Click here to switch to the map view.

The map label for this gene is rnc

Identifier: 54020492

GI number: 54020492

Start: 489865

End: 490416

Strand: Reverse

Name: rnc

Synonym: mhp412

Alternate gene names: 54020492

Gene position: 490416-489865 (Counterclockwise)

Preceding gene: 54020493

Following gene: 54020491

Centisome position: 54.93

GC content: 33.15

Gene sequence:

>552_bases
ATGCTTGAGTTTCTTGGTGATTCGGTAATTAATTATGCGGTTTCAAAGGTGATTTATGATAATTTTTATAAAAATGAGGG
AAATTCAACCCAAATTCGATCCTTACTTACATCAACTTCGAGTTTAGCTAATGCAACAAAAAAAGTTGGGCTAATGAACT
ATGTCTTGCTTGGTAGAGGTGCTAGTGAAATTCGCGAAAACAACAAGTTAAAAGCCGATATTTTTGAATCTTTTTGTGCG
GCGATCTTATTGGATCAAGGTTTTGAGAAATTAAATGAATTCTTGTCTGAGTATTTATATAAAGATGTAAATTTTGATAC
TGAAAAACAGTATAAAGACCCAAAGTCAATTTTTCAGGAAAAAATTCAAACTTTTTCAACCTCAAACAAGATCCACTATC
TACACACAAAATTAGTTGATGGAACTTTCCGGGTTGATCTTATTTGGGAGAAAAAAAAGTACGGAATTGGATATGGCAGG
TCGATAAAGGAAGCAGAATTTGCCGCTGCTACTAATGCCTTAAATATTTTTGCAGAGACTGAGGAAAAGTAA

Upstream 100 bases:

>100_bases
AAAAAAATTAAAAATAATCCCAAATTCAAAACAGATTTACATTCAGGCGCTAACCCATAAAAGTTATAATTTTATTAATC
CTGATAAACCACATTATGAA

Downstream 100 bases:

>100_bases
AATTAGTTTTTAAAAATAAATTTTAAAAATAAATTCATTAATTTTTTAGTTTTTGATTGATATTAGTAACAATAAAAATT
AAAATATTGCCTAATTTAGA

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 183; Mature: 183

Protein sequence:

>183_residues
MLEFLGDSVINYAVSKVIYDNFYKNEGNSTQIRSLLTSTSSLANATKKVGLMNYVLLGRGASEIRENNKLKADIFESFCA
AILLDQGFEKLNEFLSEYLYKDVNFDTEKQYKDPKSIFQEKIQTFSTSNKIHYLHTKLVDGTFRVDLIWEKKKYGIGYGR
SIKEAEFAAATNALNIFAETEEK

Sequences:

>Translated_183_residues
MLEFLGDSVINYAVSKVIYDNFYKNEGNSTQIRSLLTSTSSLANATKKVGLMNYVLLGRGASEIRENNKLKADIFESFCA
AILLDQGFEKLNEFLSEYLYKDVNFDTEKQYKDPKSIFQEKIQTFSTSNKIHYLHTKLVDGTFRVDLIWEKKKYGIGYGR
SIKEAEFAAATNALNIFAETEEK
>Mature_183_residues
MLEFLGDSVINYAVSKVIYDNFYKNEGNSTQIRSLLTSTSSLANATKKVGLMNYVLLGRGASEIRENNKLKADIFESFCA
AILLDQGFEKLNEFLSEYLYKDVNFDTEKQYKDPKSIFQEKIQTFSTSNKIHYLHTKLVDGTFRVDLIWEKKKYGIGYGR
SIKEAEFAAATNALNIFAETEEK

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030236, Length=187, Percent_Identity=27.807486631016, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI155030234, Length=187, Percent_Identity=27.807486631016, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17137682, Length=184, Percent_Identity=27.1739130434783, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 20908; Mature: 20908

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: PS50137 DS_RBD ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEFLGDSVINYAVSKVIYDNFYKNEGNSTQIRSLLTSTSSLANATKKVGLMNYVLLGRG
CCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
ASEIRENNKLKADIFESFCAAILLDQGFEKLNEFLSEYLYKDVNFDTEKQYKDPKSIFQE
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCHHHHHHH
KIQTFSTSNKIHYLHTKLVDGTFRVDLIWEKKKYGIGYGRSIKEAEFAAATNALNIFAET
HHHHHCCCCCEEEEEHHHCCCEEEEEEEEECHHHCCCCCCCCHHHHHHHHHHHHHEEECC
EEK
CCC
>Mature Secondary Structure
MLEFLGDSVINYAVSKVIYDNFYKNEGNSTQIRSLLTSTSSLANATKKVGLMNYVLLGRG
CCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
ASEIRENNKLKADIFESFCAAILLDQGFEKLNEFLSEYLYKDVNFDTEKQYKDPKSIFQE
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCHHHHHHH
KIQTFSTSNKIHYLHTKLVDGTFRVDLIWEKKKYGIGYGRSIKEAEFAAATNALNIFAET
HHHHHCCCCCEEEEEHHHCCCEEEEEEEEECHHHCCCCCCCCHHHHHHHHHHHHHEEECC
EEK
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA