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The map label for this gene is tdk

Identifier: 54020273

GI number: 54020273

Start: 784218

End: 784772

Strand: Direct

Name: tdk

Synonym: mhp627

Alternate gene names: 54020273

Gene position: 784218-784772 (Clockwise)

Preceding gene: 54020272

Following gene: 54020274

Centisome position: 87.84

GC content: 38.38

Gene sequence:

>555_bases
ATGTACAAAAAATTTTTTGATGGGGTCATTGAAGTAATTACAGGCCCAATGTTTTCAGGGAAATCTGATGAGTTAATTAA
AAGGATAAAAATTCTAACTTATGCCGATATTAAAACTTTAGTGATAAAACCTTCAGTTGATTACCGTTTTTCCCAGTGCG
AAATCGTCTCGCGGTCAGGCTTGAAAATTCCCACTTTTTTGGCCAGAACAACACAAGAAATCCGGGATTTATTTACAAGA
GATAACTACCAAGCAATCGCAATTGATGAAATCCAATTTTTTGACGAGGAAATTGTAACATTTTTAGAACAAATCGCCGA
TAAAGGAATTCGGGTAATTGTCAGCGGCCTTGACCAAGATTTTCGCCGCAAGCCTTTTGGTAGTTTACCAAATTTAATGG
CAATCGCCGAAAATGTTACTAAATTACAAGCGGTTTGCTCACTTTGTAAACGCGCTGCAACAACGACCGCGCGTAAAGTT
CTTAATGAGGCGCAAACTTTAATTGGTGATCAAGACGAATACGAAGCGCGGTGCCGTGCTTGTCATAGTTTATAA

Upstream 100 bases:

>100_bases
CCAAAAGCACTTGGAATTCCTTATGATAAATCACTAAAATAAATACACGAAGAAAAAAATCTAATGAAAAGGGACCTAAT
TTAGGTTTAGGAGTTATTTT

Downstream 100 bases:

>100_bases
TTTTTTTTTTTTTTTTTTTTTTTTTTAGTTTTTTCACGCGTAATTATGGTATAATTATTTTTTGCATACGCAAGTGTAGT
TTAATGGTAGAACTTCAGCC

Product: thymidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 184; Mature: 184

Protein sequence:

>184_residues
MYKKFFDGVIEVITGPMFSGKSDELIKRIKILTYADIKTLVIKPSVDYRFSQCEIVSRSGLKIPTFLARTTQEIRDLFTR
DNYQAIAIDEIQFFDEEIVTFLEQIADKGIRVIVSGLDQDFRRKPFGSLPNLMAIAENVTKLQAVCSLCKRAATTTARKV
LNEAQTLIGDQDEYEARCRACHSL

Sequences:

>Translated_184_residues
MYKKFFDGVIEVITGPMFSGKSDELIKRIKILTYADIKTLVIKPSVDYRFSQCEIVSRSGLKIPTFLARTTQEIRDLFTR
DNYQAIAIDEIQFFDEEIVTFLEQIADKGIRVIVSGLDQDFRRKPFGSLPNLMAIAENVTKLQAVCSLCKRAATTTARKV
LNEAQTLIGDQDEYEARCRACHSL
>Mature_184_residues
MYKKFFDGVIEVITGPMFSGKSDELIKRIKILTYADIKTLVIKPSVDYRFSQCEIVSRSGLKIPTFLARTTQEIRDLFTR
DNYQAIAIDEIQFFDEEIVTFLEQIADKGIRVIVSGLDQDFRRKPFGSLPNLMAIAENVTKLQAVCSLCKRAATTTARKV
LNEAQTLIGDQDEYEARCRACHSL

Specific function: Phosphorylates Both Thymidine And Deoxyuridine. [C]

COG id: COG1435

COG function: function code F; Thymidine kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine kinase family

Homologues:

Organism=Homo sapiens, GI164698438, Length=178, Percent_Identity=42.6966292134831, Blast_Score=119, Evalue=1e-27,
Organism=Escherichia coli, GI1787490, Length=175, Percent_Identity=28.5714285714286, Blast_Score=63, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17543396, Length=177, Percent_Identity=32.7683615819209, Blast_Score=92, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KITH_MYCH2 (Q5ZZT0)

Other databases:

- EMBL:   AE017332
- RefSeq:   YP_116135.1
- ProteinModelPortal:   Q5ZZT0
- SMR:   Q5ZZT0
- STRING:   Q5ZZT0
- GeneID:   3105612
- GenomeReviews:   AE017332_GR
- KEGG:   mhy:mhp627
- eggNOG:   COG1435
- HOGENOM:   HBG522108
- OMA:   VITGPMY
- PhylomeDB:   Q5ZZT0
- ProtClustDB:   PRK04296
- BioCyc:   MHYO295358:MHP627-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00124
- InterPro:   IPR001267
- InterPro:   IPR020633
- InterPro:   IPR020634
- PANTHER:   PTHR11441
- PIRSF:   PIRSF035805

Pfam domain/function: PF00265 TK

EC number: =2.7.1.21

Molecular weight: Translated: 20911; Mature: 20911

Theoretical pI: Translated: 7.82; Mature: 7.82

Prosite motif: PS00603 TK_CELLULAR_TYPE

Important sites: ACT_SITE 90-90

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYKKFFDGVIEVITGPMFSGKSDELIKRIKILTYADIKTLVIKPSVDYRFSQCEIVSRSG
CCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHCCC
LKIPTFLARTTQEIRDLFTRDNYQAIAIDEIQFFDEEIVTFLEQIADKGIRVIVSGLDQD
CCCHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCHH
FRRKPFGSLPNLMAIAENVTKLQAVCSLCKRAATTTARKVLNEAQTLIGDQDEYEARCRA
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
CHSL
HHCC
>Mature Secondary Structure
MYKKFFDGVIEVITGPMFSGKSDELIKRIKILTYADIKTLVIKPSVDYRFSQCEIVSRSG
CCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHCCC
LKIPTFLARTTQEIRDLFTRDNYQAIAIDEIQFFDEEIVTFLEQIADKGIRVIVSGLDQD
CCCHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCHH
FRRKPFGSLPNLMAIAENVTKLQAVCSLCKRAATTTARKVLNEAQTLIGDQDEYEARCRA
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
CHSL
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA