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The map label for this gene is fur

Identifier: 54293365

GI number: 54293365

Start: 460263

End: 460673

Strand: Direct

Name: fur

Synonym: lpl0414

Alternate gene names: 54293365

Gene position: 460263-460673 (Clockwise)

Preceding gene: 54293363

Following gene: 54293366

Centisome position: 13.76

GC content: 39.42

Gene sequence:

>411_bases
GTGGAAGAGAGTCAACAGTTAAAAGACGCTGGATTAAAAATCACATTACCTCGTATCAAGGTATTGCAAATATTGGAGCA
ATCAAGAAACCATCATTTGAGTGCAGAAGCAGTCTATAAAGCCTTATTGGAATCGGGTGAGGATGTTGGTTTAGCTACTG
TGTATAGAGTTCTTACTCAATTTGAAGCAGCGGGATTAGTATCGAGACATAATTTTGAAGGAGGACACTCGGTGTTTGAG
TTGTCTCAAGGCGAACATCATGACCATCTTGTTTGTGTTAAGTGTGGGCGGGTAGAGGAATTTGTAGATGAAATAATAGA
ACAAAGACAAAAAGCAATTGCCGAACGCGCTCATTTTAAAATGACAGATCATGCGCTAAACATATATGGTATATGTCCGC
AGTGTCAATGA

Upstream 100 bases:

>100_bases
TAGAGCATGAAAATTATTTTAGGCCTTGATGCTAATTATTAATCCAATTTTGCTGGAATAATGATCAAAGATCGAAATTC
GTTACAGTTAAGGAGCACAA

Downstream 100 bases:

>100_bases
CTTTGATATTTTAACTGGATTGGCTTGTCACCTCACGGAATATTATAAGCGTATTTACTATATTCTTTTGCAGTGCTTTA
TCATTACAATAATTGGAGTG

Product: ferric uptake regulation protein

Products: NA

Alternate protein names: Ferric uptake regulator

Number of amino acids: Translated: 136; Mature: 136

Protein sequence:

>136_residues
MEESQQLKDAGLKITLPRIKVLQILEQSRNHHLSAEAVYKALLESGEDVGLATVYRVLTQFEAAGLVSRHNFEGGHSVFE
LSQGEHHDHLVCVKCGRVEEFVDEIIEQRQKAIAERAHFKMTDHALNIYGICPQCQ

Sequences:

>Translated_136_residues
MEESQQLKDAGLKITLPRIKVLQILEQSRNHHLSAEAVYKALLESGEDVGLATVYRVLTQFEAAGLVSRHNFEGGHSVFE
LSQGEHHDHLVCVKCGRVEEFVDEIIEQRQKAIAERAHFKMTDHALNIYGICPQCQ
>Mature_136_residues
MEESQQLKDAGLKITLPRIKVLQILEQSRNHHLSAEAVYKALLESGEDVGLATVYRVLTQFEAAGLVSRHNFEGGHSVFE
LSQGEHHDHLVCVKCGRVEEFVDEIIEQRQKAIAERAHFKMTDHALNIYGICPQCQ

Specific function: Acts as a global negative controlling element, employing Fe(2+) as a cofactor to bind the operator of the repressed genes

COG id: COG0735

COG function: function code P; Fe2+/Zn2+ uptake regulation proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Fur family

Homologues:

Organism=Escherichia coli, GI1786899, Length=133, Percent_Identity=56.390977443609, Blast_Score=169, Evalue=7e-44,

Paralogues:

None

Copy number: 3432 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): FUR_LEGPN (Q48835)

Other databases:

- EMBL:   U06072
- ProteinModelPortal:   Q48835
- SMR:   Q48835
- GO:   GO:0005737
- InterPro:   IPR002481
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10

Pfam domain/function: PF01475 FUR

EC number: NA

Molecular weight: Translated: 15363; Mature: 15363

Theoretical pI: Translated: 6.22; Mature: 6.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEESQQLKDAGLKITLPRIKVLQILEQSRNHHLSAEAVYKALLESGEDVGLATVYRVLTQ
CCCHHHHHHCCCEEECHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHH
FEAAGLVSRHNFEGGHSVFELSQGEHHDHLVCVKCGRVEEFVDEIIEQRQKAIAERAHFK
HHHHHHHHHCCCCCCCCEEECCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCC
MTDHALNIYGICPQCQ
HHCCCEEEEECCCCCC
>Mature Secondary Structure
MEESQQLKDAGLKITLPRIKVLQILEQSRNHHLSAEAVYKALLESGEDVGLATVYRVLTQ
CCCHHHHHHCCCEEECHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHH
FEAAGLVSRHNFEGGHSVFELSQGEHHDHLVCVKCGRVEEFVDEIIEQRQKAIAERAHFK
HHHHHHHHHCCCCCCCCEEECCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCC
MTDHALNIYGICPQCQ
HHCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8200525