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The map label for this gene is hisG [H]

Identifier: 54294144

GI number: 54294144

Start: 1350423

End: 1351304

Strand: Reverse

Name: hisG [H]

Synonym: lpl1208

Alternate gene names: 54294144

Gene position: 1351304-1350423 (Counterclockwise)

Preceding gene: 54294145

Following gene: 54294143

Centisome position: 40.39

GC content: 41.95

Gene sequence:

>882_bases
GTGAAAAATCGTTTACGTCTGGCCTTACAAAAAAAAGGCCGATTATCAGATGAATCTTTAAATCTCCTGCAACGCTGTGG
TTTAAAGTTTCGTATTAAACCAAACGCATTATTAACTCATGTTGATAATTTTCCAATCGATTTACTATTTGTTCGCGATG
ATGACATCCCTACTCTCGTATTCGACAGTTTATGTGATGGTGGCATCGTGGGAGAAAATGTGCTGCTGGAAGCTTCTTTT
AACAGACCAGACAAAGCCTATAGAAAAATATTGGCATTAGGCAGTTGTACTTGTCGTTTATCGATAGCAGTACCAGAAGC
ATTCGACTATCAAGGAGCCGGTAGTTTGGATGGGAGGCGAATTGCAACCAGCTATCCAAATTTACTCAACAATTATCTTG
CTGAACGAAAAATTAGTGCGGAAATTCTGACATTATCCGGCTCGGTTGAGGTAGCGCCACGAATGGGAATGGCTGATGTC
ATATGCGATTTGGTATCCACTGGCCAAACACTCGAAGATAACAAACTCAAAGAAGTCGATACTGTTCTCAACAGTCAGGC
CGTCTTTATTCAAACTCAGAGACAATTGGATCCTGATATTCAAGAGTTGTTTGCCATGCTTGCCAGAAGAATCCAGGCTG
TCCAGCAAGCTCAGGAAAGAAAATACATAGTTTTTCATGCGCCCAAATCCGCCCTTGAGCGAATTGCTCAGAAATTACCA
GGCGCTGAGTCCCCAACCATTCTTCCATTACCGGGCAACAATGAAAAAGTTGCAGTGCATGTAGTCTCCAGTGAAGGTGT
GTTTTGGAATACGTTAGAGACAATTCAATATTTAGGTGCCAGCTCCATCCTGGTATTACCCATTGAAAAAATGCTGGAGT
AA

Upstream 100 bases:

>100_bases
AAGAAACAGGGGTCAGTGTAACAACCATCACGCGAGTTGCGCGTTGTTTAAGCTTTGGTACAGGCGGTTATCGTTTAATA
GCCGAAAGATTGGAGAAGTT

Downstream 100 bases:

>100_bases
TTCATATGTTAACAATTAAAAACTGGCAATTACTTTCTGAAAACGATAAAAAGCTATGCCTTTCAAGACCGCGACAGAGT
TCTGCAATAAAAGAAAATGT

Product: ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase [H]

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MKNRLRLALQKKGRLSDESLNLLQRCGLKFRIKPNALLTHVDNFPIDLLFVRDDDIPTLVFDSLCDGGIVGENVLLEASF
NRPDKAYRKILALGSCTCRLSIAVPEAFDYQGAGSLDGRRIATSYPNLLNNYLAERKISAEILTLSGSVEVAPRMGMADV
ICDLVSTGQTLEDNKLKEVDTVLNSQAVFIQTQRQLDPDIQELFAMLARRIQAVQQAQERKYIVFHAPKSALERIAQKLP
GAESPTILPLPGNNEKVAVHVVSSEGVFWNTLETIQYLGASSILVLPIEKMLE

Sequences:

>Translated_293_residues
MKNRLRLALQKKGRLSDESLNLLQRCGLKFRIKPNALLTHVDNFPIDLLFVRDDDIPTLVFDSLCDGGIVGENVLLEASF
NRPDKAYRKILALGSCTCRLSIAVPEAFDYQGAGSLDGRRIATSYPNLLNNYLAERKISAEILTLSGSVEVAPRMGMADV
ICDLVSTGQTLEDNKLKEVDTVLNSQAVFIQTQRQLDPDIQELFAMLARRIQAVQQAQERKYIVFHAPKSALERIAQKLP
GAESPTILPLPGNNEKVAVHVVSSEGVFWNTLETIQYLGASSILVLPIEKMLE
>Mature_293_residues
MKNRLRLALQKKGRLSDESLNLLQRCGLKFRIKPNALLTHVDNFPIDLLFVRDDDIPTLVFDSLCDGGIVGENVLLEASF
NRPDKAYRKILALGSCTCRLSIAVPEAFDYQGAGSLDGRRIATSYPNLLNNYLAERKISAEILTLSGSVEVAPRMGMADV
ICDLVSTGQTLEDNKLKEVDTVLNSQAVFIQTQRQLDPDIQELFAMLARRIQAVQQAQERKYIVFHAPKSALERIAQKLP
GAESPTILPLPGNNEKVAVHVVSSEGVFWNTLETIQYLGASSILVLPIEKMLE

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Long subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788330, Length=295, Percent_Identity=53.2203389830509, Blast_Score=302, Evalue=1e-83,
Organism=Saccharomyces cerevisiae, GI6320896, Length=294, Percent_Identity=30.2721088435374, Blast_Score=121, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- InterPro:   IPR020621
- InterPro:   IPR013115
- InterPro:   IPR011322
- InterPro:   IPR015867 [H]

Pfam domain/function: PF01634 HisG; PF08029 HisG_C [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 32490; Mature: 32490

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNRLRLALQKKGRLSDESLNLLQRCGLKFRIKPNALLTHVDNFPIDLLFVRDDDIPTLV
CCCCCEEHHHHCCCCCHHHHHHHHHCCCEEEECCCHHEEECCCCCEEEEEEECCCCCHHH
FDSLCDGGIVGENVLLEASFNRPDKAYRKILALGSCTCRLSIAVPEAFDYQGAGSLDGRR
HHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCE
IATSYPNLLNNYLAERKISAEILTLSGSVEVAPRMGMADVICDLVSTGQTLEDNKLKEVD
EEHHHHHHHHHHHHHHCCCEEEEEECCCEEECCCCCHHHHHHHHHHCCCCCCCCHHHHHH
TVLNSQAVFIQTQRQLDPDIQELFAMLARRIQAVQQAQERKYIVFHAPKSALERIAQKLP
HHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHCC
GAESPTILPLPGNNEKVAVHVVSSEGVFWNTLETIQYLGASSILVLPIEKMLE
CCCCCEEEECCCCCCEEEEEEEECCCEEEHHHHHHHHCCCCCEEEEEHHHHCC
>Mature Secondary Structure
MKNRLRLALQKKGRLSDESLNLLQRCGLKFRIKPNALLTHVDNFPIDLLFVRDDDIPTLV
CCCCCEEHHHHCCCCCHHHHHHHHHCCCEEEECCCHHEEECCCCCEEEEEEECCCCCHHH
FDSLCDGGIVGENVLLEASFNRPDKAYRKILALGSCTCRLSIAVPEAFDYQGAGSLDGRR
HHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCE
IATSYPNLLNNYLAERKISAEILTLSGSVEVAPRMGMADVICDLVSTGQTLEDNKLKEVD
EEHHHHHHHHHHHHHHCCCEEEEEECCCEEECCCCCHHHHHHHHHHCCCCCCCCHHHHHH
TVLNSQAVFIQTQRQLDPDIQELFAMLARRIQAVQQAQERKYIVFHAPKSALERIAQKLP
HHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHCC
GAESPTILPLPGNNEKVAVHVVSSEGVFWNTLETIQYLGASSILVLPIEKMLE
CCCCCEEEECCCCCCEEEEEEEECCCEEEHHHHHHHHCCCCCEEEEEHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA