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The map label for this gene is hslU

Identifier: 54293625

GI number: 54293625

Start: 734080

End: 735405

Strand: Direct

Name: hslU

Synonym: lpl0678

Alternate gene names: 54293625

Gene position: 734080-735405 (Clockwise)

Preceding gene: 54293624

Following gene: 54293626

Centisome position: 21.94

GC content: 41.93

Gene sequence:

>1326_bases
ATGGTCATGACCCCTCGAGAGATAGTTCAAGAATTAGATAAGCACATTATTGGTCAAGATGATGCAAAACGTGCCGTAGC
CATTGCATTACGAAATCGCTGGCGTCGAATGAAAATCAAAGATCCAGTATTGCGCAACGAGATAATGCCTAAAAATATTT
TAATGATAGGCCCTACCGGTGTTGGTAAGACGGAGATTGCAAGACGTTTGGCTAATTTGGCTAAAGCTCCATTTATTAAA
GTAGAAGCAACCAAATTCACGGAAGTGGGATATGTGGGACGTGATGTTGATTCGATCATTCGTGACTTAACAGATATGGC
AATCAAGCAAGAGCGTGAATTTGCCATGAAAAAAGTGGAGCACCTGGCAGAAGATGCGGCTGAAGAACGAATCCTGGATG
TTTTACTCCCTCCTGCTCGAGGAACATTAACTCCTGGTGAGAAAAACACGACAGCTCGTCAAGTGTTTCGTAAGCAATTG
CGCGAAGGTGAGCTTAATGATAATGAAATTGAAATTGAAGTAGCGGCAACGCCTGTTGGCATTGAAATTATGGCTCCTCC
AGGTATGGAAGAGATGACTAGCCAATTGCAGTCTATGTTTCAACAAGTTGGAAGCTACAGAACGAAAACTCGAAAAATGA
CCGTTGCCAAGGCAATGAAGATTTTGAGAGAGGAAGAAGCGGCAAAATTAATTAACGAAGAAGATATCAAGTTAAAAGCG
ATTGAAAGTGTTGAGCAAAATGGAATAGTGTTCATTGATGAGTTGGATAAAATTGCCAAACGCTCTGATACTGTAAGTGG
GGGAGATGTATCACGTGAGGGAGTTCAGCGAGATTTATTGCCATTAGTCGAAGGAACTACCGTTTCAACAAAATACGGCA
TGGTAAAGTCTGATCATATTTTATTCATTGCTTCAGGTGCTTTTCATGTAGCTAAACCTTCTGACTTGATTGCTGAATTA
CAAGGGCGTCTGCCGATACGCGTCGAGTTGTCAGCCCTCTCGGTGGAAGATTTCGTACGAATCCTTACTGAGCCAAGCGC
CTCTTTAACTTTACAGTATTCCGCTTTGATGGAAACCGAAGGATTGACTCTTACCTTTGATGAAACAGGAATTCGACGTA
TTGCTGAAGTAGCCTGGCAAGTGAATGAGCGTACGGAAAATATCGGAGCAAGAAGATTATATACCGTCATGGAACGTTTA
CTGGAAGTGGTTTCATTTGAAGCGACTGATAAAGCTGGCGAAACTGTGCATGTTGATAAAGCTTATGTCGATAAGAATTT
AGGCCAACTAATCGCTGATGAGGATTTGGCTCGCTATATTTTGTAA

Upstream 100 bases:

>100_bases
AAGGAGATTGTCCAGAAATCTTTAACAATCGCTGGCGACATTTGTATTTATACTAACAATAATTTAACCATAGAAGAATT
AAATGATGAAGGCAAATAAT

Downstream 100 bases:

>100_bases
TCCAGAATAGTTAAACTGAAATCAAGAATAAAATCTTTTTAACATATCAACTTTTTGTGGGGGATATGTCTCGAAAAAGA
GATATCCCTCATGTGACTCT

Product: ATP-dependent protease ATP-binding subunit HslU

Products: NA

Alternate protein names: Unfoldase HslU

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
MVMTPREIVQELDKHIIGQDDAKRAVAIALRNRWRRMKIKDPVLRNEIMPKNILMIGPTGVGKTEIARRLANLAKAPFIK
VEATKFTEVGYVGRDVDSIIRDLTDMAIKQEREFAMKKVEHLAEDAAEERILDVLLPPARGTLTPGEKNTTARQVFRKQL
REGELNDNEIEIEVAATPVGIEIMAPPGMEEMTSQLQSMFQQVGSYRTKTRKMTVAKAMKILREEEAAKLINEEDIKLKA
IESVEQNGIVFIDELDKIAKRSDTVSGGDVSREGVQRDLLPLVEGTTVSTKYGMVKSDHILFIASGAFHVAKPSDLIAEL
QGRLPIRVELSALSVEDFVRILTEPSASLTLQYSALMETEGLTLTFDETGIRRIAEVAWQVNERTENIGARRLYTVMERL
LEVVSFEATDKAGETVHVDKAYVDKNLGQLIADEDLARYIL

Sequences:

>Translated_441_residues
MVMTPREIVQELDKHIIGQDDAKRAVAIALRNRWRRMKIKDPVLRNEIMPKNILMIGPTGVGKTEIARRLANLAKAPFIK
VEATKFTEVGYVGRDVDSIIRDLTDMAIKQEREFAMKKVEHLAEDAAEERILDVLLPPARGTLTPGEKNTTARQVFRKQL
REGELNDNEIEIEVAATPVGIEIMAPPGMEEMTSQLQSMFQQVGSYRTKTRKMTVAKAMKILREEEAAKLINEEDIKLKA
IESVEQNGIVFIDELDKIAKRSDTVSGGDVSREGVQRDLLPLVEGTTVSTKYGMVKSDHILFIASGAFHVAKPSDLIAEL
QGRLPIRVELSALSVEDFVRILTEPSASLTLQYSALMETEGLTLTFDETGIRRIAEVAWQVNERTENIGARRLYTVMERL
LEVVSFEATDKAGETVHVDKAYVDKNLGQLIADEDLARYIL
>Mature_441_residues
MVMTPREIVQELDKHIIGQDDAKRAVAIALRNRWRRMKIKDPVLRNEIMPKNILMIGPTGVGKTEIARRLANLAKAPFIK
VEATKFTEVGYVGRDVDSIIRDLTDMAIKQEREFAMKKVEHLAEDAAEERILDVLLPPARGTLTPGEKNTTARQVFRKQL
REGELNDNEIEIEVAATPVGIEIMAPPGMEEMTSQLQSMFQQVGSYRTKTRKMTVAKAMKILREEEAAKLINEEDIKLKA
IESVEQNGIVFIDELDKIAKRSDTVSGGDVSREGVQRDLLPLVEGTTVSTKYGMVKSDHILFIASGAFHVAKPSDLIAEL
QGRLPIRVELSALSVEDFVRILTEPSASLTLQYSALMETEGLTLTFDETGIRRIAEVAWQVNERTENIGARRLYTVMERL
LEVVSFEATDKAGETVHVDKAYVDKNLGQLIADEDLARYIL

Specific function: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N

COG id: COG1220

COG function: function code O; ATP-dependent protease HslVU (ClpYQ), ATPase subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family. HslU subfamily

Homologues:

Organism=Escherichia coli, GI1790366, Length=442, Percent_Identity=69.4570135746606, Blast_Score=626, Evalue=1e-180,
Organism=Escherichia coli, GI1786642, Length=100, Percent_Identity=47, Blast_Score=97, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HSLU_LEGPA (Q5X7B0)

Other databases:

- EMBL:   CR628336
- RefSeq:   YP_123033.1
- ProteinModelPortal:   Q5X7B0
- SMR:   Q5X7B0
- STRING:   Q5X7B0
- GeneID:   3118978
- GenomeReviews:   CR628336_GR
- KEGG:   lpp:lpp0695
- LegioList:   lpp0695
- eggNOG:   COG1220
- HOGENOM:   HBG745965
- OMA:   EASKFTE
- ProtClustDB:   PRK05201
- BioCyc:   LPNE297246:LPP0695-MONOMER
- HAMAP:   MF_00249
- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR019489
- InterPro:   IPR004491
- PANTHER:   PTHR11262:SF3
- SMART:   SM00382
- TIGRFAMs:   TIGR00390

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF10431 ClpB_D2-small

EC number: NA

Molecular weight: Translated: 49426; Mature: 49426

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: NA

Important sites: BINDING 17-17 BINDING 253-253 BINDING 319-319 BINDING 391-391

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVMTPREIVQELDKHIIGQDDAKRAVAIALRNRWRRMKIKDPVLRNEIMPKNILMIGPTG
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCEEEECCCC
VGKTEIARRLANLAKAPFIKVEATKFTEVGYVGRDVDSIIRDLTDMAIKQEREFAMKKVE
CCHHHHHHHHHHHHHCCEEEEECCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
HLAEDAAEERILDVLLPPARGTLTPGEKNTTARQVFRKQLREGELNDNEIEIEVAATPVG
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEEECCCC
IEIMAPPGMEEMTSQLQSMFQQVGSYRTKTRKMTVAKAMKILREEEAAKLINEEDIKLKA
EEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
IESVEQNGIVFIDELDKIAKRSDTVSGGDVSREGVQRDLLPLVEGTTVSTKYGMVKSDHI
HHHHCCCCEEEEHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCEEECCCCCEECCCE
LFIASGAFHVAKPSDLIAELQGRLPIRVELSALSVEDFVRILTEPSASLTLQYSALMETE
EEEECCCEECCCHHHHHHHHHCCCCEEEEEHHHCHHHHHHHHCCCCCCEEEEEHHHCCCC
GLTLTFDETGIRRIAEVAWQVNERTENIGARRLYTVMERLLEVVSFEATDKAGETVHVDK
CCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEHH
AYVDKNLGQLIADEDLARYIL
HHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVMTPREIVQELDKHIIGQDDAKRAVAIALRNRWRRMKIKDPVLRNEIMPKNILMIGPTG
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCEEEECCCC
VGKTEIARRLANLAKAPFIKVEATKFTEVGYVGRDVDSIIRDLTDMAIKQEREFAMKKVE
CCHHHHHHHHHHHHHCCEEEEECCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
HLAEDAAEERILDVLLPPARGTLTPGEKNTTARQVFRKQLREGELNDNEIEIEVAATPVG
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEEECCCC
IEIMAPPGMEEMTSQLQSMFQQVGSYRTKTRKMTVAKAMKILREEEAAKLINEEDIKLKA
EEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
IESVEQNGIVFIDELDKIAKRSDTVSGGDVSREGVQRDLLPLVEGTTVSTKYGMVKSDHI
HHHHCCCCEEEEHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCEEECCCCCEECCCE
LFIASGAFHVAKPSDLIAELQGRLPIRVELSALSVEDFVRILTEPSASLTLQYSALMETE
EEEECCCEECCCHHHHHHHHHCCCCEEEEEHHHCHHHHHHHHCCCCCCEEEEEHHHCCCC
GLTLTFDETGIRRIAEVAWQVNERTENIGARRLYTVMERLLEVVSFEATDKAGETVHVDK
CCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEHH
AYVDKNLGQLIADEDLARYIL
HHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA