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The map label for this gene is serS

Identifier: 54020355

GI number: 54020355

Start: 148330

End: 149571

Strand: Reverse

Name: serS

Synonym: mhp128

Alternate gene names: 54020355

Gene position: 149571-148330 (Counterclockwise)

Preceding gene: 54020356

Following gene: 54020354

Centisome position: 16.75

GC content: 31.4

Gene sequence:

>1242_bases
ATGAATATTCGTTTAATTTTGAATAATAAATCCTTTGTTGAAAAAAAACTCGCAACCCGTGGTTTTGATATTTCAATAAT
TAACGAATTATATATAAAAGGTCAAAAAAGAAATATTTTACGTCAGAAAATTGATGCCTTATTAGCAAAAAAAAACTTAA
TTAGTAAAGAAATTGGAGCTTTTTCAAGACAAGAAAAGGATTCAAGTTTTCTTAAAAGCCAAGTTAGTAAAATAAAAACT
GAGATCGAAACCCTTGAAGCTGAATGATATCAGCTTGATACTTGATTAAATCAAAAAATTTTAGAAATTCCAAATTTACC
CGATGATTCAGTGCCTTTTGGAACTTCAGAACTTGATAATCAAGTAATTTCACATTGAGGAATTCCAAAAAAATTTGATC
AAAAATGTAAACCACATTATGAATTCGGGATTTCTAATAAAATTTTAGACTTTAAGCGAGCAGTAAAAATTTCCGGTAAT
CGCTTTGTAATTTATAAAAATCTTGGAGCTAAATTAGTAAGGTCCTTGATTAATTTTATGATTGATACTCATATTGCAAA
CGATTATCAGGAAATTATCCCAAATACTTTAATTCTCTCGGAATCACTTTATGGTACTGGCCAACTTCCGAAATTTCATA
ATGATTTATACCCATTAAAGGATCCAAATCGCTGGCTAATTCCGACTGCTGAGGTTCCGTTGACTAATTATTTTCGTGAA
GAAATAATTGATTTAGCAAAACCAATTTCACTTGTTGGTTATAGTAAATGTTATCGTTCCGAGGCTGGAAGCGGAGGCAG
AGACACAAAAGGACTAATTCGCCTTCATGAATTTCATAAGGTTGAACTAGTAAAAATCACAAAAGAAGCAGATGGTTTAA
CTGAATTTGAAAATGTAGTAAAGGATGCTTCGCGAATTTTAAAATTACTGGAAATCCCATTTCGTGTTGTAGTTTTATCA
ACTTATGATTTAGGATTTTCATCAAAAAAAACAGTTGATCTTGAAGCCTGACTACCATCAGAAAATACCTATCGAGAAGT
ATCATCAATTAGTTATTGCGGCGATTTTCAAGCAAGAAGAGCAAAAATTCGTTATCGTGATGGTAAAAATAACCATTATG
CGCACACAATTAATGGTTCTGGCTTGGCAATTGATCGTCTCGTCGCGATTTTATTAGAACAATATCAAAATTTAGATGGT
TCCTGAACGGTGCCAAAAGTTTTAGAACCTTATTTTCGCTAA

Upstream 100 bases:

>100_bases
ATAACCGACTTTTAGTAATCGAGGAATATCTAAATTCTTATGCAAAAGCCGATTATATTGGTAGGGAAGTTTTTTATAAC
TTAAAAAAATAGTCTAAATT

Downstream 100 bases:

>100_bases
TTAGCTCTTATTTTACAAAATTAAAGGACATTATATCATAAATAAATTTTTAAATTACAGAAAAGAATTTAAAATTTATT
TATTTATTTATTTTAAGTTT

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 413; Mature: 413

Protein sequence:

>413_residues
MNIRLILNNKSFVEKKLATRGFDISIINELYIKGQKRNILRQKIDALLAKKNLISKEIGAFSRQEKDSSFLKSQVSKIKT
EIETLEAEWYQLDTWLNQKILEIPNLPDDSVPFGTSELDNQVISHWGIPKKFDQKCKPHYEFGISNKILDFKRAVKISGN
RFVIYKNLGAKLVRSLINFMIDTHIANDYQEIIPNTLILSESLYGTGQLPKFHNDLYPLKDPNRWLIPTAEVPLTNYFRE
EIIDLAKPISLVGYSKCYRSEAGSGGRDTKGLIRLHEFHKVELVKITKEADGLTEFENVVKDASRILKLLEIPFRVVVLS
TYDLGFSSKKTVDLEAWLPSENTYREVSSISYCGDFQARRAKIRYRDGKNNHYAHTINGSGLAIDRLVAILLEQYQNLDG
SWTVPKVLEPYFR

Sequences:

>Translated_413_residues
MNIRLILNNKSFVEKKLATRGFDISIINELYIKGQKRNILRQKIDALLAKKNLISKEIGAFSRQEKDSSFLKSQVSKIKT
EIETLEAE*YQLDT*LNQKILEIPNLPDDSVPFGTSELDNQVISH*GIPKKFDQKCKPHYEFGISNKILDFKRAVKISGN
RFVIYKNLGAKLVRSLINFMIDTHIANDYQEIIPNTLILSESLYGTGQLPKFHNDLYPLKDPNRWLIPTAEVPLTNYFRE
EIIDLAKPISLVGYSKCYRSEAGSGGRDTKGLIRLHEFHKVELVKITKEADGLTEFENVVKDASRILKLLEIPFRVVVLS
TYDLGFSSKKTVDLEA*LPSENTYREVSSISYCGDFQARRAKIRYRDGKNNHYAHTINGSGLAIDRLVAILLEQYQNLDG
S*TVPKVLEPYFR
>Mature_413_residues
MNIRLILNNKSFVEKKLATRGFDISIINELYIKGQKRNILRQKIDALLAKKNLISKEIGAFSRQEKDSSFLKSQVSKIKT
EIETLEAE*YQLDT*LNQKILEIPNLPDDSVPFGTSELDNQVISH*GIPKKFDQKCKPHYEFGISNKILDFKRAVKISGN
RFVIYKNLGAKLVRSLINFMIDTHIANDYQEIIPNTLILSESLYGTGQLPKFHNDLYPLKDPNRWLIPTAEVPLTNYFRE
EIIDLAKPISLVGYSKCYRSEAGSGGRDTKGLIRLHEFHKVELVKITKEADGLTEFENVVKDASRILKLLEIPFRVVVLS
TYDLGFSSKKTVDLEA*LPSENTYREVSSISYCGDFQARRAKIRYRDGKNNHYAHTINGSGLAIDRLVAILLEQYQNLDG
S*TVPKVLEPYFR

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI8923421, Length=400, Percent_Identity=29.25, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI16306548, Length=367, Percent_Identity=29.700272479564, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI225579074, Length=323, Percent_Identity=30.6501547987616, Blast_Score=139, Evalue=5e-33,
Organism=Escherichia coli, GI1787120, Length=421, Percent_Identity=43.4679334916865, Blast_Score=318, Evalue=6e-88,
Organism=Caenorhabditis elegans, GI17539260, Length=332, Percent_Identity=28.0120481927711, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17542084, Length=325, Percent_Identity=28.9230769230769, Blast_Score=117, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6320226, Length=421, Percent_Identity=29.9287410926366, Blast_Score=181, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6321799, Length=405, Percent_Identity=29.1358024691358, Blast_Score=171, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24581334, Length=450, Percent_Identity=27.1111111111111, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI17737985, Length=355, Percent_Identity=29.8591549295775, Blast_Score=122, Evalue=4e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 46472; Mature: 46472

Theoretical pI: Translated: 9.51; Mature: 9.51

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIRLILNNKSFVEKKLATRGFDISIINELYIKGQKRNILRQKIDALLAKKNLISKEIGA
CEEEEEECCHHHHHHHHHHCCCCCEEHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
FSRQEKDSSFLKSQVSKIKTEIETLEAEYQLDTLNQKILEIPNLPDDSVPFGTSELDNQV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHH
ISHGIPKKFDQKCKPHYEFGISNKILDFKRAVKISGNRFVIYKNLGAKLVRSLINFMIDT
HHCCCCHHHHHHCCCCCCCCCCCHHHHHHHHEEECCCEEEEEECHHHHHHHHHHHHHHHH
HIANDYQEIIPNTLILSESLYGTGQLPKFHNDLYPLKDPNRWLIPTAEVPLTNYFREEII
HHHHHHHHHCCCCEEEECCCCCCCCCCCHHCCCCCCCCCCCEEECCCCCCHHHHHHHHHH
DLAKPISLVGYSKCYRSEAGSGGRDTKGLIRLHEFHKVELVKITKEADGLTEFENVVKDA
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCEEEEEEEECCCCCHHHHHHHHHHH
SRILKLLEIPFRVVVLSTYDLGFSSKKTVDLEALPSENTYREVSSISYCGDFQARRAKIR
HHHHHHHHCCEEEEEEEEECCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCHHHHCEEE
YRDGKNNHYAHTINGSGLAIDRLVAILLEQYQNLDGSTVPKVLEPYFR
EECCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCC
>Mature Secondary Structure
MNIRLILNNKSFVEKKLATRGFDISIINELYIKGQKRNILRQKIDALLAKKNLISKEIGA
CEEEEEECCHHHHHHHHHHCCCCCEEHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
FSRQEKDSSFLKSQVSKIKTEIETLEAEYQLDTLNQKILEIPNLPDDSVPFGTSELDNQV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHH
ISHGIPKKFDQKCKPHYEFGISNKILDFKRAVKISGNRFVIYKNLGAKLVRSLINFMIDT
HHCCCCHHHHHHCCCCCCCCCCCHHHHHHHHEEECCCEEEEEECHHHHHHHHHHHHHHHH
HIANDYQEIIPNTLILSESLYGTGQLPKFHNDLYPLKDPNRWLIPTAEVPLTNYFREEII
HHHHHHHHHCCCCEEEECCCCCCCCCCCHHCCCCCCCCCCCEEECCCCCCHHHHHHHHHH
DLAKPISLVGYSKCYRSEAGSGGRDTKGLIRLHEFHKVELVKITKEADGLTEFENVVKDA
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCEEEEEEEECCCCCHHHHHHHHHHH
SRILKLLEIPFRVVVLSTYDLGFSSKKTVDLEALPSENTYREVSSISYCGDFQARRAKIR
HHHHHHHHCCEEEEEEEEECCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCHHHHCEEE
YRDGKNNHYAHTINGSGLAIDRLVAILLEQYQNLDGSTVPKVLEPYFR
EECCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA