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The map label for this gene is serA [H]

Identifier: 54293248

GI number: 54293248

Start: 336262

End: 337113

Strand: Direct

Name: serA [H]

Synonym: lpl0296

Alternate gene names: 54293248

Gene position: 336262-337113 (Clockwise)

Preceding gene: 54293247

Following gene: 54293252

Centisome position: 10.05

GC content: 40.49

Gene sequence:

>852_bases
ATGCAGGAAATTCGTTCTGAATTACCAGGTCACACGATTATCAAGTGTGACAGTCGTCAGTGGAGTGATGAGCAATTAAT
AGATTTTGTGAAGGATGCAGACATCATTGCACTGACGAATCGACGTTTATCGGCTGCAGTCATTAATTCAGCGCTGCGAT
TGCAATTGATTGCAGTTGCATTTGCTGGAATCGACCATATTGATAGGGATGCTGCGAATAAAAGAAATATTTCGGTAAAA
AATGCAGCGGGTTATGCCAACACTGCGGTGTCTGAACTGGTATTTGGTCTCATGATTTCTCTTGCACGTCATATTCCTGA
TAACAATCGGAGAATAAGGGAGCAAGGCATAACCAATACCGGTATTGAACTAAAAAATAAAGTGCTGGGCATTGTCGGTT
ATGGAGCAATCGGCGCAGAAGTTGCGCGGCTTGCTAAGGCATTTCAAATGACAACTATAATTTATGACAGGAAATCTCAA
GTAACATTAGACGATTTGTTTTCCCAATCTGATTTCGTCACTTTACATGTGCCACTTACAAATGAAACCAAAGGCATGGT
TAACTTAAGACTTTTATCTCAAATGAAAAAATCAGCGTATTTGATTAATTGTGCCAGAGGGCCGATTTTGGTTAGCAGTG
ATTTAAAAAAAGCCTTGGAACAGGACATGATAGCAGGTGCCGCATTGGATGTATTTGATGTTGAACCACCATTATCTGCA
AATTATAGCCTTTGGGAGGTATCTAATCTTATCGCAACACCACACATAGGATTTAATACAAGGGAGGCCCTTGTGGCCAA
GGGGCAATTGACTATCAGAAATATCAAAGAGTTTCTTTCGTCCCGCTTATAA

Upstream 100 bases:

>100_bases
TGACAAATTGCTTGTCACAGCGGAGTGGAAAAACTTAATTAAATTTTGATTAAAGGATTTTACATGAAAATTGCCGTTGT
TGAGCCTTATAGGGATTGCG

Downstream 100 bases:

>100_bases
AACCGTTTAAAAACATAAAGAAACATAAGACGTTGATTGCAATATAGCTTGTAGTACTTCAGATGTAGTTTAACCCAGGG
CAAAATCATGCTTTAACCAT

Product: hypothetical protein

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 283; Mature: 283

Protein sequence:

>283_residues
MQEIRSELPGHTIIKCDSRQWSDEQLIDFVKDADIIALTNRRLSAAVINSALRLQLIAVAFAGIDHIDRDAANKRNISVK
NAAGYANTAVSELVFGLMISLARHIPDNNRRIREQGITNTGIELKNKVLGIVGYGAIGAEVARLAKAFQMTTIIYDRKSQ
VTLDDLFSQSDFVTLHVPLTNETKGMVNLRLLSQMKKSAYLINCARGPILVSSDLKKALEQDMIAGAALDVFDVEPPLSA
NYSLWEVSNLIATPHIGFNTREALVAKGQLTIRNIKEFLSSRL

Sequences:

>Translated_283_residues
MQEIRSELPGHTIIKCDSRQWSDEQLIDFVKDADIIALTNRRLSAAVINSALRLQLIAVAFAGIDHIDRDAANKRNISVK
NAAGYANTAVSELVFGLMISLARHIPDNNRRIREQGITNTGIELKNKVLGIVGYGAIGAEVARLAKAFQMTTIIYDRKSQ
VTLDDLFSQSDFVTLHVPLTNETKGMVNLRLLSQMKKSAYLINCARGPILVSSDLKKALEQDMIAGAALDVFDVEPPLSA
NYSLWEVSNLIATPHIGFNTREALVAKGQLTIRNIKEFLSSRL
>Mature_283_residues
MQEIRSELPGHTIIKCDSRQWSDEQLIDFVKDADIIALTNRRLSAAVINSALRLQLIAVAFAGIDHIDRDAANKRNISVK
NAAGYANTAVSELVFGLMISLARHIPDNNRRIREQGITNTGIELKNKVLGIVGYGAIGAEVARLAKAFQMTTIIYDRKSQ
VTLDDLFSQSDFVTLHVPLTNETKGMVNLRLLSQMKKSAYLINCARGPILVSSDLKKALEQDMIAGAALDVFDVEPPLSA
NYSLWEVSNLIATPHIGFNTREALVAKGQLTIRNIKEFLSSRL

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=257, Percent_Identity=36.1867704280156, Blast_Score=160, Evalue=1e-39,
Organism=Homo sapiens, GI6912396, Length=271, Percent_Identity=29.8892988929889, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI145580575, Length=254, Percent_Identity=29.5275590551181, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI145580578, Length=254, Percent_Identity=29.5275590551181, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI4557499, Length=254, Percent_Identity=29.5275590551181, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI61743967, Length=254, Percent_Identity=30.3149606299213, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI4557497, Length=254, Percent_Identity=30.3149606299213, Blast_Score=103, Evalue=2e-22,
Organism=Escherichia coli, GI1789279, Length=272, Percent_Identity=37.5, Blast_Score=151, Evalue=6e-38,
Organism=Escherichia coli, GI87082289, Length=278, Percent_Identity=29.4964028776978, Blast_Score=118, Evalue=4e-28,
Organism=Escherichia coli, GI1787645, Length=247, Percent_Identity=29.5546558704453, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI87081824, Length=146, Percent_Identity=32.8767123287671, Blast_Score=77, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17532191, Length=265, Percent_Identity=32.0754716981132, Blast_Score=129, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI25147481, Length=238, Percent_Identity=29.8319327731092, Blast_Score=91, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6320925, Length=270, Percent_Identity=35.1851851851852, Blast_Score=147, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6322116, Length=270, Percent_Identity=34.0740740740741, Blast_Score=142, Evalue=6e-35,
Organism=Saccharomyces cerevisiae, GI6324964, Length=241, Percent_Identity=30.7053941908714, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6324055, Length=247, Percent_Identity=27.9352226720648, Blast_Score=99, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6324980, Length=140, Percent_Identity=31.4285714285714, Blast_Score=77, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6325144, Length=298, Percent_Identity=23.1543624161074, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24585516, Length=285, Percent_Identity=30.5263157894737, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI28574286, Length=259, Percent_Identity=30.1158301158301, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI19921140, Length=259, Percent_Identity=32.4324324324324, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24585514, Length=270, Percent_Identity=29.2592592592593, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI28574282, Length=270, Percent_Identity=29.2592592592593, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI28574284, Length=270, Percent_Identity=29.2592592592593, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI45551003, Length=270, Percent_Identity=29.2592592592593, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI45552429, Length=270, Percent_Identity=29.2592592592593, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24646446, Length=228, Percent_Identity=34.6491228070175, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI24646448, Length=228, Percent_Identity=34.6491228070175, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI24646452, Length=228, Percent_Identity=34.6491228070175, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI24646450, Length=228, Percent_Identity=34.6491228070175, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI62472511, Length=228, Percent_Identity=34.6491228070175, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI28571528, Length=263, Percent_Identity=30.0380228136882, Blast_Score=97, Evalue=9e-21,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 31214; Mature: 31214

Theoretical pI: Translated: 9.06; Mature: 9.06

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQEIRSELPGHTIIKCDSRQWSDEQLIDFVKDADIIALTNRRLSAAVINSALRLQLIAVA
CCCHHHHCCCCEEEEECCCCCCHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHH
FAGIDHIDRDAANKRNISVKNAAGYANTAVSELVFGLMISLARHIPDNNRRIREQGITNT
HHCCHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCC
GIELKNKVLGIVGYGAIGAEVARLAKAFQMTTIIYDRKSQVTLDDLFSQSDFVTLHVPLT
CCHHHHHEEEEEECCHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHCCCCEEEEEEEEC
NETKGMVNLRLLSQMKKSAYLINCARGPILVSSDLKKALEQDMIAGAALDVFDVEPPLSA
CCCCCHHHHHHHHHHHHHHEEEEECCCCEEECHHHHHHHHHHHHHCCEEEEEECCCCCCC
NYSLWEVSNLIATPHIGFNTREALVAKGQLTIRNIKEFLSSRL
CCCHHHHHHHHCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MQEIRSELPGHTIIKCDSRQWSDEQLIDFVKDADIIALTNRRLSAAVINSALRLQLIAVA
CCCHHHHCCCCEEEEECCCCCCHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHH
FAGIDHIDRDAANKRNISVKNAAGYANTAVSELVFGLMISLARHIPDNNRRIREQGITNT
HHCCHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCC
GIELKNKVLGIVGYGAIGAEVARLAKAFQMTTIIYDRKSQVTLDDLFSQSDFVTLHVPLT
CCHHHHHEEEEEECCHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHCCCCEEEEEEEEC
NETKGMVNLRLLSQMKKSAYLINCARGPILVSSDLKKALEQDMIAGAALDVFDVEPPLSA
CCCCCHHHHHHHHHHHHHHEEEEECCCCEEECHHHHHHHHHHHHHCCEEEEEECCCCCCC
NYSLWEVSNLIATPHIGFNTREALVAKGQLTIRNIKEFLSSRL
CCCHHHHHHHHCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]