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The map label for this gene is mscL

Identifier: 52842748

GI number: 52842748

Start: 2872433

End: 2872816

Strand: Reverse

Name: mscL

Synonym: lpg2540

Alternate gene names: 52842748

Gene position: 2872816-2872433 (Counterclockwise)

Preceding gene: 52842749

Following gene: 52842747

Centisome position: 84.55

GC content: 35.94

Gene sequence:

>384_bases
ATGAGTTTACTAAAGGAATTCAAAGAATTTGCCATGCGAGGCAATGTGATGGATTTGGCAGTTGCTGTTGTAATGGGTGT
TGCTTTTAATAAAATTGTCACTGCTTTGGTCGATGGAATTATCATGCCTTGCGTTGGTTTGTTATTGGGAGGCATCAATA
TTGCAGGATTGAGTTTTACTGTAGGAGACGTTCAAATCAAGTGGGGAAATTTTTTACAAAACGTCATTGATTTTATTATC
GTTGCTTTTGCTATTTTTGTACTCATCAAATTAATCAATCTGCTGCAGAGAAAAAAAGCAAATGAACCAGAACCAGTCAC
TCCAGAAATTCAATTACTTACTGAAATACGGGATCTGCTTGCAAGAAATAGCAGTAAAATCTGA

Upstream 100 bases:

>100_bases
CTACAAGCTAACAGGCTCAGAACAGTCTGTAATTGAAAGATTGGAAAAATTTTGCGAATATACATTTCATCGCATAACTT
AATCATGATAGGGATGTCTG

Downstream 100 bases:

>100_bases
AATTGGCTGGCAAAAATAAATCTCTATATATTTGCAGTCGGATACCCCCGTTCAAAATGGTTTGTTAAACAGCTTATGTT
TTATTTCGGTAAGATGTATA

Product: large conductance mechanosensitive channel

Products: non-specific ion/solute [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 127; Mature: 126

Protein sequence:

>127_residues
MSLLKEFKEFAMRGNVMDLAVAVVMGVAFNKIVTALVDGIIMPCVGLLLGGINIAGLSFTVGDVQIKWGNFLQNVIDFII
VAFAIFVLIKLINLLQRKKANEPEPVTPEIQLLTEIRDLLARNSSKI

Sequences:

>Translated_127_residues
MSLLKEFKEFAMRGNVMDLAVAVVMGVAFNKIVTALVDGIIMPCVGLLLGGINIAGLSFTVGDVQIKWGNFLQNVIDFII
VAFAIFVLIKLINLLQRKKANEPEPVTPEIQLLTEIRDLLARNSSKI
>Mature_126_residues
SLLKEFKEFAMRGNVMDLAVAVVMGVAFNKIVTALVDGIIMPCVGLLLGGINIAGLSFTVGDVQIKWGNFLQNVIDFIIV
AFAIFVLIKLINLLQRKKANEPEPVTPEIQLLTEIRDLLARNSSKI

Specific function: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell [H]

COG id: COG1970

COG function: function code M; Large-conductance mechanosensitive channel

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mscL family [H]

Homologues:

Organism=Escherichia coli, GI1789686, Length=136, Percent_Identity=55.1470588235294, Blast_Score=135, Evalue=9e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019823
- InterPro:   IPR001185
- InterPro:   IPR015089 [H]

Pfam domain/function: PF01741 MscL [H]

EC number: NA

Molecular weight: Translated: 13941; Mature: 13810

Theoretical pI: Translated: 8.51; Mature: 8.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLLKEFKEFAMRGNVMDLAVAVVMGVAFNKIVTALVDGIIMPCVGLLLGGINIAGLSFT
CHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCEEE
VGDVQIKWGNFLQNVIDFIIVAFAIFVLIKLINLLQRKKANEPEPVTPEIQLLTEIRDLL
ECCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
ARNSSKI
HCCCCCC
>Mature Secondary Structure 
SLLKEFKEFAMRGNVMDLAVAVVMGVAFNKIVTALVDGIIMPCVGLLLGGINIAGLSFT
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCEEE
VGDVQIKWGNFLQNVIDFIIVAFAIFVLIKLINLLQRKKANEPEPVTPEIQLLTEIRDLL
ECCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
ARNSSKI
HCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: non-specific ion/solute [Cytoplasm] [C]

Specific reaction: non-specific ion/solute [Cytoplasm] = non-specific ion/solute [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA