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The map label for this gene is dnaX

Identifier: 54020353

GI number: 54020353

Start: 143240

End: 145420

Strand: Reverse

Name: dnaX

Synonym: mhp123

Alternate gene names: 54020353

Gene position: 145420-143240 (Counterclockwise)

Preceding gene: 54020354

Following gene: 54020352

Centisome position: 16.29

GC content: 26.27

Gene sequence:

>2181_bases
TTGAAAGGGGTTTTTGTGGAAATAAGAAAAGATTATATTGCCTTCTATCGAAAATATCGGCCAAAAAAATTTTCTGATAT
TGTCGGTCAAAAATTTTTGCTTGAAAGTTTAAAAAACATCATCAAATCAGGTAATTTTTTTCATGCCTACCTTTTTTCAG
GACCTCATGGCACTGGAAAGACAACTGTTGCAAAAATTTTTGCAAACGCTATAAATTGCACCCACAAAACGGATTTAATT
GAACCTTGTCAAAACTGCATTAAAAATTTTAATAATTCACTTGATATTATTGAAATGGATGCCGCATCGCATAATGGCGT
GAAGGAAATTAGAGAAATTATCGAAAATTCAATCAATTTTCCCCAAATTAGCCCCTATAAAATTTATATTTTAGATGAAG
TTCATATGCTTTCAACTTCTGCTTTTAATGCTTTTTTAAAAACCTTAGAAGAACCACCAAAACATATGATTTTTATTCTA
GCAACAACAGAAGTCCACAAAATTCCTTTAACAATTCTCTCCCGTGTCCAAAGATATAATTTTCTAGCACTAAAAGAAGA
CGAAATTTGTCACCGATTAGAATTTATTCTTGAAAAAGAAAAAATAAAATACGAAAAAAATGCTTTAAAATCAGTCTTTT
TATTAAGTCAGGGTAGTCTTCGCGATGCAATTTCAATTCTAGAGCAAGTAGCAACATTTGGGTCAGGGTATGTTAATCAG
AAAAATATTAATGAACTTTTTGGTCTAGTAAATAAGGAAATTCTTGTCAATTTTGTTAATGCCTTATTTTTAGCTGATTC
TAAAATTTCTTATGAAATTTTAGAACAAATTTCATTTCAAAGTAAAAATTTCCAATTATTTTTAGAATCATTAATTAACC
TTGTAAAAGAATGAATTATTTGAAAGTCAACCAAAACAAATGAACTACTTGAATTTTATAGCAATTTTGATTTAGAAAAT
CTAAAAATAAGCCAGGATTTTGCTTTTAAATTTTTAGAAATTGCATTTTCAAGTCTAAAAGATATAAATTTTGCTGATTT
TCAAAATTTAACTCTTGAAATTTTTATTATGCGCATATTATCGCTAAGTAATTTAGAAATTAGTGATCAAAATAATATTA
AATTTAAAAAAATAGAGGAAAATAAAGTCGATAAAATTGATATCCCCGAAAAAATTACGGAGAAAGTTAGCGAGAAAGTT
AGTGAGATTAAGTCTACCCCTACTAATTTTTATAAAATTGAGGATCGACTTGAAAAGTTAGGAAAATTTGATCTAAAAAA
TTTAGAAGAAGATATGCAAATAAAGCAAAATAAAAATTATTCATCAATTTTTAATCGAAAATTAGAACAAAATTTGGAAA
GACCACCTTTAAAAACAGAGGTTTTTTCCAAATCAACAACTGAATTTAACCAATTTGGACAAATAGGTAATCCATTTATT
GAAACTGAAAATCATAAAAAAATTGAAAATCAAAATCTGAAAAATAATGGTGAATTTGATGGTGAAATTGATTTTTCTAA
TTCTTTTATGCCTGAAAATGGTAATAAAATTGATGAAAATATAAATTCTGTGTCTGATTTTAGTGATATTTCGGCTAATT
TATCAGAAGATAAGACAAATTTTGCCCAATCCTTTAATAACAAGGATACTAATTTAATAAATTTAGATACAAATTTTGGT
AATAATTCTAGTAAATTTTTAAAAAAAATTGGTTCAAAAGACTATTTGAGTGCTGAAGAAGTTTTGAATTTTATATTATT
AGCTAAAAATTTTCATAGTCAAAATCAGGTGGAATATGAAAATTTAGTTCAAAATTGAAGAAAAAATTTGCCACTTTTCG
AGTATAATGTTGAATTTATGGAAATTGTTAGCGTTTTAAAATATGCTAAAATTCTCTCATTAGGTGCAAATTTTGTTTTT
TTTATGGCCGCTCGTGATGAATATGAAGATTTATTAATTGAAACTATAAAGGAAAAATATCAAGTCAATGAGTTATTATT
ACAAATTTTTAACGTGGAAATGCATCCATTAGTTGCAAGCAAAAACCTTATTAATAAAACTAAAATTTTGCTTAACAAAA
TGCGGAATGACGGTAAACGAATTGTTGCAAAACCTTTTGAAATCCCCAAAAAAACGACTATTTCAAAGGAGGATTTGGAA
AAACTTTTTTTTGATAAGTAA

Upstream 100 bases:

>100_bases
TCCTTTTATTTATAAAATTAATGTTTTTATTTTATTATAATTTATAATTATAAACTATTAAAGAATTAATTTTATTTATA
ATTAAATTTATTTTATAATT

Downstream 100 bases:

>100_bases
AATTTCTAATAAATCTAATAAATTTATATAATTTATTTTGTAATTTTTAAAATTATCGAAAGGACCAATTATGAATTTTC
AAAAATTATTAAAACAAGCA

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 726; Mature: 726

Protein sequence:

>726_residues
MKGVFVEIRKDYIAFYRKYRPKKFSDIVGQKFLLESLKNIIKSGNFFHAYLFSGPHGTGKTTVAKIFANAINCTHKTDLI
EPCQNCIKNFNNSLDIIEMDAASHNGVKEIREIIENSINFPQISPYKIYILDEVHMLSTSAFNAFLKTLEEPPKHMIFIL
ATTEVHKIPLTILSRVQRYNFLALKEDEICHRLEFILEKEKIKYEKNALKSVFLLSQGSLRDAISILEQVATFGSGYVNQ
KNINELFGLVNKEILVNFVNALFLADSKISYEILEQISFQSKNFQLFLESLINLVKEWIIWKSTKTNELLEFYSNFDLEN
LKISQDFAFKFLEIAFSSLKDINFADFQNLTLEIFIMRILSLSNLEISDQNNIKFKKIEENKVDKIDIPEKITEKVSEKV
SEIKSTPTNFYKIEDRLEKLGKFDLKNLEEDMQIKQNKNYSSIFNRKLEQNLERPPLKTEVFSKSTTEFNQFGQIGNPFI
ETENHKKIENQNLKNNGEFDGEIDFSNSFMPENGNKIDENINSVSDFSDISANLSEDKTNFAQSFNNKDTNLINLDTNFG
NNSSKFLKKIGSKDYLSAEEVLNFILLAKNFHSQNQVEYENLVQNWRKNLPLFEYNVEFMEIVSVLKYAKILSLGANFVF
FMAARDEYEDLLIETIKEKYQVNELLLQIFNVEMHPLVASKNLINKTKILLNKMRNDGKRIVAKPFEIPKKTTISKEDLE
KLFFDK

Sequences:

>Translated_726_residues
MKGVFVEIRKDYIAFYRKYRPKKFSDIVGQKFLLESLKNIIKSGNFFHAYLFSGPHGTGKTTVAKIFANAINCTHKTDLI
EPCQNCIKNFNNSLDIIEMDAASHNGVKEIREIIENSINFPQISPYKIYILDEVHMLSTSAFNAFLKTLEEPPKHMIFIL
ATTEVHKIPLTILSRVQRYNFLALKEDEICHRLEFILEKEKIKYEKNALKSVFLLSQGSLRDAISILEQVATFGSGYVNQ
KNINELFGLVNKEILVNFVNALFLADSKISYEILEQISFQSKNFQLFLESLINLVKE*II*KSTKTNELLEFYSNFDLEN
LKISQDFAFKFLEIAFSSLKDINFADFQNLTLEIFIMRILSLSNLEISDQNNIKFKKIEENKVDKIDIPEKITEKVSEKV
SEIKSTPTNFYKIEDRLEKLGKFDLKNLEEDMQIKQNKNYSSIFNRKLEQNLERPPLKTEVFSKSTTEFNQFGQIGNPFI
ETENHKKIENQNLKNNGEFDGEIDFSNSFMPENGNKIDENINSVSDFSDISANLSEDKTNFAQSFNNKDTNLINLDTNFG
NNSSKFLKKIGSKDYLSAEEVLNFILLAKNFHSQNQVEYENLVQN*RKNLPLFEYNVEFMEIVSVLKYAKILSLGANFVF
FMAARDEYEDLLIETIKEKYQVNELLLQIFNVEMHPLVASKNLINKTKILLNKMRNDGKRIVAKPFEIPKKTTISKEDLE
KLFFDK
>Mature_726_residues
MKGVFVEIRKDYIAFYRKYRPKKFSDIVGQKFLLESLKNIIKSGNFFHAYLFSGPHGTGKTTVAKIFANAINCTHKTDLI
EPCQNCIKNFNNSLDIIEMDAASHNGVKEIREIIENSINFPQISPYKIYILDEVHMLSTSAFNAFLKTLEEPPKHMIFIL
ATTEVHKIPLTILSRVQRYNFLALKEDEICHRLEFILEKEKIKYEKNALKSVFLLSQGSLRDAISILEQVATFGSGYVNQ
KNINELFGLVNKEILVNFVNALFLADSKISYEILEQISFQSKNFQLFLESLINLVKE*II*KSTKTNELLEFYSNFDLEN
LKISQDFAFKFLEIAFSSLKDINFADFQNLTLEIFIMRILSLSNLEISDQNNIKFKKIEENKVDKIDIPEKITEKVSEKV
SEIKSTPTNFYKIEDRLEKLGKFDLKNLEEDMQIKQNKNYSSIFNRKLEQNLERPPLKTEVFSKSTTEFNQFGQIGNPFI
ETENHKKIENQNLKNNGEFDGEIDFSNSFMPENGNKIDENINSVSDFSDISANLSEDKTNFAQSFNNKDTNLINLDTNFG
NNSSKFLKKIGSKDYLSAEEVLNFILLAKNFHSQNQVEYENLVQN*RKNLPLFEYNVEFMEIVSVLKYAKILSLGANFVF
FMAARDEYEDLLIETIKEKYQVNELLLQIFNVEMHPLVASKNLINKTKILLNKMRNDGKRIVAKPFEIPKKTTISKEDLE
KLFFDK

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI31563534, Length=258, Percent_Identity=29.4573643410853, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI4506491, Length=280, Percent_Identity=27.8571428571429, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI31881687, Length=280, Percent_Identity=27.8571428571429, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI6677723, Length=262, Percent_Identity=25.5725190839695, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI194306571, Length=257, Percent_Identity=26.0700389105058, Blast_Score=86, Evalue=2e-16,
Organism=Homo sapiens, GI194306567, Length=257, Percent_Identity=26.0700389105058, Blast_Score=86, Evalue=2e-16,
Organism=Escherichia coli, GI1786676, Length=358, Percent_Identity=32.4022346368715, Blast_Score=226, Evalue=4e-60,
Organism=Escherichia coli, GI1787119, Length=225, Percent_Identity=28, Blast_Score=74, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17541988, Length=325, Percent_Identity=25.8461538461538, Blast_Score=93, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI71986063, Length=233, Percent_Identity=26.6094420600858, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17554730, Length=269, Percent_Identity=26.7657992565056, Blast_Score=89, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6322528, Length=264, Percent_Identity=30.6818181818182, Blast_Score=108, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6324039, Length=223, Percent_Identity=28.2511210762332, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6324478, Length=235, Percent_Identity=28.0851063829787, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI18859927, Length=314, Percent_Identity=27.0700636942675, Blast_Score=110, Evalue=3e-24,
Organism=Drosophila melanogaster, GI19921076, Length=258, Percent_Identity=24.8062015503876, Blast_Score=85, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17647857, Length=273, Percent_Identity=24.1758241758242, Blast_Score=82, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 83767; Mature: 83767

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGVFVEIRKDYIAFYRKYRPKKFSDIVGQKFLLESLKNIIKSGNFFHAYLFSGPHGTGK
CCCEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCH
TTVAKIFANAINCTHKTDLIEPCQNCIKNFNNSLDIIEMDAASHNGVKEIREIIENSINF
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHCCCCC
PQISPYKIYILDEVHMLSTSAFNAFLKTLEEPPKHMIFILATTEVHKIPLTILSRVQRYN
CCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHHHCC
FLALKEDEICHRLEFILEKEKIKYEKNALKSVFLLSQGSLRDAISILEQVATFGSGYVNQ
EEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCC
KNINELFGLVNKEILVNFVNALFLADSKISYEILEQISFQSKNFQLFLESLINLVKEIIK
CHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
STKTNELLEFYSNFDLENLKISQDFAFKFLEIAFSSLKDINFADFQNLTLEIFIMRILSL
CCCHHHHHHHHHCCCCCCEEECHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
SNLEISDQNNIKFKKIEENKVDKIDIPEKITEKVSEKVSEIKSTPTNFYKIEDRLEKLGK
CCCEECCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCC
FDLKNLEEDMQIKQNKNYSSIFNRKLEQNLERPPLKTEVFSKSTTEFNQFGQIGNPFIET
CCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHCCCHHHHHHHCCCCCCCCCC
ENHKKIENQNLKNNGEFDGEIDFSNSFMPENGNKIDENINSVSDFSDISANLSEDKTNFA
CCCCHHCCCCCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHH
QSFNNKDTNLINLDTNFGNNSSKFLKKIGSKDYLSAEEVLNFILLAKNFHSQNQVEYENL
HHCCCCCCEEEEEECCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHH
VQNRKNLPLFEYNVEFMEIVSVLKYAKILSLGANFVFFMAARDEYEDLLIETIKEKYQVN
HHCCCCCCEEEECHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHH
ELLLQIFNVEMHPLVASKNLINKTKILLNKMRNDGKRIVAKPFEIPKKTTISKEDLEKLF
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCHHHHHHHH
FDK
CCC
>Mature Secondary Structure
MKGVFVEIRKDYIAFYRKYRPKKFSDIVGQKFLLESLKNIIKSGNFFHAYLFSGPHGTGK
CCCEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCH
TTVAKIFANAINCTHKTDLIEPCQNCIKNFNNSLDIIEMDAASHNGVKEIREIIENSINF
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHCCCCC
PQISPYKIYILDEVHMLSTSAFNAFLKTLEEPPKHMIFILATTEVHKIPLTILSRVQRYN
CCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHHHCC
FLALKEDEICHRLEFILEKEKIKYEKNALKSVFLLSQGSLRDAISILEQVATFGSGYVNQ
EEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCC
KNINELFGLVNKEILVNFVNALFLADSKISYEILEQISFQSKNFQLFLESLINLVKEIIK
CHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
STKTNELLEFYSNFDLENLKISQDFAFKFLEIAFSSLKDINFADFQNLTLEIFIMRILSL
CCCHHHHHHHHHCCCCCCEEECHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
SNLEISDQNNIKFKKIEENKVDKIDIPEKITEKVSEKVSEIKSTPTNFYKIEDRLEKLGK
CCCEECCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCC
FDLKNLEEDMQIKQNKNYSSIFNRKLEQNLERPPLKTEVFSKSTTEFNQFGQIGNPFIET
CCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHCCCHHHHHHHCCCCCCCCCC
ENHKKIENQNLKNNGEFDGEIDFSNSFMPENGNKIDENINSVSDFSDISANLSEDKTNFA
CCCCHHCCCCCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHH
QSFNNKDTNLINLDTNFGNNSSKFLKKIGSKDYLSAEEVLNFILLAKNFHSQNQVEYENL
HHCCCCCCEEEEEECCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHH
VQNRKNLPLFEYNVEFMEIVSVLKYAKILSLGANFVFFMAARDEYEDLLIETIKEKYQVN
HHCCCCCCEEEECHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHH
ELLLQIFNVEMHPLVASKNLINKTKILLNKMRNDGKRIVAKPFEIPKKTTISKEDLEKLF
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCHHHHHHHH
FDK
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2124672; 7584024; 9384377; 2452406; 2468993; 1698458 [H]