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The map label for this gene is serA [C]

Identifier: 54293287

GI number: 54293287

Start: 386027

End: 387238

Strand: Direct

Name: serA [C]

Synonym: lpl0335

Alternate gene names: 54293287

Gene position: 386027-387238 (Clockwise)

Preceding gene: 54293280

Following gene: 54293289

Centisome position: 11.54

GC content: 44.72

Gene sequence:

>1212_bases
ATGTTCAACCAGAGTCAGCAAAAAATTGTTTGTGTGCTTTATGATGATCCTAAGGGGGGATTTCCTCCAAACTATGCCAG
AGAATCCATTCCAGAATTGAAACAATATCCTGATGGTCAAAGTTTACCCATTCCTGATTCGATAGATTTTATTCCAGGTG
AACTGCTAGGTTCTGTTAGTGGTGAATTGGGACTGAGACAATTTCTTGAAAACAATGGACATCAATTTGTAGTAACCTCT
GATAAGGATGGTCCTGATTCAGTATTTGCAAGGGAGCTGAAAGACGCTACTGTCGTCATTTCCCAACCTTTTTGGCCAGC
CTATTTAACTCGTGATCGTATTGAGAGAGCGCCTAAACTTAAGTTGGCAATTACAGCAGGTATTGGTTCCGATCATGTCG
ATTTGCAAGCGGCCATGGAACATAATATCACTGTTTGTGAGGTTACTTATTGTAACAGCATCAGCGTTGCTGAACATACC
GTGATGATGATTTTGGCCTTGGTTCGGGATTTTATTCCCCAATACAATACGGTAATTGATGGCGGGTGGAATATTGCGGA
TTGCGTCAGCCGCTCTTATGATTTGGAAGGCATGCAAGTGGGATGTGTTGCTGCAGGCCGAATTGGATTAGCTGTTTTAA
GACGCTTAAAACCGTTTGCTGTAAAACTGCATTATACCGACAGGCATAGACTACCAGTACAGTTGGAGCAGGAACTGAAT
TTGACTTATCACCCCTCTGTTGAATCCATGGTGAAAGTTTGTGATGTGGTATCGATTCATTGCCCATTGCATCCGGAAAC
AGAATACCTTTTTGATGAGCGATTAATAAAACAGATGAGACGAGGCTCTTATTTAATCAATACCGCCAGGGGGAAAATAT
GCGATCAGCACGCTGTGGCCAAAGCTCTGGAATCCGGACATTTGGCTGGTTATGCCGGAGACGTTTGGTTTCCACAACCC
CCTGCCAAAAACCATCCATGGCGATCGATGCCACATCACGCCATGACACCACATACCTCAGGAACTACCTTGTCCGCGCA
AGCGCGGTATGCGGCGGGAGTCAGAGAAATATTAGAGTGTTGGCTAGGGAACAAACCAATTAGGGATGAATATCTGATCG
TGTCTCAAGGCCGTTTAGCCGGGGTTGGTTCTCACTCCTATAGTGCGGGCAATAGTACAACAGGTGCTGAGCAAGAAGCA
GAATTGGTTTGA

Upstream 100 bases:

>100_bases
GAATAGTATTTTTATTGAGATGAATGACTTAAATCAAGTATAGTGAGCACTGTAAAAAAATCAGGATGTTTTTACTTCAA
ACTATGAAAAGGAGTCAGGT

Downstream 100 bases:

>100_bases
TTCACCGTCGCTTAAGCCGTCTTATGTCTTTCTGTTTTCATTCAAAGTAGCCGCTGCCTTTAAAGACAGCGGCAGTTCAG
GGAAAGGGGCAAATAGTGGA

Product: formate dehydrogenase

Products: NA

Alternate protein names: NAD-dependent formate dehydrogenase; FDH [H]

Number of amino acids: Translated: 403; Mature: 403

Protein sequence:

>403_residues
MFNQSQQKIVCVLYDDPKGGFPPNYARESIPELKQYPDGQSLPIPDSIDFIPGELLGSVSGELGLRQFLENNGHQFVVTS
DKDGPDSVFARELKDATVVISQPFWPAYLTRDRIERAPKLKLAITAGIGSDHVDLQAAMEHNITVCEVTYCNSISVAEHT
VMMILALVRDFIPQYNTVIDGGWNIADCVSRSYDLEGMQVGCVAAGRIGLAVLRRLKPFAVKLHYTDRHRLPVQLEQELN
LTYHPSVESMVKVCDVVSIHCPLHPETEYLFDERLIKQMRRGSYLINTARGKICDQHAVAKALESGHLAGYAGDVWFPQP
PAKNHPWRSMPHHAMTPHTSGTTLSAQARYAAGVREILECWLGNKPIRDEYLIVSQGRLAGVGSHSYSAGNSTTGAEQEA
ELV

Sequences:

>Translated_403_residues
MFNQSQQKIVCVLYDDPKGGFPPNYARESIPELKQYPDGQSLPIPDSIDFIPGELLGSVSGELGLRQFLENNGHQFVVTS
DKDGPDSVFARELKDATVVISQPFWPAYLTRDRIERAPKLKLAITAGIGSDHVDLQAAMEHNITVCEVTYCNSISVAEHT
VMMILALVRDFIPQYNTVIDGGWNIADCVSRSYDLEGMQVGCVAAGRIGLAVLRRLKPFAVKLHYTDRHRLPVQLEQELN
LTYHPSVESMVKVCDVVSIHCPLHPETEYLFDERLIKQMRRGSYLINTARGKICDQHAVAKALESGHLAGYAGDVWFPQP
PAKNHPWRSMPHHAMTPHTSGTTLSAQARYAAGVREILECWLGNKPIRDEYLIVSQGRLAGVGSHSYSAGNSTTGAEQEA
ELV
>Mature_403_residues
MFNQSQQKIVCVLYDDPKGGFPPNYARESIPELKQYPDGQSLPIPDSIDFIPGELLGSVSGELGLRQFLENNGHQFVVTS
DKDGPDSVFARELKDATVVISQPFWPAYLTRDRIERAPKLKLAITAGIGSDHVDLQAAMEHNITVCEVTYCNSISVAEHT
VMMILALVRDFIPQYNTVIDGGWNIADCVSRSYDLEGMQVGCVAAGRIGLAVLRRLKPFAVKLHYTDRHRLPVQLEQELN
LTYHPSVESMVKVCDVVSIHCPLHPETEYLFDERLIKQMRRGSYLINTARGKICDQHAVAKALESGHLAGYAGDVWFPQP
PAKNHPWRSMPHHAMTPHTSGTTLSAQARYAAGVREILECWLGNKPIRDEYLIVSQGRLAGVGSHSYSAGNSTTGAEQEA
ELV

Specific function: Serine biosynthesis; first step. [C]

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=288, Percent_Identity=32.9861111111111, Blast_Score=125, Evalue=5e-29,
Organism=Homo sapiens, GI145580578, Length=281, Percent_Identity=30.2491103202847, Blast_Score=118, Evalue=9e-27,
Organism=Homo sapiens, GI4557499, Length=281, Percent_Identity=30.2491103202847, Blast_Score=118, Evalue=9e-27,
Organism=Homo sapiens, GI145580575, Length=281, Percent_Identity=30.2491103202847, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI4557497, Length=266, Percent_Identity=29.6992481203008, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI61743967, Length=266, Percent_Identity=29.6992481203008, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI6912396, Length=232, Percent_Identity=30.1724137931034, Blast_Score=101, Evalue=1e-21,
Organism=Escherichia coli, GI1789279, Length=247, Percent_Identity=33.1983805668016, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1787645, Length=188, Percent_Identity=31.3829787234043, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI87082289, Length=233, Percent_Identity=26.6094420600858, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI1788660, Length=251, Percent_Identity=26.6932270916335, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=291, Percent_Identity=30.2405498281787, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI25147481, Length=247, Percent_Identity=26.3157894736842, Blast_Score=83, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6324964, Length=347, Percent_Identity=47.5504322766571, Blast_Score=311, Evalue=1e-85,
Organism=Saccharomyces cerevisiae, GI6324980, Length=211, Percent_Identity=44.0758293838863, Blast_Score=164, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6324979, Length=119, Percent_Identity=56.3025210084034, Blast_Score=141, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6324055, Length=235, Percent_Identity=31.9148936170213, Blast_Score=109, Evalue=7e-25,
Organism=Saccharomyces cerevisiae, GI6320925, Length=270, Percent_Identity=27.7777777777778, Blast_Score=100, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6322116, Length=250, Percent_Identity=28.4, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24646446, Length=265, Percent_Identity=31.3207547169811, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24646448, Length=265, Percent_Identity=31.3207547169811, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24646452, Length=265, Percent_Identity=31.3207547169811, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24646450, Length=265, Percent_Identity=31.3207547169811, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI19921140, Length=256, Percent_Identity=31.25, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI62472511, Length=265, Percent_Identity=31.3207547169811, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI28571528, Length=252, Percent_Identity=28.1746031746032, Blast_Score=92, Evalue=8e-19,
Organism=Drosophila melanogaster, GI28574286, Length=230, Percent_Identity=27.8260869565217, Blast_Score=92, Evalue=8e-19,
Organism=Drosophila melanogaster, GI28574284, Length=234, Percent_Identity=26.4957264957265, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24585514, Length=234, Percent_Identity=26.4957264957265, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI28574282, Length=234, Percent_Identity=26.4957264957265, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI45551003, Length=233, Percent_Identity=26.6094420600858, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI45552429, Length=233, Percent_Identity=26.6094420600858, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24585516, Length=257, Percent_Identity=24.124513618677, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.2.1.2 [H]

Molecular weight: Translated: 44660; Mature: 44660

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFNQSQQKIVCVLYDDPKGGFPPNYARESIPELKQYPDGQSLPIPDSIDFIPGELLGSVS
CCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHCC
GELGLRQFLENNGHQFVVTSDKDGPDSVFARELKDATVVISQPFWPAYLTRDRIERAPKL
HHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHCCCEEEEECCCCHHHHHHHHHHCCCCE
KLAITAGIGSDHVDLQAAMEHNITVCEVTYCNSISVAEHTVMMILALVRDFIPQYNTVID
EEEEEECCCCCCHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCEEEC
GGWNIADCVSRSYDLEGMQVGCVAAGRIGLAVLRRLKPFAVKLHYTDRHRLPVQLEQELN
CCCCHHHHHHCCCCCCCEEEEEEEHHHHHHHHHHHCCCEEEEEEECCCCCCCEEECCCCC
LTYHPSVESMVKVCDVVSIHCPLHPETEYLFDERLIKQMRRGSYLINTARGKICDQHAVA
CEECCCHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHH
KALESGHLAGYAGDVWFPQPPAKNHPWRSMPHHAMTPHTSGTTLSAQARYAAGVREILEC
HHHHCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHH
WLGNKPIRDEYLIVSQGRLAGVGSHSYSAGNSTTGAEQEAELV
HCCCCCCCCCEEEEECCCEEECCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MFNQSQQKIVCVLYDDPKGGFPPNYARESIPELKQYPDGQSLPIPDSIDFIPGELLGSVS
CCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHCC
GELGLRQFLENNGHQFVVTSDKDGPDSVFARELKDATVVISQPFWPAYLTRDRIERAPKL
HHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHCCCEEEEECCCCHHHHHHHHHHCCCCE
KLAITAGIGSDHVDLQAAMEHNITVCEVTYCNSISVAEHTVMMILALVRDFIPQYNTVID
EEEEEECCCCCCHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCEEEC
GGWNIADCVSRSYDLEGMQVGCVAAGRIGLAVLRRLKPFAVKLHYTDRHRLPVQLEQELN
CCCCHHHHHHCCCCCCCEEEEEEEHHHHHHHHHHHCCCEEEEEEECCCCCCCEEECCCCC
LTYHPSVESMVKVCDVVSIHCPLHPETEYLFDERLIKQMRRGSYLINTARGKICDQHAVA
CEECCCHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHH
KALESGHLAGYAGDVWFPQPPAKNHPWRSMPHHAMTPHTSGTTLSAQARYAAGVREILEC
HHHHCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHH
WLGNKPIRDEYLIVSQGRLAGVGSHSYSAGNSTTGAEQEAELV
HCCCCCCCCCEEEEECCCEEECCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1954846; 2357236; 1597184; 8484798 [H]