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The map label for this gene is aas [H]

Identifier: 54293579

GI number: 54293579

Start: 681282

End: 683480

Strand: Direct

Name: aas [H]

Synonym: lpl0631

Alternate gene names: 54293579

Gene position: 681282-683480 (Clockwise)

Preceding gene: 54293577

Following gene: 54293580

Centisome position: 20.36

GC content: 38.88

Gene sequence:

>2199_bases
ATGACAAAAACAAATGAGGAAAATTTGACCTGGAAGGAAAAACAAAAACAGCGGGCTAGGGCATGGATAAAAGTTTTTCT
GGAGAAATGGTTTCGCATGGAGGTTAAAGGACAATATCAGGCCAACAGCCATTCTGTCATTATTGCCAACAGGGCTTCTA
TAATTGATGTGTTACTCCTTTCTGTATTTTTACCCGAACGATTAACTTTAGCTTTACATCCTGATATGTTTAAAAAAATA
TGGGTAAAAACGTTATTATTTTTTGCTGATGTCATAGTAGTTGATCCAGGCAGCGCTCAGGCAACAAGAATTTTAATAAG
GGCAATACGGGCTGGCAAGCGTTGTCTTCTATTTCCACAAGGGCTATTAAGACAGCAGGAAGACAGCTTAAAGGTTTTTG
AAGGACCTGGATTGATACTCCAAAAGGTTGGCGCCGAGGTAATTCCTGTTCGTATTGAAGGGGCGGAGCACAGTATTTTT
TCTAATAGCAAAAATAAACATCGAATACGGATTTTTCCGAAAATTACTCTTCATATATTACCTGCTCAAAAATTGAGTCA
AGCTGAAAATACAGGTGTCGACAGAGGAGGTATCAGTTTACGTTTATTTCAACTAATAAGCGATTTATCATTCGCCAATA
GTTTTAAGCCATATGTTTTATTTTCTGCTTTAATTGAAGGAGTAAGTATAGGAACTAAAAACAAAACTAAAATAGAAGAC
AATAATCGTATTCCATTAACTTACAGACAGTTCTTGGCTCGTTGTTTTATTCTGGGGCGCCAAATTAAAAAGCAAACGGC
TGTAGGCGAAACTGTTGGGGTAATGATGCCGACTACTATAGCTGGCATGGTCACTTTTTTTGCTTTACAAGCTTATAGAC
GAATACCTGCCATGTTAAATTTTAGCATGGGTTTTTATAACTTATATTCAGCTTGTAATACAGCAAGAATTAAATCAATT
TATACCGCAAGACAATTCATAGAAACCGCCAAATTAGAGCCCTTGGTAGAAGAGTTACAACAGGCGGGTATAAGAATTCA
TTATTTAGAAGATTTTAAATCAACCATTCATTTAGGTAACAAGCTTTCCGGGATATTCAAAGGCTTCTTTCCTACTCTAA
GCTACCGTTTTCTTGGTGACAAAATATCCCCTGATACAACAGGCATAATCCTGTTTACCTCTGGTTCTGAGGGAATACCC
AAAGGGGTTGCTCTTAGTCATGCCAATATATTGGCTAATTGTTGGCAAATGACTTCCAGAGTCGACTTTACTCCACGAGA
TGTTTTATTTAATTCCTTACCTATATTCCATTGTTTTGGCCTTACAGCAGGAAGTGTGCTTCCTTTGGTTAATGGTTTGA
ATTGTTTTTTCTACCCTTCCCCTCTTCATTATAAGGTAATTCCTGGATTGGTTTATCAAACAGGGGCTACTATTTTGTTT
GGCACAGATACTTTTCTAACGGGTTATGCAAGGGCTGCGGGCAAACATGATTTCAACAGCGTCCGCTATATCTTCGCTGG
CGCCGAGAAAGTGAAACCGGAAACCATTAGATACTGGAGCGAAGCGTTTGGAGCAAGAATTTATGAAGGCTATGGTGCTA
CTGAGGCATCGCCAGTCATATCGCTTAATTGTCCGTTGGCATCAGTACCGGGTAGTGTCGGAATGATTTTACCTTTTATG
GACTTCAAAGTAGAACCAGTAGAGGGAATTGTACAAGGCGGGCGTTTAAAATTATGTGGACCCAATATCATGTTAGGTTA
TCTTGATGAGGATAAACCTGGAGTAATTATAGAACCTGAAGATGGTTGGCATGATACGGGAGATATCGTCACCGTGAATG
CGGATGGATTCATTACTATAGCGGGTCGCGCCAAACGTTTTGCCAAGATTGCTGGTGAAATGGTATCTCTTACAGCGGTG
GAAGGAATTGCAGCTTCAATTTGGCCTGAATTATTACATGCCGCTGTTGTGCAAAAATCTCCAAGAAAGGGGGAGCAAAT
TTTCTTATTTACTGAAGCAGAGTATGCAGATAAAGTATCATTTATAAAAAAGGTTAAGGATAGAGGGCAATCAGAATTGC
TGGTTCCTCATATGATTTATCCGGCATGCCAAATTCCTGTCCTGCCTTCAGGAAAAATTGATTATATAACGCTTGAAAAG
CAATTTTTAGAACAGAAAGAAACCATGGAAACAGTATAA

Upstream 100 bases:

>100_bases
GTTTTTTAAATGAAATCAACATGATTCATAAACCTATCTATTCAAATCGTTTTGAATCTTGCAGAATAAAAGTCAATATA
GAGATAACTGATGCGACATA

Downstream 100 bases:

>100_bases
ATGAAATTAATATGGATAGTATTAGCCCTTATTTTAGCCTTTGTTGTCATTCTTTATTTATTTCCTCAAATCAATTTTCG
AGAAATGCCGAAGGGGTTAG

Product: hypothetical protein

Products: NA

Alternate protein names: 2-acylglycerophosphoethanolamine acyltransferase; 2-acyl-GPE acyltransferase; Acyl-[acyl-carrier-protein]--phospholipid O-acyltransferase; Acyl-[acyl-carrier-protein] synthetase; Acyl-ACP synthetase; Long-chain-fatty-acid--[acyl-carrier-protein] ligase [H]

Number of amino acids: Translated: 732; Mature: 731

Protein sequence:

>732_residues
MTKTNEENLTWKEKQKQRARAWIKVFLEKWFRMEVKGQYQANSHSVIIANRASIIDVLLLSVFLPERLTLALHPDMFKKI
WVKTLLFFADVIVVDPGSAQATRILIRAIRAGKRCLLFPQGLLRQQEDSLKVFEGPGLILQKVGAEVIPVRIEGAEHSIF
SNSKNKHRIRIFPKITLHILPAQKLSQAENTGVDRGGISLRLFQLISDLSFANSFKPYVLFSALIEGVSIGTKNKTKIED
NNRIPLTYRQFLARCFILGRQIKKQTAVGETVGVMMPTTIAGMVTFFALQAYRRIPAMLNFSMGFYNLYSACNTARIKSI
YTARQFIETAKLEPLVEELQQAGIRIHYLEDFKSTIHLGNKLSGIFKGFFPTLSYRFLGDKISPDTTGIILFTSGSEGIP
KGVALSHANILANCWQMTSRVDFTPRDVLFNSLPIFHCFGLTAGSVLPLVNGLNCFFYPSPLHYKVIPGLVYQTGATILF
GTDTFLTGYARAAGKHDFNSVRYIFAGAEKVKPETIRYWSEAFGARIYEGYGATEASPVISLNCPLASVPGSVGMILPFM
DFKVEPVEGIVQGGRLKLCGPNIMLGYLDEDKPGVIIEPEDGWHDTGDIVTVNADGFITIAGRAKRFAKIAGEMVSLTAV
EGIAASIWPELLHAAVVQKSPRKGEQIFLFTEAEYADKVSFIKKVKDRGQSELLVPHMIYPACQIPVLPSGKIDYITLEK
QFLEQKETMETV

Sequences:

>Translated_732_residues
MTKTNEENLTWKEKQKQRARAWIKVFLEKWFRMEVKGQYQANSHSVIIANRASIIDVLLLSVFLPERLTLALHPDMFKKI
WVKTLLFFADVIVVDPGSAQATRILIRAIRAGKRCLLFPQGLLRQQEDSLKVFEGPGLILQKVGAEVIPVRIEGAEHSIF
SNSKNKHRIRIFPKITLHILPAQKLSQAENTGVDRGGISLRLFQLISDLSFANSFKPYVLFSALIEGVSIGTKNKTKIED
NNRIPLTYRQFLARCFILGRQIKKQTAVGETVGVMMPTTIAGMVTFFALQAYRRIPAMLNFSMGFYNLYSACNTARIKSI
YTARQFIETAKLEPLVEELQQAGIRIHYLEDFKSTIHLGNKLSGIFKGFFPTLSYRFLGDKISPDTTGIILFTSGSEGIP
KGVALSHANILANCWQMTSRVDFTPRDVLFNSLPIFHCFGLTAGSVLPLVNGLNCFFYPSPLHYKVIPGLVYQTGATILF
GTDTFLTGYARAAGKHDFNSVRYIFAGAEKVKPETIRYWSEAFGARIYEGYGATEASPVISLNCPLASVPGSVGMILPFM
DFKVEPVEGIVQGGRLKLCGPNIMLGYLDEDKPGVIIEPEDGWHDTGDIVTVNADGFITIAGRAKRFAKIAGEMVSLTAV
EGIAASIWPELLHAAVVQKSPRKGEQIFLFTEAEYADKVSFIKKVKDRGQSELLVPHMIYPACQIPVLPSGKIDYITLEK
QFLEQKETMETV
>Mature_731_residues
TKTNEENLTWKEKQKQRARAWIKVFLEKWFRMEVKGQYQANSHSVIIANRASIIDVLLLSVFLPERLTLALHPDMFKKIW
VKTLLFFADVIVVDPGSAQATRILIRAIRAGKRCLLFPQGLLRQQEDSLKVFEGPGLILQKVGAEVIPVRIEGAEHSIFS
NSKNKHRIRIFPKITLHILPAQKLSQAENTGVDRGGISLRLFQLISDLSFANSFKPYVLFSALIEGVSIGTKNKTKIEDN
NRIPLTYRQFLARCFILGRQIKKQTAVGETVGVMMPTTIAGMVTFFALQAYRRIPAMLNFSMGFYNLYSACNTARIKSIY
TARQFIETAKLEPLVEELQQAGIRIHYLEDFKSTIHLGNKLSGIFKGFFPTLSYRFLGDKISPDTTGIILFTSGSEGIPK
GVALSHANILANCWQMTSRVDFTPRDVLFNSLPIFHCFGLTAGSVLPLVNGLNCFFYPSPLHYKVIPGLVYQTGATILFG
TDTFLTGYARAAGKHDFNSVRYIFAGAEKVKPETIRYWSEAFGARIYEGYGATEASPVISLNCPLASVPGSVGMILPFMD
FKVEPVEGIVQGGRLKLCGPNIMLGYLDEDKPGVIIEPEDGWHDTGDIVTVNADGFITIAGRAKRFAKIAGEMVSLTAVE
GIAASIWPELLHAAVVQKSPRKGEQIFLFTEAEYADKVSFIKKVKDRGQSELLVPHMIYPACQIPVLPSGKIDYITLEKQ
FLEQKETMETV

Specific function: Plays a role in lysophospholipid acylation. Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-

COG id: COG0318

COG function: function code IQ; Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the ATP- dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI156151445, Length=444, Percent_Identity=27.2522522522523, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI57165412, Length=459, Percent_Identity=26.797385620915, Blast_Score=99, Evalue=2e-20,
Organism=Homo sapiens, GI40807491, Length=312, Percent_Identity=26.6025641025641, Blast_Score=94, Evalue=6e-19,
Organism=Homo sapiens, GI57165410, Length=458, Percent_Identity=25.764192139738, Blast_Score=93, Evalue=1e-18,
Organism=Homo sapiens, GI187761345, Length=312, Percent_Identity=26.2820512820513, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI187761343, Length=312, Percent_Identity=26.2820512820513, Blast_Score=74, Evalue=4e-13,
Organism=Escherichia coli, GI1789201, Length=710, Percent_Identity=41.1267605633803, Blast_Score=527, Evalue=1e-151,
Organism=Escherichia coli, GI145693145, Length=367, Percent_Identity=27.7929155313352, Blast_Score=112, Evalue=7e-26,
Organism=Escherichia coli, GI1788107, Length=465, Percent_Identity=24.5161290322581, Blast_Score=109, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI17558820, Length=293, Percent_Identity=26.6211604095563, Blast_Score=99, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI17560308, Length=361, Percent_Identity=27.1468144044321, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI32563687, Length=306, Percent_Identity=25.8169934640523, Blast_Score=92, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71994690, Length=274, Percent_Identity=27.7372262773723, Blast_Score=90, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI71994694, Length=274, Percent_Identity=27.7372262773723, Blast_Score=90, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI71994703, Length=274, Percent_Identity=27.7372262773723, Blast_Score=89, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6319699, Length=379, Percent_Identity=25.5936675461741, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI18859661, Length=361, Percent_Identity=26.3157894736842, Blast_Score=101, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24581924, Length=363, Percent_Identity=26.1707988980716, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21355181, Length=358, Percent_Identity=25.9776536312849, Blast_Score=73, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002123
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF01553 Acyltransferase; PF00501 AMP-binding [H]

EC number: =2.3.1.40; =6.2.1.20 [H]

Molecular weight: Translated: 81630; Mature: 81499

Theoretical pI: Translated: 9.59; Mature: 9.59

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKTNEENLTWKEKQKQRARAWIKVFLEKWFRMEVKGQYQANSHSVIIANRASIIDVLLL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCEEECCCEECCCCEEEEECCHHHHHHHHH
SVFLPERLTLALHPDMFKKIWVKTLLFFADVIVVDPGSAQATRILIRAIRAGKRCLLFPQ
HHHCCCCEEEEECHHHHHHHHHHHHHHHHCEEEECCCCCHHHHHHHHHHHCCCEEEECCH
GLLRQQEDSLKVFEGPGLILQKVGAEVIPVRIEGAEHSIFSNSKNKHRIRIFPKITLHIL
HHHCCCCCCCEEECCCCHHHHHCCCEEEEEEEECCCCHHHCCCCCCEEEEEEEEEEEEEE
PAQKLSQAENTGVDRGGISLRLFQLISDLSFANSFKPYVLFSALIEGVSIGTKNKTKIED
CCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCEECC
NNRIPLTYRQFLARCFILGRQIKKQTAVGETVGVMMPTTIAGMVTFFALQAYRRIPAMLN
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHHHHHHHCHHHHH
FSMGFYNLYSACNTARIKSIYTARQFIETAKLEPLVEELQQAGIRIHYLEDFKSTIHLGN
HCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCEEEEHHHHHHHHHCCC
KLSGIFKGFFPTLSYRFLGDKISPDTTGIILFTSGSEGIPKGVALSHANILANCWQMTSR
HHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCEEEHHHHHHHHHHHHHHC
VDFTPRDVLFNSLPIFHCFGLTAGSVLPLVNGLNCFFYPSPLHYKVIPGLVYQTGATILF
CCCCHHHHHHHCCCHHHHHCCCCCCHHHHHCCCEEEECCCCCCEEECCCHHHHCCCEEEE
GTDTFLTGYARAAGKHDFNSVRYIFAGAEKVKPETIRYWSEAFGARIYEGYGATEASPVI
ECCHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCEEEECCCCCCCCCEE
SLNCPLASVPGSVGMILPFMDFKVEPVEGIVQGGRLKLCGPNIMLGYLDEDKPGVIIEPE
EECCCHHCCCCCCCEEEECCCCEECCHHHHHCCCEEEEECCCEEEEEECCCCCCEEECCC
DGWHDTGDIVTVNADGFITIAGRAKRFAKIAGEMVSLTAVEGIAASIWPELLHAAVVQKS
CCCCCCCCEEEECCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PRKGEQIFLFTEAEYADKVSFIKKVKDRGQSELLVPHMIYPACQIPVLPSGKIDYITLEK
CCCCCEEEEEECCHHHHHHHHHHHHHHCCCCCEECHHHHCCCCCCCCCCCCCEEEEEECH
QFLEQKETMETV
HHHHHHHHHCCC
>Mature Secondary Structure 
TKTNEENLTWKEKQKQRARAWIKVFLEKWFRMEVKGQYQANSHSVIIANRASIIDVLLL
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCEEECCCEECCCCEEEEECCHHHHHHHHH
SVFLPERLTLALHPDMFKKIWVKTLLFFADVIVVDPGSAQATRILIRAIRAGKRCLLFPQ
HHHCCCCEEEEECHHHHHHHHHHHHHHHHCEEEECCCCCHHHHHHHHHHHCCCEEEECCH
GLLRQQEDSLKVFEGPGLILQKVGAEVIPVRIEGAEHSIFSNSKNKHRIRIFPKITLHIL
HHHCCCCCCCEEECCCCHHHHHCCCEEEEEEEECCCCHHHCCCCCCEEEEEEEEEEEEEE
PAQKLSQAENTGVDRGGISLRLFQLISDLSFANSFKPYVLFSALIEGVSIGTKNKTKIED
CCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCEECC
NNRIPLTYRQFLARCFILGRQIKKQTAVGETVGVMMPTTIAGMVTFFALQAYRRIPAMLN
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHHHHHHHCHHHHH
FSMGFYNLYSACNTARIKSIYTARQFIETAKLEPLVEELQQAGIRIHYLEDFKSTIHLGN
HCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCEEEEHHHHHHHHHCCC
KLSGIFKGFFPTLSYRFLGDKISPDTTGIILFTSGSEGIPKGVALSHANILANCWQMTSR
HHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCEEEHHHHHHHHHHHHHHC
VDFTPRDVLFNSLPIFHCFGLTAGSVLPLVNGLNCFFYPSPLHYKVIPGLVYQTGATILF
CCCCHHHHHHHCCCHHHHHCCCCCCHHHHHCCCEEEECCCCCCEEECCCHHHHCCCEEEE
GTDTFLTGYARAAGKHDFNSVRYIFAGAEKVKPETIRYWSEAFGARIYEGYGATEASPVI
ECCHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCEEEECCCCCCCCCEE
SLNCPLASVPGSVGMILPFMDFKVEPVEGIVQGGRLKLCGPNIMLGYLDEDKPGVIIEPE
EECCCHHCCCCCCCEEEECCCCEECCHHHHHCCCEEEEECCCEEEEEECCCCCCEEECCC
DGWHDTGDIVTVNADGFITIAGRAKRFAKIAGEMVSLTAVEGIAASIWPELLHAAVVQKS
CCCCCCCCEEEECCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PRKGEQIFLFTEAEYADKVSFIKKVKDRGQSELLVPHMIYPACQIPVLPSGKIDYITLEK
CCCCCEEEEEECCHHHHHHHHHHHHHHCCCCCEECHHHHCCCCCCCCCCCCCEEEEEECH
QFLEQKETMETV
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA