAGAAAATTTTACTAGCGCTCAATAT
GGTACAATCAAGACCACTATGGCAATTATGCATTTATTAGGTACCGCTTGTTGTGGCTTAATAGCAAAATATTATCATAG
TATCCAATTAACAAAATTAGGAGTACGTTTCTTTATTTTCGCAGCATTCTTGATGTGGTTATTTGTCTTTTCTGCTGAAA
ATATATATTTGACTTTTATAGTGCCTATGGTGATTTATTATTTTGGTACAGGTTTTATTGTTGCATCAGCAACAGCATCA
GCTGTTCGCCCTTTTCCTCAGCATATGGCTCTTGCATTAGCTATCACTTTATTTTGTCAATTTAACTGCTCCGCTTTCTT
TAGTTTTATTACCAGCATGATAGGAATTCAGCAAGTAGAAACTTTTATGTTCTTATTAAGTTTGGTAATTATTTTGAGTT
TTCTTGCCCTTCTAAAACTTCAACGAATGGAGCCCTGCTGA

Upstream 100 bases:

>100_bases
CCGGAATTTATAGTTTATTCGCGATTTTTGTTTACGGGTATGATCGGCTAAATGTCAGGCAGATGACAGATTTTTCTAAT
TCTTATTTTAACATGAAATC

Downstream 100 bases:

>100_bases
AAAAACCATGATCTTTGATCCTGGTAAGAAAATACAAAGTTTGCGTGTATTTCTGCCTAAAGAAGACTATGCTTATTTAA
AATAAGTTCTTAATCGTATT

Product: hypothetical protein

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 386; Mature: 386

Protein sequence:

>386_residues
MKKNALLIVLLTWFLGNMDIHFLTPALPSLVDYFSITPNTAQLTISLFLLGKALSMILWGLLSERYGRKPIFIGGLLLFI
LSNFLIALNHSILLFLVCRFLQGISVGATLLMGRAMINDTHNEQNATKYFAWLFTLAGLFICFLPFFGGLINSYWNWQIA
SLIIAAYGLLLLPLCRGLKETKPHYVKFPRLGHSIMVVFNHPLFVSYLLISALMMAGESAFNTSASFILIKGENFTSAQY
GTIKTTMAIMHLLGTACCGLIAKYYHSIQLTKLGVRFFIFAAFLMWLFVFSAENIYLTFIVPMVIYYFGTGFIVASATAS
AVRPFPQHMALALAITLFCQFNCSAFFSFITSMIGIQQVETFMFLLSLVIILSFLALLKLQRMEPC

Sequences:

>Translated_386_residues
MKKNALLIVLLTWFLGNMDIHFLTPALPSLVDYFSITPNTAQLTISLFLLGKALSMILWGLLSERYGRKPIFIGGLLLFI
LSNFLIALNHSILLFLVCRFLQGISVGATLLMGRAMINDTHNEQNATKYFAWLFTLAGLFICFLPFFGGLINSYWNWQIA
SLIIAAYGLLLLPLCRGLKETKPHYVKFPRLGHSIMVVFNHPLFVSYLLISALMMAGESAFNTSASFILIKGENFTSAQY
GTIKTTMAIMHLLGTACCGLIAKYYHSIQLTKLGVRFFIFAAFLMWLFVFSAENIYLTFIVPMVIYYFGTGFIVASATAS
AVRPFPQHMALALAITLFCQFNCSAFFSFITSMIGIQQVETFMFLLSLVIILSFLALLKLQRMEPC
>Mature_386_residues
MKKNALLIVLLTWFLGNMDIHFLTPALPSLVDYFSITPNTAQLTISLFLLGKALSMILWGLLSERYGRKPIFIGGLLLFI
LSNFLIALNHSILLFLVCRFLQGISVGATLLMGRAMINDTHNEQNATKYFAWLFTLAGLFICFLPFFGGLINSYWNWQIA
SLIIAAYGLLLLPLCRGLKETKPHYVKFPRLGHSIMVVFNHPLFVSYLLISALMMAGESAFNTSASFILIKGENFTSAQY
GTIKTTMAIMHLLGTACCGLIAKYYHSIQLTKLGVRFFIFAAFLMWLFVFSAENIYLTFIVPMVIYYFGTGFIVASATAS
AVRPFPQHMALALAITLFCQFNCSAFFSFITSMIGIQQVETFMFLLSLVIILSFLALLKLQRMEPC

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI48994889, Length=383, Percent_Identity=25.3263707571802, Blast_Score=95, Evalue=9e-21,
Organism=Escherichia coli, GI87082312, Length=329, Percent_Identity=25.8358662613982, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI1790146, Length=221, Percent_Identity=27.1493212669683, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1788509, Length=230, Percent_Identity=25.2173913043478, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1787065, Length=239, Percent_Identity=25.1046025104602, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43309; Mature: 43309

Theoretical pI: Translated: 9.45; Mature: 9.45

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKNALLIVLLTWFLGNMDIHFLTPALPSLVDYFSITPNTAQLTISLFLLGKALSMILWG
CCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
LLSERYGRKPIFIGGLLLFILSNFLIALNHSILLFLVCRFLQGISVGATLLMGRAMINDT
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCC
HNEQNATKYFAWLFTLAGLFICFLPFFGGLINSYWNWQIASLIIAAYGLLLLPLCRGLKE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCHHH
TKPHYVKFPRLGHSIMVVFNHPLFVSYLLISALMMAGESAFNTSASFILIKGENFTSAQY
CCCCEEECCCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCC
GTIKTTMAIMHLLGTACCGLIAKYYHSIQLTKLGVRFFIFAAFLMWLFVFSAENIYLTFI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
VPMVIYYFGTGFIVASATASAVRPFPQHMALALAITLFCQFNCSAFFSFITSMIGIQQVE
HHHHHHHHCCHHHHHHCHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
TFMFLLSLVIILSFLALLKLQRMEPC
HHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKKNALLIVLLTWFLGNMDIHFLTPALPSLVDYFSITPNTAQLTISLFLLGKALSMILWG
CCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
LLSERYGRKPIFIGGLLLFILSNFLIALNHSILLFLVCRFLQGISVGATLLMGRAMINDT
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCC
HNEQNATKYFAWLFTLAGLFICFLPFFGGLINSYWNWQIASLIIAAYGLLLLPLCRGLKE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCHHH
TKPHYVKFPRLGHSIMVVFNHPLFVSYLLISALMMAGESAFNTSASFILIKGENFTSAQY
CCCCEEECCCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCC
GTIKTTMAIMHLLGTACCGLIAKYYHSIQLTKLGVRFFIFAAFLMWLFVFSAENIYLTFI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
VPMVIYYFGTGFIVASATASAVRPFPQHMALALAITLFCQFNCSAFFSFITSMIGIQQVE
HHHHHHHHCCHHHHHHCHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
TFMFLLSLVIILSFLALLKLQRMEPC
HHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503 [H]