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The map label for this gene is hypB

Identifier: 52842683

GI number: 52842683

Start: 2790102

End: 2790860

Strand: Reverse

Name: hypB

Synonym: lpg2475

Alternate gene names: 52842683

Gene position: 2790860-2790102 (Counterclockwise)

Preceding gene: 52842684

Following gene: 52842682

Centisome position: 82.14

GC content: 40.32

Gene sequence:

>759_bases
ATGTGCGGGATATGCGGATGTTCAGTAGAAAAAGGTCAAACCATGGATAATGGGCATCATGCTGCTCACCATGAGCATTC
TGTGCCTCATGAACATTCAGTTGATATCGAGCAGAATATTTTAGCGCAAAACAATGAATTTGCTGCTCATAACCGGGATT
ATTTTCTCAGGCATAAAATTTTGGCTTTGAATTTGATGTCAAGCCCTGGATCCGGGAAGACAACATTGCTTTCCAAAACC
ATTTCCGAACTTGGCAAGGAAATGGATATTGCAGTCATAGTAGGTGATCAACAAACAAATTGTGATGCCCAAATGCTAAA
ATCTCATGGAGGGGATGCCTGGCAAATTAATACTGGAAAAGTATGCCATTTGGATGCCCATATGATCAGTCACGCCATAC
AAGATATTTCCCTAAAAAAGCAATCGCTTTTATTTATCGAAAATGTGGGTAATCTCGTTTGCCCGGCTTCATTTCATCTG
GGCGAGCAATTCAGAATAGTAGTTCTTTCTGTGACGGAAGGAGAGAATAAACCGCTCAAATACCCTGATATGTTTCATTC
AGCAGATTTGCTTCTGATAACCAAAGCAGATTTATTACCCCATGTGAATTTTGATTTGGATTTATGTAAGGAATATGTAC
GCCGCACGAATCCATCCATAGACATTATTACCCTGTCAGCGGTTAATGGTGTTGGATTGAAGGATTGGCACGATTGGTTG
TTGCATTCTTTTAGGTTGAATGTCCAGTCTTCTTCATAG

Upstream 100 bases:

>100_bases
CGATGAAACAGTATTATGATGAATGCCTGGTTTGCGGCAATCATTCCTTAACACTGACAAAAGGTGAAGAATTAAAAGTG
AAATCAATGGTGGTGGAATA

Downstream 100 bases:

>100_bases
AAAAAGTGGTAGCCCATGGAATTGGAACGGGTACAAATTAGCATTCAAGGACTAGTGCAAGGGGTTGGTTTTAGACCGTG
CGTTTATAAGCTTGCCAAAC

Product: hydrogenase nickel incorporation protein HypB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 252; Mature: 252

Protein sequence:

>252_residues
MCGICGCSVEKGQTMDNGHHAAHHEHSVPHEHSVDIEQNILAQNNEFAAHNRDYFLRHKILALNLMSSPGSGKTTLLSKT
ISELGKEMDIAVIVGDQQTNCDAQMLKSHGGDAWQINTGKVCHLDAHMISHAIQDISLKKQSLLFIENVGNLVCPASFHL
GEQFRIVVLSVTEGENKPLKYPDMFHSADLLLITKADLLPHVNFDLDLCKEYVRRTNPSIDIITLSAVNGVGLKDWHDWL
LHSFRLNVQSSS

Sequences:

>Translated_252_residues
MCGICGCSVEKGQTMDNGHHAAHHEHSVPHEHSVDIEQNILAQNNEFAAHNRDYFLRHKILALNLMSSPGSGKTTLLSKT
ISELGKEMDIAVIVGDQQTNCDAQMLKSHGGDAWQINTGKVCHLDAHMISHAIQDISLKKQSLLFIENVGNLVCPASFHL
GEQFRIVVLSVTEGENKPLKYPDMFHSADLLLITKADLLPHVNFDLDLCKEYVRRTNPSIDIITLSAVNGVGLKDWHDWL
LHSFRLNVQSSS
>Mature_252_residues
MCGICGCSVEKGQTMDNGHHAAHHEHSVPHEHSVDIEQNILAQNNEFAAHNRDYFLRHKILALNLMSSPGSGKTTLLSKT
ISELGKEMDIAVIVGDQQTNCDAQMLKSHGGDAWQINTGKVCHLDAHMISHAIQDISLKKQSLLFIENVGNLVCPASFHL
GEQFRIVVLSVTEGENKPLKYPDMFHSADLLLITKADLLPHVNFDLDLCKEYVRRTNPSIDIITLSAVNGVGLKDWHDWL
LHSFRLNVQSSS

Specific function: Could be involved in nickel binding and accumulation [H]

COG id: COG0378

COG function: function code OK; Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hypB/hupM family [H]

Homologues:

Organism=Escherichia coli, GI1789082, Length=224, Percent_Identity=51.3392857142857, Blast_Score=233, Evalue=8e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003495
- InterPro:   IPR004392
- InterPro:   IPR012202 [H]

Pfam domain/function: PF02492 cobW [H]

EC number: NA

Molecular weight: Translated: 28001; Mature: 28001

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGICGCSVEKGQTMDNGHHAAHHEHSVPHEHSVDIEQNILAQNNEFAAHNRDYFLRHKI
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCHHHEEE
LALNLMSSPGSGKTTLLSKTISELGKEMDIAVIVGDQQTNCDAQMLKSHGGDAWQINTGK
EEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHCCCCEEEECCCC
VCHLDAHMISHAIQDISLKKQSLLFIENVGNLVCPASFHLGEQFRIVVLSVTEGENKPLK
EEEEHHHHHHHHHHHHHCCHHHEEEEECCCCEECCCCCCCCCEEEEEEEEEECCCCCCCC
YPDMFHSADLLLITKADLLPHVNFDLDLCKEYVRRTNPSIDIITLSAVNGVGLKDWHDWL
CCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHH
LHSFRLNVQSSS
HHHHEEEEECCC
>Mature Secondary Structure
MCGICGCSVEKGQTMDNGHHAAHHEHSVPHEHSVDIEQNILAQNNEFAAHNRDYFLRHKI
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCHHHEEE
LALNLMSSPGSGKTTLLSKTISELGKEMDIAVIVGDQQTNCDAQMLKSHGGDAWQINTGK
EEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHCCCCEEEECCCC
VCHLDAHMISHAIQDISLKKQSLLFIENVGNLVCPASFHLGEQFRIVVLSVTEGENKPLK
EEEEHHHHHHHHHHHHHCCHHHEEEEECCCCEECCCCCCCCCEEEEEEEEEECCCCCCCC
YPDMFHSADLLLITKADLLPHVNFDLDLCKEYVRRTNPSIDIITLSAVNGVGLKDWHDWL
CCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHH
LHSFRLNVQSSS
HHHHEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8486288 [H]