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The map label for this gene is pth

Identifier: 54020384

GI number: 54020384

Start: 216190

End: 216744

Strand: Reverse

Name: pth

Synonym: mhp177

Alternate gene names: 54020384

Gene position: 216744-216190 (Counterclockwise)

Preceding gene: 54020385

Following gene: 54020383

Centisome position: 24.28

GC content: 32.07

Gene sequence:

>555_bases
ATGAAACTAATTGTCGGCCTTGGTAATCCCGGGGAGAAATATGCTAAAACCAAACATAATGTCGGCTATTGAGTTCTCGA
TTTACTAGCGGAAAAATTAGCTCTTAGTTTTGATCAGAAAACCGAAAATGGAATTTATGTAAAACAGCCCGATTTTATTC
TAGCAAAACCGACAACTTTTATGAATAAGTCCGGCGATTTTGTCGAGGAATTAATTAAATTTTATAAAATTAATACTCAA
GATTTAATGATTATCTATGATGATATGAATTTTGAGGTCGGCCAGGCAGCAATCAAAACAACCGGCAGTGCCGGTGGTCA
ACGCGGTATGGCCCATATTATCGAAAAATGCAAAACAAAAGAAATTAAAAGGCTAAAAATTGGTATTTCTCGGGGCGAAA
ATGCAAAGGAATATGTTTTATCACCCTTTTTACCTAAAGATAATGCAAAAATTAAACTTGTAATTGAAGAAGCAGCTAAT
ATTCTGATTTTTTATTTATCTAATAGTTTTATTACAACAATCGAAAAATTTAATGCAAATAAAAATAAAGTCTAA

Upstream 100 bases:

>100_bases
TGATGATATAATAAATTTTTTGCGTGATGATGAAGTAATTAGCCTTCCAATTTGACTCCAAAAATAAAAAAATAATATAA
AAACAAAGGTAAATTTAGAA

Downstream 100 bases:

>100_bases
AGAAAAATATTTAATAGGTGTCTCAGGTGGCTCTGATTCAATGTTTTTGCTCAATAAATATAAAAATCAGGATGTAATTG
TAGCTCATATAAATTACAAT

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH [H]

Number of amino acids: Translated: 184; Mature: 184

Protein sequence:

>184_residues
MKLIVGLGNPGEKYAKTKHNVGYWVLDLLAEKLALSFDQKTENGIYVKQPDFILAKPTTFMNKSGDFVEELIKFYKINTQ
DLMIIYDDMNFEVGQAAIKTTGSAGGQRGMAHIIEKCKTKEIKRLKIGISRGENAKEYVLSPFLPKDNAKIKLVIEEAAN
ILIFYLSNSFITTIEKFNANKNKV

Sequences:

>Translated_184_residues
MKLIVGLGNPGEKYAKTKHNVGY*VLDLLAEKLALSFDQKTENGIYVKQPDFILAKPTTFMNKSGDFVEELIKFYKINTQ
DLMIIYDDMNFEVGQAAIKTTGSAGGQRGMAHIIEKCKTKEIKRLKIGISRGENAKEYVLSPFLPKDNAKIKLVIEEAAN
ILIFYLSNSFITTIEKFNANKNKV
>Mature_184_residues
MKLIVGLGNPGEKYAKTKHNVGY*VLDLLAEKLALSFDQKTENGIYVKQPDFILAKPTTFMNKSGDFVEELIKFYKINTQ
DLMIIYDDMNFEVGQAAIKTTGSAGGQRGMAHIIEKCKTKEIKRLKIGISRGENAKEYVLSPFLPKDNAKIKLVIEEAAN
ILIFYLSNSFITTIEKFNANKNKV

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis [H]

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family [H]

Homologues:

Organism=Homo sapiens, GI50897284, Length=174, Percent_Identity=24.7126436781609, Blast_Score=76, Evalue=2e-14,
Organism=Escherichia coli, GI1787455, Length=190, Percent_Identity=32.6315789473684, Blast_Score=83, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001328
- InterPro:   IPR018171 [H]

Pfam domain/function: PF01195 Pept_tRNA_hydro [H]

EC number: =3.1.1.29 [H]

Molecular weight: Translated: 20540; Mature: 20540

Theoretical pI: Translated: 9.75; Mature: 9.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLIVGLGNPGEKYAKTKHNVGYVLDLLAEKLALSFDQKTENGIYVKQPDFILAKPTTFM
CEEEEECCCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCCEEEECCCHHC
NKSGDFVEELIKFYKINTQDLMIIYDDMNFEVGQAAIKTTGSAGGQRGMAHIIEKCKTKE
CCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHH
IKRLKIGISRGENAKEYVLSPFLPKDNAKIKLVIEEAANILIFYLSNSFITTIEKFNANK
HHEEEEECCCCCCCHHHEECCCCCCCCCEEEEEEECCCCEEEEEECCCHHHHHHHHCCCC
NKV
CCC
>Mature Secondary Structure
MKLIVGLGNPGEKYAKTKHNVGYVLDLLAEKLALSFDQKTENGIYVKQPDFILAKPTTFM
CEEEEECCCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCCEEEECCCHHC
NKSGDFVEELIKFYKINTQDLMIIYDDMNFEVGQAAIKTTGSAGGQRGMAHIIEKCKTKE
CCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHH
IKRLKIGISRGENAKEYVLSPFLPKDNAKIKLVIEEAANILIFYLSNSFITTIEKFNANK
HHEEEEECCCCCCCHHHEECCCCCCCCCEEEEEEECCCCEEEEEECCCHHHHHHHHCCCC
NKV
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA