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The map label for this gene is adk

Identifier: 54020090

GI number: 54020090

Start: 240071

End: 240709

Strand: Direct

Name: adk

Synonym: mhp208

Alternate gene names: 54020090

Gene position: 240071-240709 (Clockwise)

Preceding gene: 54020089

Following gene: 54020091

Centisome position: 26.89

GC content: 28.95

Gene sequence:

>639_bases
ATGAAAAGCAATAAAAAAATTCTTTTTATAGGAGCTCCTGGCTCAGGTAAAGGAACTATTTCAAAAATTTTAGTTGAAAA
ATACAAGTTAGTTCATATTTCTACAGGTGATCTTTTTCGAAAAAAAATTAGTGAAGATTCCCGATTTGCAGCACAAATTC
AAAATTATTTAAGTTCAGGAAGTTATGTCCCTGATGAAATAACAAATAAATTAGTTGCTGATTTTATCAAAAAAATCCCT
AAAAATCAAGGTTATATTCTTGATGGTTATCCTCGAACGCTTCAACAGTTGGAATTTATGATCAAAAATGGCATTAATCT
AGATTGTGTTTTTTATCTAAAAATAAAAAATGAGACGATAATTTCGCGTCTTTCTCAGCGACTTTTTTGTCAAAAATGTC
AAAAATCTTATAATTTATTGCTTGCAAAACCGAAAAACGGACTAAAATGTGACCTTGATAACACCGATTTAATTACCAGA
AATGATGATCGTCCCGAAATTATCACACATCGAATTGAAAAATTCAATAATTCAGTGATTCCAATTGTTGAATTTTTCAA
AAAAAGTGGTATAATATATTATCTAGATGCCGAGCAAACCCTTGAAGAAACAGTTATAGAAATTGAAAAATGGCTATAA

Upstream 100 bases:

>100_bases
ACAAGTTCGAAAAAATTCTCCTTCTATTGATTCAAATCAGGATCTTTTATGGTAAAATTTAATTTTTAACATTTTTGATT
AAAAGAAGGCAAACTTAAAA

Downstream 100 bases:

>100_bases
TTAAAAATGAATTTGAAATAAGCCAGTTGAAAATTGCTGGCAAAATCTTGGCAGAAGTTAAGGCAAAAATTTATGACTTT
GTAAGACCAGGAATCTCTTT

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 212; Mature: 212

Protein sequence:

>212_residues
MKSNKKILFIGAPGSGKGTISKILVEKYKLVHISTGDLFRKKISEDSRFAAQIQNYLSSGSYVPDEITNKLVADFIKKIP
KNQGYILDGYPRTLQQLEFMIKNGINLDCVFYLKIKNETIISRLSQRLFCQKCQKSYNLLLAKPKNGLKCDLDNTDLITR
NDDRPEIITHRIEKFNNSVIPIVEFFKKSGIIYYLDAEQTLEETVIEIEKWL

Sequences:

>Translated_212_residues
MKSNKKILFIGAPGSGKGTISKILVEKYKLVHISTGDLFRKKISEDSRFAAQIQNYLSSGSYVPDEITNKLVADFIKKIP
KNQGYILDGYPRTLQQLEFMIKNGINLDCVFYLKIKNETIISRLSQRLFCQKCQKSYNLLLAKPKNGLKCDLDNTDLITR
NDDRPEIITHRIEKFNNSVIPIVEFFKKSGIIYYLDAEQTLEETVIEIEKWL
>Mature_212_residues
MKSNKKILFIGAPGSGKGTISKILVEKYKLVHISTGDLFRKKISEDSRFAAQIQNYLSSGSYVPDEITNKLVADFIKKIP
KNQGYILDGYPRTLQQLEFMIKNGINLDCVFYLKIKNETIISRLSQRLFCQKCQKSYNLLLAKPKNGLKCDLDNTDLITR
NDDRPEIITHRIEKFNNSVIPIVEFFKKSGIIYYLDAEQTLEETVIEIEKWL

Specific function: This small ubiquitous enzyme is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI7524346, Length=199, Percent_Identity=30.6532663316583, Blast_Score=122, Evalue=2e-28,
Organism=Homo sapiens, GI4502013, Length=199, Percent_Identity=30.6532663316583, Blast_Score=122, Evalue=2e-28,
Organism=Homo sapiens, GI19923437, Length=195, Percent_Identity=29.7435897435897, Blast_Score=118, Evalue=5e-27,
Organism=Homo sapiens, GI310110345, Length=195, Percent_Identity=28.7179487179487, Blast_Score=111, Evalue=5e-25,
Organism=Homo sapiens, GI53832003, Length=195, Percent_Identity=28.7179487179487, Blast_Score=111, Evalue=5e-25,
Organism=Homo sapiens, GI8051579, Length=195, Percent_Identity=28.7179487179487, Blast_Score=111, Evalue=5e-25,
Organism=Homo sapiens, GI53832001, Length=195, Percent_Identity=28.7179487179487, Blast_Score=111, Evalue=5e-25,
Organism=Homo sapiens, GI4502011, Length=203, Percent_Identity=28.5714285714286, Blast_Score=99, Evalue=2e-21,
Organism=Homo sapiens, GI28144899, Length=211, Percent_Identity=27.0142180094787, Blast_Score=90, Evalue=1e-18,
Organism=Homo sapiens, GI28144897, Length=211, Percent_Identity=27.0142180094787, Blast_Score=90, Evalue=1e-18,
Organism=Homo sapiens, GI7706497, Length=210, Percent_Identity=26.1904761904762, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI22749187, Length=145, Percent_Identity=28.9655172413793, Blast_Score=77, Evalue=9e-15,
Organism=Escherichia coli, GI1786680, Length=212, Percent_Identity=31.1320754716981, Blast_Score=126, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17552384, Length=209, Percent_Identity=32.5358851674641, Blast_Score=135, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17537943, Length=209, Percent_Identity=30.622009569378, Blast_Score=114, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17567503, Length=203, Percent_Identity=31.5270935960591, Blast_Score=96, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17533833, Length=208, Percent_Identity=28.8461538461538, Blast_Score=94, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17550688, Length=208, Percent_Identity=27.4038461538462, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6320432, Length=199, Percent_Identity=31.1557788944724, Blast_Score=130, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6321018, Length=198, Percent_Identity=29.7979797979798, Blast_Score=100, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6322828, Length=209, Percent_Identity=23.444976076555, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17737899, Length=197, Percent_Identity=32.994923857868, Blast_Score=134, Evalue=6e-32,
Organism=Drosophila melanogaster, GI24645822, Length=197, Percent_Identity=32.994923857868, Blast_Score=134, Evalue=6e-32,
Organism=Drosophila melanogaster, GI22026816, Length=196, Percent_Identity=32.1428571428571, Blast_Score=128, Evalue=3e-30,
Organism=Drosophila melanogaster, GI221459597, Length=210, Percent_Identity=28.0952380952381, Blast_Score=94, Evalue=5e-20,
Organism=Drosophila melanogaster, GI21356893, Length=210, Percent_Identity=28.0952380952381, Blast_Score=94, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24663208, Length=204, Percent_Identity=25.4901960784314, Blast_Score=81, Evalue=6e-16,
Organism=Drosophila melanogaster, GI17647141, Length=204, Percent_Identity=25.4901960784314, Blast_Score=81, Evalue=6e-16,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_MYCH2 (Q601J4)

Other databases:

- EMBL:   AE017332
- RefSeq:   YP_115721.1
- ProteinModelPortal:   Q601J4
- SMR:   Q601J4
- STRING:   Q601J4
- GeneID:   3105432
- GenomeReviews:   AE017332_GR
- KEGG:   mhy:mhp208
- eggNOG:   COG0563
- HOGENOM:   HBG630208
- OMA:   CGEGYHD
- ProtClustDB:   CLSK741303
- BioCyc:   MHYO295358:MHP208-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR000850
- InterPro:   IPR007862
- PANTHER:   PTHR23359
- PRINTS:   PR00094

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid; SSF57774 Adenylate_kinase_Znf_lid

EC number: =2.7.4.3

Molecular weight: Translated: 24433; Mature: 24433

Theoretical pI: Translated: 9.56; Mature: 9.56

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSNKKILFIGAPGSGKGTISKILVEKYKLVHISTGDLFRKKISEDSRFAAQIQNYLSSG
CCCCCEEEEEECCCCCCHHHHHHHHHHHHEEEEECHHHHHHHHCCCHHHHHHHHHHHHCC
SYVPDEITNKLVADFIKKIPKNQGYILDGYPRTLQQLEFMIKNGINLDCVFYLKIKNETI
CCCCHHHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHCCCCEEEEEEEEECCHHH
ISRLSQRLFCQKCQKSYNLLLAKPKNGLKCDLDNTDLITRNDDRPEIITHRIEKFNNSVI
HHHHHHHHHHHHHHHHCCEEEECCCCCCEECCCCCEEEECCCCCHHHHHHHHHHHCCCCH
PIVEFFKKSGIIYYLDAEQTLEETVIEIEKWL
HHHHHHHHCCEEEEECCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKSNKKILFIGAPGSGKGTISKILVEKYKLVHISTGDLFRKKISEDSRFAAQIQNYLSSG
CCCCCEEEEEECCCCCCHHHHHHHHHHHHEEEEECHHHHHHHHCCCHHHHHHHHHHHHCC
SYVPDEITNKLVADFIKKIPKNQGYILDGYPRTLQQLEFMIKNGINLDCVFYLKIKNETI
CCCCHHHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHCCCCEEEEEEEEECCHHH
ISRLSQRLFCQKCQKSYNLLLAKPKNGLKCDLDNTDLITRNDDRPEIITHRIEKFNNSVI
HHHHHHHHHHHHHHHHCCEEEECCCCCCEECCCCCEEEECCCCCHHHHHHHHHHHCCCCH
PIVEFFKKSGIIYYLDAEQTLEETVIEIEKWL
HHHHHHHHCCEEEEECCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA