Click here to switch to the map view.

The map label for this gene is pdxB

Identifier: 52841153

GI number: 52841153

Start: 991514

End: 992566

Strand: Reverse

Name: pdxB

Synonym: lpg0918

Alternate gene names: 52841153

Gene position: 992566-991514 (Counterclockwise)

Preceding gene: 52841154

Following gene: 52841143

Centisome position: 29.21

GC content: 38.56

Gene sequence:

>1053_bases
ATGAACATTTTAGCAGATGCTTTATTGCCAGGATTAGATAGTGCTTTTCCACCACCATTTACCGTAACTTTGTATCATAA
GGCCGATGAAATTCCAGAATTGCTTCACTATAAGGACGTTCTTCTTTGTCGTTCAACCCTAAAAATAAATGGCGATTTAC
TCAAAAACCACCAAATAAAGTTTGTTGCGACAGCAACCAGTGGAACCGATCATATTGATTTTCCTTTTTTAGAATCACAA
AACATATCTATTATTGATGCCAAAGGATGCAATGCCATATCGGTTGCTGACTATGTTGTTGCTTGCCTTGCCTATTTAGA
TAAACAGCAACTTATTCAAGGTAAAACAGCAGGAATTATTGGTTTAGGGCAAGTAGGTACTAAAGTTTATGAACGACTAA
ATGCTGCCGAATTTCAGTTATGCCTTTATGACCCACCCAAAGCAACCAGAGATACTTCTTTTCAAAGCTGCTCTCTTGAA
GATCTTTTTGAATGTGACCTCTTATGTGTTCATGCTGAATTACATAGCGATGCGCCCTACCCAAGCCTTAACTTAATTAA
TCGGGATTTTCTCAAGGAATTAAAACCTGGCTGCATTATCATCAATGCTTCTCGAGGAGGTATCGTTAATGAAGAAGCCC
TTTTGCATCTTGGCTCTGCCATACTTTATTGCACCGACGTCTACAATAACGAACCTCATATAGATAGCCGGATTGTCTCC
AAGGCAACTCTTTGCACACCACATATTGCAGGACACAGCCTCGAAGCTAAATTTGCTGCAGTCGCAATCGTCAGTCGTAA
ATTACATCAAATGCTTGGTCTTCCATACCCACAATTTGCAACCCCTGAAAAACCTTATAGATTAAATGAAAACAGCGACT
GGAGAGAGTTGGCTTTATCAATATATAACCCGATTCATGAAACACTAGAATTAAAACACGCTGGAAATCTATCCTCAGCA
TTCTTGACTCTTCGCAAGAATCATCATCACCGCCATGATTTCACAACTTATTTTGATTCTGACTCAATAAAAAAGTATCC
ATTATTAGGTTAA

Upstream 100 bases:

>100_bases
TTTTAATATTGATTGTACTAATTTTTACTAATGTATTGGGGTATATTCTTACTCCCCTCATCTATGGTTCATTATATATT
TTAAGCGCGATTTTTAATTT

Downstream 100 bases:

>100_bases
GGTGTTGATGTCTGTTTCTAATAATTAACCCCTGTCCCGAAATTTTAATTATTCATCAAACGTCTTACAACTTCCTGATC
AGAAAAAACATGTTTTGTAT

Product: erythronate-4-phosphate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 350; Mature: 350

Protein sequence:

>350_residues
MNILADALLPGLDSAFPPPFTVTLYHKADEIPELLHYKDVLLCRSTLKINGDLLKNHQIKFVATATSGTDHIDFPFLESQ
NISIIDAKGCNAISVADYVVACLAYLDKQQLIQGKTAGIIGLGQVGTKVYERLNAAEFQLCLYDPPKATRDTSFQSCSLE
DLFECDLLCVHAELHSDAPYPSLNLINRDFLKELKPGCIIINASRGGIVNEEALLHLGSAILYCTDVYNNEPHIDSRIVS
KATLCTPHIAGHSLEAKFAAVAIVSRKLHQMLGLPYPQFATPEKPYRLNENSDWRELALSIYNPIHETLELKHAGNLSSA
FLTLRKNHHHRHDFTTYFDSDSIKKYPLLG

Sequences:

>Translated_350_residues
MNILADALLPGLDSAFPPPFTVTLYHKADEIPELLHYKDVLLCRSTLKINGDLLKNHQIKFVATATSGTDHIDFPFLESQ
NISIIDAKGCNAISVADYVVACLAYLDKQQLIQGKTAGIIGLGQVGTKVYERLNAAEFQLCLYDPPKATRDTSFQSCSLE
DLFECDLLCVHAELHSDAPYPSLNLINRDFLKELKPGCIIINASRGGIVNEEALLHLGSAILYCTDVYNNEPHIDSRIVS
KATLCTPHIAGHSLEAKFAAVAIVSRKLHQMLGLPYPQFATPEKPYRLNENSDWRELALSIYNPIHETLELKHAGNLSSA
FLTLRKNHHHRHDFTTYFDSDSIKKYPLLG
>Mature_350_residues
MNILADALLPGLDSAFPPPFTVTLYHKADEIPELLHYKDVLLCRSTLKINGDLLKNHQIKFVATATSGTDHIDFPFLESQ
NISIIDAKGCNAISVADYVVACLAYLDKQQLIQGKTAGIIGLGQVGTKVYERLNAAEFQLCLYDPPKATRDTSFQSCSLE
DLFECDLLCVHAELHSDAPYPSLNLINRDFLKELKPGCIIINASRGGIVNEEALLHLGSAILYCTDVYNNEPHIDSRIVS
KATLCTPHIAGHSLEAKFAAVAIVSRKLHQMLGLPYPQFATPEKPYRLNENSDWRELALSIYNPIHETLELKHAGNLSSA
FLTLRKNHHHRHDFTTYFDSDSIKKYPLLG

Specific function: Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. PdxB subfamily

Homologues:

Organism=Homo sapiens, GI23308577, Length=259, Percent_Identity=27.027027027027, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI4557497, Length=172, Percent_Identity=33.1395348837209, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI61743967, Length=172, Percent_Identity=33.1395348837209, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI145580575, Length=172, Percent_Identity=31.9767441860465, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI145580578, Length=172, Percent_Identity=31.9767441860465, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI4557499, Length=172, Percent_Identity=31.9767441860465, Blast_Score=69, Evalue=5e-12,
Organism=Escherichia coli, GI1788660, Length=316, Percent_Identity=33.2278481012658, Blast_Score=158, Evalue=5e-40,
Organism=Escherichia coli, GI1787645, Length=207, Percent_Identity=23.1884057971014, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17532191, Length=290, Percent_Identity=26.551724137931, Blast_Score=96, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6324055, Length=153, Percent_Identity=29.4117647058824, Blast_Score=70, Evalue=6e-13,
Organism=Drosophila melanogaster, GI19921140, Length=270, Percent_Identity=25.5555555555556, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI62472511, Length=249, Percent_Identity=26.9076305220884, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24646446, Length=238, Percent_Identity=27.7310924369748, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24646448, Length=238, Percent_Identity=27.7310924369748, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24646452, Length=238, Percent_Identity=27.7310924369748, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24646450, Length=238, Percent_Identity=27.7310924369748, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXB_LEGPA (Q5X6I6)

Other databases:

- EMBL:   CR628336
- RefSeq:   YP_123307.1
- HSSP:   P0A9T0
- ProteinModelPortal:   Q5X6I6
- SMR:   Q5X6I6
- STRING:   Q5X6I6
- GeneID:   3117357
- GenomeReviews:   CR628336_GR
- KEGG:   lpp:lpp0979
- LegioList:   lpp0979
- eggNOG:   COG0111
- HOGENOM:   HBG519932
- OMA:   PTILIAN
- ProtClustDB:   CLSK832497
- BioCyc:   LPNE297246:LPP0979-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01825
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR020921
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR10996:SF4

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C

EC number: =1.1.1.290

Molecular weight: Translated: 38952; Mature: 38952

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1; PS00670 D_2_HYDROXYACID_DH_2; PS00671 D_2_HYDROXYACID_DH_3

Important sites: ACT_SITE 205-205 ACT_SITE 231-231 ACT_SITE 248-248 BINDING 45-45 BINDING 66-66 BINDING 144-144 BINDING 226-226 BINDING 251-251

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNILADALLPGLDSAFPPPFTVTLYHKADEIPELLHYKDVLLCRSTLKINGDLLKNHQIK
CCCCHHHHHCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHEECCCEECCCCEE
FVATATSGTDHIDFPFLESQNISIIDAKGCNAISVADYVVACLAYLDKQQLIQGKTAGII
EEEEECCCCCCCCCCCCCCCCEEEEECCCCCEEHHHHHHHHHHHHHCHHHHHCCCCCCEE
GLGQVGTKVYERLNAAEFQLCLYDPPKATRDTSFQSCSLEDLFECDLLCVHAELHSDAPY
EEHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHCCCEEEEEEECCCCCCC
PSLNLINRDFLKELKPGCIIINASRGGIVNEEALLHLGSAILYCTDVYNNEPHIDSRIVS
CCHHHHCHHHHHHCCCCEEEEECCCCCCCCHHHHHHHCCEEEEEEECCCCCCCCHHHHHH
KATLCTPHIAGHSLEAKFAAVAIVSRKLHQMLGLPYPQFATPEKPYRLNENSDWRELALS
HHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCCCCCHHHHHHH
IYNPIHETLELKHAGNLSSAFLTLRKNHHHRHDFTTYFDSDSIKKYPLLG
HHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCC
>Mature Secondary Structure
MNILADALLPGLDSAFPPPFTVTLYHKADEIPELLHYKDVLLCRSTLKINGDLLKNHQIK
CCCCHHHHHCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHEECCCEECCCCEE
FVATATSGTDHIDFPFLESQNISIIDAKGCNAISVADYVVACLAYLDKQQLIQGKTAGII
EEEEECCCCCCCCCCCCCCCCEEEEECCCCCEEHHHHHHHHHHHHHCHHHHHCCCCCCEE
GLGQVGTKVYERLNAAEFQLCLYDPPKATRDTSFQSCSLEDLFECDLLCVHAELHSDAPY
EEHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHCCCEEEEEEECCCCCCC
PSLNLINRDFLKELKPGCIIINASRGGIVNEEALLHLGSAILYCTDVYNNEPHIDSRIVS
CCHHHHCHHHHHHCCCCEEEEECCCCCCCCHHHHHHHCCEEEEEEECCCCCCCCHHHHHH
KATLCTPHIAGHSLEAKFAAVAIVSRKLHQMLGLPYPQFATPEKPYRLNENSDWRELALS
HHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCCCCCHHHHHHH
IYNPIHETLELKHAGNLSSAFLTLRKNHHHRHDFTTYFDSDSIKKYPLLG
HHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA