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The map label for this gene is pepA

Identifier: 54020522

GI number: 54020522

Start: 572918

End: 574297

Strand: Reverse

Name: pepA

Synonym: mhp462

Alternate gene names: 54020522

Gene position: 574297-572918 (Counterclockwise)

Preceding gene: 54020523

Following gene: 54020521

Centisome position: 64.33

GC content: 34.93

Gene sequence:

>1380_bases
ATGAAAAATTTTTCTGAAATTTTTATCAAGTATTCAAATAAATTTGAATCCAATCGAATAACCATTGAACCAGCTTATTC
TGATTCGCAAATTCCAATGTTGATAAAAGAAGATTTAGCTATTACCGAGTATCTTGGGCAAAAAAAGGCTTATATTAATT
TAGGCTCCCGCTCAAAAGAATTAACTCCGAACCGTTTTCGCAAAATTGCTGCAAAATTAGGTCATTATCCCCGTGATATG
CAAATTAATTTTGATAAATTCCCAAATTCTTTCTTGAGATATTTAATCGAAGTTATTGCTTTTCAAAGATCTGATATTTT
CTCGCTAAGAGCCGATTATGCTAAAAATCGAGCTAAAAATCGTGATATTTTAGTGGTTTCAAGTTATTTAGATGAACTAA
AACCGATAATTGATAAATACCAAATAATTAATAACAGCGTCAATTATGCCCGTTATTACCAAAATATGCCCCCTAATATG
GCTAGTTCTGAATTTCTTGCAAGCGAGATTCAGAAAAAAATGAGCCTAAATCCAAAATTAACGGTCAAGGTTTTAGGCGA
AAATGAAGTGCGAAAATTAGGAATGAACCTGCTTTTAGCGGTCAATAGAGGATCAACTTATGATGCTAAATTAGTAGTGA
TTTCTTATGAAGGGCTTCCAGGATCACAATATAAAACTGCTTTTATTGGTAAAGGAATTACTTTTGATTCAGGTGGTTAT
AATATCAAAACTGGCATGTATATGAATGATATGAAAATTGATATGTCAGGAGCGATAATTTGTGCAGCTGCAATTGATGC
CTTATCACAATTTAATCCCTTAGCAAATGTTGTCGCTGTTTTACCACTTACCGATAACCGTCTTAATGGCGATGCAAATA
CGCCCGATGCAGTATGAAGATCAATGAATGGTAAAACAGTTGAGATTAATAATACTGACGCCGAGGGTCGGCTCATTTTA
GCAGATGCAATCACTTATGCGATTAGACAAGAAAAAGCAAGTGAAATTATTTCGATTGCAACGCTGACAGGAGCAATTCG
TGTTGCATTAGGCGAAACCTTTACTGGAGCTTTTGCAAATGAGGAAAAAATTTGAAAGAACTTTAACGAGGCATCAAAAG
AAGCCGGCGAACTAATTTGAAGAATGCCTCTTCATCAGGATTTTGCCCAAAATATCCGTGATTCAAAAGTGGCGGATTTA
AAAAATACTGATTTTTCCGGCAAAGCCGGTTCTTCTTCTGCAGCAATGTTTCTAGCTGAGTTTGTCGAAGATAAACCGTT
TATTCATCTGGATATTGCCGCGACTGCTTTTGTCAAAAATACCCCAACTGGTGTTATGGTTAGGTCTTTAGTTGAATATA
TTTTAGCAAAGCAAAACTAA

Upstream 100 bases:

>100_bases
ATATTTTAAAAAAATATTTCTAATTTTTTAACTTTTTTGTGTTATAATTTTATTTACTGCATTGCTATTAAAATGTATTA
CTAGGACTATCAAAGTTAGT

Downstream 100 bases:

>100_bases
TTCTAAAATATTTTTTTAGTTTAAAAAAGAAACCTAAAGATTTTTTTGTATCTTCAAGCTTCTTTTTATTTAACTTATAA
CTTAAAAACTAAAAAAAGTA

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 459; Mature: 459

Protein sequence:

>459_residues
MKNFSEIFIKYSNKFESNRITIEPAYSDSQIPMLIKEDLAITEYLGQKKAYINLGSRSKELTPNRFRKIAAKLGHYPRDM
QINFDKFPNSFLRYLIEVIAFQRSDIFSLRADYAKNRAKNRDILVVSSYLDELKPIIDKYQIINNSVNYARYYQNMPPNM
ASSEFLASEIQKKMSLNPKLTVKVLGENEVRKLGMNLLLAVNRGSTYDAKLVVISYEGLPGSQYKTAFIGKGITFDSGGY
NIKTGMYMNDMKIDMSGAIICAAAIDALSQFNPLANVVAVLPLTDNRLNGDANTPDAVWRSMNGKTVEINNTDAEGRLIL
ADAITYAIRQEKASEIISIATLTGAIRVALGETFTGAFANEEKIWKNFNEASKEAGELIWRMPLHQDFAQNIRDSKVADL
KNTDFSGKAGSSSAAMFLAEFVEDKPFIHLDIAATAFVKNTPTGVMVRSLVEYILAKQN

Sequences:

>Translated_459_residues
MKNFSEIFIKYSNKFESNRITIEPAYSDSQIPMLIKEDLAITEYLGQKKAYINLGSRSKELTPNRFRKIAAKLGHYPRDM
QINFDKFPNSFLRYLIEVIAFQRSDIFSLRADYAKNRAKNRDILVVSSYLDELKPIIDKYQIINNSVNYARYYQNMPPNM
ASSEFLASEIQKKMSLNPKLTVKVLGENEVRKLGMNLLLAVNRGSTYDAKLVVISYEGLPGSQYKTAFIGKGITFDSGGY
NIKTGMYMNDMKIDMSGAIICAAAIDALSQFNPLANVVAVLPLTDNRLNGDANTPDAV*RSMNGKTVEINNTDAEGRLIL
ADAITYAIRQEKASEIISIATLTGAIRVALGETFTGAFANEEKI*KNFNEASKEAGELI*RMPLHQDFAQNIRDSKVADL
KNTDFSGKAGSSSAAMFLAEFVEDKPFIHLDIAATAFVKNTPTGVMVRSLVEYILAKQN
>Mature_459_residues
MKNFSEIFIKYSNKFESNRITIEPAYSDSQIPMLIKEDLAITEYLGQKKAYINLGSRSKELTPNRFRKIAAKLGHYPRDM
QINFDKFPNSFLRYLIEVIAFQRSDIFSLRADYAKNRAKNRDILVVSSYLDELKPIIDKYQIINNSVNYARYYQNMPPNM
ASSEFLASEIQKKMSLNPKLTVKVLGENEVRKLGMNLLLAVNRGSTYDAKLVVISYEGLPGSQYKTAFIGKGITFDSGGY
NIKTGMYMNDMKIDMSGAIICAAAIDALSQFNPLANVVAVLPLTDNRLNGDANTPDAV*RSMNGKTVEINNTDAEGRLIL
ADAITYAIRQEKASEIISIATLTGAIRVALGETFTGAFANEEKI*KNFNEASKEAGELI*RMPLHQDFAQNIRDSKVADL
KNTDFSGKAGSSSAAMFLAEFVEDKPFIHLDIAATAFVKNTPTGVMVRSLVEYILAKQN

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=317, Percent_Identity=38.1703470031546, Blast_Score=193, Evalue=3e-49,
Organism=Homo sapiens, GI47155554, Length=332, Percent_Identity=31.6265060240964, Blast_Score=128, Evalue=1e-29,
Organism=Escherichia coli, GI1790710, Length=307, Percent_Identity=36.1563517915309, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI87082123, Length=292, Percent_Identity=35.2739726027397, Blast_Score=132, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17556903, Length=402, Percent_Identity=33.0845771144279, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17565172, Length=290, Percent_Identity=28.9655172413793, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21355725, Length=318, Percent_Identity=29.559748427673, Blast_Score=141, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24661038, Length=318, Percent_Identity=29.2452830188679, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI21357381, Length=337, Percent_Identity=33.5311572700297, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI221379063, Length=337, Percent_Identity=33.5311572700297, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI221379062, Length=337, Percent_Identity=33.5311572700297, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI20129969, Length=318, Percent_Identity=28.9308176100629, Blast_Score=132, Evalue=5e-31,
Organism=Drosophila melanogaster, GI24662227, Length=373, Percent_Identity=28.4182305630027, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI19922386, Length=321, Percent_Identity=31.1526479750779, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI161077148, Length=320, Percent_Identity=27.5, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI20130057, Length=320, Percent_Identity=27.5, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI21355645, Length=318, Percent_Identity=27.6729559748428, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24662223, Length=318, Percent_Identity=27.6729559748428, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI20129963, Length=320, Percent_Identity=29.0625, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24646701, Length=259, Percent_Identity=28.957528957529, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24646703, Length=259, Percent_Identity=28.957528957529, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI21358201, Length=259, Percent_Identity=28.957528957529, Blast_Score=87, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042 [H]

Pfam domain/function: PF00883 Peptidase_M17 [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 50755; Mature: 50755

Theoretical pI: Translated: 9.25; Mature: 9.25

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNFSEIFIKYSNKFESNRITIEPAYSDSQIPMLIKEDLAITEYLGQKKAYINLGSRSKE
CCCHHHHHEEECCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCC
LTPNRFRKIAAKLGHYPRDMQINFDKFPNSFLRYLIEVIAFQRSDIFSLRADYAKNRAKN
CCHHHHHHHHHHHCCCCCCCEEEHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCC
RDILVVSSYLDELKPIIDKYQIINNSVNYARYYQNMPPNMASSEFLASEIQKKMSLNPKL
CCEEEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCE
TVKVLGENEVRKLGMNLLLAVNRGSTYDAKLVVISYEGLPGSQYKTAFIGKGITFDSGGY
EEEEECCHHHHHHCCEEEEEEECCCCCCEEEEEEEECCCCCCCCEEEEEECCEEECCCCC
NIKTGMYMNDMKIDMSGAIICAAAIDALSQFNPLANVVAVLPLTDNRLNGDANTPDAVRS
EEEECEEEECEEEECCCCCHHHHHHHHHHHCCHHHHEEEEEEECCCCCCCCCCCCHHHHH
MNGKTVEINNTDAEGRLILADAITYAIRQEKASEIISIATLTGAIRVALGETFTGAFANE
CCCCEEEECCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCH
EKIKNFNEASKEAGELIRMPLHQDFAQNIRDSKVADLKNTDFSGKAGSSSAAMFLAEFVE
HHHHCHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHC
DKPFIHLDIAATAFVKNTPTGVMVRSLVEYILAKQN
CCCEEEEEEEEEEEECCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKNFSEIFIKYSNKFESNRITIEPAYSDSQIPMLIKEDLAITEYLGQKKAYINLGSRSKE
CCCHHHHHEEECCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCC
LTPNRFRKIAAKLGHYPRDMQINFDKFPNSFLRYLIEVIAFQRSDIFSLRADYAKNRAKN
CCHHHHHHHHHHHCCCCCCCEEEHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCC
RDILVVSSYLDELKPIIDKYQIINNSVNYARYYQNMPPNMASSEFLASEIQKKMSLNPKL
CCEEEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCE
TVKVLGENEVRKLGMNLLLAVNRGSTYDAKLVVISYEGLPGSQYKTAFIGKGITFDSGGY
EEEEECCHHHHHHCCEEEEEEECCCCCCEEEEEEEECCCCCCCCEEEEEECCEEECCCCC
NIKTGMYMNDMKIDMSGAIICAAAIDALSQFNPLANVVAVLPLTDNRLNGDANTPDAVRS
EEEECEEEECEEEECCCCCHHHHHHHHHHHCCHHHHEEEEEEECCCCCCCCCCCCHHHHH
MNGKTVEINNTDAEGRLILADAITYAIRQEKASEIISIATLTGAIRVALGETFTGAFANE
CCCCEEEECCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCH
EKIKNFNEASKEAGELIRMPLHQDFAQNIRDSKVADLKNTDFSGKAGSSSAAMFLAEFVE
HHHHCHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHC
DKPFIHLDIAATAFVKNTPTGVMVRSLVEYILAKQN
CCCEEEEEEEEEEEECCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7557291 [H]