Click here to switch to the map view.

The map label for this gene is hmp [H]

Identifier: 52841278

GI number: 52841278

Start: 1142681

End: 1144654

Strand: Reverse

Name: hmp [H]

Synonym: lpg1044

Alternate gene names: 52841278

Gene position: 1144654-1142681 (Counterclockwise)

Preceding gene: 52841281

Following gene: 52841277

Centisome position: 33.69

GC content: 44.17

Gene sequence:

>1974_bases
TTGGAAATTTGTTACAGAATATGGGATAAACTAATAAGAGGCAGGAAAACAAATAATCTCAGCTTGTTCAGTGCGCTTTG
GAGGGAAAGGATGCTGTTTCAATACATTAAAAAGTTTTTCCTATTTCTATGGGTTCAAGCAGTATCTATTTCTTTCCTGT
TGGCGATGGCTTCTGTTTCCTTTGCTCAACTCACAGCACAAGACCATGCTGCCCATCATCAAGGAGAAAAAGAAAGTGAG
GGAATGGGGGGCATGATGAAAAACATAGGGACTCCCTCTAAGGAACTGTACCCTTCTTTAATGAATTTACCCACATTATC
CCCCGAAAAACGCCTTGCAATTCAACAAAAGGCACATCAACGCATCACATCCGGCATGGCGCTCATGAAAGGTGGACTTA
ACGAGCTTTTGTTGGCATCCAACAATAACGATTACGCTAAAATGCAAGAAGCTTTAGAGAAATTACGGGAAGGGATAGCG
CAATATGAGAGTGCACTGGCTGCACTTCGCGCACTGTCTGAAGGAAAAAATCCTCGCGACATCGCTTTGCAGTGGTTTAA
ACGTGAAATGAATCTTCTTCCAAGTACTCCTCAAGCCAAAAATGTCTTAGGCGGTCCTTTTTTTCATTTAACGATTATCG
CTCTATTTGGTCTGTTTTTTTTGGTCATGATTTGGATGTATTTTTTCAAAATGAGAAGAGCGGCTGCTTTGCTCGATCGC
TTAACCAAACAAAATGCGACTGTATCTTCAGAGACACCACCCCAATTCTCAAAAGCACCTGAACCAACCCCTTCCTTAAC
ATCTGTAGAGCCTATTAAATCCTCTCAAGTTTCTAAAGTGCCATCAGAAACAGCCCCAACTACGCCTCCTACCTGCCCCG
CTCATAAATGTCCTGTCCCGCAATTTCCAGTCATGAGATCGCTCACCGAACCGGAAGAGAAATGGGAAGGACAACTTCGT
GTTTGCCGTATCTTTCAAGAAGCCCCGGGAATCAAAACGTTTCATTTGGCATCAACCCATGAGGTGGCTTTGCCATTTAC
CTATTATCCTGGCCAGTTCATTACGCTCACCGCCTTAATTAATGGTAAAACCGTAAGACGCAGTTACACCATGGCGTCCA
CCCCAACCCAATTGCATTATTGCGCCATCACGGTCAAGCGGGAAGAACAAGGCGTGTTTTCCCGTTATTTGCATGACGAA
ATTAAAGAAGGGGATTTACTGGAGGTGATGGGACCTAATGGTAAATTTACCTTTACTGGTGAAGAGGCAAAGAGCATTGT
ACTGATTTGTGGAGGAGTTGGTATTACCCCGATGATGAGTATCATCCGCTACCTCACCGATATTGGATGGCACAATGACA
TTTATTTGCTGTACTGTTGTCGCACGACGAGTGAGTTTCTCTTTCGCGAAGAATTAGAGCAACTTCAAGAAAGATACCTT
AATCTCCATGTGTACGCGTCGATGCTGCGTTCAGAGGGAACCATTTGGATGGGGTTGCAAGGCCTATTTACCAAGAACAT
CATCAGCCATCTTGTCCCTGATATTGCCTCTCATCGTATCCACGTTTGTGGTCCTCCTGCGATGATGGCAGCCATCCTTG
GTATCTTAAAAGAACTTAAGGTGCCCGCTGATTTGATTCTAACAGAAGCATTTGGACCAGAAAAGAAACCAGAAATAATC
CAAGAAGACTTAGAGGCCATCAAAGCCGATACCCGTTCGATGATTTCTTTTCGGAAATCTGAAAAAATGGTTCCGATTCT
TCCAGACCGTACCCTTCTTGAAATCGCTGAAGCCAATGGAATTGCGATTGATAATGCGTGTCGAACCGGGCAATGCGGGT
TATGTAAAGTGAAATTGCTGTCAGGGGAAGTGACCATGGCTTGTGAAGATGCGCTTTCAAAGGAAGACAAACAACAGAGG
CTCATCTTAGCCTGTCAGGCCAAAGCGACTCAAAACATTGAGGTGGATGCTTAA

Upstream 100 bases:

>100_bases
CAGAACCTCAAAATAGAGCAAATAACGTACTGATTTGGTTGAGTTTCTAATCCATGGAATGAATGACTGCATGAATTCCT
AATCATACCCTTTTAAGTTA

Downstream 100 bases:

>100_bases
TGAATGCGCAAGGACGTATGATGGTTTTGGGCTTAGTACTTCTAATGCTTATCACATGGCTAGGCTTTGCAGTCCATACG
TCTTATCGTTTTGCCGGGAG

Product: oxidoreductase, FAD-binding

Products: NA

Alternate protein names: Rieske-type oxygenase; RO [H]

Number of amino acids: Translated: 657; Mature: 657

Protein sequence:

>657_residues
MEICYRIWDKLIRGRKTNNLSLFSALWRERMLFQYIKKFFLFLWVQAVSISFLLAMASVSFAQLTAQDHAAHHQGEKESE
GMGGMMKNIGTPSKELYPSLMNLPTLSPEKRLAIQQKAHQRITSGMALMKGGLNELLLASNNNDYAKMQEALEKLREGIA
QYESALAALRALSEGKNPRDIALQWFKREMNLLPSTPQAKNVLGGPFFHLTIIALFGLFFLVMIWMYFFKMRRAAALLDR
LTKQNATVSSETPPQFSKAPEPTPSLTSVEPIKSSQVSKVPSETAPTTPPTCPAHKCPVPQFPVMRSLTEPEEKWEGQLR
VCRIFQEAPGIKTFHLASTHEVALPFTYYPGQFITLTALINGKTVRRSYTMASTPTQLHYCAITVKREEQGVFSRYLHDE
IKEGDLLEVMGPNGKFTFTGEEAKSIVLICGGVGITPMMSIIRYLTDIGWHNDIYLLYCCRTTSEFLFREELEQLQERYL
NLHVYASMLRSEGTIWMGLQGLFTKNIISHLVPDIASHRIHVCGPPAMMAAILGILKELKVPADLILTEAFGPEKKPEII
QEDLEAIKADTRSMISFRKSEKMVPILPDRTLLEIAEANGIAIDNACRTGQCGLCKVKLLSGEVTMACEDALSKEDKQQR
LILACQAKATQNIEVDA

Sequences:

>Translated_657_residues
MEICYRIWDKLIRGRKTNNLSLFSALWRERMLFQYIKKFFLFLWVQAVSISFLLAMASVSFAQLTAQDHAAHHQGEKESE
GMGGMMKNIGTPSKELYPSLMNLPTLSPEKRLAIQQKAHQRITSGMALMKGGLNELLLASNNNDYAKMQEALEKLREGIA
QYESALAALRALSEGKNPRDIALQWFKREMNLLPSTPQAKNVLGGPFFHLTIIALFGLFFLVMIWMYFFKMRRAAALLDR
LTKQNATVSSETPPQFSKAPEPTPSLTSVEPIKSSQVSKVPSETAPTTPPTCPAHKCPVPQFPVMRSLTEPEEKWEGQLR
VCRIFQEAPGIKTFHLASTHEVALPFTYYPGQFITLTALINGKTVRRSYTMASTPTQLHYCAITVKREEQGVFSRYLHDE
IKEGDLLEVMGPNGKFTFTGEEAKSIVLICGGVGITPMMSIIRYLTDIGWHNDIYLLYCCRTTSEFLFREELEQLQERYL
NLHVYASMLRSEGTIWMGLQGLFTKNIISHLVPDIASHRIHVCGPPAMMAAILGILKELKVPADLILTEAFGPEKKPEII
QEDLEAIKADTRSMISFRKSEKMVPILPDRTLLEIAEANGIAIDNACRTGQCGLCKVKLLSGEVTMACEDALSKEDKQQR
LILACQAKATQNIEVDA
>Mature_657_residues
MEICYRIWDKLIRGRKTNNLSLFSALWRERMLFQYIKKFFLFLWVQAVSISFLLAMASVSFAQLTAQDHAAHHQGEKESE
GMGGMMKNIGTPSKELYPSLMNLPTLSPEKRLAIQQKAHQRITSGMALMKGGLNELLLASNNNDYAKMQEALEKLREGIA
QYESALAALRALSEGKNPRDIALQWFKREMNLLPSTPQAKNVLGGPFFHLTIIALFGLFFLVMIWMYFFKMRRAAALLDR
LTKQNATVSSETPPQFSKAPEPTPSLTSVEPIKSSQVSKVPSETAPTTPPTCPAHKCPVPQFPVMRSLTEPEEKWEGQLR
VCRIFQEAPGIKTFHLASTHEVALPFTYYPGQFITLTALINGKTVRRSYTMASTPTQLHYCAITVKREEQGVFSRYLHDE
IKEGDLLEVMGPNGKFTFTGEEAKSIVLICGGVGITPMMSIIRYLTDIGWHNDIYLLYCCRTTSEFLFREELEQLQERYL
NLHVYASMLRSEGTIWMGLQGLFTKNIISHLVPDIASHRIHVCGPPAMMAAILGILKELKVPADLILTEAFGPEKKPEII
QEDLEAIKADTRSMISFRKSEKMVPILPDRTLLEIAEANGIAIDNACRTGQCGLCKVKLLSGEVTMACEDALSKEDKQQR
LILACQAKATQNIEVDA

Specific function: Catalyzes the opening of ring B of 1,4-androstadiene- 3,17,-dione (ADD) and 4-androstene-3,17-dione (ADD) with concomitant aromatization of ring A. The ring B is subsequently hydroxylated to yield a catechol and then subject to meta- cleavage [H]

COG id: COG1018

COG function: function code C; Flavodoxin reductases (ferredoxin-NADPH reductases) family 1

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding FR-type domain [H]

Homologues:

Organism=Homo sapiens, GI49574502, Length=253, Percent_Identity=29.2490118577075, Blast_Score=93, Evalue=7e-19,
Organism=Homo sapiens, GI284448553, Length=220, Percent_Identity=28.6363636363636, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI6552328, Length=220, Percent_Identity=28.6363636363636, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI193794826, Length=220, Percent_Identity=28.6363636363636, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI284448551, Length=220, Percent_Identity=28.6363636363636, Blast_Score=80, Evalue=7e-15,
Organism=Homo sapiens, GI4503327, Length=220, Percent_Identity=28.6363636363636, Blast_Score=80, Evalue=7e-15,
Organism=Homo sapiens, GI47778923, Length=240, Percent_Identity=27.0833333333333, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI1787098, Length=342, Percent_Identity=29.5321637426901, Blast_Score=132, Evalue=6e-32,
Organism=Escherichia coli, GI1787658, Length=353, Percent_Identity=28.0453257790368, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI1788104, Length=326, Percent_Identity=27.3006134969325, Blast_Score=103, Evalue=4e-23,
Organism=Escherichia coli, GI1788903, Length=259, Percent_Identity=26.2548262548263, Blast_Score=77, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17563928, Length=270, Percent_Identity=27.037037037037, Blast_Score=76, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17563926, Length=221, Percent_Identity=28.5067873303167, Blast_Score=74, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6323552, Length=194, Percent_Identity=28.3505154639175, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6323510, Length=191, Percent_Identity=26.7015706806283, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6322146, Length=194, Percent_Identity=29.8969072164948, Blast_Score=76, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6322699, Length=192, Percent_Identity=30.2083333333333, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6321673, Length=229, Percent_Identity=26.6375545851528, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006058
- InterPro:   IPR012675
- InterPro:   IPR017927
- InterPro:   IPR001041
- InterPro:   IPR001709
- InterPro:   IPR008333
- InterPro:   IPR001433
- InterPro:   IPR001221
- InterPro:   IPR017938 [H]

Pfam domain/function: PF00970 FAD_binding_6; PF00111 Fer2; PF00175 NAD_binding_1 [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 73791; Mature: 73791

Theoretical pI: Translated: 8.20; Mature: 8.20

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEICYRIWDKLIRGRKTNNLSLFSALWRERMLFQYIKKFFLFLWVQAVSISFLLAMASVS
CCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FAQLTAQDHAAHHQGEKESEGMGGMMKNIGTPSKELYPSLMNLPTLSPEKRLAIQQKAHQ
HHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHH
RITSGMALMKGGLNELLLASNNNDYAKMQEALEKLREGIAQYESALAALRALSEGKNPRD
HHHHHHHHHHCCCHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
IALQWFKREMNLLPSTPQAKNVLGGPFFHLTIIALFGLFFLVMIWMYFFKMRRAAALLDR
HHHHHHHHHHHCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LTKQNATVSSETPPQFSKAPEPTPSLTSVEPIKSSQVSKVPSETAPTTPPTCPAHKCPVP
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCC
QFPVMRSLTEPEEKWEGQLRVCRIFQEAPGIKTFHLASTHEVALPFTYYPGQFITLTALI
CCHHHHHCCCCHHHHCCHHHHHHHHHHCCCCEEEEECCCCCEEEEEEECCCCEEEEEEEE
NGKTVRRSYTMASTPTQLHYCAITVKREEQGVFSRYLHDEIKEGDLLEVMGPNGKFTFTG
CCCCCEEEEEECCCCCEEEEEEEEEECHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEEC
EEAKSIVLICGGVGITPMMSIIRYLTDIGWHNDIYLLYCCRTTSEFLFREELEQLQERYL
CCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHH
NLHVYASMLRSEGTIWMGLQGLFTKNIISHLVPDIASHRIHVCGPPAMMAAILGILKELK
HHHHHHHHHHCCCCEEECHHHHHHHHHHHHHHHHHHHCEEEEECCHHHHHHHHHHHHHHC
VPADLILTEAFGPEKKPEIIQEDLEAIKADTRSMISFRKSEKMVPILPDRTLLEIAEANG
CCHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCC
IAIDNACRTGQCGLCKVKLLSGEVTMACEDALSKEDKQQRLILACQAKATQNIEVDA
EEECCCCCCCCCCEEEEEEECCCCHHHHHHHHCCCCHHHHEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MEICYRIWDKLIRGRKTNNLSLFSALWRERMLFQYIKKFFLFLWVQAVSISFLLAMASVS
CCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FAQLTAQDHAAHHQGEKESEGMGGMMKNIGTPSKELYPSLMNLPTLSPEKRLAIQQKAHQ
HHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHH
RITSGMALMKGGLNELLLASNNNDYAKMQEALEKLREGIAQYESALAALRALSEGKNPRD
HHHHHHHHHHCCCHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
IALQWFKREMNLLPSTPQAKNVLGGPFFHLTIIALFGLFFLVMIWMYFFKMRRAAALLDR
HHHHHHHHHHHCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LTKQNATVSSETPPQFSKAPEPTPSLTSVEPIKSSQVSKVPSETAPTTPPTCPAHKCPVP
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCC
QFPVMRSLTEPEEKWEGQLRVCRIFQEAPGIKTFHLASTHEVALPFTYYPGQFITLTALI
CCHHHHHCCCCHHHHCCHHHHHHHHHHCCCCEEEEECCCCCEEEEEEECCCCEEEEEEEE
NGKTVRRSYTMASTPTQLHYCAITVKREEQGVFSRYLHDEIKEGDLLEVMGPNGKFTFTG
CCCCCEEEEEECCCCCEEEEEEEEEECHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEEC
EEAKSIVLICGGVGITPMMSIIRYLTDIGWHNDIYLLYCCRTTSEFLFREELEQLQERYL
CCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHH
NLHVYASMLRSEGTIWMGLQGLFTKNIISHLVPDIASHRIHVCGPPAMMAAILGILKELK
HHHHHHHHHHCCCCEEECHHHHHHHHHHHHHHHHHHHCEEEEECCHHHHHHHHHHHHHHC
VPADLILTEAFGPEKKPEIIQEDLEAIKADTRSMISFRKSEKMVPILPDRTLLEIAEANG
CCHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCC
IAIDNACRTGQCGLCKVKLLSGEVTMACEDALSKEDKQQRLILACQAKATQNIEVDA
EEECCCCCCCCCCEEEEEEECCCCHHHHHHHHCCCCHHHHEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]