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The map label for this gene is uvrC

Identifier: 52842851

GI number: 52842851

Start: 2991885

End: 2993741

Strand: Reverse

Name: uvrC

Synonym: lpg2645

Alternate gene names: 52842851

Gene position: 2993741-2991885 (Counterclockwise)

Preceding gene: 52842852

Following gene: 52842847

Centisome position: 88.11

GC content: 39.47

Gene sequence:

>1857_bases
ATGAATGACTTACAGCTTTCCGCTGAACTCGCTTTATTTTTAACGAAACTCCCAAGTGAACCGGGCATATACCGCATGTT
AGACGAAGAAGGCACCGTTCTATATGTGGGAAAAGCAGCCAATCTTAAAAAAAGAGTCAACAGCTATTTTAGTAAACAAA
ATACAGGAGTTAAGACACGAGCACTGGTAAGCCAAATCAAATCCATAGAAATTTCTGTGACAAGATCAGAGACAGAGGCC
TTATTATTAGAGAGTAATTTAATTAAAGCGTTAAGGCCAAAATATAATGTTTTGTTGCGTGATGACAAATCCTATCCTTA
TATTCATCTATCAAATCATCCAGACTTTCCAAGAATTGAGTTATACCGAAGTAAAAAGAAGCCGCCCTCCGGTAATTTTT
TTGGCCCCTATCCTGGGGTAGCTGCTGTAAGAGAAACGATAGTTACCATTCAAAAAATATTTAAAATTCGCAATTGCAGA
GACAGCTATTTTAAAGCTCGTTCTCGCCCTTGTTTACAATATCAAATAAAACGTTGTACCGCGCCTTGCGTTCATTATAT
TTCTCCTGAAAACTACAAATTGTCTGTAGAGGACGCCATAAGATTTTTACAGGGGAAGTGCCAAATAATTCTTGATGAAC
TTGCCGAACGAATGAAACAAGCGGTAAGTCAATTAAATTTCGAAGAAGCTGCTGTTTTGCGTGATCAGATAAAAAATTTG
CGCTTAATTCAAGAACAACAAGGAGTTGTCCAGTTACGTGGTGATGCTGATGTGATCGCAATAGAAGTACGTCCTGGTTT
CGCATGTATTCAGTGTGTGACTATTCGTGAAGGACAAGTATTGAATAGTCAAAGCTTTTTCCCTACAGTGCCTTATGCTG
TATTAGATGAAGAATTGGATGCCAATTCACTTTGGCAGCAGACTTTTGAAGCCTTTATTGGTTTTTATTATTTGGATACA
TCAGAAAGAATTCCGGATTTGATAATTACTAATCAATCAATAACAGAGAGTCGCTCATTAGAGTATATTTTGTCCCAGCG
ACGAGGCAAATCCTGTAAAATTCAAATCAATCCAAGAGGTGTCAAATCGAGATGGATGGATTTTGCAGTGAACAATTTAC
GAATTTCAGTAGCAGAATATGTCAGCAAACATTCTACGATAAGATCAAGATATCAGGCATTAAAGCAATTGCTTGCGCTT
GATAAAAATATAGAGCGAATGGAGTGTTTTGATATTAGCCATACTCAAGGTGAAGCAACTGTTGCATCTTGTGTTGTATT
TGATACAGAAGGCCCTCGCCCCAGTGAATACAGGCGATTTAACATTGAGGGTATTACTCCAGGGGATGATTACGCAGCAA
TGGAACAGGCAGTTACTCGCCGATTTAAAAGACTGATTGATGTTCAATTATTGCCAGATGTTTTGATTATTGATGGAGGT
AAAGGCCAGGTTTCTATTGTAAAACGAGTTTTAACCTCTCTGGGTGTGGAAGATATTACTTTATTAGGTGTATCCAAGGG
GCCTTCACGAAAGGCGGGATGGGAGAAATTGATACTGGTTAATGAAAACAGAGAATTTGTTTTGCCAGAGGACTCCAAAG
CGCTTCATCTTTTACAACATATTCGTGATGAAGCGCATCGTTTTGCTATTACTGCCCATCGGAAGAAAAGACAAAAGACA
CGTGTTGAATCCACTCTTGAAAGTATAGAGGGTGTTGGCGCGAAACGACGTCAAGCGTTGCTGCAGCGTTTTGGCGGGTT
GCGAGAGTTGGCTAAAGCGCCACTGGAAGAAATTTGTAAGGTCCAGGGAATCAGCGAGCAGTTGGCAAAGCGAATTTATG
AACATTTCCACCCTTGA

Upstream 100 bases:

>100_bases
TGGGGATTAAAAATGATGTGGAGCTTACTTATTTGGCTATGAAGCACCGCATTATTGAGCACCCCAATGATTTGTCACAA
GATGATTAGATGTTAATTTC

Downstream 100 bases:

>100_bases
TCAAAATTGAAGTTTTGCCATGCTTAAAAGGCTCTTACAGCACGTACAGCAGCCGTTTTATTTTTGGCAAGGTCTTTAAT
TTCCCCTGTTTTAGAATTAA

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 618; Mature: 618

Protein sequence:

>618_residues
MNDLQLSAELALFLTKLPSEPGIYRMLDEEGTVLYVGKAANLKKRVNSYFSKQNTGVKTRALVSQIKSIEISVTRSETEA
LLLESNLIKALRPKYNVLLRDDKSYPYIHLSNHPDFPRIELYRSKKKPPSGNFFGPYPGVAAVRETIVTIQKIFKIRNCR
DSYFKARSRPCLQYQIKRCTAPCVHYISPENYKLSVEDAIRFLQGKCQIILDELAERMKQAVSQLNFEEAAVLRDQIKNL
RLIQEQQGVVQLRGDADVIAIEVRPGFACIQCVTIREGQVLNSQSFFPTVPYAVLDEELDANSLWQQTFEAFIGFYYLDT
SERIPDLIITNQSITESRSLEYILSQRRGKSCKIQINPRGVKSRWMDFAVNNLRISVAEYVSKHSTIRSRYQALKQLLAL
DKNIERMECFDISHTQGEATVASCVVFDTEGPRPSEYRRFNIEGITPGDDYAAMEQAVTRRFKRLIDVQLLPDVLIIDGG
KGQVSIVKRVLTSLGVEDITLLGVSKGPSRKAGWEKLILVNENREFVLPEDSKALHLLQHIRDEAHRFAITAHRKKRQKT
RVESTLESIEGVGAKRRQALLQRFGGLRELAKAPLEEICKVQGISEQLAKRIYEHFHP

Sequences:

>Translated_618_residues
MNDLQLSAELALFLTKLPSEPGIYRMLDEEGTVLYVGKAANLKKRVNSYFSKQNTGVKTRALVSQIKSIEISVTRSETEA
LLLESNLIKALRPKYNVLLRDDKSYPYIHLSNHPDFPRIELYRSKKKPPSGNFFGPYPGVAAVRETIVTIQKIFKIRNCR
DSYFKARSRPCLQYQIKRCTAPCVHYISPENYKLSVEDAIRFLQGKCQIILDELAERMKQAVSQLNFEEAAVLRDQIKNL
RLIQEQQGVVQLRGDADVIAIEVRPGFACIQCVTIREGQVLNSQSFFPTVPYAVLDEELDANSLWQQTFEAFIGFYYLDT
SERIPDLIITNQSITESRSLEYILSQRRGKSCKIQINPRGVKSRWMDFAVNNLRISVAEYVSKHSTIRSRYQALKQLLAL
DKNIERMECFDISHTQGEATVASCVVFDTEGPRPSEYRRFNIEGITPGDDYAAMEQAVTRRFKRLIDVQLLPDVLIIDGG
KGQVSIVKRVLTSLGVEDITLLGVSKGPSRKAGWEKLILVNENREFVLPEDSKALHLLQHIRDEAHRFAITAHRKKRQKT
RVESTLESIEGVGAKRRQALLQRFGGLRELAKAPLEEICKVQGISEQLAKRIYEHFHP
>Mature_618_residues
MNDLQLSAELALFLTKLPSEPGIYRMLDEEGTVLYVGKAANLKKRVNSYFSKQNTGVKTRALVSQIKSIEISVTRSETEA
LLLESNLIKALRPKYNVLLRDDKSYPYIHLSNHPDFPRIELYRSKKKPPSGNFFGPYPGVAAVRETIVTIQKIFKIRNCR
DSYFKARSRPCLQYQIKRCTAPCVHYISPENYKLSVEDAIRFLQGKCQIILDELAERMKQAVSQLNFEEAAVLRDQIKNL
RLIQEQQGVVQLRGDADVIAIEVRPGFACIQCVTIREGQVLNSQSFFPTVPYAVLDEELDANSLWQQTFEAFIGFYYLDT
SERIPDLIITNQSITESRSLEYILSQRRGKSCKIQINPRGVKSRWMDFAVNNLRISVAEYVSKHSTIRSRYQALKQLLAL
DKNIERMECFDISHTQGEATVASCVVFDTEGPRPSEYRRFNIEGITPGDDYAAMEQAVTRRFKRLIDVQLLPDVLIIDGG
KGQVSIVKRVLTSLGVEDITLLGVSKGPSRKAGWEKLILVNENREFVLPEDSKALHLLQHIRDEAHRFAITAHRKKRQKT
RVESTLESIEGVGAKRRQALLQRFGGLRELAKAPLEEICKVQGISEQLAKRIYEHFHP

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=608, Percent_Identity=48.6842105263158, Blast_Score=562, Evalue=1e-161,
Organism=Escherichia coli, GI1788037, Length=201, Percent_Identity=28.8557213930348, Blast_Score=70, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 70507; Mature: 70507

Theoretical pI: Translated: 9.49; Mature: 9.49

Prosite motif: PS50151 UVR ; PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDLQLSAELALFLTKLPSEPGIYRMLDEEGTVLYVGKAANLKKRVNSYFSKQNTGVKTR
CCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCEEEEECCHHHHHHHHHHHHHCCCCCHHH
ALVSQIKSIEISVTRSETEALLLESNLIKALRPKYNVLLRDDKSYPYIHLSNHPDFPRIE
HHHHHHHHEEEEEECCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEECCCCCCCHHH
LYRSKKKPPSGNFFGPYPGVAAVRETIVTIQKIFKIRNCRDSYFKARSRPCLQYQIKRCT
HHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHC
APCVHYISPENYKLSVEDAIRFLQGKCQIILDELAERMKQAVSQLNFEEAAVLRDQIKNL
HHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
RLIQEQQGVVQLRGDADVIAIEVRPGFACIQCVTIREGQVLNSQSFFPTVPYAVLDEELD
HHHHHCCCCEEEECCCCEEEEEECCCCEEEEEEEECCCCEECCCCCCCCCCHHHHHCCCC
ANSLWQQTFEAFIGFYYLDTSERIPDLIITNQSITESRSLEYILSQRRGKSCKIQINPRG
HHHHHHHHHHHHHHEEEECCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCEEEEECCCC
VKSRWMDFAVNNLRISVAEYVSKHSTIRSRYQALKQLLALDKNIERMECFDISHTQGEAT
HHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEEECCCCCCCCCE
VASCVVFDTEGPRPSEYRRFNIEGITPGDDYAAMEQAVTRRFKRLIDVQLLPDVLIIDGG
EEEEEEEECCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECC
KGQVSIVKRVLTSLGVEDITLLGVSKGPSRKAGWEKLILVNENREFVLPEDSKALHLLQH
CCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCEEEEEEECCCCEECCCCCHHHHHHHH
IRDEAHRFAITAHRKKRQKTRVESTLESIEGVGAKRRQALLQRFGGLRELAKAPLEEICK
HHHHHHHEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHCCHHHHHH
VQGISEQLAKRIYEHFHP
HCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNDLQLSAELALFLTKLPSEPGIYRMLDEEGTVLYVGKAANLKKRVNSYFSKQNTGVKTR
CCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCEEEEECCHHHHHHHHHHHHHCCCCCHHH
ALVSQIKSIEISVTRSETEALLLESNLIKALRPKYNVLLRDDKSYPYIHLSNHPDFPRIE
HHHHHHHHEEEEEECCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEECCCCCCCHHH
LYRSKKKPPSGNFFGPYPGVAAVRETIVTIQKIFKIRNCRDSYFKARSRPCLQYQIKRCT
HHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHC
APCVHYISPENYKLSVEDAIRFLQGKCQIILDELAERMKQAVSQLNFEEAAVLRDQIKNL
HHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
RLIQEQQGVVQLRGDADVIAIEVRPGFACIQCVTIREGQVLNSQSFFPTVPYAVLDEELD
HHHHHCCCCEEEECCCCEEEEEECCCCEEEEEEEECCCCEECCCCCCCCCCHHHHHCCCC
ANSLWQQTFEAFIGFYYLDTSERIPDLIITNQSITESRSLEYILSQRRGKSCKIQINPRG
HHHHHHHHHHHHHHEEEECCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCEEEEECCCC
VKSRWMDFAVNNLRISVAEYVSKHSTIRSRYQALKQLLALDKNIERMECFDISHTQGEAT
HHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEEECCCCCCCCCE
VASCVVFDTEGPRPSEYRRFNIEGITPGDDYAAMEQAVTRRFKRLIDVQLLPDVLIIDGG
EEEEEEEECCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECC
KGQVSIVKRVLTSLGVEDITLLGVSKGPSRKAGWEKLILVNENREFVLPEDSKALHLLQH
CCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCEEEEEEECCCCEECCCCCHHHHHHHH
IRDEAHRFAITAHRKKRQKTRVESTLESIEGVGAKRRQALLQRFGGLRELAKAPLEEICK
HHHHHHHEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHCCHHHHHH
VQGISEQLAKRIYEHFHP
HCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA