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The map label for this gene is pepP

Identifier: 54020295

GI number: 54020295

Start: 856234

End: 857271

Strand: Direct

Name: pepP

Synonym: mhp680

Alternate gene names: 54020295

Gene position: 856234-857271 (Clockwise)

Preceding gene: 54020294

Following gene: 54020296

Centisome position: 95.91

GC content: 33.62

Gene sequence:

>1038_bases
ATGAACCGCAAATATTTAGAAAAAGCGTTTTTTGATAACCATTTAGATGTAATTATTTCTTTTTCATTCCAAAGTCGACT
CTGACTAACGAAAATTGCGGCCTCCGATGGAATTTTATTTATTGAAAAAGATCAAGCTTTTTTGTTTGTTGATGGTCGTT
ATATTGAAAAAGCTGAAAAAGATGCTAAAAATTGTCAGGTTTTTTTAACTACCAAGGCAAATCTTGAAGATTTTTTCAAG
AAAAAACCGTATCAAAAAATCGGCATTGAATCTGAATATTTAACTATTGAACAATTTGATAAAATAAAAAGTTGATTTCC
AAATGCCGATTTTGTTAAGTTACAAGCCCAACTTTTTCGAATTATAAAAACAGAAGAAGAAATCAAAAATATCGAAAAAG
CTGTTGAAATCTCACTCGCGGCTTATAATAAAATATTTCCGAAAATCAAACCGGGAATGACGGAGAAAAGTATCGATGTC
AACCTAAATTATCAAATGAAACTTTTAGGAGCCGAAAAAGAATCATTTGATTCAATAATTGCAACTGGATCTAATTCAGC
AATGCCGCATTGAAGGGCAAGTGAAGCCGAAATTTTAGATAATGATCTTTTAAAAATTGATTTTGGTGCGCTTTTTAACG
GTTATTGCGCTGATATTACAAGAACTTCTTATCTTGGTCAAATTAGTGAAAAAAAATTAGAAATTTTGGAAATAGTGGAA
AAAGCTGCTGAAATTGGTAGAAAAAAAGTTGCTCCTGGGGTTAAAGCCAGCGAAATTGACCTTGCTTGCCGGAATTTTAT
CACCGAACAAGGCTATGGAAAATATTTTATTCACTCAACTGGCCACGGTGTTGGTATTGATATCCATGAATTGCCAGTTG
TTAGTTCAACTAGCCAGACAATTTTAGAGCCCGGAATGGTAATAACTGTTGAACCCGGAATTTATATCCCTGGACTTGGA
GGCGCAAGAATTGAGGATGTTGTTTTAGTAACTGAAAATGGTTTTCGCACCCTGTCCCGAAAAGGTGAAAGAATTTAG

Upstream 100 bases:

>100_bases
ATTACTAAAAAAAACAAGAAAACCAAACCAGAAAAAATTGAAGTCAAAAAACACTGTCATAAATGCAACAAACACACTTT
GCATAGAGAAAAAAAGTAAA

Downstream 100 bases:

>100_bases
AATTGAATCAAAAATAAAAATTTTTTAACCTTTTAGATAAAAAAATCATTAAAAATGAAAAAAGCTAAGCGAAATTATAA
AATTTGGACACTAACTACCT

Product: XAA-Pro aminopeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MNRKYLEKAFFDNHLDVIISFSFQSRLWLTKIAASDGILFIEKDQAFLFVDGRYIEKAEKDAKNCQVFLTTKANLEDFFK
KKPYQKIGIESEYLTIEQFDKIKSWFPNADFVKLQAQLFRIIKTEEEIKNIEKAVEISLAAYNKIFPKIKPGMTEKSIDV
NLNYQMKLLGAEKESFDSIIATGSNSAMPHWRASEAEILDNDLLKIDFGALFNGYCADITRTSYLGQISEKKLEILEIVE
KAAEIGRKKVAPGVKASEIDLACRNFITEQGYGKYFIHSTGHGVGIDIHELPVVSSTSQTILEPGMVITVEPGIYIPGLG
GARIEDVVLVTENGFRTLSRKGERI

Sequences:

>Translated_345_residues
MNRKYLEKAFFDNHLDVIISFSFQSRL*LTKIAASDGILFIEKDQAFLFVDGRYIEKAEKDAKNCQVFLTTKANLEDFFK
KKPYQKIGIESEYLTIEQFDKIKS*FPNADFVKLQAQLFRIIKTEEEIKNIEKAVEISLAAYNKIFPKIKPGMTEKSIDV
NLNYQMKLLGAEKESFDSIIATGSNSAMPH*RASEAEILDNDLLKIDFGALFNGYCADITRTSYLGQISEKKLEILEIVE
KAAEIGRKKVAPGVKASEIDLACRNFITEQGYGKYFIHSTGHGVGIDIHELPVVSSTSQTILEPGMVITVEPGIYIPGLG
GARIEDVVLVTENGFRTLSRKGERI
>Mature_345_residues
MNRKYLEKAFFDNHLDVIISFSFQSRL*LTKIAASDGILFIEKDQAFLFVDGRYIEKAEKDAKNCQVFLTTKANLEDFFK
KKPYQKIGIESEYLTIEQFDKIKS*FPNADFVKLQAQLFRIIKTEEEIKNIEKAVEISLAAYNKIFPKIKPGMTEKSIDV
NLNYQMKLLGAEKESFDSIIATGSNSAMPH*RASEAEILDNDLLKIDFGALFNGYCADITRTSYLGQISEKKLEILEIVE
KAAEIGRKKVAPGVKASEIDLACRNFITEQGYGKYFIHSTGHGVGIDIHELPVVSSTSQTILEPGMVITVEPGIYIPGLG
GARIEDVVLVTENGFRTLSRKGERI

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=282, Percent_Identity=28.7234042553192, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI264681563, Length=166, Percent_Identity=36.7469879518072, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI93141226, Length=166, Percent_Identity=30.7228915662651, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI264681565, Length=161, Percent_Identity=32.9192546583851, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1788728, Length=335, Percent_Identity=37.6119402985075, Blast_Score=222, Evalue=2e-59,
Organism=Escherichia coli, GI1789275, Length=250, Percent_Identity=31.2, Blast_Score=127, Evalue=8e-31,
Organism=Escherichia coli, GI1786364, Length=204, Percent_Identity=25.4901960784314, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17508215, Length=287, Percent_Identity=25.7839721254355, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17509539, Length=164, Percent_Identity=30.4878048780488, Blast_Score=68, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6320922, Length=245, Percent_Identity=27.7551020408163, Blast_Score=97, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6323273, Length=250, Percent_Identity=24.4, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322999, Length=173, Percent_Identity=30.635838150289, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI19920384, Length=250, Percent_Identity=27.6, Blast_Score=104, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: 3.4.-.- [C]

Molecular weight: Translated: 38347; Mature: 38347

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRKYLEKAFFDNHLDVIISFSFQSRLLTKIAASDGILFIEKDQAFLFVDGRYIEKAEKD
CCHHHHHHHHCCCCEEEEEEECHHHHHHHHHHCCCCEEEEECCCEEEEECCHHHHHHHCC
AKNCQVFLTTKANLEDFFKKKPYQKIGIESEYLTIEQFDKIKSFPNADFVKLQAQLFRII
CCCCEEEEEECCCHHHHHHCCCCHHHCCCCCEEEHHHHHHHHCCCCCHHHHHHHHHHHHH
KTEEEIKNIEKAVEISLAAYNKIFPKIKPGMTEKSIDVNLNYQMKLLGAEKESFDSIIAT
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEEECCCHHHHHHEEEC
GSNSAMPHRASEAEILDNDLLKIDFGALFNGYCADITRTSYLGQISEKKLEILEIVEKAA
CCCCCCCCCCCCHHHHCCCCEEEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EIGRKKVAPGVKASEIDLACRNFITEQGYGKYFIHSTGHGVGIDIHELPVVSSTSQTILE
HHCHHHCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEHHHCCCCCCCCHHHHC
PGMVITVEPGIYIPGLGGARIEDVVLVTENGFRTLSRKGERI
CCEEEEECCCEEECCCCCCCEEEEEEEECCCCHHHHCCCCCC
>Mature Secondary Structure
MNRKYLEKAFFDNHLDVIISFSFQSRLLTKIAASDGILFIEKDQAFLFVDGRYIEKAEKD
CCHHHHHHHHCCCCEEEEEEECHHHHHHHHHHCCCCEEEEECCCEEEEECCHHHHHHHCC
AKNCQVFLTTKANLEDFFKKKPYQKIGIESEYLTIEQFDKIKSFPNADFVKLQAQLFRII
CCCCEEEEEECCCHHHHHHCCCCHHHCCCCCEEEHHHHHHHHCCCCCHHHHHHHHHHHHH
KTEEEIKNIEKAVEISLAAYNKIFPKIKPGMTEKSIDVNLNYQMKLLGAEKESFDSIIAT
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEEECCCHHHHHHEEEC
GSNSAMPHRASEAEILDNDLLKIDFGALFNGYCADITRTSYLGQISEKKLEILEIVEKAA
CCCCCCCCCCCCHHHHCCCCEEEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EIGRKKVAPGVKASEIDLACRNFITEQGYGKYFIHSTGHGVGIDIHELPVVSSTSQTILE
HHCHHHCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEHHHCCCCCCCCHHHHC
PGMVITVEPGIYIPGLGGARIEDVVLVTENGFRTLSRKGERI
CCEEEEECCCEEECCCCCCCEEEEEEEECCCCHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]