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The map label for this gene is gabT [H]

Identifier: 54293245

GI number: 54293245

Start: 332699

End: 334051

Strand: Direct

Name: gabT [H]

Synonym: lpl0293

Alternate gene names: 54293245

Gene position: 332699-334051 (Clockwise)

Preceding gene: 54293244

Following gene: 54293246

Centisome position: 9.94

GC content: 42.05

Gene sequence:

>1353_bases
ATGAAACACCAATTGGTTGGTACTAAACTAATGAAAAAAATTCATATCAAAACGCCAATACCCGGACCCAAATCGCAACA
GTTGATGGAATTGCGACGTCAGCATGTTGCAAGAGGGCCATTTCATGCTACTCCTATCTTTGTGAAGCAGGCCAAAGGTT
CTTTTGTGGAGGATGTTGATGGAAATGTATTTTTGGACTTTTCATCAGGGTTTGGGGTGGTCAATACAGGGCACTGTCCT
GATTCGGTGGTCAATGCCATCAAGCTCCAGGCCGAAAAATTTATACACACCGGCTTCAATATTATTCCCTATGAATCTTA
TATCAAGGTGTGTGAAAAATTAAATGATCACACCCCGGGACATTTCGAAAAAAAATCGCTCCTTTTGAATTCCGGTGCGG
AAGCAGTTGAAAATGCCATTAAAATTGCTCGTGCCTATACGGGCAAACAAGCAGTGATTTGTTTTGATCATGCTTTTCAT
GGACGCACGTACATGGCAATGACACTCACTTCGAAAAACAAACCCTATAAGCATGGATTCGGCCCGTTTCCTTCTGAAAT
TCATCGTGCTCCTTTTCCTTATGAGTATCGTTGGAAGGGAGTCAATTGTGTAGAAGAATGTTTCAATGAGTTTACCGATC
TTGCTAATTTCCGTGTCGGTGTTGAAAACATTGCTGCAGTCATTATAGAGCCGGTATTGGGTGAAGGTGGATTTATTCAA
TCTCCTGCCTTATTTTTGCAAAAACTTCGTGAGTTTTGTACGACAAACGATATCGTTTTTATTGCCGATGAAATCCAATC
CGGTTTTGGCCGCACAGGAAATCTGTTTGCGATGAATACGTTGGGAGTACCTCCCGATCTCACCATATCAGCAAAAGGGC
TTGGCGGTGGGGTAGTGCTTGCCGGTGTAACAGGTAAAGCTGAAATTATGGATGCGGCTATGGAAGGAGGGTTGGGTGGA
ACTTTTGGTGGAAATCCTCTTAGTTGTGCTGCTGCTCTTGAAGTGTTCCATATTTTTGAAGAAGGAAGCCTGCTGCAAAA
TGTTACCCATCTTGCAAAGGCACTGCAGTCCAGACTTTCTGGATTTAAGGAAAAATACAAGGTAGTTGGTGATGTTCGTG
GTTTGGGTGTCATGCAGGCAATCGAATTGGTAAAGGATAAAAACACGAAAGAACCTAATAAAGAAGCCACAGTACAATTG
GCTCAATTTTGTTTAGAACATGGATTGATCATTTTGACCTGTGGAACATATGGGAACGTCATTCGTCTCCACATGCCGCT
TTCTACTGGCGTAAAAGATTTGGAAATCGGCCTTTCGATTATTGAAGAAGGATTGAAAAAATTATCGGTATAA

Upstream 100 bases:

>100_bases
ATGCCTTGGGGCGGATACAAACAAAGTGGAGCGGGTCGTGAGTTAGGCTTGTATGGCATTGAGAGTTATCTTGAGGTCAA
GCAAGTGAATATTAACCTGG

Downstream 100 bases:

>100_bases
TAGCTAGGAAGTTTGAAATGAGAAAGGTTGCTTAATACTCACTTAATTAGTTTTTGATATCATTTGCTCTAATGAATTAC
AGGTGAATGATATGTGGTAT

Product: hypothetical protein

Products: NA

Alternate protein names: (S)-3-amino-2-methylpropionate transaminase; GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase; L-AIBAT [H]

Number of amino acids: Translated: 450; Mature: 450

Protein sequence:

>450_residues
MKHQLVGTKLMKKIHIKTPIPGPKSQQLMELRRQHVARGPFHATPIFVKQAKGSFVEDVDGNVFLDFSSGFGVVNTGHCP
DSVVNAIKLQAEKFIHTGFNIIPYESYIKVCEKLNDHTPGHFEKKSLLLNSGAEAVENAIKIARAYTGKQAVICFDHAFH
GRTYMAMTLTSKNKPYKHGFGPFPSEIHRAPFPYEYRWKGVNCVEECFNEFTDLANFRVGVENIAAVIIEPVLGEGGFIQ
SPALFLQKLREFCTTNDIVFIADEIQSGFGRTGNLFAMNTLGVPPDLTISAKGLGGGVVLAGVTGKAEIMDAAMEGGLGG
TFGGNPLSCAAALEVFHIFEEGSLLQNVTHLAKALQSRLSGFKEKYKVVGDVRGLGVMQAIELVKDKNTKEPNKEATVQL
AQFCLEHGLIILTCGTYGNVIRLHMPLSTGVKDLEIGLSIIEEGLKKLSV

Sequences:

>Translated_450_residues
MKHQLVGTKLMKKIHIKTPIPGPKSQQLMELRRQHVARGPFHATPIFVKQAKGSFVEDVDGNVFLDFSSGFGVVNTGHCP
DSVVNAIKLQAEKFIHTGFNIIPYESYIKVCEKLNDHTPGHFEKKSLLLNSGAEAVENAIKIARAYTGKQAVICFDHAFH
GRTYMAMTLTSKNKPYKHGFGPFPSEIHRAPFPYEYRWKGVNCVEECFNEFTDLANFRVGVENIAAVIIEPVLGEGGFIQ
SPALFLQKLREFCTTNDIVFIADEIQSGFGRTGNLFAMNTLGVPPDLTISAKGLGGGVVLAGVTGKAEIMDAAMEGGLGG
TFGGNPLSCAAALEVFHIFEEGSLLQNVTHLAKALQSRLSGFKEKYKVVGDVRGLGVMQAIELVKDKNTKEPNKEATVQL
AQFCLEHGLIILTCGTYGNVIRLHMPLSTGVKDLEIGLSIIEEGLKKLSV
>Mature_450_residues
MKHQLVGTKLMKKIHIKTPIPGPKSQQLMELRRQHVARGPFHATPIFVKQAKGSFVEDVDGNVFLDFSSGFGVVNTGHCP
DSVVNAIKLQAEKFIHTGFNIIPYESYIKVCEKLNDHTPGHFEKKSLLLNSGAEAVENAIKIARAYTGKQAVICFDHAFH
GRTYMAMTLTSKNKPYKHGFGPFPSEIHRAPFPYEYRWKGVNCVEECFNEFTDLANFRVGVENIAAVIIEPVLGEGGFIQ
SPALFLQKLREFCTTNDIVFIADEIQSGFGRTGNLFAMNTLGVPPDLTISAKGLGGGVVLAGVTGKAEIMDAAMEGGLGG
TFGGNPLSCAAALEVFHIFEEGSLLQNVTHLAKALQSRLSGFKEKYKVVGDVRGLGVMQAIELVKDKNTKEPNKEATVQL
AQFCLEHGLIILTCGTYGNVIRLHMPLSTGVKDLEIGLSIIEEGLKKLSV

Specific function: 4-aminobutyrate (GABA) degradation. [C]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=440, Percent_Identity=32.0454545454545, Blast_Score=182, Evalue=5e-46,
Organism=Homo sapiens, GI37574042, Length=447, Percent_Identity=30.8724832214765, Blast_Score=167, Evalue=3e-41,
Organism=Homo sapiens, GI13994255, Length=450, Percent_Identity=28.4444444444444, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI226442705, Length=447, Percent_Identity=30.4250559284116, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI24119277, Length=425, Percent_Identity=30.1176470588235, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI226442709, Length=396, Percent_Identity=31.3131313131313, Blast_Score=152, Evalue=7e-37,
Organism=Homo sapiens, GI284507298, Length=327, Percent_Identity=32.4159021406728, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI188536080, Length=414, Percent_Identity=26.8115942028986, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI38679950, Length=414, Percent_Identity=26.8115942028986, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI38679946, Length=414, Percent_Identity=26.8115942028986, Blast_Score=108, Evalue=1e-23,
Organism=Escherichia coli, GI1789016, Length=425, Percent_Identity=44.7058823529412, Blast_Score=372, Evalue=1e-104,
Organism=Escherichia coli, GI1787560, Length=400, Percent_Identity=43.25, Blast_Score=333, Evalue=2e-92,
Organism=Escherichia coli, GI1789759, Length=416, Percent_Identity=32.4519230769231, Blast_Score=206, Evalue=4e-54,
Organism=Escherichia coli, GI1788044, Length=408, Percent_Identity=32.1078431372549, Blast_Score=194, Evalue=1e-50,
Organism=Escherichia coli, GI145693181, Length=438, Percent_Identity=31.0502283105023, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI1786991, Length=395, Percent_Identity=30.6329113924051, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1786349, Length=360, Percent_Identity=27.7777777777778, Blast_Score=127, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI71992977, Length=410, Percent_Identity=29.2682926829268, Blast_Score=169, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI32564660, Length=450, Percent_Identity=29.5555555555556, Blast_Score=168, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI25144271, Length=431, Percent_Identity=28.3062645011601, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI25144274, Length=294, Percent_Identity=28.9115646258503, Blast_Score=119, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI17541228, Length=477, Percent_Identity=24.1090146750524, Blast_Score=99, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI71981843, Length=181, Percent_Identity=27.0718232044199, Blast_Score=69, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6323470, Length=439, Percent_Identity=29.6127562642369, Blast_Score=190, Evalue=4e-49,
Organism=Saccharomyces cerevisiae, GI6324432, Length=402, Percent_Identity=30.3482587064677, Blast_Score=164, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6324386, Length=416, Percent_Identity=26.2019230769231, Blast_Score=100, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6321456, Length=407, Percent_Identity=25.7985257985258, Blast_Score=80, Evalue=6e-16,
Organism=Drosophila melanogaster, GI161085790, Length=462, Percent_Identity=28.3549783549784, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI28574759, Length=457, Percent_Identity=27.5711159737418, Blast_Score=189, Evalue=4e-48,
Organism=Drosophila melanogaster, GI21357415, Length=438, Percent_Identity=30.1369863013699, Blast_Score=175, Evalue=6e-44,
Organism=Drosophila melanogaster, GI21356575, Length=422, Percent_Identity=30.0947867298578, Blast_Score=166, Evalue=4e-41,
Organism=Drosophila melanogaster, GI281366494, Length=421, Percent_Identity=25.8907363420428, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24667139, Length=421, Percent_Identity=25.8907363420428, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24667143, Length=421, Percent_Identity=25.8907363420428, Blast_Score=94, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004632
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.19; =2.6.1.22 [H]

Molecular weight: Translated: 49076; Mature: 49076

Theoretical pI: Translated: 8.00; Mature: 8.00

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHQLVGTKLMKKIHIKTPIPGPKSQQLMELRRQHVARGPFHATPIFVKQAKGSFVEDVD
CCCCHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEECCCCCEEECCC
GNVFLDFSSGFGVVNTGHCPDSVVNAIKLQAEKFIHTGFNIIPYESYIKVCEKLNDHTPG
CCEEEEECCCCCEEECCCCCHHHHHHHHHHHHHHHHCCCCEECHHHHHHHHHHHCCCCCC
HFEKKSLLLNSGAEAVENAIKIARAYTGKQAVICFDHAFHGRTYMAMTLTSKNKPYKHGF
CCHHHHHHHCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCEEEEEEEECCCCCCCCCC
GPFPSEIHRAPFPYEYRWKGVNCVEECFNEFTDLANFRVGVENIAAVIIEPVLGEGGFIQ
CCCCHHHCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCC
SPALFLQKLREFCTTNDIVFIADEIQSGFGRTGNLFAMNTLGVPPDLTISAKGLGGGVVL
CHHHHHHHHHHHHCCCCEEEEEHHHHHCCCCCCCEEEEECCCCCCCCEEEECCCCCCEEE
AGVTGKAEIMDAAMEGGLGGTFGGNPLSCAAALEVFHIFEEGSLLQNVTHLAKALQSRLS
EECCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
GFKEKYKVVGDVRGLGVMQAIELVKDKNTKEPNKEATVQLAQFCLEHGLIILTCGTYGNV
HHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCEEEEECCCCCCE
IRLHMPLSTGVKDLEIGLSIIEEGLKKLSV
EEEEECHHCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKHQLVGTKLMKKIHIKTPIPGPKSQQLMELRRQHVARGPFHATPIFVKQAKGSFVEDVD
CCCCHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEECCCCCEEECCC
GNVFLDFSSGFGVVNTGHCPDSVVNAIKLQAEKFIHTGFNIIPYESYIKVCEKLNDHTPG
CCEEEEECCCCCEEECCCCCHHHHHHHHHHHHHHHHCCCCEECHHHHHHHHHHHCCCCCC
HFEKKSLLLNSGAEAVENAIKIARAYTGKQAVICFDHAFHGRTYMAMTLTSKNKPYKHGF
CCHHHHHHHCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCEEEEEEEECCCCCCCCCC
GPFPSEIHRAPFPYEYRWKGVNCVEECFNEFTDLANFRVGVENIAAVIIEPVLGEGGFIQ
CCCCHHHCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCC
SPALFLQKLREFCTTNDIVFIADEIQSGFGRTGNLFAMNTLGVPPDLTISAKGLGGGVVL
CHHHHHHHHHHHHCCCCEEEEEHHHHHCCCCCCCEEEEECCCCCCCCEEEECCCCCCEEE
AGVTGKAEIMDAAMEGGLGGTFGGNPLSCAAALEVFHIFEEGSLLQNVTHLAKALQSRLS
EECCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
GFKEKYKVVGDVRGLGVMQAIELVKDKNTKEPNKEATVQLAQFCLEHGLIILTCGTYGNV
HHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCEEEEECCCCCCE
IRLHMPLSTGVKDLEIGLSIIEEGLKKLSV
EEEEECHHCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]