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The map label for this gene is maeB [H]

Identifier: 54293634

GI number: 54293634

Start: 766182

End: 767417

Strand: Direct

Name: maeB [H]

Synonym: lpl0687

Alternate gene names: 54293634

Gene position: 766182-767417 (Clockwise)

Preceding gene: 54293633

Following gene: 54293635

Centisome position: 22.9

GC content: 42.31

Gene sequence:

>1236_bases
TTGGATAATGAAGTAATAAAGCAGCGGGCATTGGATTATCATGAGTTCCCTGTTCCAGGGAAACTCTCTGTTCATCTTAC
AAAATCGACTAATTCCCAAGACGATTTGTCTTTGGCTTATACACCTGGTGTAGCTGCACCAGTTTTAGCCATAGCTGAAG
CGCCCGAAAATGCTTATCGTTTTACCAGCAAAGGCAATCTGGTTGCGGTGATGACCAATGGCACTGCAGTGTTAGGTTTG
GGAAATCTTGGGCCTTTAGCGAGTAAGCCTGTGATGGAAGGCAAAGCGGTATTATTTAAACGATTTGCCGATCTTGATGT
CTTTGATATAGAAATCGATGCAGAGGATCCTCAGTCTTTTATTGCTACTGCAAAACGCATTGCCCCAACTTTTGGCGGCA
TAAATCTTGAAGACATCAAAGCTCCGGAGTGTTTTGAAATAGAACAAGCTTTGATTGAGCAGTTAAATATTCCTGTATTC
CATGATGATCAGCATGGTACTGCGATTGTAGTTGCAGCTGGTTTGTTAAATGCTTTGGAACTACAGAACAAGAAATTAAG
TGACATTAAAATTGTCTGCATGGGTGCTGGAGCTGCTGGTATTGCTTCTATGCGACTCCTTGTGGCATTAGGGGCCCCAA
AAAGTAATATGCTTCTTCTGGACACCAAGGGAGTGATTCATTCAGGCCGCGAGGATTTAAATCCCTATAAGTTTGCTTTT
GCCAGAAATACTTCCAGTCGTACACTTGAAGATGCTTTGGTTGATGCCGATGTGTTTATTGGCGTTGCAAGGCCAGATTT
GCTGAATGCTCATTTATTAAGTTTGATGGCGCCCAATCCAGTGATTTTTGCTTTATCTAACCCTGATCCTGAAATCAAAC
CTGAATTGGCTCATAGTGTACGTAAAGATCTGGTGATGGCAACAGGACGAAGTGATTATCCTAATCAAGTTAATAATGTA
TTATGTTTTCCTTATATTTTTCGTGGTGCGCTAGATGTTCGTGCCACTTGCATTAACCAGGCCATGCAAATTGCAGCTGT
TGAAGCCATTCGTCAATTGGTGCATGAGCCTGTTCCTCAGGTAGTGAAGGACAATTACCCAGGAGTTGTGAATTGGGATT
TTGGACCTGACTATATTATTCCAAAGCCTATCGATCCTCGCTTAAAAGAGAGGGTCCCTGCTGCTGTAGCGAAAGCTGCA
ATAGCGAGTGGCGCAAGTCAATTTAATAATTTATAA

Upstream 100 bases:

>100_bases
AGGCACAAATTTTTTGTGCCTTTTCTCTAAGAGAGGATTAAAAATTCAAATTTTTGATATGATGTTTTCACCGCGTGATC
TGAAATAGAGAGTATGCACT

Downstream 100 bases:

>100_bases
GGTAATAAATTCACCTTGTAGAAGTAAGCAGTTTAGGTCTTAATAGCGTTTAAACAAAGGATATCTTGGAAAATACTTTG
TAAAGCCACCAGCTGGTTTG

Product: hypothetical protein

Products: NA

Alternate protein names: NADP-ME [H]

Number of amino acids: Translated: 411; Mature: 411

Protein sequence:

>411_residues
MDNEVIKQRALDYHEFPVPGKLSVHLTKSTNSQDDLSLAYTPGVAAPVLAIAEAPENAYRFTSKGNLVAVMTNGTAVLGL
GNLGPLASKPVMEGKAVLFKRFADLDVFDIEIDAEDPQSFIATAKRIAPTFGGINLEDIKAPECFEIEQALIEQLNIPVF
HDDQHGTAIVVAAGLLNALELQNKKLSDIKIVCMGAGAAGIASMRLLVALGAPKSNMLLLDTKGVIHSGREDLNPYKFAF
ARNTSSRTLEDALVDADVFIGVARPDLLNAHLLSLMAPNPVIFALSNPDPEIKPELAHSVRKDLVMATGRSDYPNQVNNV
LCFPYIFRGALDVRATCINQAMQIAAVEAIRQLVHEPVPQVVKDNYPGVVNWDFGPDYIIPKPIDPRLKERVPAAVAKAA
IASGASQFNNL

Sequences:

>Translated_411_residues
MDNEVIKQRALDYHEFPVPGKLSVHLTKSTNSQDDLSLAYTPGVAAPVLAIAEAPENAYRFTSKGNLVAVMTNGTAVLGL
GNLGPLASKPVMEGKAVLFKRFADLDVFDIEIDAEDPQSFIATAKRIAPTFGGINLEDIKAPECFEIEQALIEQLNIPVF
HDDQHGTAIVVAAGLLNALELQNKKLSDIKIVCMGAGAAGIASMRLLVALGAPKSNMLLLDTKGVIHSGREDLNPYKFAF
ARNTSSRTLEDALVDADVFIGVARPDLLNAHLLSLMAPNPVIFALSNPDPEIKPELAHSVRKDLVMATGRSDYPNQVNNV
LCFPYIFRGALDVRATCINQAMQIAAVEAIRQLVHEPVPQVVKDNYPGVVNWDFGPDYIIPKPIDPRLKERVPAAVAKAA
IASGASQFNNL
>Mature_411_residues
MDNEVIKQRALDYHEFPVPGKLSVHLTKSTNSQDDLSLAYTPGVAAPVLAIAEAPENAYRFTSKGNLVAVMTNGTAVLGL
GNLGPLASKPVMEGKAVLFKRFADLDVFDIEIDAEDPQSFIATAKRIAPTFGGINLEDIKAPECFEIEQALIEQLNIPVF
HDDQHGTAIVVAAGLLNALELQNKKLSDIKIVCMGAGAAGIASMRLLVALGAPKSNMLLLDTKGVIHSGREDLNPYKFAF
ARNTSSRTLEDALVDADVFIGVARPDLLNAHLLSLMAPNPVIFALSNPDPEIKPELAHSVRKDLVMATGRSDYPNQVNNV
LCFPYIFRGALDVRATCINQAMQIAAVEAIRQLVHEPVPQVVKDNYPGVVNWDFGPDYIIPKPIDPRLKERVPAAVAKAA
IASGASQFNNL

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=347, Percent_Identity=27.6657060518732, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI62420882, Length=227, Percent_Identity=32.5991189427313, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI62420880, Length=227, Percent_Identity=32.5991189427313, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI239049447, Length=227, Percent_Identity=32.5991189427313, Blast_Score=76, Evalue=5e-14,
Organism=Escherichia coli, GI1788806, Length=408, Percent_Identity=58.578431372549, Blast_Score=474, Evalue=1e-135,
Organism=Saccharomyces cerevisiae, GI6322823, Length=290, Percent_Identity=27.9310344827586, Blast_Score=77, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24646388, Length=347, Percent_Identity=29.971181556196, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24646386, Length=347, Percent_Identity=29.971181556196, Blast_Score=79, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR012188
- InterPro:   IPR016040
- InterPro:   IPR002505 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M; PF01515 PTA_PTB [H]

EC number: =1.1.1.40 [H]

Molecular weight: Translated: 44330; Mature: 44330

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS00331 MALIC_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNEVIKQRALDYHEFPVPGKLSVHLTKSTNSQDDLSLAYTPGVAAPVLAIAEAPENAYR
CCHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCCEEEEECCCCHHHHHHHHCCCCHHEE
FTSKGNLVAVMTNGTAVLGLGNLGPLASKPVMEGKAVLFKRFADLDVFDIEIDAEDPQSF
EECCCCEEEEEECCEEEEEECCCCCCCCCCCCCCHHHHHHHHCCCEEEEEEECCCCHHHH
IATAKRIAPTFGGINLEDIKAPECFEIEQALIEQLNIPVFHDDQHGTAIVVAAGLLNALE
HHHHHHHHHHCCCCCHHHCCCCCHHHHHHHHHHHCCCCEEECCCCCCEEEEHHHHHHHHH
LQNKKLSDIKIVCMGAGAAGIASMRLLVALGAPKSNMLLLDTKGVIHSGREDLNPYKFAF
HCCCCCCCEEEEEEECCHHHHHHHEEHEEECCCCCCEEEEECCCHHHCCCCCCCCEEEEE
ARNTSSRTLEDALVDADVFIGVARPDLLNAHLLSLMAPNPVIFALSNPDPEIKPELAHSV
ECCCCCHHHHHHHHCCHHEEEECCCCHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHH
RKDLVMATGRSDYPNQVNNVLCFPYIFRGALDVRATCINQAMQIAAVEAIRQLVHEPVPQ
HHHHEEECCCCCCCHHHCCEEEEHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
VVKDNYPGVVNWDFGPDYIIPKPIDPRLKERVPAAVAKAAIASGASQFNNL
HHHCCCCCEEECCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHCHHHHCCC
>Mature Secondary Structure
MDNEVIKQRALDYHEFPVPGKLSVHLTKSTNSQDDLSLAYTPGVAAPVLAIAEAPENAYR
CCHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCCEEEEECCCCHHHHHHHHCCCCHHEE
FTSKGNLVAVMTNGTAVLGLGNLGPLASKPVMEGKAVLFKRFADLDVFDIEIDAEDPQSF
EECCCCEEEEEECCEEEEEECCCCCCCCCCCCCCHHHHHHHHCCCEEEEEEECCCCHHHH
IATAKRIAPTFGGINLEDIKAPECFEIEQALIEQLNIPVFHDDQHGTAIVVAAGLLNALE
HHHHHHHHHHCCCCCHHHCCCCCHHHHHHHHHHHCCCCEEECCCCCCEEEEHHHHHHHHH
LQNKKLSDIKIVCMGAGAAGIASMRLLVALGAPKSNMLLLDTKGVIHSGREDLNPYKFAF
HCCCCCCCEEEEEEECCHHHHHHHEEHEEECCCCCCEEEEECCCHHHCCCCCCCCEEEEE
ARNTSSRTLEDALVDADVFIGVARPDLLNAHLLSLMAPNPVIFALSNPDPEIKPELAHSV
ECCCCCHHHHHHHHCCHHEEEECCCCHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHH
RKDLVMATGRSDYPNQVNNVLCFPYIFRGALDVRATCINQAMQIAAVEAIRQLVHEPVPQ
HHHHEEECCCCCCCHHHCCEEEEHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
VVKDNYPGVVNWDFGPDYIIPKPIDPRLKERVPAAVAKAAIASGASQFNNL
HHHCCCCCEEECCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 36376 [H]