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The map label for this gene is glyA [H]

Identifier: 54293709

GI number: 54293709

Start: 866605

End: 867858

Strand: Direct

Name: glyA [H]

Synonym: lpl0762

Alternate gene names: 54293709

Gene position: 866605-867858 (Clockwise)

Preceding gene: 54293708

Following gene: 54293710

Centisome position: 25.9

GC content: 41.31

Gene sequence:

>1254_bases
ATGTTTGACGAAAGTTATACTATAAAAAATTTTGATGATGTTCTTTTTAAAGCAATTTCTGATGAAAAACGACGTCAAGA
AGAACACATTGAATTAATAGCATCTGAAAATTATGTCAGCCCGAGAGTATTGGAAGCTCAGGGTTCTGTGTTGACGAATA
AATACGCTGAAGGATATCCAGGCAAACGCTATTACGGAGGTTGTGAGTTTGTTGATGTCGCTGAAGAGTTAGCCATTTCA
AGGGCAAAATTACTTTTTGGCGCTCATTATGTCAATGTGCAACCCCACTCGGGATCACAAGCAAACGCAGCAGTCATGAT
GGCATTATTGTCCCCAGGCGATACTTTTATGGGTATGGCTTTACCTCATGGCGGACACTTGACTCATGGGTCAAAGGTTA
ATTTTTCAGGTAAATTATACCATTCTGTCGAGTATGGTGTTGATAACAATACGGGTTTGATTGATTATGATGCTCTGGAG
AAACTTGCGCTTCAACACAAACCAAAATTGATCATTGCCGGTTTTTCAGCTTATTCCAGGATCCTGGATTGGGCTCGGTT
TAGAGAAATTGCCGATAAGGTCGGCGCTTATTTAATGGCGGACATCGCTCATGTAGCTGGTCTGGTGGCCGTAGGGTTAT
ATCCTTCTCCTGTTCCTTATGCGGATGTTGTGACGACAACAACTCATAAAACTTTAAGAGGACCTCGCGGTGGTTTAATC
CTTTGTAAGGAAAACGAAGAAATTGAGAAAAAATTAAATTCTGCTGTATTTCCTGGTATGCAAGGTGGCCCCTTAATGCA
TGTAATTGCTGCCAAGGCGGTTGCTTTTGCGGAAGCGCTGTTACCCGAATTCAAAACTTATCAGCAACAGGTTTTAGCTA
ATGCCAGAACGATGTGCAGTGTGTTACAAAGCAGAGGCTATGATATTGTTTCTGGCGGAACGGATAACCATCTTTTGCTA
GTGGATTTGATAAATAAAGGAATTACAGGTAAAGAAGCTGACGCTGCTTTAGGCAGAGCCAACATAACAGTCAATAAAAA
TTCGGTTCCCAATGATCCTCGCTCACCTTTTGTAACGAGTGGTTTACGTTTGGGTACACCTGCTGCAACCACAAGAGGCT
TTAAAGAAAGAGAGATTACTTTGTTATCTAACTGGGTAGCTGATGTCCTTGATAATGTTCATGATGAAACTAATATTTCA
AGAGTGAAAACCCAGGTGCTGCTACTCTGTCGTGAATTTCCGGTTTATGCCTAA

Upstream 100 bases:

>100_bases
AGCTGGGATTATTGCGGCTGGCGTAGATGGTGTAAAGAGTGTTCGTAATGACCTTATTATAAAAACAAGGTAAATATAAC
CTTCCAACCAAGGAACATTC

Downstream 100 bases:

>100_bases
TCATGTATTGTCCATTTTGTCATGCGGAAGAAACAAAGGTAGTGGATTCACGTCTGGTCGCGGATGGTGCTCAAGTTCGC
AGAAGGCGTGAATGTCTTGA

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT; Serine methylase [H]

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MFDESYTIKNFDDVLFKAISDEKRRQEEHIELIASENYVSPRVLEAQGSVLTNKYAEGYPGKRYYGGCEFVDVAEELAIS
RAKLLFGAHYVNVQPHSGSQANAAVMMALLSPGDTFMGMALPHGGHLTHGSKVNFSGKLYHSVEYGVDNNTGLIDYDALE
KLALQHKPKLIIAGFSAYSRILDWARFREIADKVGAYLMADIAHVAGLVAVGLYPSPVPYADVVTTTTHKTLRGPRGGLI
LCKENEEIEKKLNSAVFPGMQGGPLMHVIAAKAVAFAEALLPEFKTYQQQVLANARTMCSVLQSRGYDIVSGGTDNHLLL
VDLINKGITGKEADAALGRANITVNKNSVPNDPRSPFVTSGLRLGTPAATTRGFKEREITLLSNWVADVLDNVHDETNIS
RVKTQVLLLCREFPVYA

Sequences:

>Translated_417_residues
MFDESYTIKNFDDVLFKAISDEKRRQEEHIELIASENYVSPRVLEAQGSVLTNKYAEGYPGKRYYGGCEFVDVAEELAIS
RAKLLFGAHYVNVQPHSGSQANAAVMMALLSPGDTFMGMALPHGGHLTHGSKVNFSGKLYHSVEYGVDNNTGLIDYDALE
KLALQHKPKLIIAGFSAYSRILDWARFREIADKVGAYLMADIAHVAGLVAVGLYPSPVPYADVVTTTTHKTLRGPRGGLI
LCKENEEIEKKLNSAVFPGMQGGPLMHVIAAKAVAFAEALLPEFKTYQQQVLANARTMCSVLQSRGYDIVSGGTDNHLLL
VDLINKGITGKEADAALGRANITVNKNSVPNDPRSPFVTSGLRLGTPAATTRGFKEREITLLSNWVADVLDNVHDETNIS
RVKTQVLLLCREFPVYA
>Mature_417_residues
MFDESYTIKNFDDVLFKAISDEKRRQEEHIELIASENYVSPRVLEAQGSVLTNKYAEGYPGKRYYGGCEFVDVAEELAIS
RAKLLFGAHYVNVQPHSGSQANAAVMMALLSPGDTFMGMALPHGGHLTHGSKVNFSGKLYHSVEYGVDNNTGLIDYDALE
KLALQHKPKLIIAGFSAYSRILDWARFREIADKVGAYLMADIAHVAGLVAVGLYPSPVPYADVVTTTTHKTLRGPRGGLI
LCKENEEIEKKLNSAVFPGMQGGPLMHVIAAKAVAFAEALLPEFKTYQQQVLANARTMCSVLQSRGYDIVSGGTDNHLLL
VDLINKGITGKEADAALGRANITVNKNSVPNDPRSPFVTSGLRLGTPAATTRGFKEREITLLSNWVADVLDNVHDETNIS
RVKTQVLLLCREFPVYA

Specific function: Interconversion of serine and glycine [H]

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family [H]

Homologues:

Organism=Homo sapiens, GI261862352, Length=402, Percent_Identity=49.7512437810945, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI261862350, Length=402, Percent_Identity=49.7512437810945, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI261862348, Length=402, Percent_Identity=49.7512437810945, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI19923315, Length=402, Percent_Identity=49.7512437810945, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI22547186, Length=401, Percent_Identity=50.8728179551122, Blast_Score=348, Evalue=5e-96,
Organism=Homo sapiens, GI261862346, Length=402, Percent_Identity=48.2587064676617, Blast_Score=344, Evalue=7e-95,
Organism=Homo sapiens, GI22547189, Length=388, Percent_Identity=47.9381443298969, Blast_Score=313, Evalue=2e-85,
Organism=Escherichia coli, GI1788902, Length=418, Percent_Identity=70.5741626794258, Blast_Score=589, Evalue=1e-169,
Organism=Caenorhabditis elegans, GI25144732, Length=400, Percent_Identity=49.75, Blast_Score=377, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI25144729, Length=400, Percent_Identity=49.75, Blast_Score=377, Evalue=1e-105,
Organism=Saccharomyces cerevisiae, GI6319739, Length=397, Percent_Identity=47.3551637279597, Blast_Score=372, Evalue=1e-104,
Organism=Saccharomyces cerevisiae, GI6323087, Length=390, Percent_Identity=47.1794871794872, Blast_Score=352, Evalue=5e-98,
Organism=Drosophila melanogaster, GI24640005, Length=448, Percent_Identity=46.6517857142857, Blast_Score=390, Evalue=1e-109,
Organism=Drosophila melanogaster, GI221329721, Length=448, Percent_Identity=46.6517857142857, Blast_Score=390, Evalue=1e-109,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798 [H]

Pfam domain/function: PF00464 SHMT [H]

EC number: =2.1.2.1 [H]

Molecular weight: Translated: 45587; Mature: 45587

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDESYTIKNFDDVLFKAISDEKRRQEEHIELIASENYVSPRVLEAQGSVLTNKYAEGYP
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHCCCC
GKRYYGGCEFVDVAEELAISRAKLLFGAHYVNVQPHSGSQANAAVMMALLSPGDTFMGMA
CCCCCCCCHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCCCHHHEEEECCCCCCEEEEE
LPHGGHLTHGSKVNFSGKLYHSVEYGVDNNTGLIDYDALEKLALQHKPKLIIAGFSAYSR
CCCCCCCCCCCEECCCCEEEEEEEECCCCCCCEEEHHHHHHHHHHCCCCEEEECHHHHHH
ILDWARFREIADKVGAYLMADIAHVAGLVAVGLYPSPVPYADVVTTTTHKTLRGPRGGLI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHEECCCHHHHCCCCCCEE
LCKENEEIEKKLNSAVFPGMQGGPLMHVIAAKAVAFAEALLPEFKTYQQQVLANARTMCS
EECCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLQSRGYDIVSGGTDNHLLLVDLINKGITGKEADAALGRANITVNKNSVPNDPRSPFVTS
HHHHCCCEEEECCCCCCEEEEEECCCCCCCCCHHHHCCCEEEEECCCCCCCCCCCCHHHC
GLRLGTPAATTRGFKEREITLLSNWVADVLDNVHDETNISRVKTQVLLLCREFPVYA
CCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MFDESYTIKNFDDVLFKAISDEKRRQEEHIELIASENYVSPRVLEAQGSVLTNKYAEGYP
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHCCCC
GKRYYGGCEFVDVAEELAISRAKLLFGAHYVNVQPHSGSQANAAVMMALLSPGDTFMGMA
CCCCCCCCHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCCCHHHEEEECCCCCCEEEEE
LPHGGHLTHGSKVNFSGKLYHSVEYGVDNNTGLIDYDALEKLALQHKPKLIIAGFSAYSR
CCCCCCCCCCCEECCCCEEEEEEEECCCCCCCEEEHHHHHHHHHHCCCCEEEECHHHHHH
ILDWARFREIADKVGAYLMADIAHVAGLVAVGLYPSPVPYADVVTTTTHKTLRGPRGGLI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHEECCCHHHHCCCCCCEE
LCKENEEIEKKLNSAVFPGMQGGPLMHVIAAKAVAFAEALLPEFKTYQQQVLANARTMCS
EECCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLQSRGYDIVSGGTDNHLLLVDLINKGITGKEADAALGRANITVNKNSVPNDPRSPFVTS
HHHHCCCEEEECCCCCCEEEEEECCCCCCCCCHHHHCCCEEEEECCCCCCCCCCCCHHHC
GLRLGTPAATTRGFKEREITLLSNWVADVLDNVHDETNISRVKTQVLLLCREFPVYA
CCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA